Department of Medical, Surgical and Health Sciences, University of Trieste, 34100 Trieste, Italy.|Department of Medical, Surgical and Health Sciences, University of Trieste, 34100 Trieste, Italy, Medical Genetics, Institute for Maternal and Child Health IRCCS Burlo Garofolo, 34100 Trieste, Italy.|Human Genetics, Wellcome Trust Sanger Institute, Genome Campus, Hinxton CB10 1HH, Department of Haematology, University of Cambridge, Cambridge CB2 0AH and.|Human Genetics, Wellcome Trust Sanger Institute, Genome Campus, Hinxton CB10 1HH, EMBL-EBI, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SD, UK.