Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America.|Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota, United States of America.|Mathematics and Computer Science Division, Argonne National Laboratory, Lemont, Illinois, United States of America.|Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Surgery, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Physiology and Bioengineering, Mayo Clinic, Rochester, Minnesota, United States of America.|Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America, Institute for Systems Biology, Seattle, Washington, United States of America.