1TMT-J-H

PDB Title CHANGES IN INTERACTIONS IN COMPLEXES OF HIRUDIN DERIVATIVES AND HUMAN ALPHA-THROMBIN DUE TO DIFFERENT CRYSTAL FORMS
Resolution (Å) 2.200
Classification HYDROLASE/HYDROLASE INHIBITOR

Protein

Description ALPHA-THROMBIN (LARGE SUBUNIT)
Organism Homo sapiens
Chain H
Length 258
Binding Area (Å2) 530.81
Molecular Weight 29608.74
Aromaticity 0.11
Instability 31.98
Isoelectric Point 8.99
Sequence IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFG

Peptide

Description CGP 50,856 INHIBITOR, cleaved C-terminal hirudin fragment
Organism Hirudo medicinalis
Chain J
Length 11
Binding Area (Å2) 629.08
Hydrophobic (% a.a.)
36%
Molecular Weight 1411.47
Aromaticity 0.18
Instability 121.84
Isoelectric Point 3.45
Sequence DFEEIPEEYLQ

Clustering Classification

Sequence cluster S 79
Contact cluster C4
Interface cluster I14