Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, 10029, New York, USA. seth.berger@mssm.edu|Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, 10029, New York, USA. seth.berger@mssm.edu|Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, 10029, New York, USA. seth.berger@mssm.edu