Department of Biostatistics, University of Washington, Seattle, WA 98195-7232, USA. zhengx@u.washington.edu|Department of Biostatistics, University of Washington, Seattle, WA 98195-7232, USA. zhengx@u.washington.edu|Department of Biostatistics, University of Washington, Seattle, WA 98195-7232, USA. zhengx@u.washington.edu|Department of Biostatistics, University of Washington, Seattle, WA 98195-7232, USA. zhengx@u.washington.edu|Department of Biostatistics, University of Washington, Seattle, WA 98195-7232, USA. zhengx@u.washington.edu|Department of Biostatistics, University of Washington, Seattle, WA 98195-7232, USA. zhengx@u.washington.edu