Department of Medicine I, Johannes Gutenberg University, 55131 Mainz, Germany. kruppm@uni-mainz.de|Department of Medicine I, Johannes Gutenberg University, 55131 Mainz, Germany. kruppm@uni-mainz.de|Department of Medicine I, Johannes Gutenberg University, 55131 Mainz, Germany. kruppm@uni-mainz.de|Department of Medicine I, Johannes Gutenberg University, 55131 Mainz, Germany. kruppm@uni-mainz.de|Department of Medicine I, Johannes Gutenberg University, 55131 Mainz, Germany. kruppm@uni-mainz.de|Department of Medicine I, Johannes Gutenberg University, 55131 Mainz, Germany. kruppm@uni-mainz.de