Genetics Graduate Program, The Huck Institutes of the Life Sciences, Penn State University, University Park, Pennsylvania, United States of America.|MOX-Modeling and Scientific Computing, Department of Mathematics, Politecnico di Milano, Milano, Italy.|MOX-Modeling and Scientific Computing, Department of Mathematics, Politecnico di Milano, Milano, Italy.|Department of Statistics, Penn State University, University Park, Pennsylvania, United States of America.|Center for Medical Genomics, The Huck Institutes of the Life Sciences, Penn State University, University Park, Pennsylvania, United States of America.