Department of Biochemistry & Molecular Biophysics, Columbia University, New York, NY 10032, USA.|Department of Biochemistry & Molecular Biophysics, Columbia University, New York, NY 10032, USA.|Department of Biochemistry & Molecular Biophysics, Columbia University, New York, NY 10032, USA.|Department of Biochemistry & Molecular Biophysics, Columbia University, New York, NY 10032, USA.|Department of Biochemistry & Molecular Biophysics, Columbia University, New York, NY 10032, USA.|Department of Biochemistry & Molecular Biophysics, Columbia University, New York, NY 10032, USA.