Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA. jiacheng@mail.med.upenn.edu.|Division of Biostatistics, School of Public Health, University of Minnesota School of Public Health, Minneapolis, MN, 55455, USA. wguan@umn.edu.|Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA. sheepsheep.yang@gmail.com.|Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA. rxiao@mail.med.upenn.edu.|Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, 44195, USA. TANGW@ccf.org.|Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, 44195, USA. MORAVEC@ccf.org.|Cardiovascular Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA. Kenneth.Margulies@uphs.upenn.edu.|Cardiovascular Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA. thomas.cappola@uphs.upenn.edu.|Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA. mingyao@mail.med.upenn.edu.|Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, 44106, USA. cxl791@case.edu.