Department of Statistics and Department of Biochemistry and Molecular Biology, Penn State University, University Park, PA 16803, USA.|Department of Statistics and Department of Biochemistry and Molecular Biology, Penn State University, University Park, PA 16803, USA.|Department of Statistics and Department of Biochemistry and Molecular Biology, Penn State University, University Park, PA 16803, USA.|Department of Statistics and Department of Biochemistry and Molecular Biology, Penn State University, University Park, PA 16803, USA.