Ewha Research Center for Systems Biology (ERCSB), Ewha Womans University, Seoul 120-750, Division of Biomedical Informatics, National Institute of Health, Korea Center for Disease Control, Cheongwon 363-951 and Ewha Global Top5 Research Program, Ewha Womans University, Seoul 120-750, Republic of Korea Ewha Research Center for Systems Biology (ERCSB), Ewha Womans University, Seoul 120-750, Division of Biomedical Informatics, National Institute of Health, Korea Center for Disease Control, Cheongwon 363-951 and Ewha Global Top5 Research Program, Ewha Womans University, Seoul 120-750, Republic of Korea.