Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA, Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, USA and Department of Genetic Medicine, Weill Cornell Medical College, New York, NY, USA Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA, Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, USA and Department of Genetic Medicine, Weill Cornell Medical College, New York, NY, USA.