1TWX-A-B

PDB Title CRYSTAL STRUCTURE OF THE THROMBIN MUTANT D221A/D222K
Resolution (Å) 2.400
Classification HYDROLASE/HYDROLASE INHIBITOR

Protein

Description Prothrombin
Organism Homo sapiens
Chain B
Length 252
Binding Area (Å2) 965.50
Molecular Weight 28950.08
Aromaticity 0.11
Instability 33.26
Isoelectric Point 9.09
Sequence IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCARKGKYGFYTHVFRLKKWIQKVIDQFGE

Peptide

Description Prothrombin
Organism Homo sapiens
Chain A
Length 28
Binding Area (Å2) 1109.32
Hydrophobic (% a.a.)
35%
Molecular Weight 3298.67
Aromaticity 0.07
Instability 37.97
Isoelectric Point 4.65
Sequence ADCGLRPLFEKKSLEDKTERELLESYID

Clustering Classification

Sequence cluster S 151
Contact cluster C2
Interface cluster I2

Similar complexes

Is the complex classified in the same cluster?

Complex Sequence cluster
(S151) 		Contact cluster
(C2) 		Interface cluster
(I2)
4ueh-L-H
5jdu-C-D
1lhd-L-H
1sgi-D-E
2a0q-A-B
2od3-A-B
2zfq-L-H
3u8t-L-H
1a61-L-H
4ufd-L-H
5jfd-L-H
1lhe-L-H
1shh-D-E
1vr1-L-H
2a0q-C-D
2cf8-L-H
1bcu-L-H
1eb1-L-H
1hbt-L-H
1lhf-L-H
1t4u-L-H
1vzq-L-H
2cf9-L-H
2zg0-L-H
3biu-L-H
3hk3-A-B
1abj-L-H
4e05-L-H
4uff-L-H
5l6n-L-H
1lhg-L-H
1t4v-L-H
1w7g-L-H
2cn0-L-H
2r2m-A-B
2zgb-L-H
3biv-L-H
3utu-L-H
4ufg-L-H
1hxe-L-H
1oyt-L-H
2feq-L-H
2thf-A-B
2zgx-L-H
3bv9-A-B
3ldx-L-H
5lpd-L-H
1hxf-L-H
1qbv-L-H
1tbz-L-H
2uuf-A-B
2zhe-L-H
3c27-A-B
3s7h-A-B
4h6s-A-B
5a2m-L-H
1fpc-L-H
5mjt-L-H
7kme-L-H
1mu6-A-B
1thp-A-B
2gde-L-H
2uuj-A-B
2zhf-L-H
3p17-L-H
4ax9-L-H
8kme-1-2
1mu8-A-B
1thr-L-H
2uuk-A-B
3da9-A-B
4bah-A-B
1ai8-L-H
5afy-L-H
1mue-A-B
1xmn-E-F
2bvr-L-H
2v3h-L-H
2zhw-L-H
3dhk-L-H
4bak-A-B
1aix-L-H
4loy-L-H
2bvs-L-H
2v3o-L-H
2zi2-L-H
3dt0-L-H
4bam-A-B
1awf-L-H
4lxb-L-H
1nrr-L-H
1qur-L-H
1tmt-L-H
1ype-L-H
2bxt-L-H
3dux-L-H
4ban-A-B
1ca8-A-B
1k21-L-H
1nrs-L-H
1ypg-L-H
2zda-L-H
1a3b-L-H
4bao-A-B
1b5g-L-H
6eo8-L-H
1k22-L-H
1tom-L-H
1ypj-L-H
