Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.|Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.|Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.|Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.|Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.|Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.|Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.