Department of Surgery and Cancer, Imperial College London, London, United Kingdom.|Department of Biological Sciences, University of Tokyo, Bunkyo, Tokyo, Japan.|Department of Biological Sciences, University of Tokyo, Bunkyo, Tokyo, Japan.|Computational Biology, GlaxoSmithKline R&D, Stevenage, Hertfordshire, United Kingdom.|Department of Biological Sciences, University of Tokyo, Bunkyo, Tokyo, Japan.