Department of Biostatistics and Computational Biology, University of Rochester, 601 Elmwood Avenue, Rochester, New York 14642, USA. xqiu@bst.rochester.edu|Department of Biostatistics and Computational Biology, University of Rochester, 601 Elmwood Avenue, Rochester, New York 14642, USA. xqiu@bst.rochester.edu|Department of Biostatistics and Computational Biology, University of Rochester, 601 Elmwood Avenue, Rochester, New York 14642, USA. xqiu@bst.rochester.edu|Department of Biostatistics and Computational Biology, University of Rochester, 601 Elmwood Avenue, Rochester, New York 14642, USA. xqiu@bst.rochester.edu