Recently, LIBRA, a tool for active/ligand binding site prediction, was described. LIBRAs effectiveness was comparable to similar state-of-the-art tools, however, its scoring scheme, output presentation, dependence on local resources and overall convenience were amenable to improvements. To solve these issues, LIBRA-WA, a web application based on an improved LIBRA engine, has been developed, featuring a novel scoring scheme consistently improving LIBRAs performance, and a refined algorithm that can identify binding sites hosted at the interface between different subunits. LIBRA-WA also sports additional functionalities like ligand clustering and a completely redesigned interface for an easier analysis of the output. Extensive tests on 373 apoprotein structures indicate that LIBRA-WA is able to identify the biologically relevant ligand/ligand binding site in 357 cases (xe2x88xbc96%), with the correct prediction ranking first in 349 cases (xe2x88xbc98% of the latter, xe2x88xbc94% of the total). The earlier stand-alone tool has also been updated and dubbed LIBRA+, by integrating LIBRA-WAs improved engine for cross-compatibility purposes.