Department of Mathematics, University of Minnesota Twin Cities, St. Paul, Minnesota, United States of America.|Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, and Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, United States of America.|Industrial and Systems Engineering, University of Minnesota Twin Cities, St. Paul, Minnesota, United States of America.|Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, and Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, United States of America.|Department of Biology, Kyushu University, Fukuoka, Japan.|Blueprint Medicines, Cambridge, Massachusetts, United States of America.|Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, and Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, United States of America.