Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London WC1E 6BT, UK.|Institute of Cardiovascular Science, UCL, London, UK.|Institute of Cardiovascular Science, UCL, London, UK.|Complejo Hospitalario Universitario de A Coruxc3xb1a, Insituto de Investigacixc3xb3n Biomxc3xa9dica, Coruxc3xb1a, Spain.|Institute of Cardiovascular Science, UCL, London, UK.|Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London WC1E 6BT, UK.