Oxford Centre for Integrative Systems Biology, Department of Biochemistry, University of Oxford, Oxford, United Kingdom , de Duve Institute, Universitxc3xa9 Catholique de Louvain (UCL), Brussels, Belgium.|Facultxc3xa9 des Sciences, Universitxc3xa9 Libre de Bruxelles (ULB), Campus Plaine, Brussels, Belgium.|de Duve Institute, Universitxc3xa9 Catholique de Louvain (UCL), Brussels, Belgium.|Oxford Centre for Integrative Systems Biology, Department of Biochemistry, University of Oxford, Oxford, United Kingdom.