The Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK. ap3@sanger.ac.uk|The Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK. ap3@sanger.ac.uk|The Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK. ap3@sanger.ac.uk|The Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK. ap3@sanger.ac.uk|The Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK. ap3@sanger.ac.uk|The Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK. ap3@sanger.ac.uk