Biostatistics Unit, Centre for Epidemiology and Biostatistics, Leeds, UK. s.o.m.manda@leeds.ac.uk|Biostatistics Unit, Centre for Epidemiology and Biostatistics, Leeds, UK. s.o.m.manda@leeds.ac.uk|Biostatistics Unit, Centre for Epidemiology and Biostatistics, Leeds, UK. s.o.m.manda@leeds.ac.uk