2G56-D-B

PDB Title CRYSTAL STRUCTURE OF HUMAN INSULIN-DEGRADING ENZYME IN COMPLEX WITH INSULIN B CHAIN
Resolution (Å) 2.200
Classification HYDROLASE

Protein

Description Insulin-degrading enzyme
Organism Homo sapiens
Chain B
Length 964
Binding Area (Å2) 976.77
Molecular Weight 111585.52
Aromaticity 0.11
Instability 41.11
Isoelectric Point 5.90
Sequence NPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCQHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHIN

Peptide

Description Insulin
Organism Homo sapiens
Chain D
Length 19
Binding Area (Å2) 1166.07
Hydrophobic (% a.a.)
57%
Molecular Weight 2194.51
Aromaticity 0.16
Instability -2.93
Isoelectric Point 5.40
Sequence FVNQHLVEALYLVCGERGF

Clustering Classification

Sequence cluster S 192
Contact cluster C74
Interface cluster I94

Similar complexes

Is the complex classified in the same cluster?

Complex Sequence cluster
(S192) 		Contact cluster
(C74) 		Interface cluster
(I94)
2g56-C-A
2g54-C-A
2g54-D-B
2g47-C-A
2g47-D-B
2g49-C-A
2g49-D-B
3e4z-D-B
4wdi-C-A
4wdi-F-D
4z76-F-D
4z77-C-A
4z77-F-D
4z78-C-A
4z78-F-D
4z78-I-G