Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom. td2@sanger.ac.uk|Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom. td2@sanger.ac.uk|Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom. td2@sanger.ac.uk|Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom. td2@sanger.ac.uk