Department of Health Sciences Research, Mayo Clinic Rochester, MN 55905, USA. eckel@mayo.edu|Department of Health Sciences Research, Mayo Clinic Rochester, MN 55905, USA. eckel@mayo.edu|Department of Health Sciences Research, Mayo Clinic Rochester, MN 55905, USA. eckel@mayo.edu|Department of Health Sciences Research, Mayo Clinic Rochester, MN 55905, USA. eckel@mayo.edu|Department of Health Sciences Research, Mayo Clinic Rochester, MN 55905, USA. eckel@mayo.edu|Department of Health Sciences Research, Mayo Clinic Rochester, MN 55905, USA. eckel@mayo.edu