Department of Biology and Biochemistry, University of Houston, 4800 Calhoun Avenue, Houston, TX 77204-5001, USA. zhengdong.zhang@yale.edu|Department of Biology and Biochemistry, University of Houston, 4800 Calhoun Avenue, Houston, TX 77204-5001, USA. zhengdong.zhang@yale.edu|Department of Biology and Biochemistry, University of Houston, 4800 Calhoun Avenue, Houston, TX 77204-5001, USA. zhengdong.zhang@yale.edu|Department of Biology and Biochemistry, University of Houston, 4800 Calhoun Avenue, Houston, TX 77204-5001, USA. zhengdong.zhang@yale.edu