National Center for Toxicological Research, U.S. Food and Drug Administration, USA. jamesj.chen@fda.hhs.gov|National Center for Toxicological Research, U.S. Food and Drug Administration, USA. jamesj.chen@fda.hhs.gov|National Center for Toxicological Research, U.S. Food and Drug Administration, USA. jamesj.chen@fda.hhs.gov