Department of Biostatistics and Bioinformatics, Duke University, Durham, NC 27705, USA.|Department of Biostatistics and Bioinformatics, Duke University, Durham, NC 27705, USA.|Department of Biostatistics and Bioinformatics, Duke University, Durham, NC 27705, USA.|Department of Biostatistics and Bioinformatics, Duke University, Durham, NC 27705, USA.