Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic College of Medicine 200 First Street SW, Rochester, MN 55905, USA. oberg.ann@mayo.edu|Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic College of Medicine 200 First Street SW, Rochester, MN 55905, USA. oberg.ann@mayo.edu|Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic College of Medicine 200 First Street SW, Rochester, MN 55905, USA. oberg.ann@mayo.edu|Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic College of Medicine 200 First Street SW, Rochester, MN 55905, USA. oberg.ann@mayo.edu