Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina, USA. amb103@duke.edu.|Department of Genetics and Genomic Sciences, Icahn Institute of Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York, NY, USA. jun.zhu@mssm.edu.|Department of Genetics and Genomic Sciences, Icahn Institute of Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York, NY, USA. jun.zhu@mssm.edu.