Both xcexb2-value and M-value have been used as metrics to measure methylation levels. The M-value is more statistically valid for the differential analysis of methylation levels. However, the xcexb2-value is much more biologically interpretable and needs to be reported when M-value method is used for conducting differential methylation analysis. There is an urgent need to know how to interpret the degree of differential methylation from the M-value. In M-value linear regression model, differential methylation M-value xcex94M can be easily obtained from the coefficient estimate, but it is not straightforward to get the differential methylation xcexb2-value, xcex94xcexb2 since it cannot be obtained from the coefficient alone.