Center for Eukaryotic Gene Regulation, Department of Biochemistry & Molecular Biology, The Pennsylvania State University, University Park, PA, United States of America.|Department of Biology, New York University, 100 Washington Square East, New York, NY, United States of America.|Department of Biology, New York University, 100 Washington Square East, New York, NY, United States of America.|Center for Eukaryotic Gene Regulation, Department of Biochemistry & Molecular Biology, The Pennsylvania State University, University Park, PA, United States of America.