Center for Research in Biological Systems, University of California San Diego, La Jolla, CA 92093, USA.|Center for Research in Biological Systems, University of California San Diego, La Jolla, CA 92093, USA.|Center for Research in Biological Systems, University of California San Diego, La Jolla, CA 92093, USA.|Center for Research in Biological Systems, University of California San Diego, La Jolla, CA 92093, USA.|Center for Research in Biological Systems, University of California San Diego, La Jolla, CA 92093, USA.