Department of Pharmacology and Systems Therapeutics, Systems Biology Center New York (SBCNY), Icahn School of Medicine at Mount Sinai School, New York, NY 10029, USA. avi.maayan@mssm.edu.|Department of Pharmacology and Systems Therapeutics, Systems Biology Center New York (SBCNY), Icahn School of Medicine at Mount Sinai School, New York, NY 10029, USA. avi.maayan@mssm.edu.|School of Engineering and Science, Jacobs University Bremen, Campus Ring 1, D-28759 Bremen, Germany. w.henkel@jacobs-university.de.