Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.|Institute of Biomedicine, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.|Institute of Biomedicine, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.|Institute of Biomedicine, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.|Institute of Biomedicine, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.|Institute of Biomedicine, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.