Bacterial Proteins|Catalytic Domain|Computational Biology|Computer Simulation|Crystallography, X-Ray|Dimerization|Enzyme Stability|Escherichia coli|Escherichia coli Proteins|Hydro-Lyases|Methicillin-Resistant Staphylococcus aureus|Models, Molecular|Molecular Dynamics Simulation|Mutagenesis, Site-Directed|Protein Structure, Quaternary|Pyruvic Acid|Species Specificity|Substrate Specificity