3LDX-I-H

PDB Title DISCOVERY AND CLINICAL EVALUATION OF RWJ-671818, A THROMBIN INHIBITOR WITH AN OXYGUANIDINE P1 MOTIF
Resolution (Å) 2.250
Classification HYDROLASE/HYDROLASE INHIBITOR

Protein

Description Thrombin heavy chain
Organism Homo sapiens
Chain H
Length 250
Binding Area (Å2) 539.53
Molecular Weight -
Aromaticity 0.11
Instability -
Isoelectric Point 8.88
Sequence IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKEGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFX

Peptide

Description Hirudin variant-1
Organism Hirudo medicinalis
Chain I
Length 11
Binding Area (Å2) 600.89
Hydrophobic (% a.a.)
36%
Molecular Weight 1411.47
Aromaticity 0.18
Instability 121.84
Isoelectric Point 3.45
Sequence DFEEIPEEYLQ

Clustering Classification

Sequence cluster S 79
Contact cluster C4
Interface cluster I14