Institute of Computational Biology, Helmholtz Zentrum München 85764 Neuherberg, Germany and Department of Mathematics, Technische Universität München 85748 Garching, Germany Institute of Computational Biology, Helmholtz Zentrum München 85764 Neuherberg, Germany and Department of Mathematics, Technische Universität München 85748 Garching, Germany.|Institute of Computational Biology, Helmholtz Zentrum München 85764 Neuherberg, Germany and Department of Mathematics, Technische Universität München 85748 Garching, Germany.|Institute of Computational Biology, Helmholtz Zentrum München 85764 Neuherberg, Germany and Department of Mathematics, Technische Universität München 85748 Garching, Germany Institute of Computational Biology, Helmholtz Zentrum München 85764 Neuherberg, Germany and Department of Mathematics, Technische Universität München 85748 Garching, Germany.