The Broad Institute of MIT & Harvard University, Cambridge, MA 02141, USA. jforman@broad.harvard.edu|The Broad Institute of MIT & Harvard University, Cambridge, MA 02141, USA. jforman@broad.harvard.edu|The Broad Institute of MIT & Harvard University, Cambridge, MA 02141, USA. jforman@broad.harvard.edu|The Broad Institute of MIT & Harvard University, Cambridge, MA 02141, USA. jforman@broad.harvard.edu