Institute of Medical Biometry and Medical Informatics, University Medical Center Freiburg, Freiburg, Germany. martin.boeker@uniklinik-freiburg.de|Institute of Medical Biometry and Medical Informatics, University Medical Center Freiburg, Freiburg, Germany. martin.boeker@uniklinik-freiburg.de|Institute of Medical Biometry and Medical Informatics, University Medical Center Freiburg, Freiburg, Germany. martin.boeker@uniklinik-freiburg.de|Institute of Medical Biometry and Medical Informatics, University Medical Center Freiburg, Freiburg, Germany. martin.boeker@uniklinik-freiburg.de|Institute of Medical Biometry and Medical Informatics, University Medical Center Freiburg, Freiburg, Germany. martin.boeker@uniklinik-freiburg.de