Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA, USA.|Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA, USA.|Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA, USA.|Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA, USA.|Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA, USA.