Channing Laboratory, Brigham and Womens Hospital, Boston, MA 02115, USA. rdu@partners.org|Channing Laboratory, Brigham and Womens Hospital, Boston, MA 02115, USA. rdu@partners.org|Channing Laboratory, Brigham and Womens Hospital, Boston, MA 02115, USA. rdu@partners.org|Channing Laboratory, Brigham and Womens Hospital, Boston, MA 02115, USA. rdu@partners.org|Channing Laboratory, Brigham and Womens Hospital, Boston, MA 02115, USA. rdu@partners.org|Channing Laboratory, Brigham and Womens Hospital, Boston, MA 02115, USA. rdu@partners.org|Channing Laboratory, Brigham and Womens Hospital, Boston, MA 02115, USA. rdu@partners.org|Channing Laboratory, Brigham and Womens Hospital, Boston, MA 02115, USA. rdu@partners.org|Channing Laboratory, Brigham and Womens Hospital, Boston, MA 02115, USA. rdu@partners.org|Channing Laboratory, Brigham and Womens Hospital, Boston, MA 02115, USA. rdu@partners.org|Channing Laboratory, Brigham and Womens Hospital, Boston, MA 02115, USA. rdu@partners.org|Channing Laboratory, Brigham and Womens Hospital, Boston, MA 02115, USA. rdu@partners.org