Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, School of Medicine, Johns Hopkins University, Baltimore, MD 21205 and Department of Applied Mathematics and Statistics, Johns Hopkins University, Baltimore, MD 21218, USA.|Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, School of Medicine, Johns Hopkins University, Baltimore, MD 21205 and Department of Applied Mathematics and Statistics, Johns Hopkins University, Baltimore, MD 21218, USA.|Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, School of Medicine, Johns Hopkins University, Baltimore, MD 21205 and Department of Applied Mathematics and Statistics, Johns Hopkins University, Baltimore, MD 21218, USA.|Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, School of Medicine, Johns Hopkins University, Baltimore, MD 21205 and Department of Applied Mathematics and Statistics, Johns Hopkins University, Baltimore, MD 21218, USA.