Joint Carnegie Mellon/University of Pittsburgh PhD Program in Computational Biology, Pittsburgh, PA, USA, Computational Biology Department, Carnegie Mellon University, Pittsburgh, PA, USA, Computational Biology Branch, National Center for Biotechnology Information, U.S. National Institutes of Health, Bethesda, MD, USA, Section of Cancer Genomics, Genetics Branch, Center for Cancer Research, National Cancer Institute, U.S. National Institutes of Health, Bethesda, MD, USA and Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA, USA Joint Carnegie Mellon/University of Pittsburgh PhD Program in Computational Biology, Pittsburgh, PA, USA, Computational Biology Department, Carnegie Mellon University, Pittsburgh, PA, USA, Computational Biology Branch, National Center for Biotechnology Information, U.S. National Institutes of Health, Bethesda, MD, USA, Section of Cancer Genomics, Genetics Branch, Center for Cancer Research, National Cancer Institute, U.S. National Institutes of Health, Bethesda, MD, USA and Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA, USA.