Mashhad University of Medical Sciences, Faculty of Medicine, Department of Medical Biotechnology, Mashhad, Razavi Khorasan, Iran.|University of Tehran, College of Science, School of Biology, Department of Microbiology, Tehran, Tehran, Iran and Stem Cell Technology Research Center, Molecular Biology and Genetic Engineering Department, Tehran, Tehran, Iran.|KU Leuven, VIB Center for the Biology of Disease, Center for Human Genetics, Leuven Institute for Neurodegenerative Disorders, Leuven, Belgium.