Institute of Biochemistry and Biology, University of Potsdam, Potsdam, Germany, Graduate Research Training Program PharMetrX: Pharmacometrics & Computational Disease Modelling, Free University of Berlin and University of Potsdam, Berlin/Potsdam, Germany.|Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland, SIB Swiss Institute of Bioinformatics, Basel, Switzerland.|Institute of Mathematics, University of Potsdam, Potsdam, Germany.|Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland, SIB Swiss Institute of Bioinformatics, Basel, Switzerland.|Institute of Biochemistry and Biology, University of Potsdam, Potsdam, Germany, Institute of Mathematics, University of Potsdam, Potsdam, Germany.