Institute for Advanced Biosciences, Keio University, Fujisawa, Kanagawa, 252-8520, Japan.|Institute for Advanced Biosciences, Keio University, Fujisawa, Kanagawa, 252-8520, Japan.|Institute for Advanced Biosciences, Keio University, Fujisawa, Kanagawa, 252-8520, Japan.|Institute for Advanced Biosciences, Keio University, Fujisawa, Kanagawa, 252-8520, Japan.