Department of Computer Bioscience, Nagahama Institute of Bio-Science and Technology, 1266, Tamura-cho, Nagahama, Shiga 526-0829, Japan. m_shionyu@nagahama-i-bio.ac.jp|Department of Computer Bioscience, Nagahama Institute of Bio-Science and Technology, 1266, Tamura-cho, Nagahama, Shiga 526-0829, Japan. m_shionyu@nagahama-i-bio.ac.jp|Department of Computer Bioscience, Nagahama Institute of Bio-Science and Technology, 1266, Tamura-cho, Nagahama, Shiga 526-0829, Japan. m_shionyu@nagahama-i-bio.ac.jp