Division of Biostatistics and Bioinformatics, National Health Research Institutes, No, 35 Keyan Rd, Zhunan, Miaoli County 350, Taiwan. cylin@iis.sinica.edu.tw|Division of Biostatistics and Bioinformatics, National Health Research Institutes, No, 35 Keyan Rd, Zhunan, Miaoli County 350, Taiwan. cylin@iis.sinica.edu.tw|Division of Biostatistics and Bioinformatics, National Health Research Institutes, No, 35 Keyan Rd, Zhunan, Miaoli County 350, Taiwan. cylin@iis.sinica.edu.tw|Division of Biostatistics and Bioinformatics, National Health Research Institutes, No, 35 Keyan Rd, Zhunan, Miaoli County 350, Taiwan. cylin@iis.sinica.edu.tw|Division of Biostatistics and Bioinformatics, National Health Research Institutes, No, 35 Keyan Rd, Zhunan, Miaoli County 350, Taiwan. cylin@iis.sinica.edu.tw|Division of Biostatistics and Bioinformatics, National Health Research Institutes, No, 35 Keyan Rd, Zhunan, Miaoli County 350, Taiwan. cylin@iis.sinica.edu.tw|Division of Biostatistics and Bioinformatics, National Health Research Institutes, No, 35 Keyan Rd, Zhunan, Miaoli County 350, Taiwan. cylin@iis.sinica.edu.tw|Division of Biostatistics and Bioinformatics, National Health Research Institutes, No, 35 Keyan Rd, Zhunan, Miaoli County 350, Taiwan. cylin@iis.sinica.edu.tw|Division of Biostatistics and Bioinformatics, National Health Research Institutes, No, 35 Keyan Rd, Zhunan, Miaoli County 350, Taiwan. cylin@iis.sinica.edu.tw