Shanghai Institute of Medical Genetics, Shanghai Childrens Hospital, Shanghai Jiao Tong University, 24/1400 Beijing (W) Road, Shanghai 200040, Peoples Republic of China, Department of Bioengineering (MC 063), University of Illinois at Chicago, Chicago, IL 60607-7052, USA and Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, China.