Sandia National Laboratories, Computational Biology 9212, P.O. Box 5800, MS 310, Albuquerque, NM, 87185, USA. smartin@sandia.gov|Sandia National Laboratories, Computational Biology 9212, P.O. Box 5800, MS 310, Albuquerque, NM, 87185, USA. smartin@sandia.gov|Sandia National Laboratories, Computational Biology 9212, P.O. Box 5800, MS 310, Albuquerque, NM, 87185, USA. smartin@sandia.gov