Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia. Contact:alexei.adzhubei@eimb.ru.|Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia. Contact:alexei.adzhubei@eimb.ru.|V. A. Trapeznikov Institute of Control Sciences of Russian Academy of Sciences, 117997 Moscow, Russia.|Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia. Contact:alexei.adzhubei@eimb.ru.|Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia. Contact:alexei.adzhubei@eimb.ru.