Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK. wolfgang.rieping@bioc.cam.ac.uk|Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK. wolfgang.rieping@bioc.cam.ac.uk|Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK. wolfgang.rieping@bioc.cam.ac.uk