Department of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, United States of America.|Department of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, United States of America.|Department of Mathematics, The Ohio State University, Columbus, OH, United States of America.|Department of Anesthesiology & Perioperative Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, United States of America.|Department of Anesthesiology & Perioperative Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, United States of America.|Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, United States of America.|Department of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, United States of America.