Intelligent Systems Laboratory, University of Bristol, Bristol BS8?1UB, UK.|MRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol BS8?2BN, UK.|Institute of Medical Genetics, Cardiff University, Cardiff CF14?4XN, UK.|Institute of Medical Genetics, Cardiff University, Cardiff CF14?4XN, UK.|MRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol BS8?2BN, UK.|Intelligent Systems Laboratory, University of Bristol, Bristol BS8?1UB, UK.