Department of Biostatistics, Michigan Center for Translational Pathology, Department of Pathology, Comprehensive Cancer Center, Howard Hughes Medical Institute and Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA Department of Biostatistics, Michigan Center for Translational Pathology, Department of Pathology, Comprehensive Cancer Center, Howard Hughes Medical Institute and Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA Department of Biostatistics, Michigan Center for Translational Pathology, Department of Pathology, Comprehensive Cancer Center, Howard Hughes Medical Institute and Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA Department of Biostatistics, Michigan Center for Translational Pathology, Department of Pathology, Comprehensive Cancer Center, Howard Hughes Medical Institute and Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA Department of Biostatistics, Michigan Center for Translational Pathology, Department of Pathology, Comprehensive Cancer Center, Howard Hughes Medical Institute and Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.