5H19-B-A

PDB Title EED IN COMPLEX WITH PRC2 ALLOSTERIC INHIBITOR EED162
Resolution (Å) 1.900
Classification TRANSFERASE/TRANSFERASE INHIBITOR

Protein

Description Polycomb protein EED
Organism Homo sapiens
Chain A
Length 356
Binding Area (Å2) 1384.03
Molecular Weight -
Aromaticity 0.11
Instability -
Isoelectric Point 6.41
Sequence CKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLX

Peptide

Description Histone-lysine N-methyltransferase EZH2
Organism Homo sapiens
Chain B
Length 29
Binding Area (Å2) 1583.38
Hydrophobic (% a.a.)
31%
Molecular Weight 3616.12
Aromaticity 0.07
Instability 86.62
Isoelectric Point 10.83
Sequence SMFSSNRQKILERTEILNQEWKQRRIQPV

Clustering Classification

Sequence cluster S 175
Contact cluster C92
Interface cluster I95

Similar complexes

Is the complex classified in the same cluster?

Complex Sequence cluster
(S175) 		Contact cluster
(C92) 		Interface cluster
(I95)
5gsa-C-A
5h17-B-A
5u5t-C-A
5u5t-D-B
5u62-C-A
5wuk-B-A
2qxv-B-A
3ch1-L-J
3cc5-C-A
3cc5-F-D
3ch1-C-A
3ch1-F-D
3ch1-I-G