Department of Medical Statistics, University Medical Center Göttingen, 37099, Göttingen, Germany. Michaela.Bayerlova@med.uni-goettingen.de.|Department of Medical Statistics, University Medical Center Göttingen, 37099, Göttingen, Germany. Klaus.Jung@ams.med.uni-goettingen.de.|Department of Medical Statistics, University Medical Center Göttingen, 37099, Göttingen, Germany. Frank.Kramer@med.uni-goettingen.de.|Department of Hematology and Medical Oncology, University Medical Center Göttingen, 37099, Göttingen, Germany. Florian.Klemm@med.uni-goettingen.de.|Department of Medical Statistics, University Medical Center Göttingen, 37099, Göttingen, Germany. A.Bleckmann@med.uni-goettingen.de.|Department of Medical Statistics, University Medical Center Göttingen, 37099, Göttingen, Germany. Tim.Beissbarth@ams.med.uni-goettingen.de.