Department of Medicine and Department of Computer Science and Engineering, University of California San Diego, La Jolla, CA 92093, USA.|Department of Medicine and Department of Computer Science and Engineering, University of California San Diego, La Jolla, CA 92093, USA.|Department of Medicine and Department of Computer Science and Engineering, University of California San Diego, La Jolla, CA 92093, USA.|Department of Medicine and Department of Computer Science and Engineering, University of California San Diego, La Jolla, CA 92093, USA.|Department of Medicine and Department of Computer Science and Engineering, University of California San Diego, La Jolla, CA 92093, USA.