Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Katholieke Universiteit Leuven, B3000 Leuven, Belgium. pushpike@med.kuleuven.be|Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Katholieke Universiteit Leuven, B3000 Leuven, Belgium. pushpike@med.kuleuven.be|Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Katholieke Universiteit Leuven, B3000 Leuven, Belgium. pushpike@med.kuleuven.be|Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Katholieke Universiteit Leuven, B3000 Leuven, Belgium. pushpike@med.kuleuven.be|Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Katholieke Universiteit Leuven, B3000 Leuven, Belgium. pushpike@med.kuleuven.be|Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Katholieke Universiteit Leuven, B3000 Leuven, Belgium. pushpike@med.kuleuven.be|Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Katholieke Universiteit Leuven, B3000 Leuven, Belgium. pushpike@med.kuleuven.be|Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Katholieke Universiteit Leuven, B3000 Leuven, Belgium. pushpike@med.kuleuven.be