3E4Z-D-B

PDB Title CRYSTAL STRUCTURE OF HUMAN INSULIN DEGRADING ENZYME IN COMPLEX WITH INSULIN-LIKE GROWTH FACTOR II
Resolution (Å) 2.280
Classification HYDROLASE/HORMONE

Protein

Description Insulin-degrading enzyme
Organism Homo sapiens
Chain B
Length 953
Binding Area (Å2) 703.05
Molecular Weight -
Aromaticity 0.11
Instability -
Isoelectric Point 5.96
Sequence NNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFLQHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLSPLFDESAKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVVVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQELKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKANLNFEFFSPFAYVDPLHSNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNSGIEIYYQTDMQSTSENMFLELFAQIISEPAFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAESAKYYGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMNLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHX

Peptide

Description Insulin-like growth factor II
Organism Homo sapiens
Chain D
Length 9
Binding Area (Å2) 932.66
Hydrophobic (% a.a.)
44%
Molecular Weight 1078.22
Aromaticity 0.11
Instability -7.08
Isoelectric Point 5.88
Sequence AYRLVDTLQ

Clustering Classification

Sequence cluster S 1229
Contact cluster C74
Interface cluster I1037

Similar complexes

Is the complex classified in the same cluster?

Complex Sequence cluster
(S1229) 		Contact cluster
(C74) 		Interface cluster
(I1037)
2g47-C-A
2g47-D-B
2g49-C-A
2g49-D-B
2g54-C-A
2g54-D-B
2g56-C-A
2g56-D-B