Department of Pathology and Bioinformatics Program, Medical College of Wisconsin, Milwaukee, WI, 53226, USA. guohui@rocketmail.com|Department of Pathology and Bioinformatics Program, Medical College of Wisconsin, Milwaukee, WI, 53226, USA. guohui@rocketmail.com|Department of Pathology and Bioinformatics Program, Medical College of Wisconsin, Milwaukee, WI, 53226, USA. guohui@rocketmail.com|Department of Pathology and Bioinformatics Program, Medical College of Wisconsin, Milwaukee, WI, 53226, USA. guohui@rocketmail.com|Department of Pathology and Bioinformatics Program, Medical College of Wisconsin, Milwaukee, WI, 53226, USA. guohui@rocketmail.com|Department of Pathology and Bioinformatics Program, Medical College of Wisconsin, Milwaukee, WI, 53226, USA. guohui@rocketmail.com|Department of Pathology and Bioinformatics Program, Medical College of Wisconsin, Milwaukee, WI, 53226, USA. guohui@rocketmail.com