Department of Computational Biology, School of Medicine, University of Pittsburgh Pittsburgh, PA 15213, USA. lwy1@pitt.edu|Department of Computational Biology, School of Medicine, University of Pittsburgh Pittsburgh, PA 15213, USA. lwy1@pitt.edu|Department of Computational Biology, School of Medicine, University of Pittsburgh Pittsburgh, PA 15213, USA. lwy1@pitt.edu|Department of Computational Biology, School of Medicine, University of Pittsburgh Pittsburgh, PA 15213, USA. lwy1@pitt.edu|Department of Computational Biology, School of Medicine, University of Pittsburgh Pittsburgh, PA 15213, USA. lwy1@pitt.edu|Department of Computational Biology, School of Medicine, University of Pittsburgh Pittsburgh, PA 15213, USA. lwy1@pitt.edu|Department of Computational Biology, School of Medicine, University of Pittsburgh Pittsburgh, PA 15213, USA. lwy1@pitt.edu