Department of Molecular Biophysics & Biochemistry, Yale University, PO Box 208114, New Haven, CT 06520, USA.|Department of Molecular Biophysics & Biochemistry, Yale University, PO Box 208114, New Haven, CT 06520, USA.|Department of Molecular Biophysics & Biochemistry, Yale University, PO Box 208114, New Haven, CT 06520, USA.|Department of Molecular Biophysics & Biochemistry, Yale University, PO Box 208114, New Haven, CT 06520, USA.