The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609-1500, USA, Whitehead Institute for Biomedical Research, Cambridge, MA, USA. nat@jax.org|The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609-1500, USA, Whitehead Institute for Biomedical Research, Cambridge, MA, USA. nat@jax.org|The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609-1500, USA, Whitehead Institute for Biomedical Research, Cambridge, MA, USA. nat@jax.org|The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609-1500, USA, Whitehead Institute for Biomedical Research, Cambridge, MA, USA. nat@jax.org