Cancer biology is a field where the complexity of the phenomena battles against the availability of data. Often only a few observations per signal source, i.e. genes, are available. Such scenarios are becoming increasingly more relevant as modern sensing technologies generally have no trouble in measuring lots of channels, but where the number of subjects, such as patients or samples, is limited. In statistics, this problem falls under the heading large p, small n. Moreover, in such situations the use of asymptotic analytical results should generally be mistrusted.