Center for Statistical Genomics and Proteomics, Yale University, New Haven, CT 06520, USA. matthew.holford@yale.edu|Center for Statistical Genomics and Proteomics, Yale University, New Haven, CT 06520, USA. matthew.holford@yale.edu|Center for Statistical Genomics and Proteomics, Yale University, New Haven, CT 06520, USA. matthew.holford@yale.edu|Center for Statistical Genomics and Proteomics, Yale University, New Haven, CT 06520, USA. matthew.holford@yale.edu