Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, HFT-20, Jefferson, AR, 72079, USA.|Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, HFT-20, Jefferson, AR, 72079, USA.|Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, HFT-20, Jefferson, AR, 72079, USA.|Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, HFT-20, Jefferson, AR, 72079, USA.|Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, HFT-20, Jefferson, AR, 72079, USA.|Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, HFT-20, Jefferson, AR, 72079, USA.|Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, HFT-20, Jefferson, AR, 72079, USA.|Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, HFT-20, Jefferson, AR, 72079, USA. wen.zou@fda.hhs.gov.