VIRAL PROTEIN/HYDROLASE CIRCULATING SARS-COV-2 SPIKE N439K VARIANTS MAINTAIN FITNESS WHILE EVADING ANTIBODY-MEDIATED IMMUNITY: 0 - E SER 19 OG VS R ALA 475 O Distance: 2.661520 - Hydrogen Bonds, 1 - E SER 19 OG VS R GLY 476 N Distance: 4.200871 - Hydrogen Bonds, 2 - E SER 19 OG VS R GLY 476 O Distance: 4.229646 - Hydrogen Bonds, 3 - E SER 19 OG VS R SER 477 N Distance: 4.086087 - Hydrogen Bonds, 4 - E GLN 24 CG VS R ALA 475 CB Distance: 5.158436 - Hydrophobic, 5 - E GLN 24 NE2 VS R ALA 475 O Distance: 3.887883 - Hydrogen Bonds, 6 - E GLN 24 CG VS R ASN 487 CB Distance: 5.194541 - Hydrophobic, 7 - E GLN 24 OE1 VS R ASN 487 ND2 Distance: 3.333183 - Hydrogen Bonds, 8 - E GLN 24 O VS R TYR 489 OH Distance: 4.221925 - Hydrogen Bonds, 9 - E THR 27 CG2 VS R PHE 456 CD1 Distance: 4.584041 - Hydrophobic, 10 - E THR 27 CG2 VS R PHE 456 CE1 Distance: 4.533013 - Hydrophobic, 11 - E THR 27 CG2 VS R TYR 473 CD2 Distance: 5.384940 - Hydrophobic, 12 - E THR 27 CG2 VS R TYR 473 CE2 Distance: 4.196928 - Hydrophobic, 13 - E THR 27 CG2 VS R ALA 475 CB Distance: 4.671100 - Hydrophobic, 14 - E THR 27 O VS R TYR 489 OH Distance: 3.895204 - Hydrogen Bonds, 15 - E THR 27 OG1 VS R TYR 489 OH Distance: 4.542428 - Hydrogen Bonds, 16 - E PHE 28 N VS R TYR 489 OH Distance: 3.733563 - Hydrogen Bonds, 17 - E PHE 28 CB VS R TYR 489 CE1 Distance: 4.804312 - Hydrophobic, 18 - E PHE 28 CB VS R TYR 489 CE2 Distance: 5.349034 - Hydrophobic, 19 - E PHE 28 CG VS R TYR 489 CE1 Distance: 5.262334 - Hydrophobic, 20 - E PHE 28 CD1 VS R TYR 489 CE1 Distance: 4.666087 - Hydrophobic, 21 - E ASP 30 OD1 VS R LYS 417 NZ Distance: 5.818696 - Attractive, 22 - E ASP 30 OD2 VS R LYS 417 NZ Distance: 3.776938 - Attractive, Hydrogen Bonds, 23 - E ASP 30 CB VS R LEU 455 CD1 Distance: 5.465140 - Hydrophobic, 24 - E ASP 30 CB VS R PHE 456 CE1 Distance: 5.288090 - Hydrophobic, 25 - E LYS 31 CB VS R LEU 455 CD2 Distance: 4.605630 - Hydrophobic, 26 - E LYS 31 CG VS R LEU 455 CD2 Distance: 4.605659 - Hydrophobic, 27 - E LYS 31 CB VS R PHE 456 CD2 Distance: 5.463976 - Hydrophobic, 28 - E LYS 31 CB VS R PHE 456 CE1 Distance: 4.668686 - Hydrophobic, 29 - E LYS 31 CB VS R PHE 456 CE2 Distance: 4.080909 - Hydrophobic, 30 - E LYS 31 CB VS R PHE 456 CZ Distance: 3.558605 - Hydrophobic, 31 - E LYS 31 CG VS R PHE 456 CD2 Distance: 5.149926 - Hydrophobic, 32 - E LYS 31 CG VS R PHE 456 CE1 Distance: 5.167496 - Hydrophobic, 33 - E