Department of Pediatric Oncology and the Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.|Department of Public Health and General Medicine, School of Integrated Traditional and Western Medicine, Anhui University of Chinese Medicine , Hefei, China.|Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, USA.|Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, NY, USA.|Department of Epidemiology and Health Policy Research, University of Florida, Gainesville, Florida, USA.|Department of Statistics, University of Florida, Gainesville, FL, USA.