Division of Human Genetics, University of Southampton, Duthie Building, Southampton General Hospital, Southampton SO16 6YD, UK. xke@soton.ac.uk|Division of Human Genetics, University of Southampton, Duthie Building, Southampton General Hospital, Southampton SO16 6YD, UK. xke@soton.ac.uk|Division of Human Genetics, University of Southampton, Duthie Building, Southampton General Hospital, Southampton SO16 6YD, UK. xke@soton.ac.uk