Institute for Systems Biology, Seattle, WA 98109-5234, USA, Department of Computer Science and Information Engineering, National Cheng Kung University, Tainan, Taiwan and Seattle Biomedical Research Institute, Seattle, WA 98109-5219, USA.|Institute for Systems Biology, Seattle, WA 98109-5234, USA, Department of Computer Science and Information Engineering, National Cheng Kung University, Tainan, Taiwan and Seattle Biomedical Research Institute, Seattle, WA 98109-5219, USA.|Institute for Systems Biology, Seattle, WA 98109-5234, USA, Department of Computer Science and Information Engineering, National Cheng Kung University, Tainan, Taiwan and Seattle Biomedical Research Institute, Seattle, WA 98109-5219, USA.|Institute for Systems Biology, Seattle, WA 98109-5234, USA, Department of Computer Science and Information Engineering, National Cheng Kung University, Tainan, Taiwan and Seattle Biomedical Research Institute, Seattle, WA 98109-5219, USA.