Department of Biomedical Engineering and Institute for Computational Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America.|Department of Biomedical Engineering and Institute for Computational Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America.|Department of Applied Math and Statistics, Johns Hopkins University, Baltimore, Maryland, United States of America.|Department of Biomedical Engineering and Institute for Computational Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America, Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America.