Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697-3900, USA. lopie@uci.edu|Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697-3900, USA. lopie@uci.edu|Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697-3900, USA. lopie@uci.edu|Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697-3900, USA. lopie@uci.edu|Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697-3900, USA. lopie@uci.edu