Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA, USA. anwarren@vt.edu|Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA, USA. anwarren@vt.edu|Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA, USA. anwarren@vt.edu|Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA, USA. anwarren@vt.edu