Center for BioMedical Computing, Verona University, 37134 Verona, Italy, Max Planck Institute for Molecular Plant Physiology-Syst Bio & Math Modelling Group, 14476, Germany, University of Potsdam, Institute for Biochemistry and Biology - Bioinformatics Group, 14476, Germany and Department of Computer Science, Verona University, 37134 Verona, Italy.