LYS 31 CG VS R PHE 456 CE2 Distance: 3.831687 - Hydrophobic, 34 - E LYS 31 CG VS R PHE 456 CZ Distance: 3.848558 - Hydrophobic, 35 - E LYS 31 CD VS R PHE 456 CE2 Distance: 5.262860 - Hydrophobic, 36 - E LYS 31 CD VS R PHE 456 CZ Distance: 5.360846 - Hydrophobic, 37 - E LYS 31 NZ VS R GLU 484 OE1 Distance: 6.643871 - Attractive, 38 - E LYS 31 NZ VS R GLU 484 OE2 Distance: 5.010273 - Attractive, 39 - E LYS 31 CB VS R TYR 489 CB Distance: 5.383257 - Hydrophobic, 40 - E LYS 31 CB VS R TYR 489 CG Distance: 4.837397 - Hydrophobic, 41 - E LYS 31 CB VS R TYR 489 CD1 Distance: 4.301243 - Hydrophobic, 42 - E LYS 31 CB VS R TYR 489 CD2 Distance: 5.392402 - Hydrophobic, 43 - E LYS 31 CB VS R TYR 489 CE1 Distance: 4.403646 - Hydrophobic, 44 - E LYS 31 CB VS R TYR 489 CE2 Distance: 5.483013 - Hydrophobic, 45 - E LYS 31 CG VS R TYR 489 CB Distance: 4.455759 - Hydrophobic, 46 - E LYS 31 CG VS R TYR 489 CG Distance: 4.233491 - Hydrophobic, 47 - E LYS 31 CG VS R TYR 489 CD1 Distance: 3.713439 - Hydrophobic, 48 - E LYS 31 CG VS R TYR 489 CD2 Distance: 5.126864 - Hydrophobic, 49 - E LYS 31 CG VS R TYR 489 CE1 Distance: 4.244835 - Hydrophobic, 50 - E LYS 31 CD VS R TYR 489 CB Distance: 5.141781 - Hydrophobic, 51 - E LYS 31 CD VS R TYR 489 CG Distance: 4.934443 - Hydrophobic, 52 - E LYS 31 CD VS R TYR 489 CD1 Distance: 4.093096 - Hydrophobic, 53 - E LYS 31 CD VS R TYR 489 CE1 Distance: 4.562587 - Hydrophobic, 54 - E LYS 31 O VS R GLN 493 NE2 Distance: 4.775289 - Hydrogen Bonds, 55 - E LYS 31 CG VS R GLN 493 CG Distance: 5.411525 - Hydrophobic, 56 - E HIS 34 CG VS R TYR 453 CG Distance: 5.879134 - Aromatic Stacking, 57 - E HIS 34 ND1 VS R TYR 453 OH Distance: 3.072529 - Hydrogen Bonds, 58 - E HIS 34 NE2 VS R TYR 453 OH Distance: 4.840495 - Hydrogen Bonds, 59 - E HIS 34 CB VS R LEU 455 CD1 Distance: 5.354665 - Hydrophobic, 60 - E HIS 34 CB VS R LEU 455 CD2 Distance: 4.331892 - Hydrophobic, 61 - E HIS 34 CB VS R GLN 493 CB Distance: 5.222886 - Hydrophobic, 62 - E HIS 34 CB VS R GLN 493 CG Distance: 5.183444 - Hydrophobic, 63 - E HIS 34 NE2 VS R GLN 493 OE1 Distance: 3.540395 - Hydrogen Bonds, 64 - E HIS 34 NE2 VS R GLN 493 NE2 Distance: 3.443464 - Hydrogen Bonds, 65 - E HIS 34 ND1 VS R SER 494 N Distance: 4.855641 - Hydrogen Bonds, 66 - E HIS 34 ND1 VS R SER 494 O Distance: 3.998712 - Hydrogen Bonds, 67 - E HIS 34 NE2 VS R SER 494 N Distance: 4.229369 - Hydrogen Bonds, 68 - E HIS 34 NE2 