Department of Computational Biology, University of Pittsburgh, Pittsburgh, PA 15260, USA. abt10@pitt.edu|Department of Computational Biology, University of Pittsburgh, Pittsburgh, PA 15260, USA. abt10@pitt.edu|Department of Computational Biology, University of Pittsburgh, Pittsburgh, PA 15260, USA. abt10@pitt.edu|Department of Computational Biology, University of Pittsburgh, Pittsburgh, PA 15260, USA. abt10@pitt.edu