Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA. macisaac@mit.edu|Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA. macisaac@mit.edu|Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA. macisaac@mit.edu|Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA. macisaac@mit.edu|Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA. macisaac@mit.edu|Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA. macisaac@mit.edu