Chemical Biology & Therapeutics Science Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA.|Operational Research and Financial Engineering, Princeton University, Princeton, NJ, USA.|Operational Research and Financial Engineering, Princeton University, Princeton, NJ, USA.|Chemical Biology & Therapeutics Science Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA.|Chemical Biology & Therapeutics Science Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA.