Biostatistics Branch Laboratory of Structural Biology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. LI3@niehs.nih.gov|Biostatistics Branch Laboratory of Structural Biology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. LI3@niehs.nih.gov|Biostatistics Branch Laboratory of Structural Biology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. LI3@niehs.nih.gov|Biostatistics Branch Laboratory of Structural Biology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. LI3@niehs.nih.gov