Department of Medical Informatics, Biometry and Epidemiology, University of Munich, Marchioninistr. 15, D-81377, Munich, Germany. janitza@ibe.med.uni-muenchen.de|Department of Medical Informatics, Biometry and Epidemiology, University of Munich, Marchioninistr. 15, D-81377, Munich, Germany. janitza@ibe.med.uni-muenchen.de|Department of Medical Informatics, Biometry and Epidemiology, University of Munich, Marchioninistr. 15, D-81377, Munich, Germany. janitza@ibe.med.uni-muenchen.de