Institute of Genomic Mathematics, University of Bonn, Bonn, Germany.|Institute of Genomic Mathematics, University of Bonn, Bonn, Germany.|Channing Division of Network Medicine, Brigham and Womens Hospital.|Department of Biostatistics, Harvard School of Public Health, Boston, USA.|Institute of Human Genetics, University of Bonn, Bonn, Germany.|Institut National de la Santé et de la Recherche Médicale (INSERM) Unité Mixte de Recherche (UMR) 1087, linstitut du thorax, Nantes, France, Centre National de la Recherche Scientifique (CNRS) UMR 6291, linstitut du thorax, Nantes, France, Université de Nantes, linstitut du thorax, Nantes, France and Centre Hospitalier Universitaire (CHU) de Nantes, linstitut du thorax, Service de Cardiologie, Nantes, France.|Channing Division of Network Medicine, Brigham and Womens Hospital, Department of Biostatistics, Harvard School of Public Health, Boston, USA.|Institute of Genomic Mathematics, University of Bonn, Bonn, Germany, Department of Biostatistics, Harvard School of Public Health, Boston, USA.