Department of Computational Biology, School of Medicine, University of Pittsburgh, 3501 Fifth Avenue, Pittsburgh, PA 15213, USA. eyal@ccbb.pitt.edu|Department of Computational Biology, School of Medicine, University of Pittsburgh, 3501 Fifth Avenue, Pittsburgh, PA 15213, USA. eyal@ccbb.pitt.edu|Department of Computational Biology, School of Medicine, University of Pittsburgh, 3501 Fifth Avenue, Pittsburgh, PA 15213, USA. eyal@ccbb.pitt.edu