Institute of Molecular and Cell Biology, 61 Biopolis Drive, 138673, Singapore. ycyang@imcb.a-star.edu.sg|Institute of Molecular and Cell Biology, 61 Biopolis Drive, 138673, Singapore. ycyang@imcb.a-star.edu.sg|Institute of Molecular and Cell Biology, 61 Biopolis Drive, 138673, Singapore. ycyang@imcb.a-star.edu.sg