Murdoch Childrens Research Institute, Royal Childrens Hospital, Flemington Road, Parkville, Victoria 3052, Australia. simon.sadedin@mcri.edu.au|Murdoch Childrens Research Institute, Royal Childrens Hospital, Flemington Road, Parkville, Victoria 3052, Australia. simon.sadedin@mcri.edu.au|Murdoch Childrens Research Institute, Royal Childrens Hospital, Flemington Road, Parkville, Victoria 3052, Australia. simon.sadedin@mcri.edu.au