2G49-D-B

PDB Title CRYSTAL STRUCTURE OF HUMAN INSULIN-DEGRADING ENZYME IN COMPLEX WITH GLUCAGON
Resolution (Å) 2.500
Classification HYDROLASE

Protein

Description Insulin-degrading enzyme
Organism Homo sapiens
Chain B
Length 967
Binding Area (Å2) 788.94
Molecular Weight -
Aromaticity 0.11
Instability -
Isoelectric Point 5.90
Sequence NPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCQHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFX

Peptide

Description glucagon preproprotein
Organism Homo sapiens
Chain D
Length 9
Binding Area (Å2) 1035.27
Hydrophobic (% a.a.)
44%
Molecular Weight 1175.36
Aromaticity 0.22
Instability 35.62
Isoelectric Point 6.74
Sequence HSQFVQWLM

Clustering Classification

Sequence cluster S 1008
Contact cluster C86
Interface cluster I94

Similar complexes

Is the complex classified in the same cluster?

Complex Sequence cluster
(S1008) 		Contact cluster
(C86) 		Interface cluster
(I94)
2g47-C-A
2g47-D-B
2g49-C-A
2g54-C-A
2g54-D-B
2g56-C-A
2g56-D-B
3e4z-D-B