Institute of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, Zurich, 8057, Switzerland, Swiss Institute of Bioinformatics, Quartier Sorge, Bâtiment Génopode, Lausanne, 1015, Switzerland.|Department of Computer Science, University of Milan, via Comelico 39, Milan, 20135, Italy and.|Institute of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, Zurich, 8057, Switzerland, Swiss Institute of Bioinformatics, Quartier Sorge, Bâtiment Génopode, Lausanne, 1015, Switzerland.|Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen N, 2200, Denmark.