Partner Institute of Computational Biology, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Max-Planck Society, Shanghai 200031, China. jaeger@picb.ac.cn|Partner Institute of Computational Biology, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Max-Planck Society, Shanghai 200031, China. jaeger@picb.ac.cn|Partner Institute of Computational Biology, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Max-Planck Society, Shanghai 200031, China. jaeger@picb.ac.cn