Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605 and Bioinformatics Program, Boston University, 44 Cummington Mall, Boston, MA 02215 USAProgram in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605 and Bioinformatics Program, Boston University, 44 Cummington Mall, Boston, MA 02215 USA.