Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.|Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, United States of America.|Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, United States of America.|Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, United States of America.|Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, United States of America.|Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.|Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, United States of America , Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana, United States of America.