Cell Line|Computational Biology|Computer Simulation|Feedback, Physiological|Humans|In Vitro Techniques|Intracellular Signaling Peptides and Proteins|Models, Theoretical|Phosphoprotein Phosphatases|Phosphorylation|Protein Phosphatase 2C|Proteolysis|Proto-Oncogene Proteins|Signal Transduction|Smad Proteins, Receptor-Regulated|Transforming Growth Factor beta|Up-Regulation