3ZRL-X-A

PDB Title IDENTIFICATION OF 2-(4-PYRIDYL)THIENOPYRIDINONES AS GSK-3BETA INHIBITORS
Resolution (Å) 2.480
Classification TRANSFERASE/PEPTIDE

Protein

Description GLYCOGEN SYNTHASE KINASE-3 BETA
Organism Homo sapiens
Chain A
Length 349
Binding Area (Å2) 719.01
Molecular Weight -
Aromaticity 0.10
Instability -
Isoelectric Point 8.97
Sequence KVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSXICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQX

Peptide

Description PROTO-ONCOGENE FRAT1
Organism Homo sapiens
Chain X
Length 23
Binding Area (Å2) 759.03
Hydrophobic (% a.a.)
52%
Molecular Weight 2691.19
Aromaticity 0.00
Instability 49.63
Isoelectric Point 11.71
Sequence PHRLLQQLVLSGNLIKEAVRRLH

Clustering Classification

Sequence cluster S 173
Contact cluster C91
Interface cluster I99