Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, 110, Taiwan.|Department of Life Science, College of Science, National Taiwan Normal University, Taipei, 116, Taiwan.|Department of Life Science, College of Science, National Taiwan Normal University, Taipei, 116, Taiwan.|Department of Civil Engineering, College of Engineering, National Taiwan University College of Engineering, Taipei, 106, Taiwan.|Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, 100, Taiwan.|Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, 100, Taiwan.|Department of Life Science, College of Science, National Taiwan Normal University, Taipei, 116, Taiwan. sher@ntnu.edu.tw.