School of Medicine and Medical Science, Conway Institute, University College Dublin, Dublin 4, Ireland. fabian.sievers@ucd.ie|School of Medicine and Medical Science, Conway Institute, University College Dublin, Dublin 4, Ireland. fabian.sievers@ucd.ie|School of Medicine and Medical Science, Conway Institute, University College Dublin, Dublin 4, Ireland. fabian.sievers@ucd.ie|School of Medicine and Medical Science, Conway Institute, University College Dublin, Dublin 4, Ireland. fabian.sievers@ucd.ie