Centres for Cardiovascular Science and Inflammation Research, Queens Medical Research Institute, University of Edinburgh, EH16 4TJ, UK. jmanning@staffmail.ed.ac.uk|Centres for Cardiovascular Science and Inflammation Research, Queens Medical Research Institute, University of Edinburgh, EH16 4TJ, UK. jmanning@staffmail.ed.ac.uk|Centres for Cardiovascular Science and Inflammation Research, Queens Medical Research Institute, University of Edinburgh, EH16 4TJ, UK. jmanning@staffmail.ed.ac.uk|Centres for Cardiovascular Science and Inflammation Research, Queens Medical Research Institute, University of Edinburgh, EH16 4TJ, UK. jmanning@staffmail.ed.ac.uk