Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, Massasschusetts, United States of America.|Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, Massasschusetts, United States of America.|Department of Biology, Kyushu University, Fukuoka, Japan.|Division of Cancer Therapeutics, The Institute of Cancer Research, London, United Kingdom.|Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, Massasschusetts, United States of America.