Max Planck Institute for Molecular Genetics, Berlin, Germany. maschulz@andrew.cmu.edu|Max Planck Institute for Molecular Genetics, Berlin, Germany. maschulz@andrew.cmu.edu|Max Planck Institute for Molecular Genetics, Berlin, Germany. maschulz@andrew.cmu.edu|Max Planck Institute for Molecular Genetics, Berlin, Germany. maschulz@andrew.cmu.edu