Institute of Medical Biostatistics, Epidemiology and Informatics, Medical Center of the Johannes Gutenberg University, Mainz 55131, Germany. murat.sariyar@charite.de.|Institute of Medical Biostatistics, Epidemiology and Informatics, Medical Center of the Johannes Gutenberg University, Mainz 55131, Germany. murat.sariyar@charite.de.|Institute of Medical Biostatistics, Epidemiology and Informatics, Medical Center of the Johannes Gutenberg University, Mainz 55131, Germany. murat.sariyar@charite.de.