Biomedical Pioneering Innovation Center (BIOPIC), School of Life Sciences, Peking University, Beijing, China.|Biomedical Pioneering Innovation Center (BIOPIC), School of Life Sciences, Peking University, Beijing, China.|Biomedical Pioneering Innovation Center (BIOPIC), School of Life Sciences, Peking University, Beijing, China.|Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States of America.|Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ, United States of America.|Biomedical Pioneering Innovation Center (BIOPIC), School of Life Sciences, Peking University, Beijing, China.|Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States of America.