Program of Computational Genomics & Medicine, NorthShore University HealthSystem, Evanston, IL 60201, USA.|Department of Applied Mathematics & Statistics, Johns Hopkins University, Baltimore, MD 21218, USA.|Program of Computational Genomics & Medicine, NorthShore University HealthSystem, Evanston, IL 60201, USA.|Department of Applied Mathematics & Statistics, Johns Hopkins University, Baltimore, MD 21218, USA.|Program of Computational Genomics & Medicine, NorthShore University HealthSystem, Evanston, IL 60201, USA.|Program of Computational Genomics & Medicine, NorthShore University HealthSystem, Evanston, IL 60201, USA.