Department for Research, Forerunner Pharma Research, Co,, Ltd, Yokohama, Japan. teramoto@forerunner-pharma.co.jp.|Department for Research, Forerunner Pharma Research, Co,, Ltd, Yokohama, Japan. teramoto@forerunner-pharma.co.jp.|Department for Research, Forerunner Pharma Research, Co,, Ltd, Yokohama, Japan. teramoto@forerunner-pharma.co.jp.