Department of Biochemistry, University of Cambridge Tennis Court Road, Cambridge CB2 1GA, UK. rinaldo@cryst.bioc.cam.ac.uk|Department of Biochemistry, University of Cambridge Tennis Court Road, Cambridge CB2 1GA, UK. rinaldo@cryst.bioc.cam.ac.uk|Department of Biochemistry, University of Cambridge Tennis Court Road, Cambridge CB2 1GA, UK. rinaldo@cryst.bioc.cam.ac.uk|Department of Biochemistry, University of Cambridge Tennis Court Road, Cambridge CB2 1GA, UK. rinaldo@cryst.bioc.cam.ac.uk