Windber Research Institute, Windber, PA 15963, USA. s.guo@wriwindber.org|Windber Research Institute, Windber, PA 15963, USA. s.guo@wriwindber.org|Windber Research Institute, Windber, PA 15963, USA. s.guo@wriwindber.org|Windber Research Institute, Windber, PA 15963, USA. s.guo@wriwindber.org|Windber Research Institute, Windber, PA 15963, USA. s.guo@wriwindber.org