Division of Biostatistics, Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, USA. yang.xie@utsouthwestern.edu|Division of Biostatistics, Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, USA. yang.xie@utsouthwestern.edu|Division of Biostatistics, Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, USA. yang.xie@utsouthwestern.edu