Department of Biostatistics, Yale School of Public Health, New Haven, CT, United States of America.|Department of Biostatistics, Yale School of Public Health, New Haven, CT, United States of America.|Program of Computational Biology and Bioinformatics, Yale University, New Haven, CT, United States of America.|Yale College, New Haven, CT, United States of America.|Department of Mathematics, Hong Kong Baptist University, Kowloon, Hong Kong.|Department of Biostatistics, Yale School of Public Health, New Haven, CT, United States of America.|Department of Biostatistics, Yale School of Public Health, New Haven, CT, United States of America.|Department of Biostatistics, Yale School of Public Health, New Haven, CT, United States of America.