Wolfson Centre for Age-Related Diseases, The Wolfson Wing, Hodgkin Building, Kings College London, London SE1 1UL, UK. gareth.2.williams@kcl.ac.uk|Wolfson Centre for Age-Related Diseases, The Wolfson Wing, Hodgkin Building, Kings College London, London SE1 1UL, UK. gareth.2.williams@kcl.ac.uk