Division of Biomedical Statistics and Informatics and Center for Individualized Medicine, Mayo Clinic, Rochester, MN 55905, Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115.|Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115.|Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115.|Department of Preventive Medicine and the Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60208 and.|Center for Genetic Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60208, USA.|Division of Biomedical Statistics and Informatics and Center for Individualized Medicine, Mayo Clinic, Rochester, MN 55905.|Division of Biomedical Statistics and Informatics and Center for Individualized Medicine, Mayo Clinic, Rochester, MN 55905.|Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115.|Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115.