Chromatin immunoprecipitation followed by sequencing (ChIP-seq) can detect read-enriched DNA loci for point-source (e.g. transcription factor binding) and broad-source factors (e.g. various histone modifications). Although numerous quality metrics for ChIP-seq data have been developed, the peaks thus obtained are still difficult to assess with respect to signal-to-noise ratio (S/N) and the percentage of false positives.