IZKF Computational Biology Research Group, Institute for Biomedical Engineering, RWTH Aachen University Medical School, 52074 Aachen, Computational RNA Biology Lab and Bioinformatics Core, Max Planck Institute for Biology of Ageing, 50931 Cologne, Department of Cell Biology, Institute for Biomedical Engineering, RWTH Aachen University Medical School, 52074, Helmholtz Institute for Biomedical Engineering, 52074, Aachen Institute for Advanced Study in Computational Engineering Science (AICES), RWTH Aachen University, 52062 Aachen, Germany and Center of Informatics, Federal University of Pernambuco, 50740560 Recife-PE, Brazil IZKF Computational Biology Research Group, Institute for Biomedical Engineering, RWTH Aachen University Medical School, 52074 Aachen, Computational RNA Biology Lab and Bioinformatics Core, Max Planck Institute for Biology of Ageing, 50931 Cologne, Department of Cell Biology, Institute for Biomedical Engineering, RWTH Aachen University Medical School, 52074, Helmholtz Institute for Biomedical Engineering, 52074, Aachen Institute for Advanced Study in Computational Engineering Science (AICES), RWTH Aachen University, 52062 Aachen, Germany and Center of Informatics, Federal University of Pernambuco, 50740560 Recife-PE, Brazil.