Department of Statistics, University of Oxford, 24-29 St Giles, Oxford OX1 3LB, UK.|Department of Basic Sciences, International University of Catalonia, Josep Trueta, s/n 08195 Sant Cugat del Vallès, Spain.|Sir William Dunn School of Pathology, University of Oxford, S Parks Rd, Oxford OX1 3RE, UK.|Department of Statistics, University of Oxford, 24-29 St Giles, Oxford OX1 3LB, UK.|Sir William Dunn School of Pathology, University of Oxford, S Parks Rd, Oxford OX1 3RE, UK.|Department of Statistics, University of Oxford, 24-29 St Giles, Oxford OX1 3LB, UK.