Department of Biomedical Engineering and High-Throughput Biology Center, Johns Hopkins University, Baltimore, MD 21218, USA.|Department of Biomedical Engineering and High-Throughput Biology Center, Johns Hopkins University, Baltimore, MD 21218, USA.|Institute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Medical Center, New York, NY 10016, USA.|Department of Biomedical Engineering and High-Throughput Biology Center, Johns Hopkins University, Baltimore, MD 21218, USA.