Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.|Department of Biochemistry, Centre for Life Sciences, National University of Singapore, Singapore, Yale-NUS College, Science Division, National University of Singapore, Singapore.|Department of Biochemistry, Centre for Life Sciences, National University of Singapore, Singapore.|Institute for Chemical and Bioengineering, ETH Zurich, Zurich, Switzerland, Swiss Institute of Bioinformatics, Lausanne, Switzerland.