PharmaDesign, Inc., Tokyo 104-0032, Japan. hirose-shuichi@aist.go.jp|PharmaDesign, Inc., Tokyo 104-0032, Japan. hirose-shuichi@aist.go.jp|PharmaDesign, Inc., Tokyo 104-0032, Japan. hirose-shuichi@aist.go.jp|PharmaDesign, Inc., Tokyo 104-0032, Japan. hirose-shuichi@aist.go.jp|PharmaDesign, Inc., Tokyo 104-0032, Japan. hirose-shuichi@aist.go.jp