Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD, USA. mschatz@umiacs.umd.edu|Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD, USA. mschatz@umiacs.umd.edu|Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD, USA. mschatz@umiacs.umd.edu|Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD, USA. mschatz@umiacs.umd.edu