Department of Biological Statistics and Computational Biology, Cornell University Ithaca, NY 13101, USA. matt@dimmic.net|Department of Biological Statistics and Computational Biology, Cornell University Ithaca, NY 13101, USA. matt@dimmic.net|Department of Biological Statistics and Computational Biology, Cornell University Ithaca, NY 13101, USA. matt@dimmic.net|Department of Biological Statistics and Computational Biology, Cornell University Ithaca, NY 13101, USA. matt@dimmic.net