Department of Biology, Hong Kong Baptist University, Hong Kong, China, Department of Internal Medicine and Biochemistry, Rush University Medical Center, Chicago, IL, USA, Department of Biochemistry and HKU-SIRI, Centre for Genomic Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China and Key Laboratory of Acupuncture and Medicine Research of Minister of Education , Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210046, China.