Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America.|Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America.|Department of Health Sciences Research, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota, United States of America.|Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America.