Computational Systems Biology Group, National Center for Biotechnology (CNB-CSIC), Darwin 3, 28049, Madrid, Spain.|Computational Systems Biology Group, National Center for Biotechnology (CNB-CSIC), Darwin 3, 28049, Madrid, Spain.|Computational Systems Biology Group, National Center for Biotechnology (CNB-CSIC), Darwin 3, 28049, Madrid, Spain. monica.chagoyen@cnb.csic.es.