The Institute for Biophysical Dynamics, The University of Chicago, Chicago, Illinois, United States of America.|Department of Statistics, The University of Chicago, Chicago, Illinois, United States of America.|Department of Statistics, The University of Chicago, Chicago, Illinois, United States of America, Department of Computer Science, The University of Chicago, Chicago, Illinois, United States of America.|The Institute for Biophysical Dynamics, The University of Chicago, Chicago, Illinois, United States of America, Department of Physics and the James Franck Institute, The University of Chicago, Chicago, Illinois, United States of America.