Department of Computational Biology, School of Medicine, University of Pittsburgh, Suite 3064, Biomedical Science Tower 3, 3051 Fifth Ave., Pittsburgh, PA 15213, USA.|Department of Computational Biology, School of Medicine, University of Pittsburgh, Suite 3064, Biomedical Science Tower 3, 3051 Fifth Ave., Pittsburgh, PA 15213, USA.|Department of Computational Biology, School of Medicine, University of Pittsburgh, Suite 3064, Biomedical Science Tower 3, 3051 Fifth Ave., Pittsburgh, PA 15213, USA.|Department of Computational Biology, School of Medicine, University of Pittsburgh, Suite 3064, Biomedical Science Tower 3, 3051 Fifth Ave., Pittsburgh, PA 15213, USA.