Department of Human Genetics and Department of Biomathematics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. klange@ucla.edu|Department of Human Genetics and Department of Biomathematics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. klange@ucla.edu|Department of Human Genetics and Department of Biomathematics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. klange@ucla.edu|Department of Human Genetics and Department of Biomathematics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. klange@ucla.edu|Department of Human Genetics and Department of Biomathematics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. klange@ucla.edu|Department of Human Genetics and Department of Biomathematics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. klange@ucla.edu