Virginia Bioinformatics Institute, Washington Street, MC0477, Blacksburg, VA 24061, USA. peccoud@vt.edu|Virginia Bioinformatics Institute, Washington Street, MC0477, Blacksburg, VA 24061, USA. peccoud@vt.edu|Virginia Bioinformatics Institute, Washington Street, MC0477, Blacksburg, VA 24061, USA. peccoud@vt.edu