School of Mathematics and Statistics, University of Sydney, NSW 2006, Australia.|Department of Statistics, University of California, Berkeley, CA 94720, USA.|Childrens Hospital Oakland Research Institute, Oakland, CA 94609, USA.|The Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.|Childrens Hospital Oakland Research Institute, Oakland, CA 94609, USA.|Molecular and Computational Biology, University of Southern California, CA 90089, USA.|Department of Statistics, University of California, Berkeley, CA 94720, USA.|Department of Statistics, University of California, Berkeley, CA 94720, USA.