Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Frankfurt am Main, Germany.|Department of Molecular and Cell Biology and California Institute for Quantitative Biosciences, University of California, Berkeley, California, United States of America.|Department of Molecular and Cell Biology and California Institute for Quantitative Biosciences, University of California, Berkeley, California, United States of America.|Department of Molecular and Cell Biology and California Institute for Quantitative Biosciences, University of California, Berkeley, California, United States of America.|Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Frankfurt am Main, Germany.