5JWP-B-A

PDB Title CRYSTAL STRUCTURE OF HUMAN FIH D201E VARIANT IN COMPLEX WITH ZN, ALPHA-KETOGLUTARATE, AND HIF1 ALPHA PEPTIDE.
Resolution (Å) 2.100
Classification OXIDOREDUCTASE

Protein

Description Hypoxia-inducible factor 1-alpha inhibitor
Organism Homo sapiens
Chain A
Length 344
Binding Area (Å2) 784.73
Molecular Weight -
Aromaticity 0.13
Instability -
Isoelectric Point 5.49
Sequence AVASGSGEPREEAGALGPAWDESQLRSYSFPTRPIPRLSQSDPRAEELIENEEPVVLTDTNLVYPALKWDLEYLQENIGNGDFSVYSASTHKFLYYDEKKMANFQNFKPRSNREEMKFHEFVEKLQDIQQRGGEERLYLQQTLNDTVGRKIVMDFLGFNWNWINKQQGKRGWGQLTSNLLLIGMEGNVTPAHYEEQQNFFAQIKGYKRCILFPPDQFECLYPYPVHHPCDRQSQVDFDNPDYERFPNFQNVVGYETVVGPGDVLYIPMYWWHHIESLLNGGITITVNFWYKGAPTPKRIEYPLKAHQKVAIMRNIEKMLGEALGNPQEVGPLLNTMIKGRYNXX

Peptide

Description Hypoxia-inducible factor 1-alpha
Organism Homo sapiens
Chain B
Length 13
Binding Area (Å2) 976.83
Hydrophobic (% a.a.)
46%
Molecular Weight 1420.52
Aromaticity 0.08
Instability 42.26
Isoelectric Point 3.67
Sequence QLTSYDAEVNAPI

Clustering Classification

Sequence cluster S 34
Contact cluster C37
Interface cluster I79

Similar complexes

Is the complex classified in the same cluster?

Complex Sequence cluster
(S34) 		Contact cluster
(C37) 		Interface cluster
(I79)
3d8c-B-A
1h2k-S-A
1h2l-S-A
2xum-S-A
2y0i-S-A
3p3n-B-A
4b7e-B-A
4b7k-B-A
1h2m-S-A
6h9j-D-A
6ha6-D-A
6hc8-E-A
6hkp-S-A
6hl5-S-A
6hl6-S-A
1l3e-A-B
2ilm-S-A