Computational Biology Center, Memorial Sloan-Kettering Cancer Center, New York, NY, USA, Machine Learning in Biology Group, Friedrich Miescher Laboratory, Tübingen, Germany, LINA, Combinatorics and Bioinformatics Group, University of Nantes, Nantes, France, Machine Learning/Intelligent Data Analysis Group, Technical University, Berlin, Germany and Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.