3PTG-J-A

PDB Title DESIGN AND SYNTHESIS OF A NOVEL, ORALLY EFFICACIOUS TRI-SUBSTITUTED THIOPHENE BASED JNK INHIBITOR
Resolution (Å) 2.430
Classification TRANSFERASE/TRANSFERASE INHIBITOR

Protein

Description Mitogen-activated protein kinase 10
Organism Homo sapiens
Chain A
Length 341
Binding Area (Å2) 505.05
Molecular Weight -
Aromaticity 0.09
Instability -
Isoelectric Point 7.72
Sequence NQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLAVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPAHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSX

Peptide

Description C-Jun-amino-terminal kinase-interacting protein 1
Organism Homo sapiens
Chain J
Length 10
Binding Area (Å2) 658.18
Hydrophobic (% a.a.)
50%
Molecular Weight 1186.40
Aromaticity 0.10
Instability 60.86
Isoelectric Point 11.01
Sequence PKRPTTLNLF

Clustering Classification

Sequence cluster S 225
Contact cluster C43
Interface cluster I34

Similar complexes

Is the complex classified in the same cluster?

Complex Sequence cluster
(S225) 		Contact cluster
(C43) 		Interface cluster
(I34)
4hys-B-A
4hyu-B-A
4izy-B-A
1ukh-B-A
3oxi-J-A
4e73-B-A
4g1w-B-A
4h39-B-A
4ux9-F-A
4ux9-G-B
4ux9-H-C
4ux9-I-D
2xrw-B-A
4h3b-B-A
4h3b-D-C