Department of Biostatistics, Yale School of Public Health, New Haven, CT, USA. gregory.ryslik@yale.edu.|Program of Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA.|Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK.|Department of Biostatistics, Yale School of Public Health, New Haven, CT, USA.