5C6H-B-A

PDB Title MCL-1 COMPLEXED WITH MULE
Resolution (Å) 2.050
Classification APOPTOSIS/APOPTOSIS REGULATOR

Protein

Description Induced myeloid leukemia cell differentiation protein Mcl-1
Organism Homo sapiens
Chain A
Length 155
Binding Area (Å2) 978.51
Molecular Weight 17780.01
Aromaticity 0.08
Instability 37.67
Isoelectric Point 7.19
Sequence EDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLE

Peptide

Description Mule BH3 peptide from E3 ubiquitin-protein ligase HUWE1
Organism Homo sapiens
Chain B
Length 25
Binding Area (Å2) 1094.84
Hydrophobic (% a.a.)
44%
Molecular Weight 2858.12
Aromaticity 0.08
Instability 42.97
Isoelectric Point 3.84
Sequence PGVMTQEVGQLLQDMGDDVYQQYRS

Clustering Classification

Sequence cluster S 35
Contact cluster C60
Interface cluster I55

Similar complexes

Is the complex classified in the same cluster?

Complex Sequence cluster
(S35) 		Contact cluster
(C60) 		Interface cluster
(I55)
5uum-D-B
2jm6-A-B
2roc-B-A
2rod-B-A
5uum-C-A
3kz0-C-A
3kz0-D-B
2kbw-B-A
6mbe-B-A
6qfi-B-A
3d7v-B-A
1bxl-B-A
1g5j-B-A
5vmo-B-A
2jby-B-A
3mqp-B-A
6fbx-B-A
4bd6-C-A
6mbc-B-A
4uf1-B-A
2m04-B-A
4zif-B-A
4zih-B-A
6qg8-B-A
5fmk-B-A
2v6q-B-A
5twa-D-A
2vog-B-A
5twa-C-B
2voh-B-A
5tzp-B-A
2wh6-B-A
5tzq-C-B
2xpx-B-A
5tzq-D-A
5ua5-B-A
3i1h-B-A
5uuk-B-A
3io8-D-C