Bioinformatics and Genomics, the Huck Institute of the Life Science, Pennsylvania State University, State College, Pennsylvania, United States of America.|Department of Statistics, Pennsylvania State University, State College, Pennsylvania, United States of America.|Department of Statistics, Pennsylvania State University, State College, Pennsylvania, United States of America.|Department of Statistics, Pennsylvania State University, State College, Pennsylvania, United States of America.|Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America.|Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America.|Department of Statistics, Pennsylvania State University, State College, Pennsylvania, United States of America.