Institute of Biological Sciences, University of Tsukuba, 1-1-1 Ten-nodai, Tsukuba, Ibaraki 305-8572, Japan. hideaki.mizuno@roche.com|Institute of Biological Sciences, University of Tsukuba, 1-1-1 Ten-nodai, Tsukuba, Ibaraki 305-8572, Japan. hideaki.mizuno@roche.com|Institute of Biological Sciences, University of Tsukuba, 1-1-1 Ten-nodai, Tsukuba, Ibaraki 305-8572, Japan. hideaki.mizuno@roche.com|Institute of Biological Sciences, University of Tsukuba, 1-1-1 Ten-nodai, Tsukuba, Ibaraki 305-8572, Japan. hideaki.mizuno@roche.com