Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA. luo@cshl.edu|Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA. luo@cshl.edu|Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA. luo@cshl.edu|Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA. luo@cshl.edu|Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA. luo@cshl.edu