Department of Computational Medicine and Bioinformatics, Department of Biostatistics and Center of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA Department of Computational Medicine and Bioinformatics, Department of Biostatistics and Center of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA Department of Computational Medicine and Bioinformatics, Department of Biostatistics and Center of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.