Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK. martin.gerner@gmail.com|Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK. martin.gerner@gmail.com|Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK. martin.gerner@gmail.com|Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK. martin.gerner@gmail.com