Safety Assessment, AstraZeneca Research & Development, 43183 Mölndal, Sweden. lars.a.carlsson@astrazeneca.com|Safety Assessment, AstraZeneca Research & Development, 43183 Mölndal, Sweden. lars.a.carlsson@astrazeneca.com|Safety Assessment, AstraZeneca Research & Development, 43183 Mölndal, Sweden. lars.a.carlsson@astrazeneca.com|Safety Assessment, AstraZeneca Research & Development, 43183 Mölndal, Sweden. lars.a.carlsson@astrazeneca.com|Safety Assessment, AstraZeneca Research & Development, 43183 Mölndal, Sweden. lars.a.carlsson@astrazeneca.com