3OFI-D-B

PDB Title CRYSTAL STRUCTURE OF HUMAN INSULIN-DEGRADING ENZYME IN COMPLEX WITH UBIQUITIN
Resolution (Å) 2.350
Classification HYDROLASE

Protein

Description Insulin-degrading enzyme
Organism Homo sapiens
Chain B
Length 957
Binding Area (Å2) 231.27
Molecular Weight -
Aromaticity 0.11
Instability -
Isoelectric Point 5.98
Sequence NNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFLQHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLSPLFDESAKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVVVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQELKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKANLNFEFFSPFAYVDPLHSNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNSGIEIYYQTDMQSTSENMFLELFAQIISEPAFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAESAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMNLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHXXX

Peptide

Description Ubiquitin
Organism Homo sapiens
Chain D
Length 3
Binding Area (Å2) 374.30
Hydrophobic (% a.a.)
66%
Molecular Weight 390.50
Aromaticity 0.00
Instability -18.47
Isoelectric Point 5.27
Sequence MQI

Clustering Classification

Sequence cluster S 710
Contact cluster C112
Interface cluster I1091

Similar complexes

Is the complex classified in the same cluster?

Complex Sequence cluster
(S710) 		Contact cluster
(C112) 		Interface cluster
(I1091)
3ofi-C-A
3cww-D-B
3cww-E-A
3e50-C-A
4pes-C-A
4pes-D-B