Department of Applied Mathematics and Statistics, Stony Brook University, 100 Nicolls Road, Stony Brook, 11794, USA. peifen.kuan@stonybrook.edu.|Department of Pathology, Stony Brook University, 100 Nicolls Road, Stony Brook, 11794, USA.|Department of Applied Mathematics and Statistics, Stony Brook University, 100 Nicolls Road, Stony Brook, 11794, USA.|Department of Applied Mathematics and Statistics, Stony Brook University, 100 Nicolls Road, Stony Brook, 11794, USA.|Department of Pathology, Stony Brook University, 100 Nicolls Road, Stony Brook, 11794, USA.|Oncology Business Unit, Pfizer Inc., 558 Eastern Point Rd, Groton, 06340, USA.