5WUK-B-A

PDB Title CRYSTAL STRUCTURE OF EED [G255D] IN COMPLEX WITH EZH2 PEPTIDE AND EED226 COMPOUND
Resolution (Å) 2.030
Classification GENE REGULATION

Protein

Description Polycomb protein EED
Organism Homo sapiens
Chain A
Length 367
Binding Area (Å2) 1322.71
Molecular Weight -
Aromaticity 0.10
Instability -
Isoelectric Point 6.99
Sequence KKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCDMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLRX

Peptide

Description Histone-lysine N-methyltransferase EZH2
Organism Homo sapiens
Chain B
Length 28
Binding Area (Å2) 1520.77
Hydrophobic (% a.a.)
32%
Molecular Weight 3529.04
Aromaticity 0.07
Instability 89.36
Isoelectric Point 10.83
Sequence MFSSNRQKILERTEILNQEWKQRRIQPV

Clustering Classification

Sequence cluster S 175
Contact cluster C85
Interface cluster I95

Similar complexes

Is the complex classified in the same cluster?

Complex Sequence cluster
(S175) 		Contact cluster
(C85) 		Interface cluster
(I95)
5gsa-C-A
5h17-B-A
5h19-B-A
5u5t-C-A
5u5t-D-B
5u62-C-A
2qxv-B-A
3cc5-F-D
3ch1-C-A
3ch1-F-D
3ch1-I-G
3ch1-L-J
3cc5-C-A