State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, Department of Biostatistics and Computational Biology, School of Life Sciences, Fudan University, Shanghai 200436, Peoples Republic of China Jockey Club School of Public Health and Primary Care, the Chinese University of Hong Kong, Shatin, Hong Kong SAR.|State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, Department of Biostatistics and Computational Biology, School of Life Sciences, Fudan University, Shanghai 200436, Peoples Republic of China.