Department of Bioinformatics and Computational Biology, UT MD Anderson Cancer Center, Houston, Texas 77030, USA. bmbroom@mdanderson.org|Department of Bioinformatics and Computational Biology, UT MD Anderson Cancer Center, Houston, Texas 77030, USA. bmbroom@mdanderson.org|Department of Bioinformatics and Computational Biology, UT MD Anderson Cancer Center, Houston, Texas 77030, USA. bmbroom@mdanderson.org