Department of Biomolecular Engineering, University of California, Santa Cruz, 95064, USA. karplus@soe.ucsc.edu|Department of Biomolecular Engineering, University of California, Santa Cruz, 95064, USA. karplus@soe.ucsc.edu|Department of Biomolecular Engineering, University of California, Santa Cruz, 95064, USA. karplus@soe.ucsc.edu|Department of Biomolecular Engineering, University of California, Santa Cruz, 95064, USA. karplus@soe.ucsc.edu