Center for Evolutionary Medicine and Informatics, Biodesign Institute, Arizona State University (ASU), Tempe, AZ 85287, USA, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA, School of Computing, Informatics, and Decision Systems Engineering, ASU, Tempe, AZ 85287, USA, School of Life Sciences, ASU, Tempe, AZ 85287, USA and Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia.