Freiburg Institute for Advanced Studies, University of Freiburg, Freiburg, Germany. temerina@frias.uni-freiburg.de.|Computational Biology Department, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, 15213, PA, USA. rumi@cmu.edu.|Freiburg Institute for Advanced Studies, University of Freiburg, Freiburg, Germany. murphy@cmu.edu.