3ZRM-Y-B

PDB Title IDENTIFICATION OF 2-(4-PYRIDYL)THIENOPYRIDINONES AS GSK- 3BETA INHIBITORS
Resolution (Å) 2.490
Classification TRANSFERASE/PEPTIDE

Protein

Description GLYCOGEN SYNTHASE KINASE-3 BETA
Organism Homo sapiens
Chain B
Length 350
Binding Area (Å2) 716.14
Molecular Weight -
Aromaticity 0.10
Instability -
Isoelectric Point 8.88
Sequence KVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSXICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIX

Peptide

Description PROTO-ONCOGENE FRAT1
Organism Homo sapiens
Chain Y
Length 22
Binding Area (Å2) 766.27
Hydrophobic (% a.a.)
50%
Molecular Weight 2544.01
Aromaticity 0.00
Instability 51.44
Isoelectric Point 11.71
Sequence RLLQQLVLSGNLIKEAVRRLHS

Clustering Classification

Sequence cluster S 173
Contact cluster C91
Interface cluster I99