3ZRL-Y-B

PDB Title IDENTIFICATION OF 2-(4-PYRIDYL)THIENOPYRIDINONES AS GSK-3BETA INHIBITORS
Resolution (Å) 2.480
Classification TRANSFERASE/PEPTIDE

Protein

Description GLYCOGEN SYNTHASE KINASE-3 BETA
Organism Homo sapiens
Chain B
Length 350
Binding Area (Å2) 714.80
Molecular Weight -
Aromaticity 0.10
Instability -
Isoelectric Point 8.88
Sequence KVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSXICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIX

Peptide

Description PROTO-ONCOGENE FRAT1
Organism Homo sapiens
Chain Y
Length 23
Binding Area (Å2) 751.44
Hydrophobic (% a.a.)
47%
Molecular Weight 2700.19
Aromaticity 0.00
Instability 58.01
Isoelectric Point 12.00
Sequence RLLQQLVLSGNLIKEAVRRLHSR

Clustering Classification

Sequence cluster S 173
Contact cluster C91
Interface cluster I99