Institute of Biology and Genetics, Polytechnic University of Marche, 60131, Ancona, Italy. f.piva@univpm.it|Institute of Biology and Genetics, Polytechnic University of Marche, 60131, Ancona, Italy. f.piva@univpm.it|Institute of Biology and Genetics, Polytechnic University of Marche, 60131, Ancona, Italy. f.piva@univpm.it|Institute of Biology and Genetics, Polytechnic University of Marche, 60131, Ancona, Italy. f.piva@univpm.it