School of Computer Science and Technology, Harbin Institute of Technology, Harbin 150001, China, Center for Human Genome Variation, Duke University, Durham, NC 27708 and Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37235, USASchool of Computer Science and Technology, Harbin Institute of Technology, Harbin 150001, China, Center for Human Genome Variation, Duke University, Durham, NC 27708 and Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37235, USA.