Department of Oncology, University of Cambridge, Cambridge Research Institute, CB2 0RE, Cambridge, UK. ga303@cam.ac.uk|Department of Oncology, University of Cambridge, Cambridge Research Institute, CB2 0RE, Cambridge, UK. ga303@cam.ac.uk|Department of Oncology, University of Cambridge, Cambridge Research Institute, CB2 0RE, Cambridge, UK. ga303@cam.ac.uk|Department of Oncology, University of Cambridge, Cambridge Research Institute, CB2 0RE, Cambridge, UK. ga303@cam.ac.uk