Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA Center for Computational Biology, Johns Hopkins University, Baltimore, MD, USA.|Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA Center for Computational Biology, Johns Hopkins University, Baltimore, MD, USA.|Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA Center for Computational Biology, Johns Hopkins University, Baltimore, MD, USA.|Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA Center for Computational Biology, Johns Hopkins University, Baltimore, MD, USA.|Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA Center for Computational Biology, Johns Hopkins University, Baltimore, MD, USA.