VS R SER 494 O Distance: 4.190442 - Hydrogen Bonds, 69 - E GLU 35 OE1 VS R GLU 484 OE2 Distance: 6.926423 - Repulsive, 70 - E GLU 35 OE1 VS R GLN 493 NE2 Distance: 3.009539 - Hydrogen Bonds, 71 - E GLU 37 OE1 VS R ARG 403 NH2 Distance: 6.994508 - Attractive, 72 - E GLU 37 CB VS R TYR 505 CE1 Distance: 5.190045 - Hydrophobic, 73 - E GLU 37 CG VS R TYR 505 CD1 Distance: 4.777419 - Hydrophobic, 74 - E GLU 37 CG VS R TYR 505 CE1 Distance: 3.917120 - Hydrophobic, 75 - E GLU 37 CG VS R TYR 505 CE2 Distance: 5.371420 - Hydrophobic, 76 - E GLU 37 OE1 VS R TYR 505 OH Distance: 3.234955 - Hydrogen Bonds, 77 - E GLU 37 OE2 VS R TYR 505 OH Distance: 4.022326 - Hydrogen Bonds, 78 - E ASP 38 CB VS R TYR 449 CE1 Distance: 4.836105 - Hydrophobic, 79 - E ASP 38 OD1 VS R TYR 449 OH Distance: 2.855300 - Hydrogen Bonds, 80 - E ASP 38 OD2 VS R TYR 449 OH Distance: 3.267373 - Hydrogen Bonds, 81 - E ASP 38 O VS R GLN 498 NE2 Distance: 4.898139 - Hydrogen Bonds, 82 - E ASP 38 OD1 VS R GLN 498 NE2 Distance: 3.210253 - Hydrogen Bonds, 83 - E TYR 41 CD2 VS R GLN 498 CB Distance: 4.607378 - Hydrophobic, 84 - E TYR 41 CD2 VS R GLN 498 CG Distance: 4.257679 - Hydrophobic, 85 - E TYR 41 CE2 VS R GLN 498 CB Distance: 3.712253 - Hydrophobic, 86 - E TYR 41 CE2 VS R GLN 498 CG Distance: 3.759868 - Hydrophobic, 87 - E TYR 41 OH VS R THR 500 N Distance: 4.305727 - Hydrogen Bonds, 88 - E TYR 41 OH VS R THR 500 O Distance: 2.904784 - Hydrogen Bonds, 89 - E TYR 41 OH VS R THR 500 OG1 Distance: 2.705165 - Hydrogen Bonds, 90 - E TYR 41 OH VS R ASN 501 N Distance: 3.670987 - Hydrogen Bonds, 91 - E TYR 41 OH VS R ASN 501 ND2 Distance: 3.929372 - Hydrogen Bonds, 92 - E GLN 42 NE2 VS R GLY 446 O Distance: 3.433453 - Hydrogen Bonds, 93 - E GLN 42 OE1 VS R TYR 449 OH Distance: 3.995591 - Hydrogen Bonds, 94 - E GLN 42 NE2 VS R TYR 449 OH Distance: 3.525173 - Hydrogen Bonds, 95 - E GLN 42 OE1 VS R GLN 498 NE2 Distance: 3.331065 - Hydrogen Bonds, 96 - E LEU 45 CD1 VS R GLN 498 CB Distance: 5.136262 - Hydrophobic, 97 - E LEU 45 CD1 VS R GLN 498 CG Distance: 4.573091 - Hydrophobic, 98 - E LEU 45 CD2 VS R THR 500 CG2 Distance: 5.319158 - Hydrophobic, 99 - E LEU 79 CB VS R PHE 486 CD1 Distance: 5.046534 - Hydrophobic, 100 - E LEU 79 CB VS R PHE 486 CE1 Distance: 5.313970 - Hydrophobic, 101 - E LEU 79 CG VS R PHE 486 CB Distance: 5.484247 - Hydrophobic, 102 - E LEU 79 CG VS R PHE 486 CD1 Distance: 4.575136 - Hydrophobic, 103 - E LEU 79 CG VS R PHE 486 CE1 Distance: 5.226931 - Hydrophobic, 104 - E LEU 79 CD2 VS R PHE 486 CB Distance: 5.244673 - Hydrophobic, 105 - E LEU 79 CD2 VS R PHE 486 CG Distance: 5.469895 - Hydrophobic, 106 - E LEU 79 CD2 VS R PHE 486 CD1 Distance: 4.644996 - Hydrophobic, 107 - E LEU 79 CD2 VS R PHE 486 CE1 Distance: 5.461076 - Hydrophobic, 108 - E MET 82 CB VS R PHE 486 CD1 Distance: 4.801145 - Hydrophobic, 109 - E MET 82 CB VS R PHE 486 CD2 Distance: 5.459120 - Hydrophobic, 110 - E MET 82 CB VS R PHE 486 CE1 Distance: 3.770790 - Hydrophobic, 111 - E MET 82 CB VS R PHE 486 CE2 Distance: 4.579190 - Hydrophobic, 112 - E MET 82 CB VS R PHE 486 CZ Distance: 3.636913 - Hydrophobic, 113 - E MET 82 CG VS R PHE 486 CD1 Distance: 4.860707 - Hydrophobic, 114 - E MET 82 CG VS R PHE 486 CE1 Distance: 4.202179 - Hydrophobic, 115 - E MET 82 CG VS R PHE 486 CE2 Distance: 5.051094 - Hydrophobic, 116 - E MET 82 CG VS R PHE 486 CZ Distance: 4.318345 - Hydrophobic, 117 - E MET 82 CE VS R PHE 486 CD2 Distance: 5.417428 - Hydrophobic, 118 - E MET 82 CE VS R PHE 486 CE1 Distance: 5.380529 - Hydrophobic, 119 - E MET 82 CE VS R PHE 486 CE2 Distance: 4.940650 - Hydrophobic, 120 - E MET 82 CE VS R PHE 486 CZ Distance: 4.925742 - Hydrophobic, 121 - E TYR 83 CG VS R PHE 486 CG Distance: 5.542742 - Aromatic Stacking, 122 - E TYR 83 CG VS R PHE 486 CZ Distance: 5.394010 - Hydrophobic, 123 - E TYR 83 CD1 VS R PHE 486 CE1 Distance: 5.244667 - Hydrophobic, 124 - E TYR 83 CD1 VS R PHE 486 CZ Distance: 4.875425 - Hydrophobic, 125 - E TYR 83 CD2 VS R PHE 486 CE1 Distance: 4.955767 - Hydrophobic, 126 - E TYR 83 CD2 VS R PHE 486 CZ Distance: 5.192152 - Hydrophobic, 127 - E TYR 83 CE1 VS R PHE 486 CE1 Distance: 4.404315 - Hydrophobic, 128 - E TYR 83 CE1 VS R PHE 486 CE2 Distance: 5.089181 - Hydrophobic, 129 - E TYR 83 CE1 VS R PHE 486 CZ Distance: 4.088389 - Hydrophobic, 130 - E TYR 83 CE2 VS R PHE 486 CD1 Distance: 5.116398 - Hydrophobic, 131 - E TYR 83 CE2 VS R PHE 486 CE1 Distance: 4.054937 - Hydrophobic, 132 - E TYR 83 CE2 VS R PHE 486 CZ Distance: 4.465647 - Hydrophobic, 133 - E TYR 83 OH VS R ASN 487 N Distance: 4.647726 - Hydrogen Bonds, 134 - E TYR 83 OH VS R ASN 487 OD1 Distance: 2.413215 - Hydrogen Bonds, 135 - E TYR 83 OH VS R ASN 487 ND2 Distance: 4.192511 - Hydrogen Bonds, 136 - E TYR 83 OH VS R TYR 489 OH Distance: 3.736342 - Hydrogen Bonds, 137 - E THR 324 OG1 VS R VAL 