Medical Research Council, Institute of Public Health, Robinson Way, Cambridge CB2 2SR, UK. brian.tom@mrc-bsu.cam.ac.uk|Medical Research Council, Institute of Public Health, Robinson Way, Cambridge CB2 2SR, UK. brian.tom@mrc-bsu.cam.ac.uk|Medical Research Council, Institute of Public Health, Robinson Way, Cambridge CB2 2SR, UK. brian.tom@mrc-bsu.cam.ac.uk|Medical Research Council, Institute of Public Health, Robinson Way, Cambridge CB2 2SR, UK. brian.tom@mrc-bsu.cam.ac.uk