Institut Pasteur-Bioinformatics and Biostatistics Hub-C3BI, USR 3756 IP CNRS, Paris, France.|Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.|European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Cambridge, UK.|Oncology Innovative Medicines and Early Development, AstraZeneca, Cambridge, UK.|Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.|European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Cambridge, UK.|Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.