Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC 27710, USA. pathwayrf@gmail.com|Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC 27710, USA. pathwayrf@gmail.com|Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC 27710, USA. pathwayrf@gmail.com