Division of Medicine, University College London, London NW3xe2x80x892PF, UK.|Institute of Biotechnology, University of Helsinki, Helsinki 00014, Finland.|Division of Medicine, University College London, London NW3xe2x80x892PF, UK.|Division of Medicine, University College London, London NW3xe2x80x892PF, UK.|Division of Medicine, University College London, London NW3xe2x80x892PF, UK.