VIRAL PROTEIN/HYDROLASE CIRCULATING SARS-COV-2 SPIKE N439K VARIANTS MAINTAIN FITNESS WHILE EVADING ANTIBODY-MEDIATED IMMUNITY: 0 - F SER 19 OG VS S ALA 475 O Distance: 2.927421 - Hydrogen Bonds, 1 - F SER 19 OG VS S GLY 476 N Distance: 4.217910 - Hydrogen Bonds, 2 - F SER 19 OG VS S SER 477 N Distance: 4.821779 - Hydrogen Bonds, 3 - F GLN 24 CB VS S ALA 475 CB Distance: 4.994362 - Hydrophobic, 4 - F GLN 24 CG VS S ALA 475 CB Distance: 4.424111 - Hydrophobic, 5 - F GLN 24 OE1 VS S GLY 476 N Distance: 3.939433 - Hydrogen Bonds, 6 - F GLN 24 OE1 VS S SER 477 N Distance: 4.700637 - Hydrogen Bonds, 7 - F GLN 24 CB VS S ASN 487 CB Distance: 5.372257 - Hydrophobic, 8 - F GLN 24 CG VS S ASN 487 CB Distance: 5.022959 - Hydrophobic, 9 - F GLN 24 OE1 VS S ASN 487 ND2 Distance: 2.751101 - Hydrogen Bonds, 10 - F GLN 24 O VS S TYR 489 OH Distance: 4.342084 - Hydrogen Bonds, 11 - F THR 27 CG2 VS S PHE 456 CB Distance: 5.241823 - Hydrophobic, 12 - F THR 27 CG2 VS S PHE 456 CG Distance: 4.545446 - Hydrophobic, 13 - F THR 27 CG2 VS S PHE 456 CD1 Distance: 5.038835 - Hydrophobic, 14 - F THR 27 CG2 VS S PHE 456 CD2 Distance: 3.904721 - Hydrophobic, 15 - F THR 27 CG2 VS S PHE 456 CE1 Distance: 5.004263 - Hydrophobic, 16 - F THR 27 CG2 VS S PHE 456 CE2 Distance: 3.853344 - Hydrophobic, 17 - F THR 27 CG2 VS S PHE 456 CZ Distance: 4.448386 - Hydrophobic, 18 - F THR 27 CG2 VS S TYR 473 CD2 Distance: 4.257527 - Hydrophobic, 19 - F THR 27 CG2 VS S TYR 473 CE2 Distance: 3.835416 - Hydrophobic, 20 - F THR 27 CG2 VS S ALA 475 CB Distance: 4.146048 - Hydrophobic, 21 - F THR 27 O VS S TYR 489 OH Distance: 4.411769 - Hydrogen Bonds, 22 - F THR 27 CG2 VS S TYR 489 CG Distance: 5.116524 - Hydrophobic, 23 - F THR 27 CG2 VS S TYR 489 CD2 Distance: 4.080579 - Hydrophobic, 24 - F THR 27 CG2 VS S TYR 489 CE2 Distance: 3.759751 - Hydrophobic, 25 - F PHE 28 N VS S TYR 489 OH Distance: 3.842781 - Hydrogen Bonds, 26 - F PHE 28 CB VS S TYR 489 CE1 Distance: 5.051404 - Hydrophobic, 27 - F PHE 28 CB VS S TYR 489 CE2 Distance: 5.459762 - Hydrophobic, 28 - F PHE 28 CG VS S TYR 489 CE1 Distance: 5.481326 - Hydrophobic, 29 - F PHE 28 CD1 VS S TYR 489 CE1 Distance: 4.886642 - Hydrophobic, 30 - F ASP 30 CB VS S LYS 417 CD Distance: 5.405797 - Hydrophobic, 31 - F ASP 30 OD1 VS S LYS 417 NZ Distance: 4.938575 - Attractive, 32 - F ASP 30 OD2 VS S LYS 417 NZ Distance: 3.231650 - Attractive, Hydrogen Bonds, 33 - F ASP 30 CB VS S LEU 455 CD1 Distance: 5.334589 - Hydrophobic, 34 - F ASP 30 CB VS S LEU 455 CD2 Distance: 5.482736 - Hydrophobic, 35 - F LYS 31 CB VS S LEU 455 CD2 