Institute of Human Genetics, Newcastle University, Newcastle upon Tyne,UK. kjsiddle@pasteur.fr|Institute of Human Genetics, Newcastle University, Newcastle upon Tyne,UK. kjsiddle@pasteur.fr|Institute of Human Genetics, Newcastle University, Newcastle upon Tyne,UK. kjsiddle@pasteur.fr|Institute of Human Genetics, Newcastle University, Newcastle upon Tyne,UK. kjsiddle@pasteur.fr