Institute Pasteur Cenci-Bolognetti, DAHFMO-Unit of Histology and Medical Embryology, IIM, Sapienza University of Rome, Via A. Scarpa 16, 00161, Rome, Italy. michi_pelo@libero.it.|Dipartimento di Scienze Statistiche, Sapienza University of Rome, P. le A. Moro 5, 00185, Rome, Italy. marco.alfo@uniroma1.it.|Dipartimento di Scienze Statistiche, Sapienza University of Rome, P. le A. Moro 5, 00185, Rome, Italy. francesca.martella@uniroma1.it.|Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RF, UK. elisa.pappalardo@path.ox.ac.uk.|Institute Pasteur Cenci-Bolognetti, DAHFMO-Unit of Histology and Medical Embryology, IIM, Sapienza University of Rome, Via A. Scarpa 16, 00161, Rome, Italy. antonio.musaro@uniroma1.it.