Department of Biochemistry and Molecular Biology, The Miller School of Medicine at the University of Miami, Miami, FL 33136, USA. j.zhou1@miami.edu|Department of Biochemistry and Molecular Biology, The Miller School of Medicine at the University of Miami, Miami, FL 33136, USA. j.zhou1@miami.edu|Department of Biochemistry and Molecular Biology, The Miller School of Medicine at the University of Miami, Miami, FL 33136, USA. j.zhou1@miami.edu