School of Computer Science and Technology, University of Science and Technology of China, Hefei, Anhui 230027, P,R, China. xuyun@ustc.edu.cn.|School of Computer Science and Technology, University of Science and Technology of China, Hefei, Anhui 230027, P,R, China. xuyun@ustc.edu.cn.|School of Computer Science and Technology, University of Science and Technology of China, Hefei, Anhui 230027, P,R, China. xuyun@ustc.edu.cn.|School of Computer Science and Technology, University of Science and Technology of China, Hefei, Anhui 230027, P,R, China. xuyun@ustc.edu.cn.|School of Computer Science and Technology, University of Science and Technology of China, Hefei, Anhui 230027, P,R, China. xuyun@ustc.edu.cn.|School of Computer Science and Technology, University of Science and Technology of China, Hefei, Anhui 230027, P,R, China. xuyun@ustc.edu.cn.|Department of Pediatrics and Rady Childrens Hospital, University of California San Diego, San Diego, USA. kafrazer@ucsd.edu.