Pharmaceutical Research and Early Development Informatics/Statistics, F. Hoffmann-La Roche, Nutley, NJ 07110, USA. xin.wei@roche.com|Pharmaceutical Research and Early Development Informatics/Statistics, F. Hoffmann-La Roche, Nutley, NJ 07110, USA. xin.wei@roche.com|Pharmaceutical Research and Early Development Informatics/Statistics, F. Hoffmann-La Roche, Nutley, NJ 07110, USA. xin.wei@roche.com|Pharmaceutical Research and Early Development Informatics/Statistics, F. Hoffmann-La Roche, Nutley, NJ 07110, USA. xin.wei@roche.com|Pharmaceutical Research and Early Development Informatics/Statistics, F. Hoffmann-La Roche, Nutley, NJ 07110, USA. xin.wei@roche.com|Pharmaceutical Research and Early Development Informatics/Statistics, F. Hoffmann-La Roche, Nutley, NJ 07110, USA. xin.wei@roche.com|Pharmaceutical Research and Early Development Informatics/Statistics, F. Hoffmann-La Roche, Nutley, NJ 07110, USA. xin.wei@roche.com|Pharmaceutical Research and Early Development Informatics/Statistics, F. Hoffmann-La Roche, Nutley, NJ 07110, USA. xin.wei@roche.com