Department of Genetics, Washington University, School of Medicine, St. Louis, MO 63110, USA. xingxu@ural.wustl.edu|Department of Genetics, Washington University, School of Medicine, St. Louis, MO 63110, USA. xingxu@ural.wustl.edu|Department of Genetics, Washington University, School of Medicine, St. Louis, MO 63110, USA. xingxu@ural.wustl.edu