Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA College of Sciences, Inner Mongolia University of Technology, Hohhot 010051, China.|Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA Institute for Data Science and Engineering, East China Normal University, Shanghai 200062, China.|Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA School of Mathematical Sciences, Nankai University, Tianjin 300071, China.|Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.