Institute of Computational Biology, HMGU-German Research Center for Environmental Health, Ingolstädter Landstraße 1, Neuherberg, 85764, Germany. hahn@helmholtz-muenchen.de.|Institute of Computational Biology, HMGU-German Research Center for Environmental Health, Ingolstädter Landstraße 1, Neuherberg, 85764, Germany. massopust@ma.tum.de.|Novosibirsk State University, Institute of Computational Mathematics and Mathematical Geophysics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia. sergeim.prigarin@gmail.com.