Department of Biostatistics and Computational Biology, University of Rochester, New York 14642, USA. Xing_Qiu@urmc.rochester.edu|Department of Biostatistics and Computational Biology, University of Rochester, New York 14642, USA. Xing_Qiu@urmc.rochester.edu|Department of Biostatistics and Computational Biology, University of Rochester, New York 14642, USA. Xing_Qiu@urmc.rochester.edu|Department of Biostatistics and Computational Biology, University of Rochester, New York 14642, USA. Xing_Qiu@urmc.rochester.edu