Department of Statistics, Oxford University, OX1 3TG, Oxford, UCB Pharma, SL1 3WE Slough, UK and Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China.|Department of Statistics, Oxford University, OX1 3TG, Oxford, UCB Pharma, SL1 3WE Slough, UK and Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China.|Department of Statistics, Oxford University, OX1 3TG, Oxford, UCB Pharma, SL1 3WE Slough, UK and Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China.|Department of Statistics, Oxford University, OX1 3TG, Oxford, UCB Pharma, SL1 3WE Slough, UK and Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, ChinaDepartment of Statistics, Oxford University, OX1 3TG, Oxford, UCB Pharma, SL1 3WE Slough, UK and Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China.|Department of Statistics, Oxford University, OX1 3TG, Oxford, UCB Pharma, SL1 3WE Slough, UK and Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China.