Howard Hughes Medical Institute and Department of Genetics, Washington University, St. Louis, MO 63110 USA. robin@genetics.wustl.edu|Howard Hughes Medical Institute and Department of Genetics, Washington University, St. Louis, MO 63110 USA. robin@genetics.wustl.edu|Howard Hughes Medical Institute and Department of Genetics, Washington University, St. Louis, MO 63110 USA. robin@genetics.wustl.edu|Howard Hughes Medical Institute and Department of Genetics, Washington University, St. Louis, MO 63110 USA. robin@genetics.wustl.edu|Howard Hughes Medical Institute and Department of Genetics, Washington University, St. Louis, MO 63110 USA. robin@genetics.wustl.edu