Department of Computational Medicine and Bioinformatics and Department of Biological Chemistry, University of Michigan, 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218, USA.|Department of Computational Medicine and Bioinformatics and Department of Biological Chemistry, University of Michigan, 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218, USA.|Department of Computational Medicine and Bioinformatics and Department of Biological Chemistry, University of Michigan, 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218, USA.