Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Haertelstrasse 16-18, 04107 Leipzig, Germany. arnd.gross@imise.uni-leipzig.de.|Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Haertelstrasse 16-18, 04107 Leipzig, Germany. arnd.gross@imise.uni-leipzig.de.|Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Haertelstrasse 16-18, 04107 Leipzig, Germany. arnd.gross@imise.uni-leipzig.de.|Department of Biology, Georgetown University, 20057 Washington DC, USA. sb753@georgetown.edu.