The Hospital for Sick Children Research Institute, 555 University Ave,, Toronto, ON, M5G 1X8, Canada. phu@sickkids.ca|The Hospital for Sick Children Research Institute, 555 University Ave,, Toronto, ON, M5G 1X8, Canada. phu@sickkids.ca|The Hospital for Sick Children Research Institute, 555 University Ave,, Toronto, ON, M5G 1X8, Canada. phu@sickkids.ca