Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.|Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.|Department of Bioinformatics & Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.|Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. sshete@mdanderson.org.