Bioinformatics and Computational Biochemistry, EML Research, Schloss-Wolfsbrunnenweg 33, 69118 Heidelberg, Germany. juergen@pahle.de|Bioinformatics and Computational Biochemistry, EML Research, Schloss-Wolfsbrunnenweg 33, 69118 Heidelberg, Germany. juergen@pahle.de|Bioinformatics and Computational Biochemistry, EML Research, Schloss-Wolfsbrunnenweg 33, 69118 Heidelberg, Germany. juergen@pahle.de|Bioinformatics and Computational Biochemistry, EML Research, Schloss-Wolfsbrunnenweg 33, 69118 Heidelberg, Germany. juergen@pahle.de