Dows Institute for Dental Research, College of Dentistry, University of Iowa, Iowa City, IA 52242, USA. hmishima@nagasaki-u.ac.jp|Dows Institute for Dental Research, College of Dentistry, University of Iowa, Iowa City, IA 52242, USA. hmishima@nagasaki-u.ac.jp|Dows Institute for Dental Research, College of Dentistry, University of Iowa, Iowa City, IA 52242, USA. hmishima@nagasaki-u.ac.jp