Leeds Institute of Molecular Medicine, Wellcome Trust Brenner Building, University of Leeds, St Jamess University Hospital, Beckett Street, Leeds LS9 7TF, UK. msjimc@leeds.ac.uk|Leeds Institute of Molecular Medicine, Wellcome Trust Brenner Building, University of Leeds, St Jamess University Hospital, Beckett Street, Leeds LS9 7TF, UK. msjimc@leeds.ac.uk|Leeds Institute of Molecular Medicine, Wellcome Trust Brenner Building, University of Leeds, St Jamess University Hospital, Beckett Street, Leeds LS9 7TF, UK. msjimc@leeds.ac.uk|Leeds Institute of Molecular Medicine, Wellcome Trust Brenner Building, University of Leeds, St Jamess University Hospital, Beckett Street, Leeds LS9 7TF, UK. msjimc@leeds.ac.uk|Leeds Institute of Molecular Medicine, Wellcome Trust Brenner Building, University of Leeds, St Jamess University Hospital, Beckett Street, Leeds LS9 7TF, UK. msjimc@leeds.ac.uk|Leeds Institute of Molecular Medicine, Wellcome Trust Brenner Building, University of Leeds, St Jamess University Hospital, Beckett Street, Leeds LS9 7TF, UK. msjimc@leeds.ac.uk