3ZRK-X-A

PDB Title IDENTIFICATION OF 2-(4-PYRIDYL)THIENOPYRIDINONES AS GSK-3BETA INHIBITORS
Resolution (Å) 2.370
Classification TRANSFERASE/PEPTIDE

Protein

Description GLYCOGEN SYNTHASE KINASE-3 BETA
Organism Homo sapiens
Chain A
Length 348
Binding Area (Å2) 714.14
Molecular Weight -
Aromaticity 0.10
Instability -
Isoelectric Point 8.97
Sequence KVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSXICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIX

Peptide

Description PROTO-ONCOGENE FRAT1
Organism Homo sapiens
Chain X
Length 24
Binding Area (Å2) 758.39
Hydrophobic (% a.a.)
50%
Molecular Weight 2778.26
Aromaticity 0.00
Instability 47.98
Isoelectric Point 11.71
Sequence PHRLLQQLVLSGNLIKEAVRRLHS

Clustering Classification

Sequence cluster S 173
Contact cluster C91
Interface cluster I99

Similar complexes

Is the complex classified in the same cluster?

Complex Sequence cluster
(S173) 		Contact cluster
(C91) 		Interface cluster
(I99)
3zrm-X-A
3zrm-Y-B
4afj-X-A
4afj-Y-B
3zrk-Y-B
3zrl-X-A
3zrl-Y-B
1yye-C-A
3f7d-B-A
5ntw-S-D
6g05-P-A
1yye-D-B
3fej-B-A
5nu1-P-A
6g05-Q-B
1u3r-C-A
1zaf-C-A
3fur-H-A
5nu1-Q-B
6g07-Q-B
1u3r-D-B
1zaf-D-B
3g9e-B-A
5q0i-B-A
6g07-S-D
1u3s-C-A
1zgy-B-A
3gyt-B-A
4b7e-B-A
5two-B-A
6gev-B-A
1u3s-D-B
2a3i-B-A
3gyu-B-A
4b7k-B-A
5unj-C-A
6gg8-B-A
1u9e-C-A
2a4j-B-A
3h0a-B-A
4qjr-B-A
5z5s-C-A
6ggg-B-A
1u9e-D-B
2fvj-B-A
3h0a-E-D
4uda-B-A
5z6s-C-A
6izm-C-A
1x76-C-A
2gtk-B-A
3l3x-B-A
4udb-B-A
6ad9-B-A
6izn-C-A
1x76-D-B
2nv7-C-A
3sp6-B-A
4y29-B-A
6fzf-C-A
6k0t-B-A
1x78-C-A
2nv7-D-B
3u9q-B-A
5l7e-B-A
6fzf-D-B
6k0t-D-C
1x78-D-B
2xum-S-A
3v9t-C-A
5l7g-B-A
6fzj-C-A
6ms7-B-A
1x7b-C-A
2y0i-S-A
3v9v-C-A
5l7h-B-A
6fzj-D-B
6nwk-B-A
1x7b-D-B
3b1m-B-A
5mwp-B-A
6fzp-C-A
6nwl-B-A
1x7j-C-A
3bqd-B-A
5mwy-B-A
6fzu-P-A
1x7j-D-B
3cs8-B-A
5ntw-Q-B
6fzu-Q-B