Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA 24060, USA, Center for Tropical & Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA, Penn Center for Bioinformatics and Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, CB10 1SD, UK, Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA, Department of Computer Science and Engineering, University of Notre Dame, Notre Dame, IN 46556, USA, Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN 46656-0369, USA, University of California, Department of Microbiology and Molecular Genetics, Irvine, California, USA and The Rockefeller University, Howard Hughes Medical Institute, New York, NY 10065, USA.