Center for Computational Science, University of Miami, Miami, FL 33136, USA and Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.|Center for Computational Science, University of Miami, Miami, FL 33136, USA and Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.|Center for Computational Science, University of Miami, Miami, FL 33136, USA and Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.|Center for Computational Science, University of Miami, Miami, FL 33136, USA and Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.|Center for Computational Science, University of Miami, Miami, FL 33136, USA and Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.