Bristol Genetic Epidemology Laboratories (BGEL) and MRC Centre for Causal Analyses in Translational Epidemiology (CAiTE), Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol, BS8 2PR, UK. tom.gaunt@bristol.ac.uk|Bristol Genetic Epidemology Laboratories (BGEL) and MRC Centre for Causal Analyses in Translational Epidemiology (CAiTE), Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol, BS8 2PR, UK. tom.gaunt@bristol.ac.uk|Bristol Genetic Epidemology Laboratories (BGEL) and MRC Centre for Causal Analyses in Translational Epidemiology (CAiTE), Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol, BS8 2PR, UK. tom.gaunt@bristol.ac.uk