School of Computing, Informatics, and Decision Systems Engineering, Center for Evolutionary Medicine and Informatics, The Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA, National Key Laboratory for Novel Software Technology, Nanjing University, Nanjing 210023, China, School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA and Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia.