University of Arizona Center for Biomedical Informatics and Biostatistics (CB2), Tucson, AZ, USA, Graduate Interdisciplinary Program in Statistics, Department of Medicine and BIO5 Institute, University of Arizona, Tucson, AZ, USA University of Arizona Center for Biomedical Informatics and Biostatistics (CB2), Tucson, AZ, USA, Graduate Interdisciplinary Program in Statistics, Department of Medicine and BIO5 Institute, University of Arizona, Tucson, AZ, USA University of Arizona Center for Biomedical Informatics and Biostatistics (CB2), Tucson, AZ, USA, Graduate Interdisciplinary Program in Statistics, Department of Medicine and BIO5 Institute, University of Arizona, Tucson, AZ, USA.