Barbara Ann Karmanos Cancer Institute and Department of Oncology, Wayne State University, Detroit, MI 48201, USA, Department of Computer Science, University of Verona, 37134 Verona, Italy, The Microsoft Research-University of Trento Centre for Computational and Systems Biology, 38068 Rovereto, Italy, Department of Computer Science, Wayne State University and Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI 48201, USA.