CIAIC, School of Marine Science and Technology, Northwestern Polytechnical University, China Department of Electrical Engineering and Computer Science Department of Computational Medicine & Bioinformatics, Medical School.|Department of Electrical Engineering and Computer Science Department of Biomedical Engineering Department of Statistics.|Department of Computational Medicine & Bioinformatics, Medical School Department of Mathematics, College of Literature, Science and the Arts, University of Michigan, Ann Arbor, MI, USA.