Centre for Mathematical Medicine & Biology, School of Mathematical Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK.|Centre for Mathematical Medicine & Biology, School of Mathematical Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK.|Centre for Mathematical Medicine & Biology, School of Mathematical Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK.|Centre for Mathematical Medicine & Biology, School of Mathematical Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK.|Centre for Mathematical Medicine & Biology, School of Mathematical Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK.|Centre for Mathematical Medicine & Biology, School of Mathematical Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK.