Bioprocess Engineering Group, Spanish National Research Council, IIM-CSIC, C/Eduardo Cabello 6, Vigo, 36208, Spain. gundian@iim.csic.es.|Bioprocess Engineering Group, Spanish National Research Council, IIM-CSIC, C/Eduardo Cabello 6, Vigo, 36208, Spain. ebalsa@iim.csic.es.|esearch Group Theoretical Systems Biology, Friedrich Schiller University Jena, Leutragraben 1,, Jena, 07743, Germany. jan.ewald@uni-jena.de.|esearch Group Theoretical Systems Biology, Friedrich Schiller University Jena, Leutragraben 1,, Jena, 07743, Germany. ebalsa@iim.csic.es.|Simulation and Optimal Processes Group, Ilmenau University of Technology, P.O.Box 100565, Ilmenau, 98684, Germany. ebalsa@iim.csic.es.|Bioprocess Engineering Group, Spanish National Research Council, IIM-CSIC, C/Eduardo Cabello 6, Vigo, 36208, Spain. julio@iim.csic.es.|esearch Group Theoretical Systems Biology, Friedrich Schiller University Jena, Leutragraben 1,, Jena, 07743, Germany. c.kaleta@iem.uni-kiel.de.