Department of Statistics, University of California, Riverside, CA 92521, USA.|Department of Statistical Science, School of Mathematics and Computational Science, Sun Yat-Sen University, Guangzhou, Guangdong 510275, China.|Qingdao Institute of BioEnergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, Shandong 266101, China.|Department of Statistics, University of California, Riverside, CA 92521, USA.|Cardiovascular Institute.|Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.|Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China and.|Department of Statistics, University of California, Riverside, CA 92521, USA, Center for Plant Cell Biology, Institute for Integrative Genome Biology, University of California, Riverside, CA 92521, USA.