Pharmacometrics & Systems Pharmacology group, Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Navarra, Spain.|Department of Physics and Applied Mathematics, University of Navarra, Pamplona, Navarra, Spain.|Department of Physics and Applied Mathematics, University of Navarra, Pamplona, Navarra, Spain.|Pharmacometrics & Systems Pharmacology group, Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Navarra, Spain.