Manchester Centre for Integrative Systems Biology, The University of Manchester, Manchester, UK. i.spasic@manchester.ac.uk|Manchester Centre for Integrative Systems Biology, The University of Manchester, Manchester, UK. i.spasic@manchester.ac.uk|Manchester Centre for Integrative Systems Biology, The University of Manchester, Manchester, UK. i.spasic@manchester.ac.uk|Manchester Centre for Integrative Systems Biology, The University of Manchester, Manchester, UK. i.spasic@manchester.ac.uk|Manchester Centre for Integrative Systems Biology, The University of Manchester, Manchester, UK. i.spasic@manchester.ac.uk