Center for Theoretical Biological Physics, University of California, San Diego, California, United States of America. hermsen@ctbp.ucsd.edu|Center for Theoretical Biological Physics, University of California, San Diego, California, United States of America. hermsen@ctbp.ucsd.edu|Center for Theoretical Biological Physics, University of California, San Diego, California, United States of America. hermsen@ctbp.ucsd.edu