Department of Statistics, The George Washington University, Washington, DC 20052, USA.|Department of Statistics, The George Washington University, Washington, DC 20052, USA.|Department of Statistics, The George Washington University, Washington, DC 20052, USA.|Department of Statistics, The George Washington University, Washington, DC 20052, USA.|Department of Pharmacology and Physiology.|Division of Genomic Medicine, Department of Medicine, The George Washington University Medical Center, Washington, DC 20037, USA.