Division of Biostatistics, DKFZ, 69120 Heidelberg, Germany. m.sill@dkfz.de|Division of Biostatistics, DKFZ, 69120 Heidelberg, Germany. m.sill@dkfz.de|Division of Biostatistics, DKFZ, 69120 Heidelberg, Germany. m.sill@dkfz.de|Division of Biostatistics, DKFZ, 69120 Heidelberg, Germany. m.sill@dkfz.de