Biostatistics Branch, National Institute of Environmental Health Sciences, MD: A3-03, 111 TW Alexander Dr, Research Triangle Park, NC 27709, USA. dliu@ciit.org|Biostatistics Branch, National Institute of Environmental Health Sciences, MD: A3-03, 111 TW Alexander Dr, Research Triangle Park, NC 27709, USA. dliu@ciit.org|Biostatistics Branch, National Institute of Environmental Health Sciences, MD: A3-03, 111 TW Alexander Dr, Research Triangle Park, NC 27709, USA. dliu@ciit.org|Biostatistics Branch, National Institute of Environmental Health Sciences, MD: A3-03, 111 TW Alexander Dr, Research Triangle Park, NC 27709, USA. dliu@ciit.org