F. Hoffmann-La Roche AG, pRED, Pharma Research & Early Development, Clinical Pharmacology, Basel, Switzerland.|BioQuant, University of Heidelberg, Heidelberg, Germany.|Division of Cardiovascular Genetics, University of Utah, Salt Lake City, Utah, United States of America.|Utah Foundation for Biomedical Research, Salt Lake City, Utah, United States of America.|F. Hoffmann-La Roche AG, pRED, Pharma Research & Early Development, Clinical Pharmacology, Basel, Switzerland.