The Wellcome Trust Sanger Institute, Hinxton, UK. michele@sanger.ac.uk|The Wellcome Trust Sanger Institute, Hinxton, UK. michele@sanger.ac.uk|The Wellcome Trust Sanger Institute, Hinxton, UK. michele@sanger.ac.uk|The Wellcome Trust Sanger Institute, Hinxton, UK. michele@sanger.ac.uk