Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada.|Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada.|Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada, Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada and Canadian Institute for Advanced Research, Toronto, ON, Canada.