John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, United States of America.|Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, New York, United States of America.|Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, New York, United States of America.|Courant Institute of Mathematical Sciences, New York University, New York, New York, United States of America.