Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, The Childrens Hospital of Philadelphia, Philadelphia, PA 19104, USA. mingyao@mail.med.upenn.edu|Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, The Childrens Hospital of Philadelphia, Philadelphia, PA 19104, USA. mingyao@mail.med.upenn.edu|Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, The Childrens Hospital of Philadelphia, Philadelphia, PA 19104, USA. mingyao@mail.med.upenn.edu|Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, The Childrens Hospital of Philadelphia, Philadelphia, PA 19104, USA. mingyao@mail.med.upenn.edu|Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, The Childrens Hospital of Philadelphia, Philadelphia, PA 19104, USA. mingyao@mail.med.upenn.edu