Institute of Biostatistics and Analyses, Faculty of Medicine, Masarykova Univerzita, Kamenice 5, Brno, 62500, Czech Republic. popovici@iba.muni.cz.|Institute of Biostatistics and Analyses, Faculty of Medicine, Masarykova Univerzita, Kamenice 5, Brno, 62500, Czech Republic.|Institute of Biostatistics and Analyses, Faculty of Medicine, Masarykova Univerzita, Kamenice 5, Brno, 62500, Czech Republic.|Institute of Biostatistics and Analyses, Faculty of Medicine, Masarykova Univerzita, Kamenice 5, Brno, 62500, Czech Republic.|Institute of Biostatistics and Analyses, Faculty of Medicine, Masarykova Univerzita, Kamenice 5, Brno, 62500, Czech Republic.|Institute of Biostatistics and Analyses, Faculty of Medicine, Masarykova Univerzita, Kamenice 5, Brno, 62500, Czech Republic.|Department of Clinical Research, Faculty of Medicine, University of Bern, Bern, Switzerland.