College of Bioinformatics Science and Technology, Genomics Research Center, Harbin Medical University, Harbin 150086, China, Department of Microbiology and Infectious Diseases, University of Calgary, Calgary, AB, T2N 4N1, Canada and Bioinformatics Department, Basic Medical College, Fujian Medical University, Fuzhou 350004, China College of Bioinformatics Science and Technology, Genomics Research Center, Harbin Medical University, Harbin 150086, China, Department of Microbiology and Infectious Diseases, University of Calgary, Calgary, AB, T2N 4N1, Canada and Bioinformatics Department, Basic Medical College, Fujian Medical University, Fuzhou 350004, China.