Department of Statistics and Huck Institute for Life Sciences, Penn State University, University Park, PA, USA. hwchoi@umich.edu|Department of Statistics and Huck Institute for Life Sciences, Penn State University, University Park, PA, USA. hwchoi@umich.edu|Department of Statistics and Huck Institute for Life Sciences, Penn State University, University Park, PA, USA. hwchoi@umich.edu|Department of Statistics and Huck Institute for Life Sciences, Penn State University, University Park, PA, USA. hwchoi@umich.edu