Program in Computational Biology and Bioinformatics, Duke University, Durham, NC 27708, USA, Institute for Genome Sciences and Policy, Duke University, Durham, NC 27705, USA, Department of Computer Science, Duke University, Durham, NC 27708, USA, Department of Biostatistics and Bioinformatics, Duke University, Durham, NC 27710, USA, Berlin Institute for Medical Systems Biology, Max Delbruck Center for Molecular Medicine, Berlin 13125, Germany and Department of Biology, Humboldt University of Berlin, Berlin 10115, GermanyProgram in Computational Biology and Bioinformatics, Duke University, Durham, NC 27708, USA, Institute for Genome Sciences and Policy, Duke University, Durham, NC 27705, USA, Department of Computer Science, Duke University, Durham, NC 27708, USA, Department of Biostatistics and Bioinformatics, Duke University, Durham, NC 27710, USA, Berlin Institute for Medical Systems Biology, Max Delbruck Center for Molecular Medicine, Berlin 13125, Germany and Department of Biology, Humboldt University of Berlin, Berlin 10115, GermanyProgram in Computational Biology and Bioinformatics, Duke University, Durham, NC 27708, USA, Institute for Genome Sciences and Policy, Duke University, Durham, NC 27705, USA, Department of Computer Science, Duke University, Durham, NC 27708, USA, Department of Biostatistics and Bioinformatics, Duke University, Durham, NC 27710, USA, Berlin Institute for Medical Systems Biology, Max Delbruck Center for Molecular Medicine, Berlin 13125, Germany and Department of Biology, Humboldt University of Berlin, Berlin 10115, GermanyProgram in Computational Biology and Bioinformatics, Duke University, Durham, NC 27708, USA, Institute for Genome Sciences and Policy, Duke University, Durham, NC 27705, USA, Department of Computer Science, Duke University, Durham, NC 27708, USA, Department of Biostatistics and Bioinformatics, Duke University, Durham, NC 27710, USA, Berlin Institute for Medical Systems Biology, Max Delbruck Center for Molecular Medicin