Molecular Bioinformatics, Institute of Computer Science, Faculty of Computer Science and Mathematics and Cluster of Excellence Macromolecular Complexes, Johann Wolfgang Goethe-University Frankfurt am Main, Robert-Mayer-Str. 11-15, Frankfurt am Main, 60325, Germany.|Molecular Developmental Biology, Institute of Molecular Biosciences, Faculty for Biosciences & Cluster of Excellence Macromolecular Complexes, Johann Wolfgang Goethe-University Frankfurt am Main, Max-von-Laue-Str. 9, Frankfurt am Main, 60438, Germany.|Molecular Developmental Biology, Institute of Molecular Biosciences, Faculty for Biosciences & Cluster of Excellence Macromolecular Complexes, Johann Wolfgang Goethe-University Frankfurt am Main, Max-von-Laue-Str. 9, Frankfurt am Main, 60438, Germany.|Molecular Bioinformatics, Institute of Computer Science, Faculty of Computer Science and Mathematics and Cluster of Excellence Macromolecular Complexes, Johann Wolfgang Goethe-University Frankfurt am Main, Robert-Mayer-Str. 11-15, Frankfurt am Main, 60325, Germany. ina.koch@bioinformatik.uni-frankfurt.de.