Department of Statistics, University of Leeds, Leeds LS2 9JT, United Kingdom, Department of Statistics, Faculty of Science, King Saud University, Riyadh, Saudi Arabia, Leeds Institute Cancer and Pathology, University of Leeds, Leeds LS9 7TF, UK and Illumina UK Ltd., Chesterford Research Park, Saffron Walden, CB10 1XL, UK.|Department of Statistics, University of Leeds, Leeds LS2 9JT, United Kingdom, Department of Statistics, Faculty of Science, King Saud University, Riyadh, Saudi Arabia, Leeds Institute Cancer and Pathology, University of Leeds, Leeds LS9 7TF, UK and Illumina UK Ltd., Chesterford Research Park, Saffron Walden, CB10 1XL, UK.|Department of Statistics, University of Leeds, Leeds LS2 9JT, United Kingdom, Department of Statistics, Faculty of Science, King Saud University, Riyadh, Saudi Arabia, Leeds Institute Cancer and Pathology, University of Leeds, Leeds LS9 7TF, UK and Illumina UK Ltd., Chesterford Research Park, Saffron Walden, CB10 1XL, UKDepartment of Statistics, University of Leeds, Leeds LS2 9JT, United Kingdom, Department of Statistics, Faculty of Science, King Saud University, Riyadh, Saudi Arabia, Leeds Institute Cancer and Pathology, University of Leeds, Leeds LS9 7TF, UK and Illumina UK Ltd., Chesterford Research Park, Saffron Walden, CB10 1XL, UK.|Department of Statistics, University of Leeds, Leeds LS2 9JT, United Kingdom, Department of Statistics, Faculty of Science, King Saud University, Riyadh, Saudi Arabia, Leeds Institute Cancer and Pathology, University of Leeds, Leeds LS9 7TF, UK and Illumina UK Ltd., Chesterford Research Park, Saffron Walden, CB10 1XL, UK.|Department of Statistics, University of Leeds, Leeds LS2 9JT, United Kingdom, Department of Statistics, Faculty of Science, King Saud University, Riyadh, Saudi Arabia, Leeds Institute Cancer and Pathology, University of Leeds, Leeds LS9 7TF, UK and Illumina UK Ltd., Chesterford Research Park, Saffron Walden, CB10 1XL, UK.|Department of Statistics, University of Leeds, Leeds LS2 9JT, United Kingdom, Department of Statistics, Faculty of Science, King Saud University, Riyadh, Saudi Arabia, Leeds Institute Cancer and Pathology, University of Leeds, Leeds LS9 7TF, UK and Illumina UK Ltd., Chesterford Research Park, Saffron Walden, CB10 1XL, UK.