Department of Computer Science and Information Engineering, National Central University, Taoyuan, Taiwan, Republic of China. thtsai@csie.ncu.edu.tw.|Department of Computer Science and Information Engineering, National Central University, Taoyuan, Taiwan, Republic of China. thtsai@csie.ncu.edu.tw.|Department of Computer Science and Information Engineering, National Central University, Taoyuan, Taiwan, Republic of China. thtsai@csie.ncu.edu.tw.|Department of Pathology, Laboratory for Experimental Patho-Oncology, Erasmus MC - University Medical Center Rotterdam, Be-432, P,O, Box 2040, Rotterdam 3000 CA, Netherlands. l.looijenga@erasmusmc.nl.