Division of Biostatistics, German Cancer Research Center, Heidelberg, Germany. m.sill@dkfz.de|Division of Biostatistics, German Cancer Research Center, Heidelberg, Germany. m.sill@dkfz.de|Division of Biostatistics, German Cancer Research Center, Heidelberg, Germany. m.sill@dkfz.de|Division of Biostatistics, German Cancer Research Center, Heidelberg, Germany. m.sill@dkfz.de|Division of Biostatistics, German Cancer Research Center, Heidelberg, Germany. m.sill@dkfz.de