Lane Center for Computational Biology, Carnegie Mellon University, Pittsburgh, PA 15213, USA. sskadri@andrew.cmu.edu|Lane Center for Computational Biology, Carnegie Mellon University, Pittsburgh, PA 15213, USA. sskadri@andrew.cmu.edu|Lane Center for Computational Biology, Carnegie Mellon University, Pittsburgh, PA 15213, USA. sskadri@andrew.cmu.edu