Department of Biostatistical Science, Dana-Farber Cancer Institute, Harvard School of Public Health, and Channing Laboratory, Boston, MA, USA. jzhang@jimmy.harvard.edu|Department of Biostatistical Science, Dana-Farber Cancer Institute, Harvard School of Public Health, and Channing Laboratory, Boston, MA, USA. jzhang@jimmy.harvard.edu|Department of Biostatistical Science, Dana-Farber Cancer Institute, Harvard School of Public Health, and Channing Laboratory, Boston, MA, USA. jzhang@jimmy.harvard.edu