Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.|Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.|Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.|Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.