Division of Biostatistics, Yale University, New Haven, CT 06520, USA. deyun.pan@yale.edu|Division of Biostatistics, Yale University, New Haven, CT 06520, USA. deyun.pan@yale.edu|Division of Biostatistics, Yale University, New Haven, CT 06520, USA. deyun.pan@yale.edu|Division of Biostatistics, Yale University, New Haven, CT 06520, USA. deyun.pan@yale.edu|Division of Biostatistics, Yale University, New Haven, CT 06520, USA. deyun.pan@yale.edu|Division of Biostatistics, Yale University, New Haven, CT 06520, USA. deyun.pan@yale.edu|Division of Biostatistics, Yale University, New Haven, CT 06520, USA. deyun.pan@yale.edu|Division of Biostatistics, Yale University, New Haven, CT 06520, USA. deyun.pan@yale.edu