Univ Rennes, CNRS, Inria, IRISA - UMR 6074, Rennes, F-35000, France.|Univ Rennes, CNRS, Inria, IRISA - UMR 6074, Rennes, F-35000, France.|Univ Rennes, EHESP, REPERES (Pharmacology and Health Services Research) - EA 7449, Rennes, F-35000, France.