School of Medicine & Health Sciences, University of North Dakota, Grand Forks, ND 58202, USA. ke.zhang@med.und.edu|School of Medicine & Health Sciences, University of North Dakota, Grand Forks, ND 58202, USA. ke.zhang@med.und.edu|School of Medicine & Health Sciences, University of North Dakota, Grand Forks, ND 58202, USA. ke.zhang@med.und.edu|School of Medicine & Health Sciences, University of North Dakota, Grand Forks, ND 58202, USA. ke.zhang@med.und.edu|School of Medicine & Health Sciences, University of North Dakota, Grand Forks, ND 58202, USA. ke.zhang@med.und.edu|School of Medicine & Health Sciences, University of North Dakota, Grand Forks, ND 58202, USA. ke.zhang@med.und.edu