Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, United States of America.|Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, United States of America.|Department of Biological Science, Florida State University, Tallahassee, FL, United States of America.|Department of Genetics, University of Pennsylvania, Philadelphia, PA, United States of America.|Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, United States of America.