Stockholm Bioinformatics Center, Science for Life Laboratory, Box 1031, SE-17121 Solna, Sweden, Swedish eScience Research Center, Stockholm, Department of Biochemistry and Biophysics, Stockholm University, SE-106 91 Stockholm, Sweden, Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), 08003 Barcelona, Spain, Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain, Institucixc3xb3 Catalana de Recerca i Estudis Avanxc3xa7ats (ICREA), 08010 Barcelona, Spain, EMBL-European Bioinformatics Institute, Hinxton CB10 1SD, UK, Department of Ecology and Evolution, University of Lausanne, Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland, SwissProt, Swiss Institute of Bioinformatics, 1211 Geneva, Switzerland, Division of Bioinformatics, Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90089, USA and Department of Genetics, Evolution and Environment, and Department of Computer Science, University College London, Gower St, London WC1E 6BT, UK Stockholm Bioinformatics Center, Science for Life Laboratory, Box 1031, SE-17121 Solna, Sweden, Swedish eScience Research Center, Stockholm, Department of Biochemistry and Biophysics, Stockholm University, SE-106 91 Stockholm, Sweden, Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), 08003 Barcelona, Spain, Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain, Institucixc3xb3 Catalana de Recerca i Estudis Avanxc3xa7ats (ICREA), 08010 Barcelona, Spain, EMBL-European Bioinformatics Institute, Hinxton CB10 1SD, UK, Department of Ecology and Evolution, University of Lausanne, Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland, SwissProt, Swiss Institute of Bioinformatics, 1211 Geneva, Switzerland, Division of Bioinformatics, Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90089, USA and Department of Genetics, Evolution and Environment, and Department of Computer Science, University College London, Gower St, London