Institute for Advanced Biosciences, Keio University, Fujisawa 252-8520, Japan. gaou@sfc.keio.ac.jp|Institute for Advanced Biosciences, Keio University, Fujisawa 252-8520, Japan. gaou@sfc.keio.ac.jp|Institute for Advanced Biosciences, Keio University, Fujisawa 252-8520, Japan. gaou@sfc.keio.ac.jp|Institute for Advanced Biosciences, Keio University, Fujisawa 252-8520, Japan. gaou@sfc.keio.ac.jp|Institute for Advanced Biosciences, Keio University, Fujisawa 252-8520, Japan. gaou@sfc.keio.ac.jp