Department of Biostatistics and Applied Mathematics, The University of Texas MD Anderson Cancer Center, Houston, USA. jefmorris@mdanderson.org|Department of Biostatistics and Applied Mathematics, The University of Texas MD Anderson Cancer Center, Houston, USA. jefmorris@mdanderson.org|Department of Biostatistics and Applied Mathematics, The University of Texas MD Anderson Cancer Center, Houston, USA. jefmorris@mdanderson.org|Department of Biostatistics and Applied Mathematics, The University of Texas MD Anderson Cancer Center, Houston, USA. jefmorris@mdanderson.org|Department of Biostatistics and Applied Mathematics, The University of Texas MD Anderson Cancer Center, Houston, USA. jefmorris@mdanderson.org