Graduate Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, 77030, TX, USA.|Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, 77030, TX, USA.|Department of Pediatrics-Neurology, Jan and Dan Duncan Neurological Research Institute, Baylor College of Medicine, 1250 Moursund St., Suite 1325, Houston, 77030, TX, USA. zhandonl@bcm.edu.