Department of Environmental Sciences & Engineering, Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA.|Department of Environmental Sciences & Engineering, Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA.|Department of Environmental Sciences & Engineering, Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA.|Department of Environmental Sciences & Engineering, Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA.|Department of Environmental Sciences & Engineering, Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA.