Biostatistics Branch, National Institute of Environmental Health Sciences, Durham, NC 27713, USA. peddada@niehs.nih.gov|Biostatistics Branch, National Institute of Environmental Health Sciences, Durham, NC 27713, USA. peddada@niehs.nih.gov|Biostatistics Branch, National Institute of Environmental Health Sciences, Durham, NC 27713, USA. peddada@niehs.nih.gov|Biostatistics Branch, National Institute of Environmental Health Sciences, Durham, NC 27713, USA. peddada@niehs.nih.gov