Computational Biology and Bioinformatics, Pacific Northwest National Laboratory, Richland, Washington, United States of America. bj@pnl.gov|Computational Biology and Bioinformatics, Pacific Northwest National Laboratory, Richland, Washington, United States of America. bj@pnl.gov|Computational Biology and Bioinformatics, Pacific Northwest National Laboratory, Richland, Washington, United States of America. bj@pnl.gov