Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First St SW, Harvick 3rd, Rochester, MN, 55905, USA. Ravikumar@mayo.edu.|Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First St SW, Harvick 3rd, Rochester, MN, 55905, USA.|Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First St SW, Harvick 3rd, Rochester, MN, 55905, USA.|Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First St SW, Harvick 3rd, Rochester, MN, 55905, USA.|Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First St SW, Harvick 3rd, Rochester, MN, 55905, USA. Hongfang@mayo.edu.