Molecular Bioinformatics Group, Institute of Computer Science, Faculty of Computer Science and Mathematics, Cluster of Excellence Frankfurt Macromolecular Complexes, Goethe-University, Robert-Mayer-Str. 11-15, 60325 Frankfurt am Main, Germany, Molecular Bioenergetics Group, Medical School, Cluster of Excellence Frankfurt Macromolecular Complexes, Goethe-University, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany, Functional Proteomics, SFB815 core unit, Medical School, Goethe-University, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany and Nijmegen Centre for Mitochondrial Disorders, Radboud University Medical Centre, 6525 GA, Nijmegen, The Netherlands.