The Holm Group, Biocenter II, Institute of Biotechnology, PO Box 56, 00014 University of Helsinki, Finland. petri.toronen@helsinki.fi|The Holm Group, Biocenter II, Institute of Biotechnology, PO Box 56, 00014 University of Helsinki, Finland. petri.toronen@helsinki.fi|The Holm Group, Biocenter II, Institute of Biotechnology, PO Box 56, 00014 University of Helsinki, Finland. petri.toronen@helsinki.fi