Helsinki Institute for Information Technology HIIT, Department of Computer Science, Aalto University, Espoo 02150, Finland.|Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki 00290, Finland.|Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki 00290, Finland.|Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki 00290, Finland.|Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki 00290, Finland Science for Life Laboratory Department of Oncology and Pathology, Karolinska Institutet, Solna 17165, Sweden.|Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki 00290, Finland Department of Mathematics and Statistics, University of Turku, Turku 20014, Finland.|Helsinki Institute for Information Technology HIIT, Department of Computer Science, Aalto University, Espoo 02150, Finland.