Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK. e.ryder@gen.cam.ac.uk|Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK. e.ryder@gen.cam.ac.uk|Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK. e.ryder@gen.cam.ac.uk|Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK. e.ryder@gen.cam.ac.uk|Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK. e.ryder@gen.cam.ac.uk