Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, D-07747 Jena, Erlanger Allee 101, Network Modeling, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute Jena, Beutenbergstrasse 11a, 07745 Jena, Theoretical Bioinformatics, German Cancer Research Center, INF 580, 69121 Heidelberg, Department of Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology, and Bioquant, University of Heidelberg, Im Neuenheimer Feld 267 and Division Translational Immunology, Group Tumor Antigens, German Cancer Research Center (DKFZ), INF 280, 69120 Heidelberg, Germany Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, D-07747 Jena, Erlanger Allee 101, Network Modeling, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute Jena, Beutenbergstrasse 11a, 07745 Jena, Theoretical Bioinformatics, German Cancer Research Center, INF 580, 69121 Heidelberg, Department of Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology, and Bioquant, University of Heidelberg, Im Neuenheimer Feld 267 and Division Translational Immunology, Group Tumor Antigens, German Cancer Research Center (DKFZ), INF 280, 69120 Heidelberg, Germany.