Department of Biosciences and Informatics, Keio University, Seikei University, Japan. hacchy@dna.bio.keio.ac.jp|Department of Biosciences and Informatics, Keio University, Seikei University, Japan. hacchy@dna.bio.keio.ac.jp|Department of Biosciences and Informatics, Keio University, Seikei University, Japan. hacchy@dna.bio.keio.ac.jp|Department of Biosciences and Informatics, Keio University, Seikei University, Japan. hacchy@dna.bio.keio.ac.jp