Department of Biostatistics, University of California, Los Angeles, Los Angeles, CA 90095, USA, Department of Human Genetics and Biomathematics, University of California, Los Angeles, Los Angeles, CA 90095, USA and Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA Department of Biostatistics, University of California, Los Angeles, Los Angeles, CA 90095, USA, Department of Human Genetics and Biomathematics, University of California, Los Angeles, Los Angeles, CA 90095, USA and Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.