Center for Cardiovascular Bioinformatics and Modeling, Whitaker Biomedical Engineering Institute, Baltimore, MD 21218, USA. actan@jhu.edu|Center for Cardiovascular Bioinformatics and Modeling, Whitaker Biomedical Engineering Institute, Baltimore, MD 21218, USA. actan@jhu.edu|Center for Cardiovascular Bioinformatics and Modeling, Whitaker Biomedical Engineering Institute, Baltimore, MD 21218, USA. actan@jhu.edu|Center for Cardiovascular Bioinformatics and Modeling, Whitaker Biomedical Engineering Institute, Baltimore, MD 21218, USA. actan@jhu.edu|Center for Cardiovascular Bioinformatics and Modeling, Whitaker Biomedical Engineering Institute, Baltimore, MD 21218, USA. actan@jhu.edu