Distance: 4.489228 - Hydrophobic, 36 - F LYS 31 CG VS S LEU 455 CD2 Distance: 5.066756 - Hydrophobic, 37 - F LYS 31 CD VS S LEU 455 CD2 Distance: 4.376186 - Hydrophobic, 38 - F LYS 31 CB VS S PHE 456 CE2 Distance: 4.310591 - Hydrophobic, 39 - F LYS 31 CB VS S PHE 456 CZ Distance: 4.275537 - Hydrophobic, 40 - F LYS 31 CG VS S PHE 456 CE2 Distance: 5.158969 - Hydrophobic, 41 - F LYS 31 CG VS S PHE 456 CZ Distance: 4.720440 - Hydrophobic, 42 - F LYS 31 CD VS S PHE 456 CE1 Distance: 5.222734 - Hydrophobic, 43 - F LYS 31 CD VS S PHE 456 CE2 Distance: 5.003570 - Hydrophobic, 44 - F LYS 31 CD VS S PHE 456 CZ Distance: 4.313864 - Hydrophobic, 45 - F LYS 31 NZ VS S GLU 484 OE1 Distance: 6.219791 - Attractive, 46 - F LYS 31 NZ VS S GLU 484 OE2 Distance: 4.968719 - Attractive, 47 - F LYS 31 CB VS S TYR 489 CB Distance: 5.348137 - Hydrophobic, 48 - F LYS 31 CB VS S TYR 489 CG Distance: 4.757806 - Hydrophobic, 49 - F LYS 31 CB VS S TYR 489 CD1 Distance: 4.125851 - Hydrophobic, 50 - F LYS 31 CB VS S TYR 489 CD2 Distance: 5.342491 - Hydrophobic, 51 - F LYS 31 CB VS S TYR 489 CE1 Distance: 4.184466 - Hydrophobic, 52 - F LYS 31 CB VS S TYR 489 CE2 Distance: 5.397134 - Hydrophobic, 53 - F LYS 31 CG VS S TYR 489 CB Distance: 4.859050 - Hydrophobic, 54 - F LYS 31 CG VS S TYR 489 CG Distance: 4.429824 - Hydrophobic, 55 - F LYS 31 CG VS S TYR 489 CD1 Distance: 3.579708 - Hydrophobic, 56 - F LYS 31 CG VS S TYR 489 CD2 Distance: 5.350059 - Hydrophobic, 57 - F LYS 31 CG VS S TYR 489 CE1 Distance: 3.887946 - Hydrophobic, 58 - F LYS 31 CD VS S TYR 489 CB Distance: 4.457801 - Hydrophobic, 59 - F LYS 31 CD VS S TYR 489 CG Distance: 4.522896 - Hydrophobic, 60 - F LYS 31 CD VS S TYR 489 CD1 Distance: 3.979270 - Hydrophobic, 61 - F LYS 31 CD VS S TYR 489 CE1 Distance: 4.726403 - Hydrophobic, 62 - F LYS 31 CD VS S GLN 493 CG Distance: 4.946476 - Hydrophobic, 63 - F LYS 31 NZ VS S GLN 493 OE1 Distance: 3.354765 - Hydrogen Bonds, 64 - F HIS 34 ND1 VS S ARG 403 NH2 Distance: 6.338012 - Repulsive, 65 - F HIS 34 CG VS S TYR 453 CG Distance: 5.645293 - Aromatic Stacking, 66 - F HIS 34 ND1 VS S TYR 453 OH Distance: 2.998549 - Hydrogen Bonds, 67 - F HIS 34 NE2 VS S TYR 453 OH Distance: 4.639507 - Hydrogen Bonds, 68 - F HIS 34 CB VS S LEU 455 CD1 Distance: 5.109409 - Hydrophobic, 69 - F HIS 34 CB VS S LEU 455 CD2 Distance: 4.690700 - Hydrophobic, 70 - F HIS 34 CB VS S GLN 493 CB Distance: 5.320676 - Hydrophobic, 71 - F HIS 34 CB VS S GLN 493 CG Distance: 5.198992 - Hydrophobic, 72 - F HIS 34 ND1 VS S GLN 493 OE1 Distance: 4.751146 - Hydrogen Bonds, 73 - F HIS 34 NE2 