Applied Computer Science and Mathematics, Merck Research Laboratories, P.O. Box 2000 RY84-202, Rahway, NJ 07065 0900, USA. eugen_buehler@merck.com|Applied Computer Science and Mathematics, Merck Research Laboratories, P.O. Box 2000 RY84-202, Rahway, NJ 07065 0900, USA. eugen_buehler@merck.com|Applied Computer Science and Mathematics, Merck Research Laboratories, P.O. Box 2000 RY84-202, Rahway, NJ 07065 0900, USA. eugen_buehler@merck.com|Applied Computer Science and Mathematics, Merck Research Laboratories, P.O. Box 2000 RY84-202, Rahway, NJ 07065 0900, USA. eugen_buehler@merck.com|Applied Computer Science and Mathematics, Merck Research Laboratories, P.O. Box 2000 RY84-202, Rahway, NJ 07065 0900, USA. eugen_buehler@merck.com