2G54-C-A

PDB Title CRYSTAL STRUCTURE OF ZN-BOUND HUMAN INSULIN-DEGRADING ENZYME IN COMPLEX WITH INSULIN B CHAIN
Resolution (Å) 2.250
Classification HYDROLASE

Protein

Description Insulin-degrading enzyme
Organism Homo sapiens
Chain A
Length 972
Binding Area (Å2) 838.58
Molecular Weight -
Aromaticity 0.11
Instability -
Isoelectric Point 5.87
Sequence NNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCQHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGENDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAXX

Peptide

Description insulin
Organism Homo sapiens
Chain C
Length 13
Binding Area (Å2) 1098.75
Hydrophobic (% a.a.)
53%
Molecular Weight 1492.70
Aromaticity 0.15
Instability 3.43
Isoelectric Point 5.24
Sequence FVNQHEALYLVCG

Clustering Classification

Sequence cluster S 192
Contact cluster C74
Interface cluster I94

Similar complexes

Is the complex classified in the same cluster?

Complex Sequence cluster
(S192) 		Contact cluster
(C74) 		Interface cluster
(I94)
2g54-D-B
2g56-C-A
2g56-D-B
2g47-C-A
2g47-D-B
2g49-C-A
2g49-D-B
3e4z-D-B
4z77-F-D
4z78-C-A
4z78-F-D
4z78-I-G
4wdi-C-A
4wdi-F-D
4z76-F-D
4z77-C-A