Department of Statistics, North Carolina State University, Raleigh, North Carolina, United States of America.|Department of Statistics, North Carolina State University, Raleigh, North Carolina, United States of America.|Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America.|Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina, United States of America.|Department of Statistics, National Cheng-Kung University, Tainan, Taiwan.|Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.|Center for Pharmacogenomics and Individualized Therapy, University of North Carolina, Chapel Hill, North Carolina, United States of America.|Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America.|Department of Statistics, North Carolina State University, Raleigh, North Carolina, United States of America.|Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina, United States of America.|Department of Statistics, North Carolina State University, Raleigh, North Carolina, United States of America.