The Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. r.lowe@qmul.ac.uk.|The Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. r.lowe@qmul.ac.uk.|The Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. r.lowe@qmul.ac.uk.|Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore MD 21205, USA. jleek@jhsph.edu.