Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, 11790, NY, USA. yaoshun88@gmail.com.|Computational Science Center, Brookhaven National Laboratory, Upton, 11793, NY, USA. sjyoo@bnl.gov.|Computational Science Center, Brookhaven National Laboratory, Upton, 11793, NY, USA. dtyu@bnl.gov.