University of Pennsylvania School of Medicine, Philadelphia, PA, USA. adrianb@mail.med.upenn.edu.|University of Pennsylvania School of Medicine, Philadelphia, PA, USA. adrianb@mail.med.upenn.edu.|University of Pennsylvania School of Medicine, Philadelphia, PA, USA. adrianb@mail.med.upenn.edu.|University of Pennsylvania School of Medicine, Philadelphia, PA, USA. adrianb@mail.med.upenn.edu.|University of Pennsylvania School of Medicine, Philadelphia, PA, USA. adrianb@mail.med.upenn.edu.|University of Pennsylvania School of Medicine, Philadelphia, PA, USA. adrianb@mail.med.upenn.edu.|University of Pennsylvania School of Medicine, Philadelphia, PA, USA. adrianb@mail.med.upenn.edu.