Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. mikel@crab.org|Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. mikel@crab.org|Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. mikel@crab.org|Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. mikel@crab.org