Pharma Research and Early Development, Hoffmann-La Roche Inc., Nutley, NJ 07110, USA. jorg.hakenberg@roche.com|Pharma Research and Early Development, Hoffmann-La Roche Inc., Nutley, NJ 07110, USA. jorg.hakenberg@roche.com|Pharma Research and Early Development, Hoffmann-La Roche Inc., Nutley, NJ 07110, USA. jorg.hakenberg@roche.com|Pharma Research and Early Development, Hoffmann-La Roche Inc., Nutley, NJ 07110, USA. jorg.hakenberg@roche.com|Pharma Research and Early Development, Hoffmann-La Roche Inc., Nutley, NJ 07110, USA. jorg.hakenberg@roche.com|Pharma Research and Early Development, Hoffmann-La Roche Inc., Nutley, NJ 07110, USA. jorg.hakenberg@roche.com|Pharma Research and Early Development, Hoffmann-La Roche Inc., Nutley, NJ 07110, USA. jorg.hakenberg@roche.com|Pharma Research and Early Development, Hoffmann-La Roche Inc., Nutley, NJ 07110, USA. jorg.hakenberg@roche.com|Pharma Research and Early Development, Hoffmann-La Roche Inc., Nutley, NJ 07110, USA. jorg.hakenberg@roche.com