Dipartimento di Matematica e Informatica, Via Archirafi 34, 90123 Palermo-Italy. giosue.lobosco@unipa.it, Guo-Cheng Yuan, Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, 450 Brookline Ave., Boston, MA 02215, USA. E-mail: gcyuan@jimmy.harvard.edu.|Dipartimento di Matematica e Informatica, Via Archirafi 34, 90123 Palermo-Italy. giosue.lobosco@unipa.it, Guo-Cheng Yuan, Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, 450 Brookline Ave., Boston, MA 02215, USA. E-mail: gcyuan@jimmy.harvard.edu.|Dipartimento di Matematica e Informatica, Via Archirafi 34, 90123 Palermo-Italy. giosue.lobosco@unipa.it, Guo-Cheng Yuan, Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, 450 Brookline Ave., Boston, MA 02215, USA. E-mail: gcyuan@jimmy.harvard.edu.