Department of Biochemistry, Department of Biostatistics, State University of New York at Buffalo, Buffalo, NY 14214, USA. qzhu@buffalo.edu|Department of Biochemistry, Department of Biostatistics, State University of New York at Buffalo, Buffalo, NY 14214, USA. qzhu@buffalo.edu|Department of Biochemistry, Department of Biostatistics, State University of New York at Buffalo, Buffalo, NY 14214, USA. qzhu@buffalo.edu