Department of Statistics, Life Sciences Division, University of California, Lawrence Berkeley National Laboratory, Berkeley, USA. hb@stat.berkeley.edu|Department of Statistics, Life Sciences Division, University of California, Lawrence Berkeley National Laboratory, Berkeley, USA. hb@stat.berkeley.edu|Department of Statistics, Life Sciences Division, University of California, Lawrence Berkeley National Laboratory, Berkeley, USA. hb@stat.berkeley.edu|Department of Statistics, Life Sciences Division, University of California, Lawrence Berkeley National Laboratory, Berkeley, USA. hb@stat.berkeley.edu