University of California, Santa Cruz, 1156 High St, 95064 Santa Cruz, USA. benedict@soe.ucsc.edu.|University of California, Santa Cruz, 1156 High St, 95064 Santa Cruz, USA. benedict@soe.ucsc.edu.|University of California, Santa Cruz, 1156 High St, 95064 Santa Cruz, USA. benedict@soe.ucsc.edu.|University of California, Santa Cruz, 1156 High St, 95064 Santa Cruz, USA. benedict@soe.ucsc.edu.|University of California, Santa Cruz, 1156 High St, 95064 Santa Cruz, USA. benedict@soe.ucsc.edu.|Institute of Molecular Medicine and Cell Research, University of Freiburg, D-79104 Freiburg, Germany. oliver.schilling@mol-med.uni-freiburg.de.