4E05-I-H

PDB Title ANOPHELIN FROM THE MALARIA VECTOR INHIBITS THROMBIN THROUGH A NOVEL REVERSE-BINDING MECHANISM
Resolution (Å) 2.300
Classification HYDROLASE/HYDROLASE INHIBITOR

Protein

Description Thrombin
Organism Homo sapiens
Chain H
Length 254
Binding Area (Å2) 1291.08
Molecular Weight -
Aromaticity 0.11
Instability -
Isoelectric Point 8.88
Sequence IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGEX

Peptide

Description Salivary anti-thrombin peptide anophelin
Organism Anopheles albimanus
Chain I
Length 30
Binding Area (Å2) 1548.46
Hydrophobic (% a.a.)
46%
Molecular Weight 3153.33
Aromaticity 0.07
Instability 57.57
Isoelectric Point 4.36
Sequence EDYAAIEASLSETFNTAADPGRRLGEGSKP

Clustering Classification

Sequence cluster S 1376
Contact cluster C4
Interface cluster I278

Similar complexes

Is the complex classified in the same cluster?

Complex Sequence cluster
(S1376) 		Contact cluster
(C4) 		Interface cluster
(I278)
5nhu-I-H
5nhu-J-A
1ldt-L-T
1smf-I-E
2plx-B-A
3ldx-I-H
4dt7-E-B
4zks-P-U
6a8n-C-B
1f2s-I-E
1lhc-I-H
1tab-I-E
2pux-C-B
3lu9-C-B
4dt7-F-D
5afy-I-H
6bvh-I-A
1fn8-B-A
1lhd-I-H
1thr-I-H
2r2m-H-B
3m61-P-U
4gux-D-A
5gim-C-B
6d3y-C-A
1fph-I-H
1lhe-I-H
1tmt-J-H
2sta-I-E
3ox7-P-U
4gux-E-B
5gim-D-B
6d3z-C-A
1fy4-B-A
1lhf-I-H
1vzq-I-H
2stb-I-E
3oy5-P-U
4k1e-B-A
5jbt-X-A
6d40-C-A
1fy5-B-A
1g37-B-A
1lhg-I-H
1w7g-I-H
2vu8-I-E
3oy6-P-U
4k8y-B-A
5jbt-Y-A
6e5m-I-A
1g9i-I-E
1mct-I-A
1xvm-B-A
2wpm-L-S
3p6z-C-B
4kel-B-A
6eat-I-A
1gdn-B-A
1nrr-R-H
1ycp-F-H
2xtt-A-B
3p6z-I-H
4ktu-B-A
6eau-I-A
1gdu-B-A
1nrs-R-H
2btc-I-E
2z7f-I-E
3p8f-I-A
4u2w-B-A
5nhu-K-C
6eav-I-A
1a3b-I-H
1gl1-I-A
1ny2-4-2
2cmy-B-A
3b23-C-B
3tvj-I-B
4ud9-I-H
5wxq-P-U
6eaw-I-A
1a3e-I-H
1gl1-J-B
1ook-P-B
2f3c-I-E
3bf6-I-H
3vxe-J-H
4x1q-P-U
5wxr-P-U
6eax-I-A
1an1-I-E
1gl1-K-C
1ox1-B-A
2f91-B-A
3c27-H-B
4aoq-F-C
4xoj-B-A
5xwj-C-A
6o21-B-A
1b7x-C-B
1h9h-I-E
1oxg-B-A
2h9t-I-H
3fp7-I-E
4aor-E-B
4zhl-P-U
5xwj-D-B
6xvd-P-U
1bbr-I-N
1h9i-I-E
1pq8-C-A
2hgt-J-H
3fp7-J-E
4aor-F-C
4zkn-P-U
5xwl-C-A
1co7-I-E
1hxe-I-H
1sbw-I-A
2nwn-B-A
3hki-C-B
4ax9-I-H
4zko-P-U
5xwl-D-B
1dm4-C-B
1hxf-I-H
1sfi-I-A
2o9q-C-A
3hki-F-E
4doq-B-A
4zko-Q-U
6a8n-P-A
1eb1-A-H