Locating the regions of similarity in a genome requires the availability of appropriate tools such as Accelerated Search for SImilar Regions in Chromosomes (ASSIRC, Vincens et al., Bioinformatics, 14, 715-725, 1998). The aim of this paper is to present different strategies for improving this program by distributing the operations and data to multiple processing units and to assess the efficiency of the different implementations in terms of running time as a function of the number of processing units.