Department of Biosystems Science and Engineering, ETH Zurich, 4058 Basel, Switzerland.|Institute of Computational Biology, Helmholtz Zentrum Mxc3xbcnchen, 85764 Neuherberg, Germany.|Institute of Computational Biology, Helmholtz Zentrum Mxc3xbcnchen, 85764 Neuherberg, Germany.|Institute of Computational Biology, Helmholtz Zentrum Mxc3xbcnchen, 85764 Neuherberg, Germany.