Statistical Sciences, AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK. Chris.Harbron@AstraZeneca.Com|Statistical Sciences, AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK. Chris.Harbron@AstraZeneca.Com|Statistical Sciences, AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK. Chris.Harbron@AstraZeneca.Com