Centre of Molecular Bioinformatics, Department of Biology, University of Tor Vergata Rome, Italy. enrico@cbm.bio.uniroma2.it|Centre of Molecular Bioinformatics, Department of Biology, University of Tor Vergata Rome, Italy. enrico@cbm.bio.uniroma2.it|Centre of Molecular Bioinformatics, Department of Biology, University of Tor Vergata Rome, Italy. enrico@cbm.bio.uniroma2.it|Centre of Molecular Bioinformatics, Department of Biology, University of Tor Vergata Rome, Italy. enrico@cbm.bio.uniroma2.it