VS S GLN 493 OE1 Distance: 3.547045 - Hydrogen Bonds, 74 - F HIS 34 ND1 VS S SER 494 O Distance: 4.396947 - Hydrogen Bonds, 75 - F HIS 34 NE2 VS S SER 494 N Distance: 3.917771 - Hydrogen Bonds, 76 - F HIS 34 NE2 VS S SER 494 O Distance: 3.256606 - Hydrogen Bonds, 77 - F GLU 35 OE1 VS S GLU 484 OE2 Distance: 6.530342 - Repulsive, 78 - F GLU 35 OE2 VS S GLU 484 OE1 Distance: 6.580441 - Repulsive, 79 - F GLU 35 OE2 VS S GLU 484 OE2 Distance: 6.105243 - Repulsive, 80 - F GLU 37 OE2 VS S ARG 403 NH1 Distance: 6.825107 - Attractive, 81 - F GLU 37 OE2 VS S ARG 403 NH2 Distance: 6.803332 - Attractive, 82 - F GLU 37 CB VS S TYR 505 CE2 Distance: 5.397128 - Hydrophobic, 83 - F GLU 37 CG VS S TYR 505 CD2 Distance: 4.778584 - Hydrophobic, 84 - F GLU 37 CG VS S TYR 505 CE2 Distance: 4.116033 - Hydrophobic, 85 - F GLU 37 OE1 VS S TYR 505 OH Distance: 4.013375 - Hydrogen Bonds, 86 - F GLU 37 OE2 VS S TYR 505 OH Distance: 3.737656 - Hydrogen Bonds, 87 - F ASP 38 CB VS S TYR 449 CE1 Distance: 4.839726 - Hydrophobic, 88 - F ASP 38 OD1 VS S TYR 449 OH Distance: 3.276836 - Hydrogen Bonds, 89 - F ASP 38 OD2 VS S TYR 449 OH Distance: 3.180005 - Hydrogen Bonds, 90 - F ASP 38 OD1 VS S GLY 496 N Distance: 4.894736 - Hydrogen Bonds, 91 - F ASP 38 OD1 VS S GLN 498 NE2 Distance: 3.715357 - Hydrogen Bonds, 92 - F TYR 41 CD2 VS S GLN 498 CB Distance: 4.642644 - Hydrophobic, 93 - F TYR 41 CD2 VS S GLN 498 CG Distance: 4.481687 - Hydrophobic, 94 - F TYR 41 CE2 VS S GLN 498 CB Distance: 3.778735 - Hydrophobic, 95 - F TYR 41 CE2 VS S GLN 498 CG Distance: 4.007501 - Hydrophobic, 96 - F TYR 41 OH VS S THR 500 N Distance: 4.292115 - Hydrogen Bonds, 97 - F TYR 41 OH VS S THR 500 O Distance: 2.965445 - Hydrogen Bonds, 98 - F TYR 41 OH VS S THR 500 OG1 Distance: 2.614497 - Hydrogen Bonds, 99 - F TYR 41 CE2 VS S ASN 501 CB Distance: 5.496655 - Hydrophobic, 100 - F TYR 41 OH VS S ASN 501 N Distance: 3.571576 - Hydrogen Bonds, 101 - F TYR 41 OH VS S ASN 501 ND2 Distance: 3.741433 - Hydrogen Bonds, 102 - F GLN 42 OE1 VS S TYR 449 OH Distance: 3.994814 - Hydrogen Bonds, 103 - F GLN 42 NE2 VS S TYR 449 OH Distance: 3.171177 - Hydrogen Bonds, 104 - F GLN 42 OE1 VS S GLN 498 NE2 Distance: 4.074341 - Hydrogen Bonds, 105 - F GLN 42 NE2 VS S GLN 498 OE1 Distance: 4.200678 - Hydrogen Bonds, 106 - F LEU 45 CD2 VS S GLN 498 CG Distance: 5.324185 - Hydrophobic, 107 - F LEU 45 CD1 VS S THR 500 CG2 Distance: 5.372296 - Hydrophobic, 108 - F LEU 79 CB VS S PHE 486 CD1 Distance: 5.471393 - Hydrophobic, 109 - F LEU 79 CG VS S PHE 486 CD1 Distance: 5.335286 - Hydrophobic, 110 - F