Center for Bioinformatics and Biostatistics, BMFZ, Heinrich Heine University Düsseldorf, Institut für Virologie, and Mathematical Institute, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany Center for Bioinformatics and Biostatistics, BMFZ, Heinrich Heine University Düsseldorf, Institut für Virologie, and Mathematical Institute, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany.