Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.|Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America.|Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.|Centre for Integrative Biology (CIBIO), University of Trento, Trento, Trentino, Italy.|Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America.|Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.