Department of Biochemistry, University of Toronto, Medical Sciences Building, 1 Kings College Circle, Toronto, ON M5S 1A8, Canada.|Department of Biochemistry, University of Toronto, Medical Sciences Building, 1 Kings College Circle, Toronto, ON M5S 1A8, Canada.|Department of Biochemistry, University of Toronto, Medical Sciences Building, 1 Kings College Circle, Toronto, ON M5S 1A8, Canada.|Department of Biochemistry, University of Toronto, Medical Sciences Building, 1 Kings College Circle, Toronto, ON M5S 1A8, Canada.