IBM T.J. Watson Research Center, Computational Biology Center, Yorktown Heights, NY 10003, USA, Philip Morris International R&D, Philip Morris Products S.A., 2000 Neuchâtel, Switzerland, Telethon Institute of Genetics and Medicine, Via Pietro Castellino, 111, 80131 Naples, Italy, ProtATonce Ltd, Scientific Park Lefkippos, Patriarchou Grigoriou & Neapoleos 15343 Ag. Paraskevi, Attiki and National Technical University of Athens, Heroon Polytechniou 9, Zografou 15780, Greece IBM T.J. Watson Research Center, Computational Biology Center, Yorktown Heights, NY 10003, USA, Philip Morris International R&D, Philip Morris Products S.A., 2000 Neuchâtel, Switzerland, Telethon Institute of Genetics and Medicine, Via Pietro Castellino, 111, 80131 Naples, Italy, ProtATonce Ltd, Scientific Park Lefkippos, Patriarchou Grigoriou & Neapoleos 15343 Ag. Paraskevi, Attiki and National Technical University of Athens, Heroon Polytechniou 9, Zografou 15780, Greece.