Department of Pharmacology, University of California, San Diego, Gilman Drive, La Jolla, CA 92093-0743, USA.|Department of Pharmacology, University of California, San Diego, Gilman Drive, La Jolla, CA 92093-0743, USA.|Department of Pharmacology, University of California, San Diego, Gilman Drive, La Jolla, CA 92093-0743, USA.