MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 2SR, UK. irina.abnizova@mrc-bsu.cam.ac.uk|MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 2SR, UK. irina.abnizova@mrc-bsu.cam.ac.uk|MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 2SR, UK. irina.abnizova@mrc-bsu.cam.ac.uk|MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 2SR, UK. irina.abnizova@mrc-bsu.cam.ac.uk