Global Pricing and Market Access, F. Hoffmann-La Roche Ltd, CH-4070 Basel, Switzerland.|Lancaster Medical School, Lancaster University, Lancaster, LA1 4YQ, UK.|MRC Biostatistics Unit, University of Cambridge, Cambridge, CB2 0SR, UK.|Department of Bioinformatics and Computational Biology.|Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.|Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.|German Centre for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany.