Department of Epidemiology and Biostatistics, Imperial College London, UK. l.bottolo@imperial.ac.uk|Department of Epidemiology and Biostatistics, Imperial College London, UK. l.bottolo@imperial.ac.uk|Department of Epidemiology and Biostatistics, Imperial College London, UK. l.bottolo@imperial.ac.uk|Department of Epidemiology and Biostatistics, Imperial College London, UK. l.bottolo@imperial.ac.uk|Department of Epidemiology and Biostatistics, Imperial College London, UK. l.bottolo@imperial.ac.uk|Department of Epidemiology and Biostatistics, Imperial College London, UK. l.bottolo@imperial.ac.uk|Department of Epidemiology and Biostatistics, Imperial College London, UK. l.bottolo@imperial.ac.uk|Department of Epidemiology and Biostatistics, Imperial College London, UK. l.bottolo@imperial.ac.uk