Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK. rh497@cam.ac.uk|Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK. rh497@cam.ac.uk|Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK. rh497@cam.ac.uk