Department of Biochemistry and Molecular Biophysics, Center for Computational Biology, Washington University in St Louis, St Louis, MO 63110, USA.|Department of Biochemistry and Molecular Biophysics, Center for Computational Biology, Washington University in St Louis, St Louis, MO 63110, USA.|Department of Biochemistry and Molecular Biophysics, Center for Computational Biology, Washington University in St Louis, St Louis, MO 63110, USA.|Department of Biochemistry and Molecular Biophysics, Center for Computational Biology, Washington University in St Louis, St Louis, MO 63110, USA.