Departments of Pharmacology and Medicine, University of California at San Diego, La Jolla, CA 92093, USA.|Departments of Pharmacology and Medicine, University of California at San Diego, La Jolla, CA 92093, USA.|Departments of Pharmacology and Medicine, University of California at San Diego, La Jolla, CA 92093, USA.|Departments of Pharmacology and Medicine, University of California at San Diego, La Jolla, CA 92093, USA.|Departments of Pharmacology and Medicine, University of California at San Diego, La Jolla, CA 92093, USA.|Departments of Pharmacology and Medicine, University of California at San Diego, La Jolla, CA 92093, USA.|Departments of Pharmacology and Medicine, University of California at San Diego, La Jolla, CA 92093, USA.|Departments of Pharmacology and Medicine, University of California at San Diego, La Jolla, CA 92093, USA.|Departments of Pharmacology and Medicine, University of California at San Diego, La Jolla, CA 92093, USA.