4E05-I-H

PDB Title ANOPHELIN FROM THE MALARIA VECTOR INHIBITS THROMBIN THROUGH A NOVEL REVERSE-BINDING MECHANISM
Resolution (Å) 2.300
Classification HYDROLASE/HYDROLASE INHIBITOR

Protein

Description Thrombin
Organism Homo sapiens
Chain H
Length 254
Binding Area (Å2) 1291.08
Molecular Weight -
Aromaticity 0.11
Instability -
Isoelectric Point 8.88
Sequence IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGEX

Peptide

Description Salivary anti-thrombin peptide anophelin
Organism Anopheles albimanus
Chain I
Length 30
Binding Area (Å2) 1548.46
Hydrophobic (% a.a.)
46%
Molecular Weight 3153.33
Aromaticity 0.07
Instability 57.57
Isoelectric Point 4.36
Sequence EDYAAIEASLSETFNTAADPGRRLGEGSKP

Clustering Classification

Sequence cluster S 1376
Contact cluster C4
Interface cluster I278