Howard Hughes Medical Institute and Department of Genetics, Washington University School of Medicine, 4444 Forest Park Blvd, Box 8510, St. Louis, MO 63108, USA. rdd@mit.edu|Howard Hughes Medical Institute and Department of Genetics, Washington University School of Medicine, 4444 Forest Park Blvd, Box 8510, St. Louis, MO 63108, USA. rdd@mit.edu