School of Computer Science, University of Manchester, Manchester, United Kingdom.|School of Computer Science, University of Manchester, Manchester, United Kingdom.|School of Computer Science, University of Manchester, Manchester, United Kingdom.|Portland State University, Portland, Oregon, United States of America.|UK EQUATOR Centre, Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.|UK EQUATOR Centre, Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.|UK EQUATOR Centre, Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.|College of Arts and Social Sciences, Australian National University, Canberra, Australia.|Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge, United Kingdom.|Numerical Algorithms Group, Oxford, United Kingdom.|School of Computer Science, University of St. Andrews, St. Andrews, Scotland, United Kingdom.|Oxford e-Research Centre, University of Oxford, Oxford, United Kingdom.|Electronics and Computer Science, University of Southampton, Southampton, United Kingdom.|ELIXIR Hub, Wellcome Genome Campus, Cambridge, United Kingdom.|EGI Foundation, Amsterdam, the Netherlands.|School of Media and Communication, University of Leeds, Leeds, United Kingdom.|Scientific Computing Department, Science and Technology Facilities Council, Rutherford Appleton Laboratory, Didcot, United Kingdom.|School of Social Sciences, University of Manchester, Manchester, United Kingdom.