Johns Hopkins University School of Medicine, Oncology Biostatistics, Baltimore, MD 21205, USA. zahurma@jhmi.edu|Johns Hopkins University School of Medicine, Oncology Biostatistics, Baltimore, MD 21205, USA. zahurma@jhmi.edu|Johns Hopkins University School of Medicine, Oncology Biostatistics, Baltimore, MD 21205, USA. zahurma@jhmi.edu|Johns Hopkins University School of Medicine, Oncology Biostatistics, Baltimore, MD 21205, USA. zahurma@jhmi.edu|Johns Hopkins University School of Medicine, Oncology Biostatistics, Baltimore, MD 21205, USA. zahurma@jhmi.edu|Johns Hopkins University School of Medicine, Oncology Biostatistics, Baltimore, MD 21205, USA. zahurma@jhmi.edu|Johns Hopkins University School of Medicine, Oncology Biostatistics, Baltimore, MD 21205, USA. zahurma@jhmi.edu|Johns Hopkins University School of Medicine, Oncology Biostatistics, Baltimore, MD 21205, USA. zahurma@jhmi.edu