Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States of America.|Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States of America.|Department of Physiology, Michigan State University, East Lansing, MI, United States of America.|Department of Internal Medicine, University of Michigan, Ann Arbor, MI, United States of America.|Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States of America.