Department of Quantitative Health Sciences, The Cleveland Clinic, 9500 Euclid Ave. Cleveland, OH 44195, USA. chenx3@ccf.org|Department of Quantitative Health Sciences, The Cleveland Clinic, 9500 Euclid Ave. Cleveland, OH 44195, USA. chenx3@ccf.org|Department of Quantitative Health Sciences, The Cleveland Clinic, 9500 Euclid Ave. Cleveland, OH 44195, USA. chenx3@ccf.org|Department of Quantitative Health Sciences, The Cleveland Clinic, 9500 Euclid Ave. Cleveland, OH 44195, USA. chenx3@ccf.org