Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America.|Channing Division of Network Medicine, Brigham and Womens Hospital, Boston, Massachusetts, United States of America.|Channing Division of Network Medicine, Brigham and Womens Hospital, Boston, Massachusetts, United States of America.|Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America.