Department of Pharmacology and San Diego Supercomputer Center, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0537, USA. bourne@sdsc.edu|Department of Pharmacology and San Diego Supercomputer Center, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0537, USA. bourne@sdsc.edu|Department of Pharmacology and San Diego Supercomputer Center, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0537, USA. bourne@sdsc.edu