Channing Laboratory, Department of Medicine, I2B2 National Center for Biocomputing, Brigham and Womens Hospital, Boston, MA 02115, USA. stvjc@channing.harvard.edu|Channing Laboratory, Department of Medicine, I2B2 National Center for Biocomputing, Brigham and Womens Hospital, Boston, MA 02115, USA. stvjc@channing.harvard.edu|Channing Laboratory, Department of Medicine, I2B2 National Center for Biocomputing, Brigham and Womens Hospital, Boston, MA 02115, USA. stvjc@channing.harvard.edu|Channing Laboratory, Department of Medicine, I2B2 National Center for Biocomputing, Brigham and Womens Hospital, Boston, MA 02115, USA. stvjc@channing.harvard.edu|Channing Laboratory, Department of Medicine, I2B2 National Center for Biocomputing, Brigham and Womens Hospital, Boston, MA 02115, USA. stvjc@channing.harvard.edu