2G49-C-A

PDB Title CRYSTAL STRUCTURE OF HUMAN INSULIN-DEGRADING ENZYME IN COMPLEX WITH GLUCAGON
Resolution (Å) 2.500
Classification HYDROLASE

Protein

Description Insulin-degrading enzyme
Organism Homo sapiens
Chain A
Length 971
Binding Area (Å2) 843.74
Molecular Weight -
Aromaticity 0.11
Instability -
Isoelectric Point 5.87
Sequence NNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCQHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGENDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAX

Peptide

Description glucagon preproprotein
Organism Homo sapiens
Chain C
Length 11
Binding Area (Å2) 1142.30
Hydrophobic (% a.a.)
45%
Molecular Weight 1346.51
Aromaticity 0.18
Instability 37.82
Isoelectric Point 6.74
Sequence HSQGFVQWLMN

Clustering Classification

Sequence cluster S 1007
Contact cluster C86
Interface cluster I94

Similar complexes

Is the complex classified in the same cluster?

Complex Sequence cluster
(S1007) 		Contact cluster
(C86) 		Interface cluster
(I94)
2g54-D-B
2g56-C-A
2g56-D-B
2g47-C-A
2g47-D-B
2g49-D-B
2g54-C-A
3e4z-D-B