Center for Molecular Medicine and Genetics, Wayne State University, Detroit, Michigan, USA. binyao@genetics.wayne.edu|Center for Molecular Medicine and Genetics, Wayne State University, Detroit, Michigan, USA. binyao@genetics.wayne.edu|Center for Molecular Medicine and Genetics, Wayne State University, Detroit, Michigan, USA. binyao@genetics.wayne.edu|Center for Molecular Medicine and Genetics, Wayne State University, Detroit, Michigan, USA. binyao@genetics.wayne.edu|Center for Molecular Medicine and Genetics, Wayne State University, Detroit, Michigan, USA. binyao@genetics.wayne.edu|Center for Molecular Medicine and Genetics, Wayne State University, Detroit, Michigan, USA. binyao@genetics.wayne.edu|Center for Molecular Medicine and Genetics, Wayne State University, Detroit, Michigan, USA. binyao@genetics.wayne.edu