Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, United States of America.|Ludwig Institute for Cancer Research, La Jolla, CA, United States of America.|Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, United States of America.|Ludwig Institute for Cancer Research, La Jolla, CA, United States of America.|Ludwig Institute for Cancer Research, La Jolla, CA, United States of America.|Ludwig Institute for Cancer Research, La Jolla, CA, United States of America.|Ludwig Institute for Cancer Research, La Jolla, CA, United States of America.|Ludwig Institute for Cancer Research, La Jolla, CA, United States of America.|Departments of Genetics, Biostatistics, and Computer Science, University of North Carolina, Chapel Hill, NC, United States of America.|Departments of Genetics, Biostatistics, and Computer Science, University of North Carolina, Chapel Hill, NC, United States of America.|Ludwig Institute for Cancer Research, La Jolla, CA, United States of America.|Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, United States of America.