Department of Systems Pharmacology and Translational Therapeutics, Institute for Translational Medicine and Therapeutics.|Division of Sleep Medicine Center for Sleep and Circadian Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.|Department of Biology, University of Missouri-St. Louis, St. Louis, MO 63121, USA.|Emeritus Professor of Sensory Biophysics, the Ohio State University, Columbus, OH 43210, USA.|Department of Systems Pharmacology and Translational Therapeutics, Institute for Translational Medicine and Therapeutics.