Center for Computational Pharmacology, Department of Pharmacology, School of Medicine, C236, University of Colorado Health Sciences Center, 4200 E. Ninth Avenue, Denver CO 80206, USA. larry.hunter@uchsc.edu|Center for Computational Pharmacology, Department of Pharmacology, School of Medicine, C236, University of Colorado Health Sciences Center, 4200 E. Ninth Avenue, Denver CO 80206, USA. larry.hunter@uchsc.edu|Center for Computational Pharmacology, Department of Pharmacology, School of Medicine, C236, University of Colorado Health Sciences Center, 4200 E. Ninth Avenue, Denver CO 80206, USA. larry.hunter@uchsc.edu|Center for Computational Pharmacology, Department of Pharmacology, School of Medicine, C236, University of Colorado Health Sciences Center, 4200 E. Ninth Avenue, Denver CO 80206, USA. larry.hunter@uchsc.edu