MINES ParisTech, PSL-Research University, CBIO-Centre for Computational Biology, Fontainebleau, Institut Curie, Paris, INSERM U900, Paris, Universitxc3xa9 Paris Descartes, Paris, INSERM UMR-S 1124, Paris, Agro ParisTech, Paris and Mathxc3xa9matiques et Informatique Appliquxc3xa9es, INRA, Jouy-en-Josas, France.