National Center of Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, United States of America. wuchtys@ncbi.nlm.nih.gov|National Center of Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, United States of America. wuchtys@ncbi.nlm.nih.gov|National Center of Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, United States of America. wuchtys@ncbi.nlm.nih.gov