Department of Epidemiology and Biostatistics, Center for Bioinformatics and Molecular Biostatistics, University of California, San Francisco, CA 94107, USA. yxiao@itsa.ucsf.edu|Department of Epidemiology and Biostatistics, Center for Bioinformatics and Molecular Biostatistics, University of California, San Francisco, CA 94107, USA. yxiao@itsa.ucsf.edu|Department of Epidemiology and Biostatistics, Center for Bioinformatics and Molecular Biostatistics, University of California, San Francisco, CA 94107, USA. yxiao@itsa.ucsf.edu|Department of Epidemiology and Biostatistics, Center for Bioinformatics and Molecular Biostatistics, University of California, San Francisco, CA 94107, USA. yxiao@itsa.ucsf.edu