Department of Physiology and Membrane Biology, Department of Pharmacology, School of Medicine, University of California Davis, Davis, California, United States of America.|San Diego Supercomputer Center (SDSC), University of California, San Diego, La Jolla, California, United States of America.|Department of Chemistry and Biochemistry, National Biomedical Computation Resource, Drug Design Data Resource (D3R), University of California San Diego, La Jolla, California, United States of America.|Department of Physiology and Membrane Biology, Department of Pharmacology, School of Medicine, University of California Davis, Davis, California, United States of America.|Department of Physiology and Membrane Biology, Department of Pharmacology, School of Medicine, University of California Davis, Davis, California, United States of America.|Department of Physiology and Membrane Biology, Department of Pharmacology, School of Medicine, University of California Davis, Davis, California, United States of America.|Departments of Bioengineering and Medicine, University of California, San Diego, La Jolla, California, United States of America.|San Diego Supercomputer Center (SDSC), University of California, San Diego, La Jolla, California, United States of America.|Department of Chemistry and Biochemistry, National Biomedical Computation Resource, Drug Design Data Resource (D3R), University of California San Diego, La Jolla, California, United States of America.|Department of Physiology and Membrane Biology, Department of Pharmacology, School of Medicine, University of California Davis, Davis, California, United States of America.