Medical statistics, Department of Biomedical Data Science, Leiden University Medical Center, Leiden, The Netherlands.|Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.|Medical statistics, Department of Biomedical Data Science, Leiden University Medical Center, Leiden, The Netherlands.|Medical statistics, Department of Biomedical Data Science, Leiden University Medical Center, Leiden, The Netherlands.|Medical statistics, Department of Biomedical Data Science, Leiden University Medical Center, Leiden, The Netherlands.