Channing Laboratory, Brigham and Womens Hospital, 75 Francis Street, Boston 02115, USA. stvjc@channing.harvard.edu|Channing Laboratory, Brigham and Womens Hospital, 75 Francis Street, Boston 02115, USA. stvjc@channing.harvard.edu|Channing Laboratory, Brigham and Womens Hospital, 75 Francis Street, Boston 02115, USA. stvjc@channing.harvard.edu|Channing Laboratory, Brigham and Womens Hospital, 75 Francis Street, Boston 02115, USA. stvjc@channing.harvard.edu|Channing Laboratory, Brigham and Womens Hospital, 75 Francis Street, Boston 02115, USA. stvjc@channing.harvard.edu