Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI 53792, USA.|Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH 44106, USA.|Department of Animal Science, University of Wisconsin-Madison, Madison, WI 53706, USA.|Biomedical Informatics Research Center.|Biomedical Informatics Research Center.|Center for Human Genetics, Marshfield Clinic Research Institute, Marshfield, WI 54449, USA.|Center for Human Genetics, Marshfield Clinic Research Institute, Marshfield, WI 54449, USA.|Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI 53792, USA.|Center for Human Genetics, Marshfield Clinic Research Institute, Marshfield, WI 54449, USA.|Center for Human Genetics, Marshfield Clinic Research Institute, Marshfield, WI 54449, USA.