Centre for Systems Biology, School of Biosciences, University of Birmingham, Birmingham, United Kingdom. k.j.alden@bham.ac.uk|Centre for Systems Biology, School of Biosciences, University of Birmingham, Birmingham, United Kingdom. k.j.alden@bham.ac.uk|Centre for Systems Biology, School of Biosciences, University of Birmingham, Birmingham, United Kingdom. k.j.alden@bham.ac.uk|Centre for Systems Biology, School of Biosciences, University of Birmingham, Birmingham, United Kingdom. k.j.alden@bham.ac.uk|Centre for Systems Biology, School of Biosciences, University of Birmingham, Birmingham, United Kingdom. k.j.alden@bham.ac.uk|Centre for Systems Biology, School of Biosciences, University of Birmingham, Birmingham, United Kingdom. k.j.alden@bham.ac.uk