Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC, USA. annamaria.masci@duke.edu|Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC, USA. annamaria.masci@duke.edu|Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC, USA. annamaria.masci@duke.edu|Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC, USA. annamaria.masci@duke.edu|Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC, USA. annamaria.masci@duke.edu|Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC, USA. annamaria.masci@duke.edu|Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC, USA. annamaria.masci@duke.edu|Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC, USA. annamaria.masci@duke.edu