Center for Computational Biology and Department of Genetics, Washington University School of Medicine, 700 S. Euclid Ave, St Louis, MO 63110, USA.|Center for Computational Biology and Department of Genetics, Washington University School of Medicine, 700 S. Euclid Ave, St Louis, MO 63110, USA.|Center for Computational Biology and Department of Genetics, Washington University School of Medicine, 700 S. Euclid Ave, St Louis, MO 63110, USA.