Department of Theoretical Biophysics, Humboldt-University of Berlin, 10115 Berlin, Germany and Therapeutic Research Group Oncology, Bayer Pharma AG, 13353 Berlin, Germany.|Department of Theoretical Biophysics, Humboldt-University of Berlin, 10115 Berlin, Germany and Therapeutic Research Group Oncology, Bayer Pharma AG, 13353 Berlin, Germany.