Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.|Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.|Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.|Department of Philosophy, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA.|Department of Computer Science, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.|Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.|Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.|Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.|Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.|Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.|Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.|Department of Philosophy, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA.|Department of Philosophy, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA.|Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.