School of Biomedicine, The University of Manchester, Manchester M13 9PT, UK.|School of Biomedicine, The University of Manchester, Manchester M13 9PT, UK.|School of Biomedicine, The University of Manchester, Manchester M13 9PT, UK.|School of Biomedicine, The University of Manchester, Manchester M13 9PT, UK.|School of Biomedicine, The University of Manchester, Manchester M13 9PT, UK.|School of Biomedicine, The University of Manchester, Manchester M13 9PT, UK.|School of Biomedicine, The University of Manchester, Manchester M13 9PT, UK.|School of Biomedicine, The University of Manchester, Manchester M13 9PT, UK.|School of Biomedicine, The University of Manchester, Manchester M13 9PT, UK.