Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. yudi.pawitan@meb.ki.se|Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. yudi.pawitan@meb.ki.se|Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. yudi.pawitan@meb.ki.se|Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. yudi.pawitan@meb.ki.se