Department of Biostatistics, University of Michigan, 1415 Washington Heights, Ann Arbor, MI, 48109, USA. yancylo@umich.edu.|Department of Biostatistics, University of Michigan, 1415 Washington Heights, Ann Arbor, MI, 48109, USA. hmkang@umich.edu.|GlaxoSmithKline, Quantitative Sciences, Research Triangle Park, NC, USA. matthew.r.nelson@gsk.com.|Department of Ophthalmology, University of Michigan, Ann Arbor, MI, USA. miothman@med.umich.edu.|GlaxoSmithKline, Quantitative Sciences, Research Triangle Park, NC, USA. stephanie.l.chissoe@gsk.com.|GlaxoSmithKline, Quantitative Sciences, Research Triangle Park, NC, USA. meg.g.ehm@gsk.com.|Department of Biostatistics, University of Michigan, 1415 Washington Heights, Ann Arbor, MI, 48109, USA. goncalo@umich.edu.|Department of Biostatistics, University of Michigan, 1415 Washington Heights, Ann Arbor, MI, 48109, USA. szoellne@umich.edu.