Department of Theoretical Bioinformatics, German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), University of Heidelberg, Im 69120 Heidelberg, Germany. r.piro@dkfz.de|Department of Theoretical Bioinformatics, German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), University of Heidelberg, Im 69120 Heidelberg, Germany. r.piro@dkfz.de|Department of Theoretical Bioinformatics, German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), University of Heidelberg, Im 69120 Heidelberg, Germany. r.piro@dkfz.de|Department of Theoretical Bioinformatics, German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), University of Heidelberg, Im 69120 Heidelberg, Germany. r.piro@dkfz.de|Department of Theoretical Bioinformatics, German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), University of Heidelberg, Im 69120 Heidelberg, Germany. r.piro@dkfz.de