National Cancer Institute, Biometric Research Branch, 6130 Executive Blvd., MSC 7434, Bethesda, MD 20892, USA. dobbinke@mail.nih.gov|National Cancer Institute, Biometric Research Branch, 6130 Executive Blvd., MSC 7434, Bethesda, MD 20892, USA. dobbinke@mail.nih.gov|National Cancer Institute, Biometric Research Branch, 6130 Executive Blvd., MSC 7434, Bethesda, MD 20892, USA. dobbinke@mail.nih.gov