Computational Biology and Bioinformatics, Pacific Northwest National Laboratory, Richland, WA 99352, USA. bj@pnl.gov|Computational Biology and Bioinformatics, Pacific Northwest National Laboratory, Richland, WA 99352, USA. bj@pnl.gov|Computational Biology and Bioinformatics, Pacific Northwest National Laboratory, Richland, WA 99352, USA. bj@pnl.gov