Department of Statistics, College of Pharmacy, Seoul National University Seoul, Korea. tspark@stats.snu.ac.kr|Department of Statistics, College of Pharmacy, Seoul National University Seoul, Korea. tspark@stats.snu.ac.kr|Department of Statistics, College of Pharmacy, Seoul National University Seoul, Korea. tspark@stats.snu.ac.kr|Department of Statistics, College of Pharmacy, Seoul National University Seoul, Korea. tspark@stats.snu.ac.kr