Department of Statistics G. Parenti, University of Florence & Biostatistic Unit CSPO, Florence, Italy. m.blangiardo@imperial.ac.uk|Department of Statistics G. Parenti, University of Florence & Biostatistic Unit CSPO, Florence, Italy. m.blangiardo@imperial.ac.uk|Department of Statistics G. Parenti, University of Florence & Biostatistic Unit CSPO, Florence, Italy. m.blangiardo@imperial.ac.uk|Department of Statistics G. Parenti, University of Florence & Biostatistic Unit CSPO, Florence, Italy. m.blangiardo@imperial.ac.uk|Department of Statistics G. Parenti, University of Florence & Biostatistic Unit CSPO, Florence, Italy. m.blangiardo@imperial.ac.uk|Department of Statistics G. Parenti, University of Florence & Biostatistic Unit CSPO, Florence, Italy. m.blangiardo@imperial.ac.uk|Department of Statistics G. Parenti, University of Florence & Biostatistic Unit CSPO, Florence, Italy. m.blangiardo@imperial.ac.uk|Department of Statistics G. Parenti, University of Florence & Biostatistic Unit CSPO, Florence, Italy. m.blangiardo@imperial.ac.uk|Department of Statistics G. Parenti, University of Florence & Biostatistic Unit CSPO, Florence, Italy. m.blangiardo@imperial.ac.uk