Clinical and Translational Science Institute, School of Medicine and Dentistry, University of Rochester, 265 Crittenden Boulevard CU 420708, Rochester, 14642, NY, USA. dongmei_li@urmc.rochester.edu.|Department of Biostatistics and Computational Biology, University of Rochester, 265 Crittenden Boulevard CU 420708, Rochester, 14642, NY, USA. xzd482@yahoo.com.|John A. Burns School of Medicine, University of Hawaii, 651 Ilalo Street 101, Honolulu, 96813, HI, USA. lepape@hawaii.edu.|Department of Obstetrics and Gynecology, University of Rochester, 500 Red Creek Drive Suite 220, Rochester, 14623, NY, USA. Tim_Dye@URMC.Rochester.edu.