Department of Biostatistics & Bioinformatics, Duke University, Durham, North Carolina 27708, USA. lu000014@mc.duke.edu|Department of Biostatistics & Bioinformatics, Duke University, Durham, North Carolina 27708, USA. lu000014@mc.duke.edu|Department of Biostatistics & Bioinformatics, Duke University, Durham, North Carolina 27708, USA. lu000014@mc.duke.edu