Department of Genetics, University of Cambridge, Downing Street, Cambridge, CB2 3EH, UK. xm227@cam.ac.uk.|Department of Genetics, University of Cambridge, Downing Street, Cambridge, CB2 3EH, UK. de276@cam.ac.uk.|Cambridge Systems Biology Center, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QR, UK. cnluzon@decsai.ugr.es.|Department of Genetics, University of Cambridge, Downing Street, Cambridge, CB2 3EH, UK. ba255@cam.ac.uk.