Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA.|Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA.|Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA.|Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA.|Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA.|Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA.|Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA.|Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA.