Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.|Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.|Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.|Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.|Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.|Graduate School of Public Health and Health Policy, City University of New York, New York, NY 10027, USA.|Centre for Integrative Biology, University of Trento, Trento 38123, Italy.|Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.