LBSI, Fundación Instituto Leloir (IIBBA-CONICET), Buenos Aires, C1405BWE, Argentina.|RWTH Aachen University, Faculty of Medicine, Joint Research Centre for Computational Biomedicine, Aachen D-52074, Germany.|IRCCyN UMR CNRS 6597, École Centrale de Nantes, Nantes 44321, France.|CNRS, UMR 6074-IRISA, 35042 Rennes, France.