Institute of Quantitative Biomedical Sciences, Geisel School of Medicine, Lebanon, NH, 03756, USA. rob.frost@dartmouth.edu.|Institute of Quantitative Biomedical Sciences, Geisel School of Medicine, Lebanon, NH, 03756, USA. zhigang.li@dartmouth.edu.|Institute of Quantitative Biomedical Sciences, Geisel School of Medicine, Lebanon, NH, 03756, USA. jason.h.moore@dartmouth.edu.