Hematological Malignancies Program, St. Jude Childrens Research Hospital, Memphis, Tennessee, United States of America.|High Performance Computing Facility, St. Jude Childrens Research Hospital, Memphis, Tennessee, United States of America.|Department of Pharmaceutical Sciences, St. Jude Childrens Research Hospital, Memphis, Tennessee, United States of America.|Hematological Malignancies Program, St. Jude Childrens Research Hospital, Memphis, Tennessee, United States of America.|Department of Structural Biology, St. Jude Childrens Research Hospital, Memphis, Tennessee, United States of America.|High Performance Computing Facility, St. Jude Childrens Research Hospital, Memphis, Tennessee, United States of America.|Molecular Interaction Analysis Laboratory, St. Jude Childrens Research Hospital, Memphis, Tennessee, United States of America.|Functional Genomics Laboratory, Hartwell Center for Bioinformatics & Biotechnology, St. Jude Childrens Research Hospital, Memphis, Tennessee, United States of America.|Functional Genomics Laboratory, Hartwell Center for Bioinformatics & Biotechnology, St. Jude Childrens Research Hospital, Memphis, Tennessee, United States of America.|Computer Science and Mathematics Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, United States of America.|Doctoral Training Centre, University of Oxford, Oxford, United Kingdom.|Department of Pharmaceutical Sciences, St. Jude Childrens Research Hospital, Memphis, Tennessee, United States of America.|Hematological Malignancies Program, St. Jude Childrens Research Hospital, Memphis, Tennessee, United States of America.|Hematological Malignancies Program, St. Jude Childrens Research Hospital, Memphis, Tennessee, United States of America.|Department of Information Sciences, St. Jude Childrens Research Hospital, Memphis, Tennessee, United States of America.|Computer Science and Mathematics Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, United States of America.|Hematological Malignancies Program, St. Jude Childrens Research Hospital, Memphis, Tennessee, United States of America.|Hematological Malignancies Program, St. Jude Childrens Research Hospital, Memphis, Tennessee, United States of America.