The change of one amino acid by another within a tertiary structure may or may not affect the function of a protein. Identifying this effect and understanding what structural changes may occur with a mutation is a crucial problem for both bioinformatics and biochemistry and other areas. The objective of this work is to present a computational model able to predict and evaluate the effect of the substitution of a single amino acid for another in a protein complex in order to evaluate the effect of this malfunction on the affinity of the complex.

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View the effects of Mutation 1A22B_D326A (A_B)

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Universidade Federal de Minas Gerais, 2016 - Programa de pós-graduação em Bioinformática.