Department of Preclinical and Clinical Pharmacology, Department of Statistics, University of Florence, Florence, Italy. duccio.cavalieri@unifi.it|Department of Preclinical and Clinical Pharmacology, Department of Statistics, University of Florence, Florence, Italy. duccio.cavalieri@unifi.it|Department of Preclinical and Clinical Pharmacology, Department of Statistics, University of Florence, Florence, Italy. duccio.cavalieri@unifi.it|Department of Preclinical and Clinical Pharmacology, Department of Statistics, University of Florence, Florence, Italy. duccio.cavalieri@unifi.it|Department of Preclinical and Clinical Pharmacology, Department of Statistics, University of Florence, Florence, Italy. duccio.cavalieri@unifi.it|Department of Preclinical and Clinical Pharmacology, Department of Statistics, University of Florence, Florence, Italy. duccio.cavalieri@unifi.it|Department of Preclinical and Clinical Pharmacology, Department of Statistics, University of Florence, Florence, Italy. duccio.cavalieri@unifi.it|Department of Preclinical and Clinical Pharmacology, Department of Statistics, University of Florence, Florence, Italy. duccio.cavalieri@unifi.it