4PES-C-A

PDB Title CRYSTAL STRUCTURE OF INSULIN DEGRADING ENZYME COMPLEXED WITH INHIBITOR TERT-BUTYL [(2S)-2-(2,5-DIFLUOROPHENYL)-3-(QUINOLIN-3-YL) PROPYL]CARBAMATE
Resolution (Å) 2.210
Classification HYDROLASE/HYDROLASE INHIBITOR

Protein

Description Insulin-degrading enzyme
Organism Homo sapiens
Chain A
Length 957
Binding Area (Å2) 161.69
Molecular Weight -
Aromaticity 0.11
Instability -
Isoelectric Point 5.94
Sequence NPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFLQHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLSPLFDESAKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVVVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQELKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKANLNFEFFSPFAYVDPLHSNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNSGIEIYYQTDMQSTSENMFLELFAQIISEPAFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAESAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHIXX

Peptide

Description Ala-Ala-Ala
Organism Homo sapiens
Chain C
Length 3
Binding Area (Å2) 255.25
Hydrophobic (% a.a.)
100%
Molecular Weight 231.25
Aromaticity 0.00
Instability 6.67
Isoelectric Point 5.57
Sequence AAA

Clustering Classification

Sequence cluster S 137
Contact cluster C416
Interface cluster I169

Similar complexes

Is the complex classified in the same cluster?

Complex Sequence cluster
(S137)
Contact cluster
(C416)
Interface cluster
(I169)
4pes-D-B
3cww-D-B
3cww-E-A
3e50-C-A
4c2c-B-A
4c2f-B-A