Laboratory for Statistical Genomics and Systems Biology, Department of Environmental Health, University of Cincinnati College of Medicine, 3223 Eden Av, ML 56, Cincinnati OH 45267-0056, USA. freudejm@uc.edu|Laboratory for Statistical Genomics and Systems Biology, Department of Environmental Health, University of Cincinnati College of Medicine, 3223 Eden Av, ML 56, Cincinnati OH 45267-0056, USA. freudejm@uc.edu|Laboratory for Statistical Genomics and Systems Biology, Department of Environmental Health, University of Cincinnati College of Medicine, 3223 Eden Av, ML 56, Cincinnati OH 45267-0056, USA. freudejm@uc.edu|Laboratory for Statistical Genomics and Systems Biology, Department of Environmental Health, University of Cincinnati College of Medicine, 3223 Eden Av, ML 56, Cincinnati OH 45267-0056, USA. freudejm@uc.edu