Center for Bioinformatics, Saarland University, Saarland Informatics Campus E2.1, 66123 Saarbrxc3xbccken, Germany.|Department of Computer Science, University of Helsinki, Helsinki, Finland.|Center for Bioinformatics, Saarland University, Saarland Informatics Campus E2.1, 66123 Saarbrxc3xbccken, Germany.