Center for Computational Biology and Bioinformatics (C2B2), and Department of Electrical Engineering, Columbia University, New York, NY 10027, USA.|Center for Computational Biology and Bioinformatics (C2B2), and Department of Electrical Engineering, Columbia University, New York, NY 10027, USA.|Center for Computational Biology and Bioinformatics (C2B2), and Department of Electrical Engineering, Columbia University, New York, NY 10027, USA.