3E50-C-A

PDB Title CRYSTAL STRUCTURE OF HUMAN INSULIN DEGRADING ENZYME IN COMPLEX WITH TRANSFORMING GROWTH FACTOR-ALPHA
Resolution (Å) 2.300
Classification HYDROLASE/HORMONE

Protein

Description Insulin-degrading enzyme
Organism Homo sapiens
Chain A
Length 962
Binding Area (Å2) 223.39
Molecular Weight -
Aromaticity 0.11
Instability -
Isoelectric Point 5.94
Sequence NNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCQHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGNLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHX

Peptide

Description Protransforming growth factor alpha
Organism Homo sapiens
Chain C
Length 5
Binding Area (Å2) 341.46
Hydrophobic (% a.a.)
60%
Molecular Weight 587.67
Aromaticity 0.20
Instability -12.74
Isoelectric Point 6.71
Sequence VVSHF

Clustering Classification

Sequence cluster S 1230
Contact cluster C112
Interface cluster I169

Similar complexes

Is the complex classified in the same cluster?

Complex Sequence cluster
(S1230) 		Contact cluster
(C112) 		Interface cluster
(I169)
3cww-D-B
3cww-E-A
4pes-C-A
4pes-D-B
3ofi-C-A
3ofi-D-B