Division of Biomedical Statistics and Informatics, Mayo Clinic, 200 First Street SW, Rochester MN 55905, Department of Health Sciences Research, Mayo Clinic, 4500 San Pablo Road South, Jacksonville FL 32224, Department of Laboratory Medicine and Pathology, Division of Hematology, Department of Internal Medicine, Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester MN 55905 and Department of Cancer Biology, Mayo Clinic, 4500 San Pablo Road South, Jacksonville FL 32224, USA.