Centre for Computational Biology, Mines ParisTech, 35 rue Saint-Honoré, Fontainebleau, Institut Curie, INSERM, U900, Paris, France.|Centre for Computational Biology, Mines ParisTech, 35 rue Saint-Honoré, Fontainebleau, Institut Curie, INSERM, U900, Paris, France.|Centre for Computational Biology, Mines ParisTech, 35 rue Saint-Honoré, Fontainebleau, Institut Curie, INSERM, U900, Paris, France.