Conway Institute of Biomolecular and Biomedical Research, and UCD School of Medicine and Medical Science, University College Dublin, Dublin 4, Ireland.|Conway Institute of Biomolecular and Biomedical Research, and UCD School of Medicine and Medical Science, University College Dublin, Dublin 4, Ireland.|Conway Institute of Biomolecular and Biomedical Research, and UCD School of Medicine and Medical Science, University College Dublin, Dublin 4, Ireland.