Computational Biology, GlaxoSmithKline R&D, 709 Swedeland Road, UMW2230, King of Prussia, PA 19406, USA. yong.2.li@gsk.com|Computational Biology, GlaxoSmithKline R&D, 709 Swedeland Road, UMW2230, King of Prussia, PA 19406, USA. yong.2.li@gsk.com|Computational Biology, GlaxoSmithKline R&D, 709 Swedeland Road, UMW2230, King of Prussia, PA 19406, USA. yong.2.li@gsk.com