School of Medicine, Cardiff University, Cardiff, United Kingdom. BrownMR@cf.ac.uk|School of Medicine, Cardiff University, Cardiff, United Kingdom. BrownMR@cf.ac.uk|School of Medicine, Cardiff University, Cardiff, United Kingdom. BrownMR@cf.ac.uk|School of Medicine, Cardiff University, Cardiff, United Kingdom. BrownMR@cf.ac.uk|School of Medicine, Cardiff University, Cardiff, United Kingdom. BrownMR@cf.ac.uk|School of Medicine, Cardiff University, Cardiff, United Kingdom. BrownMR@cf.ac.uk