Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06511, USA.|Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06511, USA.|Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06511, USA.|Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06511, USA.