Department of Biostatistics, St. Jude Childrens Research Hospital, 262 Danny Thomas Place, Memphis, 38105, USA.|Department of Pharmaceutical Sciences, St. Jude Childrens Research Hospital, 262 Danny Thomas Place, Memphis, 38105, USA.|Department of Pathology, St. Jude Childrens Research Hospital, 262 Danny Thomas Place, Memphis, 38105, USA.|Department of Pharmacotherapy and Translational Research, University of Florida, 1333 Center Drive, Gainesville, 32610, USA.|Department of Biostatistics, St. Jude Childrens Research Hospital, 262 Danny Thomas Place, Memphis, 38105, USA. stanley.pounds@stjude.org.