Paterson Institute for Cancer Research, Cancer Research UK, Manchester, M20 4BX, UK. cmoller@picr.man.ac.uk|Paterson Institute for Cancer Research, Cancer Research UK, Manchester, M20 4BX, UK. cmoller@picr.man.ac.uk|Paterson Institute for Cancer Research, Cancer Research UK, Manchester, M20 4BX, UK. cmoller@picr.man.ac.uk