With the increasing pace of new Genetically Modified Organisms (GMOs) authorized or in pipeline for commercialization worldwide, the task of the laboratories in charge to test the compliance of food, feed or seed samples with their relevant regulations became difficult and costly. Many of them have already adopted the so called matrix approach to rationalize the resources and efforts used to increase their efficiency within a limited budget. Most of the time, the matrix approach is implemented using limited information and some proprietary (if any) computational tool to efficiently use the available data.