PDB Title | CRYSTAL STRUCTURE ANALYSIS OF THROMBIN IN COMPLEX WITH COMPOUND D57, 5-CHLOROTHIOPHENE-2-CARBOXYLIC ACID [(S)-2-[2-METHYL-3-(2- OXOPYRROLIDIN-1-YL)BENZENESULFONYLAMINO]-3-(4-METHYLPIPERAZIN-1- YL)- 3-OXOPROPYL]AMIDE (SAR107375) |
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Resolution (Å) | 1.770 |
Classification | HYDROLASE/HYDROLASE INHIBITOR |
Description | Thrombin heavy chain |
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Organism | Homo sapiens |
Chain | H |
Length | 253 |
Binding Area (Å2) | 1000.20 |
Molecular Weight | - |
Aromaticity | 0.11 |
Instability | - |
Isoelectric Point | 8.88 |
Sequence | IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFXXX |
Description | Thrombin light chain |
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Organism | Homo sapiens |
Chain | L |
Length | 27 |
Binding Area (Å2) | 1129.20 |
Hydrophobic (% a.a.) |
|
Molecular Weight | 3183.59 |
Aromaticity | 0.07 |
Instability | 39.01 |
Isoelectric Point | 4.77 |
Sequence | ADCGLRPLFEKKSLEDKTERELLESYI |
Is the complex classified in the same cluster?