State Key Laboratory of Software Engineering, School of Computer, Wuhan University, Wuhan, 430072, China.|State Key Laboratory of Software Engineering, School of Computer, Wuhan University, Wuhan, 430072, China. liujuan@whu.edu.cn.|Key Laboratory of Systems Biology, Innovation Center for Cell Signaling Network, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.|Key Laboratory of Systems Biology, Innovation Center for Cell Signaling Network, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China. zengtao@sibs.ac.cn.|Key Laboratory of Systems Biology, Innovation Center for Cell Signaling Network, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China. lnchen@sibs.ac.cn.