Laboratory of Computational and Medicinal Chemistry, Center for Structural Molecular Biotechnology, Institute of Physics of São Carlos, University of São Paulo, São Carlos-SP 13566-970, Brazil.|Laboratory of Computational and Medicinal Chemistry, Center for Structural Molecular Biotechnology, Institute of Physics of São Carlos, University of São Paulo, São Carlos-SP 13566-970, Brazil.|Laboratory of Computational and Medicinal Chemistry, Center for Structural Molecular Biotechnology, Institute of Physics of São Carlos, University of São Paulo, São Carlos-SP 13566-970, Brazil.|Laboratory of Computational and Medicinal Chemistry, Center for Structural Molecular Biotechnology, Institute of Physics of São Carlos, University of São Paulo, São Carlos-SP 13566-970, Brazil.