Differential network analysis is an important way to understand network rewiring involved in disease progression and development. Building differential networks from multiple omics data provides insight into the holistic differences of the interactive system under different patient-specific groups. DINGO was developed to infer group-specific dependencies and build differential networks. However, DINGO and other existing tools are limited to analyze data arising from a single platform, and modeling each of the multiple omics data independently does not account for the hierarchical structure of the data.