Mines ParisTech, Centre for Computational Biology, 35 rue Saint Honoré, F-77305 Fontainebleau, Institut Curie and INSERM, U900, F-75248, Paris, France. laurent.jacob@ensmp.fr|Mines ParisTech, Centre for Computational Biology, 35 rue Saint Honoré, F-77305 Fontainebleau, Institut Curie and INSERM, U900, F-75248, Paris, France. laurent.jacob@ensmp.fr