Human Genetics, Genome Institute of Singapore, 60 Biopolis Street, #02-01 Genome, Singapore 138672, Singapore. zakharovs99@gis.a-star.edu.sg.|Human Genetics, Genome Institute of Singapore, 60 Biopolis Street, #02-01 Genome, Singapore 138672, Singapore. zakharovs99@gis.a-star.edu.sg.|Human Genetics, Genome Institute of Singapore, 60 Biopolis Street, #02-01 Genome, Singapore 138672, Singapore. zakharovs99@gis.a-star.edu.sg.|Collaborative Research Center SFB 876, TU Dortmund University, Dortmund, Germany. Sven.Rahmann@uni-due.de.