Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, Washington, DC 20057, USA. zh9@georgetown.edu|Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, Washington, DC 20057, USA. zh9@georgetown.edu|Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, Washington, DC 20057, USA. zh9@georgetown.edu|Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, Washington, DC 20057, USA. zh9@georgetown.edu|Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, Washington, DC 20057, USA. zh9@georgetown.edu