Center for Computational Pharmacology, University of Colorado School of Medicine, Aurora, CO, USA. chris.roeder@ucdenver.edu|Center for Computational Pharmacology, University of Colorado School of Medicine, Aurora, CO, USA. chris.roeder@ucdenver.edu|Center for Computational Pharmacology, University of Colorado School of Medicine, Aurora, CO, USA. chris.roeder@ucdenver.edu|Center for Computational Pharmacology, University of Colorado School of Medicine, Aurora, CO, USA. chris.roeder@ucdenver.edu|Center for Computational Pharmacology, University of Colorado School of Medicine, Aurora, CO, USA. chris.roeder@ucdenver.edu|Center for Computational Pharmacology, University of Colorado School of Medicine, Aurora, CO, USA. chris.roeder@ucdenver.edu