Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. vwalter@email.unc.edu|Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. vwalter@email.unc.edu|Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. vwalter@email.unc.edu