Department of Biostatistics and Applied Mathematics, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.|Department of Biostatistics and Applied Mathematics, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.|Department of Biostatistics and Applied Mathematics, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.|Department of Biostatistics and Applied Mathematics, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.|Department of Biostatistics and Applied Mathematics, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.