Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden.|Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.|Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA.|Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA.|Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA.|Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden.|Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden.