Division of Biometry and Risk Assessment, National Center for Toxicology Research, Food and Drug Administration, Jefferson, AR 72079, USA. jchen@nctr.fda.gov|Division of Biometry and Risk Assessment, National Center for Toxicology Research, Food and Drug Administration, Jefferson, AR 72079, USA. jchen@nctr.fda.gov|Division of Biometry and Risk Assessment, National Center for Toxicology Research, Food and Drug Administration, Jefferson, AR 72079, USA. jchen@nctr.fda.gov|Division of Biometry and Risk Assessment, National Center for Toxicology Research, Food and Drug Administration, Jefferson, AR 72079, USA. jchen@nctr.fda.gov|Division of Biometry and Risk Assessment, National Center for Toxicology Research, Food and Drug Administration, Jefferson, AR 72079, USA. jchen@nctr.fda.gov|Division of Biometry and Risk Assessment, National Center for Toxicology Research, Food and Drug Administration, Jefferson, AR 72079, USA. jchen@nctr.fda.gov|Division of Biometry and Risk Assessment, National Center for Toxicology Research, Food and Drug Administration, Jefferson, AR 72079, USA. jchen@nctr.fda.gov|Division of Biometry and Risk Assessment, National Center for Toxicology Research, Food and Drug Administration, Jefferson, AR 72079, USA. jchen@nctr.fda.gov