Harvard Medical School and Harvard Pilgrim Healthcare Institute, Boston, MA 02215, USA. pscshi@gmail.com|Harvard Medical School and Harvard Pilgrim Healthcare Institute, Boston, MA 02215, USA. pscshi@gmail.com|Harvard Medical School and Harvard Pilgrim Healthcare Institute, Boston, MA 02215, USA. pscshi@gmail.com|Harvard Medical School and Harvard Pilgrim Healthcare Institute, Boston, MA 02215, USA. pscshi@gmail.com