Department of Oncological Sciences, University of Torino, Candiolo, Italy. claudio.isella@ircc.it|Department of Oncological Sciences, University of Torino, Candiolo, Italy. claudio.isella@ircc.it|Department of Oncological Sciences, University of Torino, Candiolo, Italy. claudio.isella@ircc.it|Department of Oncological Sciences, University of Torino, Candiolo, Italy. claudio.isella@ircc.it