MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh EH4 2XU, UK, School of Informatics, University of Edinburgh, Edinburgh EH8 9AB, UK, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA, Centre for Systems, Dynamics and Control, College of Engineering, Mathematics & Physical Sciences, University of Exeter, Exeter EX4 4QF, UK.|MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh EH4 2XU, UK, School of Informatics, University of Edinburgh, Edinburgh EH8 9AB, UK, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA, Centre for Systems, Dynamics and Control, College of Engineering, Mathematics & Physical Sciences, University of Exeter, Exeter EX4 4QF, UK MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh EH4 2XU, UK, School of Informatics, University of Edinburgh, Edinburgh EH8 9AB, UK, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA, Centre for Systems, Dynamics and Control, College of Engineering, Mathematics & Physical Sciences, University of Exeter, Exeter EX4 4QF, UK.|MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh EH4 2XU, UK, School of Informatics, University of Edinburgh, Edinburgh EH8 9AB, UK, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA, Centre for Systems, Dynamics and Control, College of Engineering, Mathematics & Physical Sciences, University of Exeter, Exeter EX4 4QF, UK.