Department of Biostatistics, University of North Carolina, Chapel Hill, NC, USA.|Department of Statistics, University of California, Davis, Davis, CA, USA.|Genomics and Computational Biology Graduate Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.|Department of Statistics, The Wharton School, University of Pennsylvania, Philadelphia, PA, USA.|Department of Biostatistics, University of North Carolina, Chapel Hill, NC, USA.