Department of Statistics, Pennsylvania State University, University Park, Pennsylvania, United States of America.|HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, United States of America.|HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, United States of America.|HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, United States of America.|Department of Statistics, Pennsylvania State University, University Park, Pennsylvania, United States of America.