Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Bari, 70126, Italy.|Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Bari, 70126, Italy.|Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Bari, 70126, Italy. marcella.attimonelli@uniba.it.