Center for Computational Pharmacology, University of Colorado School of Medicine, Denver, Colorado, USA. kino@strad.ssg.fujitsu.com|Center for Computational Pharmacology, University of Colorado School of Medicine, Denver, Colorado, USA. kino@strad.ssg.fujitsu.com|Center for Computational Pharmacology, University of Colorado School of Medicine, Denver, Colorado, USA. kino@strad.ssg.fujitsu.com|Center for Computational Pharmacology, University of Colorado School of Medicine, Denver, Colorado, USA. kino@strad.ssg.fujitsu.com