Division of Pathway Medicine, University of Edinburgh Medical School, Edinburgh, United Kingdom. tfreeman@staffmail.ed.ac.uk|Division of Pathway Medicine, University of Edinburgh Medical School, Edinburgh, United Kingdom. tfreeman@staffmail.ed.ac.uk|Division of Pathway Medicine, University of Edinburgh Medical School, Edinburgh, United Kingdom. tfreeman@staffmail.ed.ac.uk|Division of Pathway Medicine, University of Edinburgh Medical School, Edinburgh, United Kingdom. tfreeman@staffmail.ed.ac.uk