Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA 15261, USA.|Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA 15261, USA.|Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA 15261, USA.|Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA 15261, USA.|Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA 15261, USA.