Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, Peoples Republic of China.|Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, Peoples Republic of China.|Center for Quantitative Sciences, Vanderbilt University, Nashville, TN 37232, USA.|Department of Public Health Sciences, Division of Biostatistics, University of Miami Miller School of Medicine, Miami, FL 33136, USA.|Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, Peoples Republic of China.