Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.|Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E1, Canada.|Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.|McGill University and Génome Québec Innovation Centre, Montreal, QC H3A 0G1, Canada.