Department of Biostatistics and Computational Biology, University of Rochester Medical Center, NY, USA. hayoun@bst.rochester.edu|Department of Biostatistics and Computational Biology, University of Rochester Medical Center, NY, USA. hayoun@bst.rochester.edu|Department of Biostatistics and Computational Biology, University of Rochester Medical Center, NY, USA. hayoun@bst.rochester.edu|Department of Biostatistics and Computational Biology, University of Rochester Medical Center, NY, USA. hayoun@bst.rochester.edu