Department of Pharmacology and Columbia Genome Center, Columbia University, 630 West 168th street, PH 7 W Room 318, New York, NY 10032, USA. ay1@columbia.edu|Department of Pharmacology and Columbia Genome Center, Columbia University, 630 West 168th street, PH 7 W Room 318, New York, NY 10032, USA. ay1@columbia.edu