Department of Quantitative Health Sciences, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland OH 44195, USA. hemant.ishwaran@gmail.com|Department of Quantitative Health Sciences, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland OH 44195, USA. hemant.ishwaran@gmail.com|Department of Quantitative Health Sciences, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland OH 44195, USA. hemant.ishwaran@gmail.com