Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, 48109-2029, USA. qin@umich.edu|Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, 48109-2029, USA. qin@umich.edu|Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, 48109-2029, USA. qin@umich.edu|Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, 48109-2029, USA. qin@umich.edu|Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, 48109-2029, USA. qin@umich.edu|Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, 48109-2029, USA. qin@umich.edu|Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, 48109-2029, USA. qin@umich.edu|Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, 48109-2029, USA. qin@umich.edu