Faculty of Life Sciences, The University of Manchester, Michael Smith Building, UK. william.rowe@manchester.ac.uk|Faculty of Life Sciences, The University of Manchester, Michael Smith Building, UK. william.rowe@manchester.ac.uk|Faculty of Life Sciences, The University of Manchester, Michael Smith Building, UK. william.rowe@manchester.ac.uk|Faculty of Life Sciences, The University of Manchester, Michael Smith Building, UK. william.rowe@manchester.ac.uk|Faculty of Life Sciences, The University of Manchester, Michael Smith Building, UK. william.rowe@manchester.ac.uk