National Center for Biotechnology Information, National Library of Medicine, Bethesda, MD 20894, USA and Computational Biology Research Center, National Institute of Advanced Industrial Science and Technology, Tokyo 135-0064, Japan.|National Center for Biotechnology Information, National Library of Medicine, Bethesda, MD 20894, USA and Computational Biology Research Center, National Institute of Advanced Industrial Science and Technology, Tokyo 135-0064, Japan.|National Center for Biotechnology Information, National Library of Medicine, Bethesda, MD 20894, USA and Computational Biology Research Center, National Institute of Advanced Industrial Science and Technology, Tokyo 135-0064, Japan.|National Center for Biotechnology Information, National Library of Medicine, Bethesda, MD 20894, USA and Computational Biology Research Center, National Institute of Advanced Industrial Science and Technology, Tokyo 135-0064, Japan.