VIRAL PROTEIN/HYDROLASE CIRCULATING SARS-COV-2 SPIKE N439K VARIANTS MAINTAIN FITNESS WHILE EVADING ANTIBODY-MEDIATED IMMUNITY: 0 - E SER 19 OG VS R ALA 475 O Distance: 2.661628 - Hydrogen Bonds, 1 - E SER 19 OG VS R GLY 476 N Distance: 4.200672 - Hydrogen Bonds, 2 - E SER 19 OG VS R GLY 476 O Distance: 4.229451 - Hydrogen Bonds, 3 - E SER 19 OG VS R SER 477 N Distance: 4.085606 - Hydrogen Bonds, 4 - E GLN 24 CG VS R ALA 475 CB Distance: 5.157702 - Hydrophobic, 5 - E GLN 24 NE2 VS R ALA 475 O Distance: 3.888059 - Hydrogen Bonds, 6 - E GLN 24 CG VS R ASN 487 CB Distance: 5.194000 - Hydrophobic, 7 - E GLN 24 OE1 VS R ASN 487 ND2 Distance: 3.333129 - Hydrogen Bonds, 8 - E GLN 24 O VS R TYR 489 OH Distance: 4.221963 - Hydrogen Bonds, 9 - E THR 27 CG2 VS R PHE 456 CD1 Distance: 4.584151 - Hydrophobic, 10 - E THR 27 CG2 VS R PHE 456 CE1 Distance: 4.533071 - Hydrophobic, 11 - E THR 27 CG2 VS R TYR 473 CD2 Distance: 5.384918 - Hydrophobic, 12 - E THR 27 CG2 VS R TYR 473 CE2 Distance: 4.196513 - Hydrophobic, 13 - E THR 27 CG2 VS R ALA 475 CB Distance: 4.671114 - Hydrophobic, 14 - E THR 27 O VS R TYR 489 OH Distance: 3.895880 - Hydrogen Bonds, 15 - E THR 27 OG1 VS R TYR 489 OH Distance: 4.542474 - Hydrogen Bonds, 16 - E PHE 28 N VS R TYR 489 OH Distance: 3.733888 - Hydrogen Bonds, 17 - E PHE 28 CB VS R TYR 489 CE1 Distance: 4.803839 - Hydrophobic, 18 - E PHE 28 CB VS R TYR 489 CE2 Distance: 5.348502 - Hydrophobic, 19 - E PHE 28 CG VS R TYR 489 CE1 Distance: 5.262122 - Hydrophobic, 20 - E PHE 28 CD1 VS R TYR 489 CE1 Distance: 4.665601 - Hydrophobic, 21 - E ASP 30 OD1 VS R LYS 417 NZ Distance: 5.818059 - Attractive, 22 - E ASP 30 OD2 VS R LYS 417 NZ Distance: 3.776520 - Attractive, Hydrogen Bonds, 23 - E ASP 30 CB VS R LEU 455 CD1 Distance: 5.465218 - Hydrophobic, 24 - E ASP 30 CB VS R PHE 456 CE1 Distance: 5.288012 - Hydrophobic, 25 - E LYS 31 CB VS R LEU 455 CD2 Distance: 4.605717 - Hydrophobic, 26 - E LYS 31 CG VS R LEU 455 CD2 Distance: 4.605659 - Hydrophobic, 27 - E LYS 31 CB VS R PHE 456 CD2 Distance: 5.463870 - Hydrophobic, 28 - E LYS 31 CB VS R PHE 456 CE1 Distance: 4.668106 - Hydrophobic, 29 - E LYS 31 CB VS R PHE 456 CE2 Distance: 4.080387 - Hydrophobic, 30 - E LYS 31 CB VS R PHE 456 CZ Distance: 3.558178 - Hydrophobic, 31 - E LYS 31 CG VS R PHE 456 CD2 Distance: 5.150062 - Hydrophobic, 32 - E LYS 31 CG VS R PHE 456 CE1 Distance: 5.166709 - Hydrophobic, 33 - E