Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, OX3 7BN and Department of Statistics, University of Oxford, 1 South Parks Road, OX1 3TG, Oxford, UK.|Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, OX3 7BN and Department of Statistics, University of Oxford, 1 South Parks Road, OX1 3TG, Oxford, UK.|Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, OX3 7BN and Department of Statistics, University of Oxford, 1 South Parks Road, OX1 3TG, Oxford, UK.