Greehey Childrens Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA.|Department of Medical Research, Taichung Veterans General Hospital, No. 1650, Section 4, Taiwan Blvd., Xitun District, Taichung City, 40705, Taiwan.|Department of Public Health, National Taiwan University, Taipei, 10055, Taiwan.|Department of Medical Research, Taichung Veterans General Hospital, No. 1650, Section 4, Taiwan Blvd., Xitun District, Taichung City, 40705, Taiwan. thsiao@vghtc.gov.tw.|Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, No. 1, Section 4, Roosevelt Rd., Taipei, 10617, Taiwan. chuangey@ntu.edu.tw.|Greehey Childrens Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA. ChenY8@uthscsa.edu.