LEU 79 CD2 VS S PHE 486 CB Distance: 4.682571 - Hydrophobic, 111 - F LEU 79 CD2 VS S PHE 486 CG Distance: 4.832842 - Hydrophobic, 112 - F LEU 79 CD2 VS S PHE 486 CD1 Distance: 3.995934 - Hydrophobic, 113 - F LEU 79 CD2 VS S PHE 486 CE1 Distance: 4.830111 - Hydrophobic, 114 - F MET 82 CB VS S PHE 486 CG Distance: 5.444048 - Hydrophobic, 115 - F MET 82 CB VS S PHE 486 CD1 Distance: 4.438485 - Hydrophobic, 116 - F MET 82 CB VS S PHE 486 CE1 Distance: 3.448339 - Hydrophobic, 117 - F MET 82 CB VS S PHE 486 CE2 Distance: 4.847202 - Hydrophobic, 118 - F MET 82 CB VS S PHE 486 CZ Distance: 3.716102 - Hydrophobic, 119 - F MET 82 CG VS S PHE 486 CD1 Distance: 4.653494 - Hydrophobic, 120 - F MET 82 CG VS S PHE 486 CE1 Distance: 4.060783 - Hydrophobic, 121 - F MET 82 CG VS S PHE 486 CE2 Distance: 5.468000 - Hydrophobic, 122 - F MET 82 CG VS S PHE 486 CZ Distance: 4.541308 - Hydrophobic, 123 - F MET 82 CE VS S PHE 486 CG Distance: 5.294017 - Hydrophobic, 124 - F MET 82 CE VS S PHE 486 CD1 Distance: 5.031944 - Hydrophobic, 125 - F MET 82 CE VS S PHE 486 CD2 Distance: 5.172059 - Hydrophobic, 126 - F MET 82 CE VS S PHE 486 CE1 Distance: 4.663818 - Hydrophobic, 127 - F MET 82 CE VS S PHE 486 CE2 Distance: 4.810766 - Hydrophobic, 128 - F MET 82 CE VS S PHE 486 CZ Distance: 4.546344 - Hydrophobic, 129 - F TYR 83 CG VS S PHE 486 CG Distance: 5.310562 - Aromatic Stacking, 130 - F TYR 83 CG VS S PHE 486 CE1 Distance: 5.249796 - Hydrophobic, 131 - F TYR 83 CG VS S PHE 486 CZ Distance: 5.126631 - Hydrophobic, 132 - F TYR 83 CD1 VS S PHE 486 CE1 Distance: 5.035657 - Hydrophobic, 133 - F TYR 83 CD1 VS S PHE 486 CZ Distance: 4.603961 - Hydrophobic, 134 - F TYR 83 CD2 VS S PHE 486 CE1 Distance: 4.817270 - Hydrophobic, 135 - F TYR 83 CD2 VS S PHE 486 CZ Distance: 5.048908 - Hydrophobic, 136 - F TYR 83 CE1 VS S PHE 486 CD1 Distance: 5.479151 - Hydrophobic, 137 - F TYR 83 CE1 VS S PHE 486 CE1 Distance: 4.379010 - Hydrophobic, 138 - F TYR 83 CE1 VS S PHE 486 CE2 Distance: 4.781829 - Hydrophobic, 139 - F TYR 83 CE1 VS S PHE 486 CZ Distance: 3.955795 - Hydrophobic, 140 - F TYR 83 CE2 VS S PHE 486 CD1 Distance: 5.053716 - Hydrophobic, 141 - F TYR 83 CE2 VS S PHE 486 CE1 Distance: 4.125817 - Hydrophobic, 142 - F TYR 83 CE2 VS S PHE 486 CZ Distance: 4.470806 - Hydrophobic, 143 - F TYR 83 OH VS S PHE 486 O Distance: 4.211115 - Hydrogen Bonds, 144 - F TYR 83 OH VS S ASN 487 OD1 Distance: 2.369619 - Hydrogen Bonds, 145 - F TYR 83 OH VS S ASN 487 ND2 Distance: 3.736987 - Hydrogen Bonds, 146 - F TYR 83 OH VS S TYR 489 OH Distance: 3.570312 - Hydrogen Bonds, 147 - F GLN 325 OE1 VS S LYS 439 NZ Distance: 3.679085 - Hydrogen Bonds, 148 - F GLN 325 CB VS S VAL 503 CG2 Distance: 5.487007 - Hydrophobic, 149 - F GLU 329 OE1 VS S LYS 439 NZ Distance: 4.737420 - Attractive, Hydrogen Bonds, 150 - F GLU 329 OE2 VS S LYS 439 NZ Distance: 3.476344 - Attractive, Hydrogen Bonds, 151 - F ASN 330 CB VS S THR 500 CG2 Distance: 4.739071 - Hydrophobic, 152 - F ASN 330 ND2 VS S THR 500 O Distance: 3.987667 - Hydrogen Bonds, 153 - F LYS 353 NZ VS S GLY 496 O Distance: 2.785587 - Hydrogen Bonds, 154 - F LYS 353 NZ VS S GLN 498 OE1 Distance: 4.347800 - Hydrogen Bonds, 155 - F LYS 353 O VS S ASN 501 N Distance: 4.894823 - Hydrogen Bonds, 156 - F LYS 353 O VS S ASN 501 ND2 Distance: 4.255482 - Hydrogen Bonds, 157 - F LYS 353 CB VS S ASN 501 CB Distance: 4.949619 - Hydrophobic, 158 - F LYS 353 O VS S GLY 502 N Distance: 2.699436 - Hydrogen Bonds, 159 - F LYS 353 CB VS S TYR 505 CB Distance: 4.231331 - Hydrophobic, 160 - F LYS 353 CB VS S TYR 505 CG Distance: 4.047069 - Hydrophobic, 161 - F LYS 353 CB VS S TYR 505 CD1 Distance: 4.367537 - Hydrophobic, 162 - F LYS 353 CB VS S TYR 505 CD2 Distance: 4.269850 - Hydrophobic, 163 - F LYS 353 CB VS S TYR 505 CE1 Distance: 4.863197 - Hydrophobic, 164 - F LYS 353 CB VS S TYR 505 CE2 Distance: 4.777843 - Hydrophobic, 165 - F LYS 353 CG VS S TYR 505 CB Distance: 4.759021 - Hydrophobic, 166 - F LYS 353 CG VS S TYR 505 CG Distance: 4.453601 - Hydrophobic, 167 - F LYS 353 CG VS S TYR 505 CD1 Distance: 5.038269 - Hydrophobic, 168 - F LYS 353 CG VS S TYR 505 CD2 Distance: 4.196614 - Hydrophobic, 169 - F LYS 353 CG VS S TYR 505 CE1 Distance: 5.366636 - Hydrophobic, 170 - F LYS 353 CG VS S TYR 505 CE2 Distance: 4.582699 - Hydrophobic, 171 - F LYS 353 CD VS S TYR 505 CB Distance: 4.638238 - Hydrophobic, 172 - F LYS 353 CD VS S TYR 505 CG Distance: 4.690477 - Hydrophobic, 173 - F LYS 353 CD VS S TYR 505 CD2 Distance: 4.360214 - Hydrophobic, 174 - F LYS 353 CD VS S TYR 505 CE2 Distance: 5.041853 - Hydrophobic, 175 - F GLY 354 O VS S GLY 502 N Distance: 3.795612 - Hydrogen Bonds, 176 - F ASP 355 N VS S THR 500 O Distance: 4.808882 - Hydrogen Bonds, 177 - F ASP 355 OD2 VS S THR 500 OG1 Distance: 3.736763 - Hydrogen Bonds, 178 - F ARG 357 NH1 VS S THR 500 O Distance: 4.683185 - Hydrogen Bonds, 179 - F ARG 357 NH1 VS S THR 500 OG1 Distance: 3.321791 - Hydrogen Bonds, 180 - F ALA 386 O VS S TYR 505 OH Distance: 4.588020 - Hydrogen Bonds, 181 - F ARG 393 NH1 VS S TYR 505 OH Distance: 4.285642 - Hydrogen Bonds, 182 - F ARG 393 NH2 VS S TYR 505 OH Distance: 3.966650 - Hydrogen Bonds,