Department of Molecular Biophysics and Biochemistry, Yale University New Haven, CT 06520, USA.|Department of Molecular Biophysics and Biochemistry, Yale University New Haven, CT 06520, USA.|Department of Molecular Biophysics and Biochemistry, Yale University New Haven, CT 06520, USA.|Department of Molecular Biophysics and Biochemistry, Yale University New Haven, CT 06520, USA.