Whitehead Institute for Biomedical Research Cambridge, MA 02142, USA. jcbarret@broad.mit.edu|Whitehead Institute for Biomedical Research Cambridge, MA 02142, USA. jcbarret@broad.mit.edu|Whitehead Institute for Biomedical Research Cambridge, MA 02142, USA. jcbarret@broad.mit.edu|Whitehead Institute for Biomedical Research Cambridge, MA 02142, USA. jcbarret@broad.mit.edu