Wilmer Institute, Johns Hopkins University School of Medicine, Maumenee Building 844, 600 N, Wolfe Street, Baltimore, MD 21287, USA. xliu09@gmail.com|Wilmer Institute, Johns Hopkins University School of Medicine, Maumenee Building 844, 600 N, Wolfe Street, Baltimore, MD 21287, USA. xliu09@gmail.com|Wilmer Institute, Johns Hopkins University School of Medicine, Maumenee Building 844, 600 N, Wolfe Street, Baltimore, MD 21287, USA. xliu09@gmail.com|Wilmer Institute, Johns Hopkins University School of Medicine, Maumenee Building 844, 600 N, Wolfe Street, Baltimore, MD 21287, USA. xliu09@gmail.com|Wilmer Institute, Johns Hopkins University School of Medicine, Maumenee Building 844, 600 N, Wolfe Street, Baltimore, MD 21287, USA. xliu09@gmail.com