Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC 27708, USA.|Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC 27708, USA.|Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC 27708, USA.|Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC 27708, USA.|Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC 27708, USA.|Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC 27708, USA.