School of Computer Science and School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK, Manchester Institute of Biotechnology, School of Chemistry and School of Computer Science, The University of Manchester, Manchester M13 9JD, UK School of Computer Science and School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK, Manchester Institute of Biotechnology, School of Chemistry and School of Computer Science, The University of Manchester, Manchester M13 9JD, UK.