Theoretical Biology and Bioinformatics, Department of Biology, Science faculty, Utrecht University, Utrecht, The Netherlands.|Theoretical Biology and Bioinformatics, Department of Biology, Science faculty, Utrecht University, Utrecht, The Netherlands.|Theoretical Biology and Bioinformatics, Department of Biology, Science faculty, Utrecht University, Utrecht, The Netherlands.|Theoretical Biology and Bioinformatics, Department of Biology, Science faculty, Utrecht University, Utrecht, The Netherlands.