3OXI-J-A

PDB Title DESIGN AND SYNTHESIS OF DISUBSTITUTED THIOPHENE AND THIAZOLE BASED INHIBITORS OF JNK FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
Resolution (Å) 2.200
Classification TRANSFERASE/TRANSFERASE INHIBITOR

Protein

Description Mitogen-activated protein kinase 10
Organism Homo sapiens
Chain A
Length 323
Binding Area (Å2) 523.54
Molecular Weight -
Aromaticity 0.10
Instability -
Isoelectric Point 8.53
Sequence NQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVREHTIEEWKELIYKEVMNX

Peptide

Description Mitogen-activated protein kinase 8 interacting protein 1
Organism Homo sapiens
Chain J
Length 10
Binding Area (Å2) 669.29
Hydrophobic (% a.a.)
50%
Molecular Weight 1186.40
Aromaticity 0.10
Instability 60.86
Isoelectric Point 11.01
Sequence PKRPTTLNLF

Clustering Classification

Sequence cluster S 225
Contact cluster C43
Interface cluster I34

Similar complexes

Is the complex classified in the same cluster?

Complex Sequence cluster
(S225) 		Contact cluster
(C43) 		Interface cluster
(I34)
1ukh-B-A
3ptg-J-A
4e73-B-A
4g1w-B-A
4h39-B-A
4hys-B-A
4hyu-B-A
4izy-B-A
2xrw-B-A
4h3b-B-A
4h3b-D-C
4ux9-F-A
4ux9-G-B
4ux9-H-C
4ux9-I-D