Department of Biostatistics and Computational Biology, University of Rochester, 601 Elmwood Avenue, Rochester, New York 14642, USA. yxiao@bst.rochester.edu <yxiao@bst.rochester.edu>|Department of Biostatistics and Computational Biology, University of Rochester, 601 Elmwood Avenue, Rochester, New York 14642, USA. yxiao@bst.rochester.edu <yxiao@bst.rochester.edu>|Department of Biostatistics and Computational Biology, University of Rochester, 601 Elmwood Avenue, Rochester, New York 14642, USA. yxiao@bst.rochester.edu <yxiao@bst.rochester.edu>|Department of Biostatistics and Computational Biology, University of Rochester, 601 Elmwood Avenue, Rochester, New York 14642, USA. yxiao@bst.rochester.edu <yxiao@bst.rochester.edu>|Department of Biostatistics and Computational Biology, University of Rochester, 601 Elmwood Avenue, Rochester, New York 14642, USA. yxiao@bst.rochester.edu <yxiao@bst.rochester.edu>