Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. z.r.yang@ex.ac.uk|Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. z.r.yang@ex.ac.uk|Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. z.r.yang@ex.ac.uk|Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. z.r.yang@ex.ac.uk|Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. z.r.yang@ex.ac.uk|Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. z.r.yang@ex.ac.uk