Institute for Advanced Biosciences, Keio University, Fujisawa, Kanagawa, 252-8520, Japan. yoshiya@sfc.keio.ac.jp|Institute for Advanced Biosciences, Keio University, Fujisawa, Kanagawa, 252-8520, Japan. yoshiya@sfc.keio.ac.jp|Institute for Advanced Biosciences, Keio University, Fujisawa, Kanagawa, 252-8520, Japan. yoshiya@sfc.keio.ac.jp|Institute for Advanced Biosciences, Keio University, Fujisawa, Kanagawa, 252-8520, Japan. yoshiya@sfc.keio.ac.jp