Banting and Best Department of Medical Research, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College St, Toronto ON, Canada M5S 3E1, Canada. sumedha@cantab.net|Banting and Best Department of Medical Research, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College St, Toronto ON, Canada M5S 3E1, Canada. sumedha@cantab.net