Department of Preventive Medicine, Department of Biomedical Informatics, and Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, NY 11794, Department of Biostatistics, Yale University, New Haven, CT 06520, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, Department of Pathology, Stony Brook University, Stony Brook, NY 11794, Department of Medicine, Washington University St Louis, St Louis, MO 63110 and Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA.