Cancer Research UK, Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK and School of Biosciences, University of Nottingham, Sutton Bonington Campus, Leicestershire LE12 5RD, UK.|Cancer Research UK, Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK and School of Biosciences, University of Nottingham, Sutton Bonington Campus, Leicestershire LE12 5RD, UK.