Center for Integrative Genomics (CIG), University of Lausanne, Lausanne, Switzerland, Instituto de Engenharia de Sistemas e Computadores-Investigação e Desenvolvimento (INESC-ID), Lisbon, Portugal, Instituto Gulbenkian de Ciência (IGC), Oeiras, Portugal, Medical Systems Biology, Ulm University, Germany, Friedrich-Schiller University Jena, Jena, Germany, Leibniz Institute for Age Research, Fritz Lipmann Institute, Jena, Germany, Institut de Biologie de lÉcole Normale Supérieure (IBENS)-UMR CNRS 8197-INSERM 1024, Paris, France, Swiss-Prot & Vital-IT group, Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland, European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, United Kingdom and Department of Biochemistry, University of Nebraska-Lincoln, Lincoln, USA Center for Integrative Genomics (CIG), University of Lausanne, Lausanne, Switzerland, Instituto de Engenharia de Sistemas e Computadores-Investigação e Desenvolvimento (INESC-ID), Lisbon, Portugal, Instituto Gulbenkian de Ciência (IGC), Oeiras, Portugal, Medical Systems Biology, Ulm University, Germany, Friedrich-Schiller University Jena, Jena, Germany, Leibniz Institute for Age Research, Fritz Lipmann Institute, Jena, Germany, Institut de Biologie de lÉcole Normale Supérieure (IBENS)-UMR CNRS 8197-INSERM 1024, Paris, France, Swiss-Prot & Vital-IT group, Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland, European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, United Kingdom and Department of Biochemistry, University of Nebraska-Lincoln, Lincoln, USA.