503 N Distance: 4.751917 - Hydrogen Bonds, 138 - E GLN 325 OE1 VS R LYS 439 NZ Distance: 3.048162 - Hydrogen Bonds, 139 - E GLN 325 CB VS R VAL 503 CG2 Distance: 5.183983 - Hydrophobic, 140 - E GLU 329 OE1 VS R LYS 439 NZ Distance: 3.619995 - Attractive, Hydrogen Bonds, 141 - E GLU 329 OE2 VS R LYS 439 NZ Distance: 3.988668 - Attractive, Hydrogen Bonds, 142 - E ASN 330 CB VS R THR 500 CG2 Distance: 4.813596 - Hydrophobic, 143 - E ASN 330 ND2 VS R THR 500 O Distance: 4.537221 - Hydrogen Bonds, 144 - E LYS 353 NZ VS R GLY 496 O Distance: 2.912958 - Hydrogen Bonds, 145 - E LYS 353 NZ VS R GLN 498 OE1 Distance: 3.121081 - Hydrogen Bonds, 146 - E LYS 353 O VS R ASN 501 ND2 Distance: 4.511910 - Hydrogen Bonds, 147 - E LYS 353 CB VS R ASN 501 CB Distance: 5.110688 - Hydrophobic, 148 - E LYS 353 O VS R GLY 502 N Distance: 2.697346 - Hydrogen Bonds, 149 - E LYS 353 CB VS R TYR 505 CB Distance: 4.128867 - Hydrophobic, 150 - E LYS 353 CB VS R TYR 505 CG Distance: 3.896204 - Hydrophobic, 151 - E LYS 353 CB VS R TYR 505 CD1 Distance: 4.015213 - Hydrophobic, 152 - E LYS 353 CB VS R TYR 505 CD2 Distance: 4.297390 - Hydrophobic, 153 - E LYS 353 CB VS R TYR 505 CE1 Distance: 4.518272 - Hydrophobic, 154 - E LYS 353 CB VS R TYR 505 CE2 Distance: 4.768779 - Hydrophobic, 155 - E LYS 353 CG VS R TYR 505 CB Distance: 4.556202 - Hydrophobic, 156 - E LYS 353 CG VS R TYR 505 CG Distance: 4.137594 - Hydrophobic, 157 - E LYS 353 CG VS R TYR 505 CD1 Distance: 3.730602 - Hydrophobic, 158 - E LYS 353 CG VS R TYR 505 CD2 Distance: 4.780665 - Hydrophobic, 159 - E LYS 353 CG VS R TYR 505 CE1 Distance: 4.067720 - Hydrophobic, 160 - E LYS 353 CG VS R TYR 505 CE2 Distance: 5.051322 - Hydrophobic, 161 - E LYS 353 CD VS R TYR 505 CB Distance: 4.992380 - Hydrophobic, 162 - E LYS 353 CD VS R TYR 505 CG Distance: 4.930321 - Hydrophobic, 163 - E LYS 353 CD VS R TYR 505 CD1 Distance: 4.459511 - Hydrophobic, 164 - E LYS 353 CD VS R TYR 505 CE1 Distance: 5.026655 - Hydrophobic, 165 - E GLY 354 O VS R GLY 502 N Distance: 3.862797 - Hydrogen Bonds, 166 - E ASP 355 OD2 VS R THR 500 OG1 Distance: 3.933655 - Hydrogen Bonds, 167 - E ARG 357 NH1 VS R THR 500 O Distance: 4.704320 - Hydrogen Bonds, 168 - E ARG 357 NH1 VS R THR 500 OG1 Distance: 3.602826 - Hydrogen Bonds, 169 - E ARG 393 NH1 VS R TYR 505 OH Distance: 3.687443 - Hydrogen Bonds, 170 - E ARG 393 NH2 VS R TYR 505 OH Distance: 4.666931 - Hydrogen Bonds,