Institute of Molecular Medicine and Department of Life Science, National Tsing Hua University, HsinChu, 30013, Taiwan, Republic of China.|Institute of Molecular Medicine and Department of Life Science, National Tsing Hua University, HsinChu, 30013, Taiwan, Republic of China.|Institute of Molecular Medicine and Department of Life Science, National Tsing Hua University, HsinChu, 30013, Taiwan, Republic of China.|Institute of Molecular Medicine and Department of Life Science, National Tsing Hua University, HsinChu, 30013, Taiwan, Republic of China.