Department of Biochemical Science and Technology, National Taiwan University, Taiwan.|Department of Mathematics and Statistics at South Dakota State University, Brookings, SD, USA.|Department of Mathematics and Statistics at South Dakota State University, Brookings, SD, USA.|Department of Internal Medicine at University of South Dakota Sanford School of Medicine.|Beijing Institute of Genomics of Chinese Academy of Sciences.|Department of Mathematics and Statistics at South Dakota State University and BioSNTR, SD, USA.