Institute of Medical Science, University of Toronto, Medical Sciences Building, 1 Kings College Circle, Toronto, M5S 1A8, Canada. sejalr.patel@mail.utoronto.ca.|European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK. paola@ebi.ac.uk.|Centre for Cardiovascular Genetics, Institute of Cardiovascular Science, University College London, Rayne Building, 5 University Street, London, WC1E 6JF, UK. r.lovering@ucl.ac.uk.