3EQS-B-A

PDB Title CRYSTAL STRUCTURE OF HUMAN MDM2 IN COMPLEX WITH A 12-MER PEPTIDE INHIBITOR
Resolution (Å) 1.650
Classification LIGASE

Protein

Description E3 ubiquitin-protein ligase Mdm2
Organism Homo sapiens
Chain A
Length 85
Binding Area (Å2) 509.33
Molecular Weight -
Aromaticity 0.12
Instability -
Isoelectric Point 9.55
Sequence TLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVX

Peptide

Description 12-mer peptide inhibitor
Organism -
Chain B
Length 11
Binding Area (Å2) 635.11
Hydrophobic (% a.a.)
36%
Molecular Weight 1330.44
Aromaticity 0.27
Instability 10.88
Isoelectric Point 4.00
Sequence TSFAEYWNLLS

Clustering Classification

Sequence cluster S 155
Contact cluster C46
Interface cluster I31

Similar complexes

Is the complex classified in the same cluster?

Complex Sequence cluster
(S155) 		Contact cluster
(C46) 		Interface cluster
(I31)
3eqy-D-B
3lnz-J-I
3lnz-L-K
3dab-B-A
3dab-D-C
3dab-H-G
1t4f-P-M
3jzo-P-A
1ycq-B-A
3jzp-P-A
3jzq-P-A
3jzq-Q-B
3jzr-P-A
3jzs-P-A
2mps-B-A
2mwy-B-A
3qkk-C-A
3qkl-C-A
3e87-D-B
1o6k-C-A
3e88-D-B
1o6l-C-A
2jdo-C-A
2jdr-C-A
2uw9-C-A
2x39-C-A
3cqu-C-A
3mv5-C-A
3cqw-C-A
3mvh-B-A