Department of Biostatistics, Department of Medicine, Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA. liny@upmc.edu|Department of Biostatistics, Department of Medicine, Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA. liny@upmc.edu|Department of Biostatistics, Department of Medicine, Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA. liny@upmc.edu|Department of Biostatistics, Department of Medicine, Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA. liny@upmc.edu|Department of Biostatistics, Department of Medicine, Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA. liny@upmc.edu|Department of Biostatistics, Department of Medicine, Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA. liny@upmc.edu