LYS 31 CG VS R PHE 456 CE2 Distance: 3.831331 - Hydrophobic, 34 - E LYS 31 CG VS R PHE 456 CZ Distance: 3.847883 - Hydrophobic, 35 - E LYS 31 CD VS R PHE 456 CE2 Distance: 5.262909 - Hydrophobic, 36 - E LYS 31 CD VS R PHE 456 CZ Distance: 5.360769 - Hydrophobic, 37 - E LYS 31 NZ VS R GLU 484 OE1 Distance: 6.644104 - Attractive, 38 - E LYS 31 NZ VS R GLU 484 OE2 Distance: 5.010495 - Attractive, 39 - E LYS 31 CB VS R TYR 489 CB Distance: 5.382342 - Hydrophobic, 40 - E LYS 31 CB VS R TYR 489 CG Distance: 4.837195 - Hydrophobic, 41 - E LYS 31 CB VS R TYR 489 CD1 Distance: 4.300954 - Hydrophobic, 42 - E LYS 31 CB VS R TYR 489 CD2 Distance: 5.392149 - Hydrophobic, 43 - E LYS 31 CB VS R TYR 489 CE1 Distance: 4.403344 - Hydrophobic, 44 - E LYS 31 CB VS R TYR 489 CE2 Distance: 5.482430 - Hydrophobic, 45 - E LYS 31 CG VS R TYR 489 CB Distance: 4.455445 - Hydrophobic, 46 - E LYS 31 CG VS R TYR 489 CG Distance: 4.233931 - Hydrophobic, 47 - E LYS 31 CG VS R TYR 489 CD1 Distance: 3.713769 - Hydrophobic, 48 - E LYS 31 CG VS R TYR 489 CD2 Distance: 5.127097 - Hydrophobic, 49 - E LYS 31 CG VS R TYR 489 CE1 Distance: 4.244954 - Hydrophobic, 50 - E LYS 31 CD VS R TYR 489 CB Distance: 5.141364 - Hydrophobic, 51 - E LYS 31 CD VS R TYR 489 CG Distance: 4.934987 - Hydrophobic, 52 - E LYS 31 CD VS R TYR 489 CD1 Distance: 4.093341 - Hydrophobic, 53 - E LYS 31 CD VS R TYR 489 CE1 Distance: 4.562593 - Hydrophobic, 54 - E LYS 31 O VS R GLN 493 NE2 Distance: 4.775938 - Hydrogen Bonds, 55 - E LYS 31 CG VS R GLN 493 CG Distance: 5.412080 - Hydrophobic, 56 - E HIS 34 CG VS R TYR 453 CG Distance: 5.879320 - Aromatic Stacking, 57 - E HIS 34 ND1 VS R TYR 453 OH Distance: 3.071851 - Hydrogen Bonds, 58 - E HIS 34 NE2 VS R TYR 453 OH Distance: 4.840857 - Hydrogen Bonds, 59 - E HIS 34 CB VS R LEU 455 CD1 Distance: 5.354915 - Hydrophobic, 60 - E HIS 34 CB VS R LEU 455 CD2 Distance: 4.331699 - Hydrophobic, 61 - E HIS 34 CB VS R GLN 493 CB Distance: 5.222928 - Hydrophobic, 62 - E HIS 34 CB VS R GLN 493 CG Distance: 5.184028 - Hydrophobic, 63 - E HIS 34 NE2 VS R GLN 493 OE1 Distance: 3.540384 - Hydrogen Bonds, 64 - E HIS 34 NE2 VS R GLN 493 NE2 Distance: 3.443183 - Hydrogen Bonds, 65 - E HIS 34 ND1 VS R SER 494 N Distance: 4.856127 - Hydrogen Bonds, 66 - E HIS 34 ND1 VS R SER 494 O Distance: 3.998431 - Hydrogen Bonds, 67 - E HIS 34 NE2 VS R SER 494 N Distance: 4.229679 - Hydrogen Bonds, 68 - E HIS 34 NE2 VS R SER 494 O Distance: 4.190170 - Hydrogen Bonds, 69 - E GLU 35 OE1 VS R GLU 484 OE2 Distance: 6.926054 - Repulsive, 70 - E GLU 35 OE1 VS R GLN 493 NE2 Distance: 3.009705 - Hydrogen Bonds, 71 - E GLU 37 OE1 VS R ARG 403 NH2 Distance: 6.995123 - Attractive, 72 - E GLU 37 CB VS R TYR 505 CE1 Distance: 5.190045 - Hydrophobic, 73 - E GLU 37 CG VS R TYR 505 CD1 Distance: 4.777612 - Hydrophobic, 74 - E GLU 37 CG VS R TYR 505 CE1 Distance: 3.917483 - Hydrophobic, 75 - E GLU 37 CG VS R TYR 505 CE2 Distance: 5.371866 - Hydrophobic, 76 - E GLU 37 OE1 VS R TYR 505 OH Distance: 3.234945 - Hydrogen Bonds, 77 - E GLU 37 OE2 VS R TYR 505 OH Distance: 4.022037 - Hydrogen Bonds, 78 - E ASP 38 CB VS R TYR 449 CE1 Distance: 4.836373 - Hydrophobic, 79 - E ASP 38 OD1 VS R TYR 449 OH Distance: 2.854968 - Hydrogen Bonds, 80 - E ASP 38 OD2 VS R TYR 449 OH Distance: 3.267390 - Hydrogen Bonds, 81 - E ASP 38 O VS R GLN 498 NE2 Distance: 4.897611 - Hydrogen Bonds, 82 - E ASP 38 OD1 VS R GLN 498 NE2 Distance: 3.210272 - Hydrogen Bonds, 83 - E TYR 41 CD2 VS R GLN 498 CB Distance: 4.607130 - Hydrophobic, 84 - E TYR 41 CD2 VS R GLN 498 CG Distance: 4.257353 - Hydrophobic, 85 - E TYR 41 CE2 VS R GLN 498 CB Distance: 3.712246 - Hydrophobic, 86 - E TYR 41 CE2 VS R GLN 498 CG Distance: 3.759796 - Hydrophobic, 87 - E TYR 41 OH VS R THR 500 N Distance: 4.304804 - Hydrogen Bonds, 88 - E TYR 41 OH VS R THR 500 O Distance: 2.905165 - Hydrogen Bonds, 89 - E TYR 41 OH VS R THR 500 OG1 Distance: 2.705143 - Hydrogen Bonds, 90 - E TYR 41 OH VS R ASN 501 N Distance: 3.670189 - Hydrogen Bonds, 91 - E TYR 41 OH VS R ASN 501 ND2 Distance: 3.928726 - Hydrogen Bonds, 92 - E GLN 42 NE2 VS R GLY 446 O Distance: 3.433695 - Hydrogen Bonds, 93 - E GLN 42 OE1 VS R TYR 449 OH Distance: 3.994666 - Hydrogen Bonds, 94 - E GLN 42 NE2 VS R TYR 449 OH Distance: 3.524916 - Hydrogen Bonds, 95 - E GLN 42 OE1 VS R GLN 498 NE2 Distance: 3.330129 - Hydrogen Bonds, 96 - E LEU 45 CD1 VS R GLN 498 CB Distance: 5.135867 - Hydrophobic, 97 - E LEU 45 CD1 VS R GLN 498 CG Distance: 4.572563 - Hydrophobic, 98 - E LEU 45 CD2 VS R THR 500 CG2 Distance: 5.319073 - Hydrophobic, 99 - E LEU 79 CB VS R PHE 486 CD1 Distance: 5.047197 - Hydrophobic, 100 - E LEU 79 CB VS R PHE 486 CE1 Distance: 5.314046 - Hydrophobic, 101 - E LEU 79 CG VS R PHE 486 CB Distance: 5.484096 - Hydrophobic, 102 - E LEU 79 CG VS R PHE 486 CD1 Distance: 4.575859 - Hydrophobic, 103 - E LEU 79 CG VS R PHE 486 CE1 Distance: 5.226903 - Hydrophobic, 104 - E LEU 79 CD2 VS R PHE 486 CB Distance: 5.243760 - Hydrophobic, 105 - E LEU 79 CD2 VS R PHE 486 CG Distance: 5.469303 - Hydrophobic, 106 - E LEU 79 CD2 VS R PHE 486 CD1 Distance: 4.645106 - Hydrophobic, 107 - E LEU 79 CD2 VS R PHE 486 CE1 Distance: 5.460378 - Hydrophobic, 108 - E MET 82 CB VS R PHE 486 CD1 Distance: 4.800917 - Hydrophobic, 109 - E MET 82 CB VS R PHE 486 CD2 Distance: 5.459195 - Hydrophobic, 110 - E MET 82 CB VS R PHE 486 CE1 Distance: 3.771146 - Hydrophobic, 111 - E MET 82 CB VS R PHE 486 CE2 Distance: 4.578900 - Hydrophobic, 112 - E MET 82 CB VS R PHE 486 CZ Distance: 3.636336 - Hydrophobic, 113 - E MET 82 CG VS R PHE 486 CD1 Distance: 4.860215 - Hydrophobic, 114 - E MET 82 CG VS R PHE 486 CE1 Distance: 4.202302 - Hydrophobic, 115 - E MET 82 CG VS R PHE 486 CE2 Distance: 5.050465 - Hydrophobic, 116 - E MET 82 CG VS R PHE 486 CZ Distance: 4.317437 - Hydrophobic, 117 - E MET 82 CE VS R PHE 486 CD2 Distance: 5.416978 - Hydrophobic, 118 - E MET 82 CE VS R PHE 486 CE1 Distance: 5.380490 - Hydrophobic, 119 - E MET 82 CE VS R PHE 486 CE2 Distance: 4.939938 - Hydrophobic, 120 - E MET 82 CE VS R PHE 486 CZ Distance: 4.924763 - Hydrophobic, 121 - E TYR 83 CG VS R PHE 486 CG Distance: 5.543192 - Aromatic Stacking, 122 - E TYR 83 CG VS R PHE 486 CZ Distance: 5.394202 - Hydrophobic, 123 - E TYR 83 CD1 VS R PHE 486 CE1 Distance: 5.244147 - Hydrophobic, 124 - E TYR 83 CD1 VS R PHE 486 CZ Distance: 4.875168 - Hydrophobic, 125 - E TYR 83 CD2 VS R PHE 486 CE1 Distance: 4.955691 - Hydrophobic, 126 - E TYR 83 CD2 VS R PHE 486 CZ Distance: 5.192051 - Hydrophobic, 127 - E TYR 83 CE1 VS R PHE 486 CE1 Distance: 4.404327 - Hydrophobic, 128 - E TYR 83 CE1 VS R PHE 486 CE2 Distance: 5.089450 - Hydrophobic, 129 - E TYR 83 CE1 VS R PHE 486 CZ Distance: 4.088901 - Hydrophobic, 130 - E TYR 83 CE2 VS R PHE 486 CD1 Distance: 5.115887 - Hydrophobic, 131 - E TYR 83 CE2 VS R PHE 486 CE1 Distance: 4.054117 - Hydrophobic, 132 - E TYR 83 CE2 VS R PHE 486 CZ Distance: 4.465133 - Hydrophobic, 133 - E TYR 83 OH VS R ASN 487 N Distance: 4.647606 - Hydrogen Bonds, 134 - E TYR 83 OH VS R ASN 487 OD1 Distance: 2.412494 - Hydrogen Bonds, 135 - E TYR 83 OH VS R ASN 487 ND2 Distance: 4.192030 - Hydrogen Bonds, 136 - E TYR 83 OH VS R TYR 489 OH Distance: 3.735608 - Hydrogen Bonds, 137 - E THR 324 OG1 VS R VAL 