6IVX-B-A

PDB Title DISCOVERY OF THE SECOND GENERATION ROR GAMMA INHIBITORS COMPOSED OF AN AZOLE SCAFFOLD.
Resolution (Å) 2.350
Classification NUCLEAR PROTEIN/INHIBITOR

Protein

Description Nuclear receptor ROR-gamma
Organism Homo sapiens
Chain A
Length 228
Binding Area (Å2) 679.32
Molecular Weight -
Aromaticity 0.09
Instability -
Isoelectric Point 7.19
Sequence SLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPAGKLASLCSQHVERLQIFQHLHPIX

Peptide

Description Nuclear receptor corepressor 2
Organism Homo sapiens
Chain B
Length 14
Binding Area (Å2) 715.19
Hydrophobic (% a.a.)
64%
Molecular Weight 1560.92
Aromaticity 0.00
Instability -1.45
Isoelectric Point 8.41
Sequence TNMGLEAIIRKALM

Clustering Classification

Sequence cluster S 198
Contact cluster C155
Interface cluster I11

Similar complexes

Is the complex classified in the same cluster?

Complex Sequence cluster
(S198) 		Contact cluster
(C155) 		Interface cluster
(I11)
6ivx-F-E
6ivx-H-G
5x8q-D-C
5x8q-H-G
5ntw-S-D
6g07-S-D
5nu1-P-A
5nu1-Q-B
4wpf-B-A
4xt9-B-A
5aph-C-A
5x8u-B-A
5apj-C-A
5x8w-B-A
6r7a-C-A
5g42-C-A
5yp6-B-A
6r7j-C-A
5g44-C-A
6e3g-C-A
6r7k-C-A
5g45-C-A
6e3g-D-B
5g46-C-A
6esn-C-A
5ni5-C-A
6fzu-P-A
5ni7-C-A
6fzu-Q-B
5ni8-C-A
6g05-P-A
3kyt-C-A
5nib-C-A
6g05-Q-B
3l0j-C-A
5ntw-Q-B
6g07-Q-B
3q5u-B-A
4mdd-C-A
4oar-B-A
6oni-D-B
6pdz-C-B
6pdz-D-A