Computational Bioscience Program, University of Colorado, Aurora, CO, USA.|Department of Biostatistics and Informatics, University of Colorado, Aurora, CO, USA.|Department of Biostatistics and Informatics, University of Colorado, Aurora, CO, USA.|Channing Division of Network Medicine, Brigham and Womens Hospital, Boston, MA, USA.|Channing Division of Network Medicine, Brigham and Womens Hospital, Boston, MA, USA.|Channing Division of Network Medicine, Brigham and Womens Hospital, Boston, MA, USA.|Department of Biostatistics and Informatics, University of Colorado, Aurora, CO, USA.|Center for Genes, Environment & Health, National Jewish Health, Denver, CO, USA.|Channing Division of Network Medicine, Brigham and Womens Hospital, Boston, MA, USA.|Department of Pharmaceutical Sciences, University of Colorado, Aurora, CO, USA.|Department of Biostatistics and Informatics, University of Colorado, Aurora, CO, USA.