School of Electrical and Computer Engineering, NTUA, Zografou 15773, IMIS Institute, Athena RC, Marousi 15125, DIANA-Lab, Institute of Molecular Oncology, BSRC Alexander Fleming, Vari 16672, Department of Computer & Communication Engineering, University of Thessaly, Volos 38221, Greece and School of Computer Science & Info Tech, RMIT University, Melbourne 3001, Australia.