Theoretical Biology and Bioinformatics, Institute of Microbiology and Genetics, Department of Biology, TU Darmstadt, Schnittspahnstrasse 10, 64289 Darmstadt, Germany. hoffgaard@bio.tu-darmstadt.de|Theoretical Biology and Bioinformatics, Institute of Microbiology and Genetics, Department of Biology, TU Darmstadt, Schnittspahnstrasse 10, 64289 Darmstadt, Germany. hoffgaard@bio.tu-darmstadt.de|Theoretical Biology and Bioinformatics, Institute of Microbiology and Genetics, Department of Biology, TU Darmstadt, Schnittspahnstrasse 10, 64289 Darmstadt, Germany. hoffgaard@bio.tu-darmstadt.de