National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20804, USA. rogozin@ncbi.nlm.nih.gov|National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20804, USA. rogozin@ncbi.nlm.nih.gov|National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20804, USA. rogozin@ncbi.nlm.nih.gov|National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20804, USA. rogozin@ncbi.nlm.nih.gov|National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20804, USA. rogozin@ncbi.nlm.nih.gov