Division of Biostatistics, Yale University Schools of Public Health and Medicine, 60 College St., New Haven, CT 06519, USA. annette.molinaro@yale.edu|Division of Biostatistics, Yale University Schools of Public Health and Medicine, 60 College St., New Haven, CT 06519, USA. annette.molinaro@yale.edu|Division of Biostatistics, Yale University Schools of Public Health and Medicine, 60 College St., New Haven, CT 06519, USA. annette.molinaro@yale.edu