Department of Statistics, University of Oxford, Oxford, UK.|Roche Pharma Research and Early Development, Large Molecule Research Roche Innovation Center Munich, Penzberg, Germany.|Roche Pharma Research and Early Development, Large Molecule Research Roche Innovation Center Munich, Penzberg, Germany.|UCB Pharma, Slough, UK.|Computational and Modelling Sciences, GlaxoSmithKline Research and Development, Stevenage, UK.|Antibody Discovery and Protein Engineering, MedImmune, Granta Park, Cambridge, UK.|Department of Statistics, University of Oxford, Oxford, UK.|Department of Statistics, University of Oxford, Oxford, UK.