Quantitative and Computational Biology Group, Max-Planck Institute for Biophysical Chemistry, 37077?Gxc3xb6ttingen, Germany.|Quantitative and Computational Biology Group, Max-Planck Institute for Biophysical Chemistry, 37077?Gxc3xb6ttingen, Germany.|Universitxc3xa9 Clermont Auvergne, CNRS, LMGE, F-63000 Clermont-Ferrand, France.|Universitxc3xa9 Clermont Auvergne, CNRS, LMGE, F-63000 Clermont-Ferrand, France.|Quantitative and Computational Biology Group, Max-Planck Institute for Biophysical Chemistry, 37077?Gxc3xb6ttingen, Germany.