School of Bioscience and Bioengineering, South China University of Technology 510006, Guangzhou, China, BGI-Shenzhen, Shenzhen 518083, China, HKU-BGI Bioinformatics Algorithms and Core Technology Research Laboratory and Department of Computer Science, University of Hong Kong, Pokfulam, Hong Kong, Institute of Biomedical Engineering, XiangYa School of Medicine, Central South University, Changsha 410008, China, BGI-tech, BGI-Shenzhen, Shenzhen 518083, China, Department of Medicine, University of Alberta, Edmonton, AB T6G 2E1, Canada, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China, Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada, The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen DK-2200, Denmark, Department of Biology, University of Copenhagen, Copenhagen DK-2200, Denmark and Princess Al Jawhara Center of Excellence in the Research of Hereditary Disorders, King Abdulaziz University, Jeddah 21589, Saudi Arabia.