Department of Biostatistics, Bioinformatics and Epidemiology, Charleston, SC 29425, USA. stanisrc@musc.edu|Department of Biostatistics, Bioinformatics and Epidemiology, Charleston, SC 29425, USA. stanisrc@musc.edu|Department of Biostatistics, Bioinformatics and Epidemiology, Charleston, SC 29425, USA. stanisrc@musc.edu|Department of Biostatistics, Bioinformatics and Epidemiology, Charleston, SC 29425, USA. stanisrc@musc.edu|Department of Biostatistics, Bioinformatics and Epidemiology, Charleston, SC 29425, USA. stanisrc@musc.edu