Department of Biomedicine, University of Bergen, Bergen, Norway. lars.skjarven@biomed.uib.no.|Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA. xinqyao@umich.edu.|Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA. guidos@umich.edu.|Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA. bjgrant@umich.edu.