Institute for Systems Biology, 401 Terry Ave N, Seattle, WA 98092, USA. john.boyle@systemsbiology.org|Institute for Systems Biology, 401 Terry Ave N, Seattle, WA 98092, USA. john.boyle@systemsbiology.org|Institute for Systems Biology, 401 Terry Ave N, Seattle, WA 98092, USA. john.boyle@systemsbiology.org|Institute for Systems Biology, 401 Terry Ave N, Seattle, WA 98092, USA. john.boyle@systemsbiology.org