Institute of Computational Science, Faculty of Informatics, University of Lugano, Lugano, Switzerland.|Division of Applied Mathematics, Brown University, Providence, Rhode Island, United States of America.|Pacific Northwest National Laboratory, Richland, Washington, United States of America.|Institute of Computational Science, Faculty of Informatics, University of Lugano, Lugano, Switzerland, Swiss Institute of Bioinformatics, Lausanne, Switzerland.|Division of Applied Mathematics, Brown University, Providence, Rhode Island, United States of America.