Department of Statistics, University of Oxford, Oxford, UK.|Department of Statistics, University of Oxford, Oxford, UK.|Pharma Research and Early Development, Informatics.|Pharma Research and Early Development, Large Molecule Research, Roche Innovation Center Munich, Penzberg, DE, Germany.|Pharma Research and Early Development, Large Molecule Research, Roche Innovation Center Munich, Penzberg, DE, Germany.|Department of Informatics, UCB Pharma, Slough, UK.|Department of Informatics, UCB Pharma, Slough, UK.|Department of Statistics, University of Oxford, Oxford, UK.