Department of Medical Informatics and Biomathematics, University of Münster, Domagkstrasse 9, 48149 Münster, Germany. h.klein@uni-muenster.de|Department of Medical Informatics and Biomathematics, University of Münster, Domagkstrasse 9, 48149 Münster, Germany. h.klein@uni-muenster.de|Department of Medical Informatics and Biomathematics, University of Münster, Domagkstrasse 9, 48149 Münster, Germany. h.klein@uni-muenster.de|Department of Medical Informatics and Biomathematics, University of Münster, Domagkstrasse 9, 48149 Münster, Germany. h.klein@uni-muenster.de|Department of Medical Informatics and Biomathematics, University of Münster, Domagkstrasse 9, 48149 Münster, Germany. h.klein@uni-muenster.de|Department of Medical Informatics and Biomathematics, University of Münster, Domagkstrasse 9, 48149 Münster, Germany. h.klein@uni-muenster.de|Department of Medical Informatics and Biomathematics, University of Münster, Domagkstrasse 9, 48149 Münster, Germany. h.klein@uni-muenster.de