Center for Human Genetics Research, Department of Biomedical Informatics, Vanderbilt University, Nashville, TN 37232, Departments of Developmental Biology and Computational & Systems Biology, University of Pittsburgh, Pittsburgh, PA 15201, USA Center for Human Genetics Research, Department of Biomedical Informatics, Vanderbilt University, Nashville, TN 37232, Departments of Developmental Biology and Computational & Systems Biology, University of Pittsburgh, Pittsburgh, PA 15201, USA.