Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 250 Longwood Avenue and Center for Cancer Systems Biology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.|Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 250 Longwood Avenue and Center for Cancer Systems Biology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.|Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 250 Longwood Avenue and Center for Cancer Systems Biology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.|Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 250 Longwood Avenue and Center for Cancer Systems Biology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.|Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 250 Longwood Avenue and Center for Cancer Systems Biology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.