Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.|Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.|Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.|Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.|Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.|Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.