Wellcome Trust Centre for Cell Biology and School of Biological Sciences, The University of Edinburgh, Edinburgh, UK. andrew.winter@ed.ac.uk|Wellcome Trust Centre for Cell Biology and School of Biological Sciences, The University of Edinburgh, Edinburgh, UK. andrew.winter@ed.ac.uk|Wellcome Trust Centre for Cell Biology and School of Biological Sciences, The University of Edinburgh, Edinburgh, UK. andrew.winter@ed.ac.uk