6T2E-B-A

PDB Title MULTICOMPONENT PEPTIDE STAPLING AS A DIVERSITY-DRIVEN TOOL FOR THE DEVELOPMENT OF INHIBITORS OF PROTEIN-PROTEIN INTERACTIONS
Resolution (Å) 2.400
Classification PEPTIDE BINDING PROTEIN

Protein

Description E3 ubiquitin-protein ligase Mdm2
Organism Homo sapiens
Chain A
Length 85
Binding Area (Å2) 653.83
Molecular Weight 10045.72
Aromaticity 0.12
Instability 23.88
Isoelectric Point 9.24
Sequence ETLVRPKPELLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVV

Peptide

Description Stapled peptide GAR300-Gm
Organism synthetic construct
Chain B
Length 14
Binding Area (Å2) 756.08
Hydrophobic (% a.a.)
42%
Molecular Weight 1656.79
Aromaticity 0.21
Instability 22.09
Isoelectric Point 3.79
Sequence LTFEQYWAQLESAA

Clustering Classification

Sequence cluster S 166
Contact cluster C817
Interface cluster I1838

Similar complexes

Is the complex classified in the same cluster?

Complex Sequence cluster
(S166) 		Contact cluster
(C817) 		Interface cluster
(I1838)
3jzo-P-A
3jzp-P-A
3jzq-P-A
3jzq-Q-B
3jzr-P-A
3jzs-P-A
3sjh-B-A
3u8x-B-A
3u8x-D-C
3u9d-B-A
3u9d-D-C
3u9z-C-A
6ijq-A-B
1sqk-B-A
2mps-B-A