Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA. Zhongxue.Chen@uth.tmc.edu|Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA. Zhongxue.Chen@uth.tmc.edu|Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA. Zhongxue.Chen@uth.tmc.edu