Program in Cardiovascular & Metabolic Disorders and Centre for Computational Biology, Duke-NUS Graduate Medical School, Singapore, MRC Clinical Sciences Centre, Imperial College London, UK.|Department of Statistics, Athens University of Economics and Business, Greece and.|Program in Cardiovascular & Metabolic Disorders and Centre for Computational Biology, Duke-NUS Graduate Medical School, Singapore, MRC Clinical Sciences Centre, Imperial College London, UK.|Department of Mathematics, Imperial College London, UK.