503 N Distance: 4.751379 - Hydrogen Bonds, 138 - E GLN 325 OE1 VS R LYS 439 NZ Distance: 3.047473 - Hydrogen Bonds, 139 - E GLN 325 CB VS R VAL 503 CG2 Distance: 5.183908 - Hydrophobic, 140 - E GLU 329 OE1 VS R LYS 439 NZ Distance: 3.620444 - Attractive, Hydrogen Bonds, 141 - E GLU 329 OE2 VS R LYS 439 NZ Distance: 3.988522 - Attractive, Hydrogen Bonds, 142 - E ASN 330 CB VS R THR 500 CG2 Distance: 4.813515 - Hydrophobic, 143 - E ASN 330 ND2 VS R THR 500 O Distance: 4.536720 - Hydrogen Bonds, 144 - E LYS 353 NZ VS R GLY 496 O Distance: 2.913394 - Hydrogen Bonds, 145 - E LYS 353 NZ VS R GLN 498 OE1 Distance: 3.120782 - Hydrogen Bonds, 146 - E LYS 353 O VS R ASN 501 ND2 Distance: 4.511726 - Hydrogen Bonds, 147 - E LYS 353 CB VS R ASN 501 CB Distance: 5.110719 - Hydrophobic, 148 - E LYS 353 O VS R GLY 502 N Distance: 2.697239 - Hydrogen Bonds, 149 - E LYS 353 CB VS R TYR 505 CB Distance: 4.128608 - Hydrophobic, 150 - E LYS 353 CB VS R TYR 505 CG Distance: 3.896121 - Hydrophobic, 151 - E LYS 353 CB VS R TYR 505 CD1 Distance: 4.015944 - Hydrophobic, 152 - E LYS 353 CB VS R TYR 505 CD2 Distance: 4.298180 - Hydrophobic, 153 - E LYS 353 CB VS R TYR 505 CE1 Distance: 4.519100 - Hydrophobic, 154 - E LYS 353 CB VS R TYR 505 CE2 Distance: 4.768760 - Hydrophobic, 155 - E LYS 353 CG VS R TYR 505 CB Distance: 4.555309 - Hydrophobic, 156 - E LYS 353 CG VS R TYR 505 CG Distance: 4.136868 - Hydrophobic, 157 - E LYS 353 CG VS R TYR 505 CD1 Distance: 3.730623 - Hydrophobic, 158 - E LYS 353 CG VS R TYR 505 CD2 Distance: 4.781090 - Hydrophobic, 159 - E LYS 353 CG VS R TYR 505 CE1 Distance: 4.068033 - Hydrophobic, 160 - E LYS 353 CG VS R TYR 505 CE2 Distance: 5.050884 - Hydrophobic, 161 - E LYS 353 CD VS R TYR 505 CB Distance: 4.991891 - Hydrophobic, 162 - E LYS 353 CD VS R TYR 505 CG Distance: 4.929855 - Hydrophobic, 163 - E LYS 353 CD VS R TYR 505 CD1 Distance: 4.459480 - Hydrophobic, 164 - E LYS 353 CD VS R TYR 505 CE1 Distance: 5.026710 - Hydrophobic, 165 - E GLY 354 O VS R GLY 502 N Distance: 3.862763 - Hydrogen Bonds, 166 - E ASP 355 OD2 VS R THR 500 OG1 Distance: 3.934478 - Hydrogen Bonds, 167 - E ARG 357 NH1 VS R THR 500 O Distance: 4.704377 - Hydrogen Bonds, 168 - E ARG 357 NH1 VS R THR 500 OG1 Distance: 3.602611 - Hydrogen Bonds, 169 - E ARG 393 NH1 VS R TYR 505 OH Distance: 3.687135 - Hydrogen Bonds, 170 - E ARG 393 NH2 VS R TYR 505 OH Distance: 4.667302 - Hydrogen Bonds,