Institute of Biostatistics, School of Life Sciences, Fudan University, 2005 Songhu Road, Shanghai, 200438, Peoples Republic of China.|Institute of Biostatistics, School of Life Sciences, Fudan University, 2005 Songhu Road, Shanghai, 200438, Peoples Republic of China.|Institute of Biostatistics, School of Life Sciences, Fudan University, 2005 Songhu Road, Shanghai, 200438, Peoples Republic of China. zhanghfd@fudan.edu.cn.