Applied Bioinformatics Laboratory, University of Kansas, 2034 Becker Drive, Lawrence, KS 66047, USA. jianwen.fang@nih.gov.|Applied Bioinformatics Laboratory, University of Kansas, 2034 Becker Drive, Lawrence, KS 66047, USA. jianwen.fang@nih.gov.|School of Medical and Molecular Biosciences, ithree institute at the University of Technology Sydney (UTS), Sydney, Australia. John.Ellis@uts.edu.au.