Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Denver, 4200 East Ninth Avenue, B-119, Denver, CO 80262, USA. katerina.kechris@ucdenver.edu|Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Denver, 4200 East Ninth Avenue, B-119, Denver, CO 80262, USA. katerina.kechris@ucdenver.edu