Department of Biostatistics, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, 66160, KS, USA. dkoestler@kumc.edu.|Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics, The University of British Columbia, 950 West 28th Ave., Vancouver, V5Z 4H4, BC, Canada. mjones@cmmt.ubc.ca.|Department of Biostatistics, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, 66160, KS, USA. jusset@kumc.edu.|Department of Epidemiology, Geisel School of Medicine, Dartmouth College, 1 Medical Center Dr., Lebanon, 03756, NH, USA. brock.c.christensen@dartmouth.edu.|Department of Pathology and Laboratory Medicine, Brown University, 70 Ship St., Providence, 02912, RI, USA. rondi_butler@brown.edu.|Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics, The University of British Columbia, 950 West 28th Ave., Vancouver, V5Z 4H4, BC, Canada. msk@cmmt.ubc.ca.|Department of Neurological Surgery, University of California San Francisco, 505 Parnassus Ave., San Francisco, 94143, CA, USA. john.wiencke@ucsf.edu.|Department of Pathology and Laboratory Medicine, Brown University, 70 Ship St., Providence, 02912, RI, USA. karl_kelsey@brown.edu.