D. E. Shaw Research, New York, New York, United States of America.|D. E. Shaw Research, New York, New York, United States of America.|D. E. Shaw Research, New York, New York, United States of America.|D. E. Shaw Research, New York, New York, United States of America, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York, United States of America.