Division of Biostatistics, Department of Health Sciences Research 200 First Street SW, Rochester, MN 55905, USA. eckel@mayo.edu|Division of Biostatistics, Department of Health Sciences Research 200 First Street SW, Rochester, MN 55905, USA. eckel@mayo.edu|Division of Biostatistics, Department of Health Sciences Research 200 First Street SW, Rochester, MN 55905, USA. eckel@mayo.edu|Division of Biostatistics, Department of Health Sciences Research 200 First Street SW, Rochester, MN 55905, USA. eckel@mayo.edu|Division of Biostatistics, Department of Health Sciences Research 200 First Street SW, Rochester, MN 55905, USA. eckel@mayo.edu|Division of Biostatistics, Department of Health Sciences Research 200 First Street SW, Rochester, MN 55905, USA. eckel@mayo.edu|Division of Biostatistics, Department of Health Sciences Research 200 First Street SW, Rochester, MN 55905, USA. eckel@mayo.edu|Division of Biostatistics, Department of Health Sciences Research 200 First Street SW, Rochester, MN 55905, USA. eckel@mayo.edu