5N4V-D-A

PDB Title CRYSTAL STRUCTURE OF HUMAN PIM-1 KINASE IN COMPLEX WITH A CONSENSUSPEPTIDE AND FRAGMENT LIKE MOLEKULE 2-CYCLOPROPYL-4,5- DIMETHYLTHIENO[5,4-D]PYRIMIDINE-6-CARBOXYLIC ACID
Resolution (Å) 1.850
Classification TRANSFERASE

Protein

Description Serine/threonine-protein kinase pim-1
Organism Homo sapiens
Chain A
Length 274
Binding Area (Å2) 506.68
Molecular Weight -
Aromaticity 0.10
Instability -
Isoelectric Point 5.20
Sequence PLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIGGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHX

Peptide

Description Pimtide
Organism Homo sapiens
Chain D
Length 9
Binding Area (Å2) 652.55
Hydrophobic (% a.a.)
22%
Molecular Weight 1149.31
Aromaticity 0.00
Instability 212.00
Isoelectric Point 12.48
Sequence RKRRRHPSG

Clustering Classification

Sequence cluster S 217
Contact cluster C17
Interface cluster I17

Similar complexes

Is the complex classified in the same cluster?

Complex Sequence cluster
(S217) 		Contact cluster
(C17) 		Interface cluster
(I17)
2c3i-A-B
5n4x-B-A
5n4z-B-A
5n50-B-A
5n51-B-A
5n52-B-A
3cxw-B-A
5n5l-B-A
3cy2-B-A
5n5m-B-A
3cy3-B-A
5ndt-B-A
3jpv-B-A
3ma3-B-A
6pcw-B-A
3qf9-B-A
6pdi-B-A
4gw8-B-A
5mzl-B-A
6pdn-B-A
4jx7-B-A
5n4n-B-A
6pdo-B-A
5n4o-B-A
6pdp-B-A
5n4r-E-A
6qxk-A-B
2bzk-A-B
5n4u-B-A
4pis-B-A
2ynr-B-A
4wx4-C-A
2ynr-C-A
4wx6-B-A
2yns-C-A
4wx6-D-C
2yns-D-B
4wx7-B-A
4wx7-D-C
4yi0-A-C
5ctt-B-A
5ekf-B-A
5x8n-B-A
5ekf-C-A
5fgy-B-A
4pid-B-A
1nln-B-A
4pie-B-A
4piq-B-A