Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany, Division of Mathematical Modeling of Biological Systems, Department of Mathematics, University of Technology Munich, Munich, Germany.|Max Planck Institute for Molecular Genetics, Berlin, Germany.|Max Planck Institute for Molecular Genetics, Berlin, Germany, Division of Experimental Anesthesiology and Pain Research, Department of Anesthesiology and Intensive Care Medicine, University Hospital Cologne, Cologne, Germany.|Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany, Division of Mathematical Modeling of Biological Systems, Department of Mathematics, University of Technology Munich, Munich, Germany.