1SP4-A-B

PDB Title CRYSTAL STRUCTURE OF NS-134 IN COMPLEX WITH BOVINE CATHEPSIN B: A TWO HEADED EPOXYSUCCINYL INHIBITOR EXTENDS ALONG THE WHOLE ACTIVE SITE CLEFT
Resolution (Å) 2.200
Classification HYDROLASE/HYDROLASE INHIBITOR

Protein

Description Cathepsin B
Organism Bos taurus
Chain B
Length 206
Binding Area (Å2) 2190.02
Molecular Weight -
Aromaticity 0.11
Instability -
Isoelectric Point 5.31
Sequence RVNVEVSAEDMLTCCGGECGDGCNGGFPSGAWNFWTKKGLVSGGLYNSHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCNKTCEPGYSPSYKEDKHFGCSSYSVANNEKEIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVSGEIMGGHAIRILGWGVENGTPYWLVGNSWNTDWGDNGFFKILRGQDHCGIESEIVAGMPCTX

Peptide

Description Cathepsin B
Organism Bos taurus
Chain A
Length 48
Binding Area (Å2) 2589.41
Hydrophobic (% a.a.)
41%
Molecular Weight 5295.83
Aromaticity 0.08
Instability 45.16
Isoelectric Point 4.70
Sequence LPESFDAREQWPNCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHSNG

Clustering Classification

Sequence cluster S 80
Contact cluster C162
Interface cluster I179

Similar complexes

Is the complex classified in the same cluster?

Complex Sequence cluster
(S80) 		Contact cluster
(C162) 		Interface cluster
(I179)
1huc-C-D
1csb-D-E
1huc-A-B
5grg-C-A