Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland IBM T.J. Watson Research Center, Computational Biology, Yorktown Heights, NY 10598, USA, Department of Computer Science and Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland IBM T.J. Watson Research Center, Computational Biology, Yorktown Heights, NY 10598, USA, Department of Computer Science and Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.