Loschmidt Laboratories, Department of Experimental Biology and Research Centre for Toxic Compounds in the Environment, Faculty of Science, Masaryk University, Brno, Czech Republic , Department of Information Systems, Faculty of Information Technology, Brno University of Technology, Brno, Czech Republic , Center of Biomolecular and Cellular Engineering, International Centre for Clinical Research, St. Annes University Hospital Brno, Brno, Czech Republic.