Drexel University, 19104 Philadelphia, USA. acohen@coe.drexel.edu.|Drexel University, 19104 Philadelphia, USA. acohen@coe.drexel.edu.|Department of Biostatistics and Computational Biology, University of Rochester, Rochester, NY 14642, USA. jian_zhu@urmc.rochester.edu.|Department of Biostatistics and Computational Biology, University of Rochester, Rochester, NY 14642, USA. jian_zhu@urmc.rochester.edu.