Department of Biochemical Sciences A. Rossi Fanelli, Sapienza Università di Roma, Rome, Italy.|Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.|Department of Biochemical Sciences A. Rossi Fanelli, Sapienza Università di Roma, Rome, Italy.|Department of Biology and Biotechnology Charles Darwin, Sapienza Università di Roma, Rome, Italy.