Centre for Molecular Bioinformatics, Department of Biology, University of Tor Vergata, Rome, Italy. enrico@cbm.bio.uniroma2.it|Centre for Molecular Bioinformatics, Department of Biology, University of Tor Vergata, Rome, Italy. enrico@cbm.bio.uniroma2.it|Centre for Molecular Bioinformatics, Department of Biology, University of Tor Vergata, Rome, Italy. enrico@cbm.bio.uniroma2.it|Centre for Molecular Bioinformatics, Department of Biology, University of Tor Vergata, Rome, Italy. enrico@cbm.bio.uniroma2.it