CCBI, Department Applied Mathematics and Theoretical Physics, University of Cambridge, Wilberforce Road, Cambridge, CB3 0WA, UK. cep46@cam.ac.uk.|Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK.|CCBI, Department Applied Mathematics and Theoretical Physics, University of Cambridge, Wilberforce Road, Cambridge, CB3 0WA, UK.