Department of Biostatistics, St Jude Childrens Research Hospital, Memphis TN 38105, USA. stanley.pounds@stjude.org.|Department of Biostatistics, St Jude Childrens Research Hospital, Memphis TN 38105, USA. stanley.pounds@stjude.org.|Department of Biostatistics, St Jude Childrens Research Hospital, Memphis TN 38105, USA. stanley.pounds@stjude.org.|Molecular Medicine Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia. rafa@jimmy.harvard.edu.|Molecular Medicine Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia. rafa@jimmy.harvard.edu.