Dept. of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, 135 Cannon St, Suite 303, Charleston, SC 29425, USA. lux@musc.edu|Dept. of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, 135 Cannon St, Suite 303, Charleston, SC 29425, USA. lux@musc.edu|Dept. of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, 135 Cannon St, Suite 303, Charleston, SC 29425, USA. lux@musc.edu|Dept. of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, 135 Cannon St, Suite 303, Charleston, SC 29425, USA. lux@musc.edu