Harvard-Partners Center for Genetics and Genomics, Brigham and Womens Hospital, Boston, MA 02115, USA. tolstorukov@gmail.com|Harvard-Partners Center for Genetics and Genomics, Brigham and Womens Hospital, Boston, MA 02115, USA. tolstorukov@gmail.com|Harvard-Partners Center for Genetics and Genomics, Brigham and Womens Hospital, Boston, MA 02115, USA. tolstorukov@gmail.com|Harvard-Partners Center for Genetics and Genomics, Brigham and Womens Hospital, Boston, MA 02115, USA. tolstorukov@gmail.com|Harvard-Partners Center for Genetics and Genomics, Brigham and Womens Hospital, Boston, MA 02115, USA. tolstorukov@gmail.com