Department of Pharmacology and Systems Therapeutics, One Gustave L. Levy Place Box 1215, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.|Department of Pharmacology and Systems Therapeutics, One Gustave L. Levy Place Box 1215, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.|Department of Pharmacology and Systems Therapeutics, One Gustave L. Levy Place Box 1215, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.