Applied Mathematics and Scientific Computation Program, Center for Bioinformatics and Computational Biology, University of Maryland, College Park, Maryland, United States of America.|Applied Mathematics and Scientific Computation Program, Center for Bioinformatics and Computational Biology, University of Maryland, College Park, Maryland, United States of America.|Applied Mathematics and Scientific Computation Program, Center for Bioinformatics and Computational Biology, University of Maryland, College Park, Maryland, United States of America.