2NWN-B-A

PDB Title NEW PHARMACOPHORE FOR SERINE PROTEASE INHIBITION REVEALED BY CRYSTAL STRUCTURE OF HUMAN UROKINASE-TYPE PLASMINOGEN ACTIVATOR COMPLEXED WITH A CYCLIC PEPTIDYL INHIBITOR, UPAIN-1
Resolution (Å) 2.150
Classification HYDROLASE

Protein

Description Plasminogen activator, urokinase
Organism Homo sapiens
Chain A
Length 240
Binding Area (Å2) 600.10
Molecular Weight 27055.65
Aromaticity 0.10
Instability 45.70
Isoelectric Point 8.49
Sequence IIGGEFTTIENQPWFAAIYRRSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSALAHHNDIALLKIRSKEGRCAQPSRTIQTIALPSMYNDPQFGTSCEITGFGKEQSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTK

Peptide

Description upain-1
Organism -
Chain B
Length 12
Binding Area (Å2) 821.40
Hydrophobic (% a.a.)
25%
Molecular Weight 1491.72
Aromaticity 0.08
Instability 2.09
Isoelectric Point 8.08
Sequence CSWRGLENHRMC

Clustering Classification

Sequence cluster S 205
Contact cluster C4
Interface cluster I50