Center for Computational Medicine and Biology, Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA. szpiechz@umich.edu|Center for Computational Medicine and Biology, Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA. szpiechz@umich.edu|Center for Computational Medicine and Biology, Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA. szpiechz@umich.edu