Department of Bioinformatics and Computational Biology, The University of Texas M,D, Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA. kchen3@mdanderson.org.|Department of Bioinformatics and Computational Biology, The University of Texas M,D, Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA. kchen3@mdanderson.org.|Department of Bioinformatics and Computational Biology, The University of Texas M,D, Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA. kchen3@mdanderson.org.|Department of Bioinformatics and Computational Biology, The University of Texas M,D, Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA. kchen3@mdanderson.org.|Department of Bioinformatics and Computational Biology, The University of Texas M,D, Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA. kchen3@mdanderson.org.|Bioinformatics Institute, A*STAR, Singapore, Singapore. chengli@bii.a-star.edu.sg.