Department of Biostatistics and Informatics, University of Colorado School of Public Health, Aurora, CO 80045, USA.|Computational Bioscience Program, University of Colorado School of Medicine, Aurora, CO 80045, USA.|Department of Biostatistics and Informatics, University of Colorado School of Public Health, Aurora, CO 80045, USA.|Department of Biostatistics and Informatics, University of Colorado School of Public Health, Aurora, CO 80045, USA.|Department of Biology, University of Oregon, Eugene, OR, USA.|Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, Boulder, CO 80303, USA.|Department of Pharmaceutical Sciences, University of Colorado Skaggs School of Pharmaceutical Sciences, Aurora, CO 80045, USA.|Department of Pharmaceutical Sciences, University of Colorado Skaggs School of Pharmaceutical Sciences, Aurora, CO 80045, USA.|Department of Biostatistics and Informatics, University of Colorado School of Public Health, Aurora, CO 80045, USA. katerina.kechris@ucdenver.edu.