Department of Pharmaceutical Pharmacology, Uppsala University, SE-751 24, Sweden. maris.lapins@farmbio.uu.se|Department of Pharmaceutical Pharmacology, Uppsala University, SE-751 24, Sweden. maris.lapins@farmbio.uu.se|Department of Pharmaceutical Pharmacology, Uppsala University, SE-751 24, Sweden. maris.lapins@farmbio.uu.se|Department of Pharmaceutical Pharmacology, Uppsala University, SE-751 24, Sweden. maris.lapins@farmbio.uu.se|Department of Pharmaceutical Pharmacology, Uppsala University, SE-751 24, Sweden. maris.lapins@farmbio.uu.se