Institute for Computational Biomedicine, Dept. of Physiology and Biophysics, Weill Cornell Medical College, 1300 York Ave, New York, NY 10021, USA. les2007@med.cornell.edu|Institute for Computational Biomedicine, Dept. of Physiology and Biophysics, Weill Cornell Medical College, 1300 York Ave, New York, NY 10021, USA. les2007@med.cornell.edu