Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA. mpertea@umiacs.umd.edu|Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA. mpertea@umiacs.umd.edu|Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA. mpertea@umiacs.umd.edu