Department of Health Sciences Research and Center for Individualized Medicine, Mayo Clinic, Scottsdale, AZ, USA.|Department of Hematology, Mayo Clinic, Scottsdale, AZ, USA.|Department of Cancer Biology, Mayo Clinic, Scottsdale, AZ, USA.|Department of Neurologic Surgery, Mayo Clinic, Scottsdale, AZ, USA.|Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.|Department of Chemistry, The University of Hong Kong, Hong Kong SAR, China.|Department of Health Sciences Research and Center for Individualized Medicine, Mayo Clinic, Scottsdale, AZ, USA.