Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029 and Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA 15260, USA.|Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029 and Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA 15260, USA.|Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029 and Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA 15260, USA.