Department of Pharmacology, University of California Davis, Davis, California, United States of America.|Department of Biomedical Engineering, University of California San Diego, La Jolla, California, United States of America.|Department of Pharmacology, University of California Davis, Davis, California, United States of America.|Department of Pharmacology, University of California Davis, Davis, California, United States of America.|Department of Mathematics, University of California Davis, Davis, California, United States of America.|Department of Biomedical Engineering, University of California San Diego, La Jolla, California, United States of America.|Department of Pharmacology, Center for Molecular Medicine, School of Medicine, University of Nevada Reno, Reno, Nevada, United States of America.|Department of Pharmacology, University of California Davis, Davis, California, United States of America.