Department of Physiology and Biophysics, Boston University School of Medicine, Boston, Massachusetts, United States of America, Internal Medicine Residency Program, University of Pittsburgh Medical Center, UPMC Montefiore Hospital, Pittsburgh, Pennsylvania, United States of America.|Department of Physiology and Biophysics, Boston University School of Medicine, Boston, Massachusetts, United States of America.|Center for Systems and Computational Biology, and Molecular and Cellular Oncogenesis Program, the Wistar Institute, Philadelphia, Pennsylvania, United States of America, Genomics and Computational Biology Graduate Group, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.|Center for Systems and Computational Biology, and Molecular and Cellular Oncogenesis Program, the Wistar Institute, Philadelphia, Pennsylvania, United States of America.|Center for Systems and Computational Biology, and Molecular and Cellular Oncogenesis Program, the Wistar Institute, Philadelphia, Pennsylvania, United States of America, Genomics and Computational Biology Graduate Group, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.|Department of Physiology and Biophysics, Boston University School of Medicine, Boston, Massachusetts, United States of America.