2jh0-C-D
2zo3-L-H
3r3g-A-B
1a3e-L-H
4baq-A-B
1b7x-A-B
6eo9-L-H
1sb1-L-H
1ypk-L-H
2jh5-C-D
3b23-A-B
3u69-L-H
1a46-L-H
1sfq-D-E
1ypl-L-H
2jh6-C-D
3eq0-L-H
3u8o-L-H
1a4w-L-H
4ch2-C-D
1bb0-A-B
1h8i-L-H
1lhc-L-H
1nzq-L-H
1sg8-A-B
1ypm-L-H
3f68-L-H
3u8r-L-H
1a5g-L-H
4ch8-A-B
1dit-L-H
1hah-L-H
6gbw-L-H
1o0d-L-H
1uvt-L-H
2c93-A-B
3bei-A-B
3gic-A-B
3rm2-L-H
4dt7-A-B
1bbr-M-N
1dm4-A-B
1hai-L-H
1o2g-L-H
2pgb-A-B
2zfr-L-H
3bf6-L-H
3hat-L-H
3rml-L-H
3u98-L-H
1abi-L-H
4dt7-C-D
4ufe-L-H
5jzy-L-H
1o5g-L-H
2a2x-L-H
2pux-A-B
3rmm-L-H
3u9a-L-H
1bth-L-H
1etr-L-H
1hgt-L-H
1ook-A-B
2afq-A-B
3jz2-A-B
3rmn-L-H
1ad8-L-H
4e7r-L-H
1bth-J-K
1ets-L-H
5lce-L-H
1mkw-L-H
1tb6-L-H
1way-A-B
2afq-C-D
3rmo-L-H
3uwj-L-H
1ae8-L-H
4e7r-M-G
1c1u-L-H
4yes-A-B
1ett-L-H
1mkx-L-H
1wbg-A-B
2ank-L-H
2fes-L-H
3lu9-D-E
3vxe-L-H
1afe-L-H
1c1v-L-H
1id5-L-H
1qhr-A-B
1xmn-A-B
2anm-L-H
3d49-L-H
3sha-L-H
1aht-L-H
4htc-L-H
1c4u-1-2
5af9-L-H
1fph-L-H
5mls-L-H
1ihs-L-H
1qj1-A-B
1xmn-C-D
2b5t-C-D
2gp9-A-B
2zhq-L-H
3shc-L-H
1c4v-1-2
1g30-A-B
5mm6-L-H
1iht-L-H
1qj6-A-B
1ths-L-H
2h9t-L-H
3qto-L-H
3si3-L-H
1c5l-L-H
1c5n-L-H
5afz-L-H
1g32-A-B
5to3-A-B
1jmo-L-H
1no9-L-H
1qj7-A-B
1tmb-L-H
1xmn-G-H
2hgt-L-H
3qtv-L-H
3si4-L-H
4mlf-A-B
1c5o-L-H
5ahg-L-H
1ghv-L-H
1jou-E-F
2hwl-A-B
2zc9-L-H
2ziq-L-H
3qwc-L-H
3sv2-L-H
1a2c-L-H
1ay6-L-H
4rko-A-B
1ghw-L-H
1rd3-A-B
1tmu-L-H
2c8w-A-B
2hwl-C-D
2znk-L-H
3edx-C-D
3qx5-L-H
3t5f-L-H
4thn-L-H
1d3d-A-B
5e8e-L-H
1gj4-L-H
1nu7-A-B
1rd3-C-D
2c8x-A-B
2zdv-L-H
3edx-E-F
3tu7-L-H
4ud9-L-H
1d3p-A-B
5gds-L-H
1gj5-L-H
1kts-A-B
1nu7-E-F
1ucy-J-K
2c8y-A-B
2zf0-L-H
3egk-L-H
3rlw-L-H
4ch2-A-B
1ba8-A-B
4udw-L-H
1d4p-A-B
5gim-A-B
1ktt-A-B
1ny2-1-2
1ucy-M-N
2c8z-A-B
2zff-L-H
3b9f-L-H
3rly-L-H
4ue7-L-H
1de7-L-H
5jdu-A-B
6fjt-L-H
1uma-L-H
2c90-A-B
2ocv-A-B
2zfp-L-H
3bef-D-E
3rm0-L-H
1bbr-J-K
4i7y-L-H
6eo6-L-H
6hsx-L-H
6i51-L-H
6pxj-L-H
6pxj-A-B
6rot-L-H
3qlp-L-H
5do4-L-H
6eo7-L-H
1h8d-L-H
6evv-L-H