Department of Biostatistics and Clinical Research, CHU de Caen, Caen F-14000, France. anndo.pham@gmail.com.|Department of Biostatistics and Clinical Research, CHU de Caen, Caen F-14000, France. anndo.pham@gmail.com.|Department of Biostatistics and Clinical Research, CHU de Caen, Caen F-14000, France. anndo.pham@gmail.com.|Department of Biostatistics and Clinical Research, CHU de Caen, Caen F-14000, France. anndo.pham@gmail.com.|Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. xwxu@ualr.edu.|Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. xwxu@ualr.edu.