BARDS, Merck Research Laboratories, RY34-A3086h, 126 E. Lincoln Avenue, Rahway, 07065, NJ, USA. ag454@njit.edu.|Department of Mathematical Sciences, New Jersey Institute of Technology, Newark, 07102, NJ, USA. wenge.guo@njit.edu.|Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, T.W.Alexander Drive, Research Triangle Park, 27709, NC, USA. peddada@niehs.nih.gov.