Bioinformatics Program, Boston University, Boston, MA 02215, USA. zjhu@bu.edu|Bioinformatics Program, Boston University, Boston, MA 02215, USA. zjhu@bu.edu|Bioinformatics Program, Boston University, Boston, MA 02215, USA. zjhu@bu.edu|Bioinformatics Program, Boston University, Boston, MA 02215, USA. zjhu@bu.edu