The tenth annual conference of the MidSouth Computational Biology and Bioinformatics Society (MCBIOS 2013), The 10th Anniversary in a Decade of Change: Discovery in a Sea of Data, took place at the Stoney Creek Inn & Conference Center in Columbia, Missouri on April 5-6, 2013. This years Conference Chairs were Gordon Springer and Chi-Ren Shyu from the University of Missouri and Edward Perkins from the US Army Corps of Engineers Engineering Research and Development Center, who is also the current MCBIOS President (2012-3). There were 151 registrants and a total of 111 abstracts (51 oral presentations and 60 poster session abstracts). 