Department of Computational Medicine and Bioinformatics, Department of Biostatistics and Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.|Department of Computational Medicine and Bioinformatics, Department of Biostatistics and Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.|Department of Computational Medicine and Bioinformatics, Department of Biostatistics and Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.|Department of Computational Medicine and Bioinformatics, Department of Biostatistics and Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.|Department of Computational Medicine and Bioinformatics, Department of Biostatistics and Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA Department of Computational Medicine and Bioinformatics, Department of Biostatistics and Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.