The Burnham Institute, 10901 N. Torrey Pines Road, La Jolla, CA 92037, USA. liwz@burnham-inst.org|The Burnham Institute, 10901 N. Torrey Pines Road, La Jolla, CA 92037, USA. liwz@burnham-inst.org|The Burnham Institute, 10901 N. Torrey Pines Road, La Jolla, CA 92037, USA. liwz@burnham-inst.org