The need for efficient molecular docking tools for high-throughput screening is growing alongside the rapid growth of drug-fragment databases. AutoDock Vina (Vina) is a widely used docking tool with parallelization for speed. QuickVina (QVina 1) then further enhanced the speed via a heuristics, requiring high exhaustiveness. With low exhaustiveness, its accuracy was compromised. We present in this article the latest version of QuickVina (QVina 2) that inherits both the speed of QVina 1 and the reliability of the original Vina.