Department of Computer Science and Engineering, Washington University, St. Louis, Missouri, United States of America.|Department of Biology, Washington University, St. Louis, Missouri, United States of America, Department of Genetics, Washington University, St. Louis, Missouri, United States of America, Institute of Evolution, and Department of Evolutionary and Environmental Biology, University of Haifa, Haifa, Israel.|Department of Computer Science and Engineering, Washington University, St. Louis, Missouri, United States of America, Department of Genetics, Washington University, St. Louis, Missouri, United States of America, Institute for Systems Biology, Jianghan University, Wuhan, Hubei, China.