Cambridge Systems Biology Centre, Department of Biochemistry, University of Cambridge, Sanger Building, 80 Tennis Court Road, Cambridge CB2 1GA and Department of Genetics, Evolution and Environment, and UCL Cancer Institute, University College London, Darwin Building, Gower Street, London WC1E 6BT, UKCambridge Systems Biology Centre, Department of Biochemistry, University of Cambridge, Sanger Building, 80 Tennis Court Road, Cambridge CB2 1GA and Department of Genetics, Evolution and Environment, and UCL Cancer Institute, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK.|Cambridge Systems Biology Centre, Department of Biochemistry, University of Cambridge, Sanger Building, 80 Tennis Court Road, Cambridge CB2 1GA and Department of Genetics, Evolution and Environment, and UCL Cancer Institute, University College London, Darwin Building, Gower Street, London WC1E 6BT, UKCambridge Systems Biology Centre, Department of Biochemistry, University of Cambridge, Sanger Building, 80 Tennis Court Road, Cambridge CB2 1GA and Department of Genetics, Evolution and Environment, and UCL Cancer Institute, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK.|Cambridge Systems Biology Centre, Department of Biochemistry, University of Cambridge, Sanger Building, 80 Tennis Court Road, Cambridge CB2 1GA and Department of Genetics, Evolution and Environment, and UCL Cancer Institute, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK.|Cambridge Systems Biology Centre, Department of Biochemistry, University of Cambridge, Sanger Building, 80 Tennis Court Road, Cambridge CB2 1GA and Department of Genetics, Evolution and Environment, and UCL Cancer Institute, University College London, Darwin Building, Gower Street, London WC1E 6BT, UKCambridge Systems Biology Centre, Department of Biochemistry, University of Cambridge, Sanger Building, 80 Tennis Court Road, Cambridge CB2 1GA and Department of Genetics, Evolution and Environment, and UCL Cancer Institute, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK.|Cambridge Systems Biology Centre, Department of Biochemistry, University of Cambridge, Sanger Building, 80 Tennis Court Road, Cambridge CB2 1GA and Department of Genetics, Evolution and Environment, and UCL Cancer Institute, University College London, Darwin Building, Gower Street, London WC1E 6BT, UKCambridge Systems Biology Centre, Department of Biochemistry, University of Cambridge, Sanger Building, 80 Tennis Court Road, Cambridge CB2 1GA and Department of Genetics, Evolution and Environment, and UCL Cancer Institute, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK.