Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA 15217, USA and Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.|Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA 15217, USA and Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.|Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA 15217, USA and Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.