Antibodies, Neutralizing|Antibody Affinity|Complementarity Determining Regions|Computational Biology|Evolution, Molecular|Genes, Immunoglobulin|HIV Antibodies|HIV Infections|HIV-1|High-Throughput Nucleotide Sequencing|Humans|Immunoglobulin Variable Region|Longitudinal Studies|Models, Genetic|Models, Immunological|Mutation|Selection, Genetic|Somatic Hypermutation, Immunoglobulin