Spectra resulting from Surface-Enhanced Laser Desorption/Ionisation (SELDI) mass spectrometry measurements are constructed by combining sub-spectra, each of which are the result of a single firing of the laser responsible for the process of desorption/ionisation. These firings are performed at different locations of the spot on which the sample is analysed. The final spectrum is then constructed by summing over all these sub-spectra. This process is sub-optimal in that it can average out peaks from peptides that are present in low abundance or are unevenly distributed across the spot, particularly because the amount of noise varies considerably between sub-spectra. This argues for analysing sub-spectra separately and combining results afterwards.