Bioinformatics Graduate Program, Boston University, Boston, MA, USA. zhengyu@alum.bu.edu|Bioinformatics Graduate Program, Boston University, Boston, MA, USA. zhengyu@alum.bu.edu|Bioinformatics Graduate Program, Boston University, Boston, MA, USA. zhengyu@alum.bu.edu|Bioinformatics Graduate Program, Boston University, Boston, MA, USA. zhengyu@alum.bu.edu