The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA. manidr@broad.mit.edu|The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA. manidr@broad.mit.edu|The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA. manidr@broad.mit.edu