INRIA Grenoble Rhône-Alpes & Université de Lyon, F-69000 Lyon, Université Lyon 1, CNRS, UMR5558 LBBE, France, Laboratório Nacional de Computação Científica (LNCC), Petrópolis, Brazil, LISBP, UMR CNRS 5504 - INRA 792, Toulouse, France, Mathomics, Center for Mathematical Modeling (UMI-2807 CNRS) and Center for Genome Regulation (Fondap 15090007), University of Chile, Santiago, Chile Lab. Statistique et Génome, CNRS UMR8071 INRA1152, Université dÉvry, France, Scuola Normale Superiore, 56126 Pisa, Italy, Laboratoire dEtude du Métabolisme des Médicaments, DSV/iBiTecS/SPI, CEA/Saclay, 91191 Gif-sur-Yvette, France, La Sapienza University of Rome, Rome, Dipartimento di Sistemi e Informatica, Università di Firenze, I-50134 Firenze, Italy, VU University and CWI, Amsterdam, The Netherlands and INRA UMR1331 - Toxalim, Toulouse, France.