Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, 825 N.E. 13th Street, Oklahoma City, OK, 73104-5005, USA. jonathan-wren@omrf.org.|Department of Clinical Sciences, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, 75390-9066, USA.|Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA.|Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi, MS, USA.|Bioinformatics Facility, Institute for Integrative Genome Biology, University of California, Riverside, California, USA.|Department of Biostatistics, Richmond Academy of Medicine, Virginia Commonwealth University, Virginia, USA.|Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA.