Department of Statistics, Harvard University, Cambridge, Boston, 02138-2901xe2x80x89MA, USA, Centre for Genomic Sciences.|Centre for Genomic Sciences, Department of Psychiatry.|Centre for Genomic Sciences, Department of Anaesthesiology.|Department of Statistics, Harvard University, Cambridge, Boston, 02138-2901xe2x80x89MA, USA.|Centre for Genomic Sciences.|Centre for Genomic Sciences, School of Biomedical Sciences.|Centre for Genomic Sciences.|Department of Anaesthesiology.|Centre for Genomic Sciences, Department of Psychiatry.|Department of Health Sciences Research, Center for Individualized Medicine, Mayo Clinic, Scottsdale, AZ 85259, USA and.|Centre for Genomic Sciences, Department of Psychiatry, Centre for Reproduction, Development and Growth, LKS Faculty of Medicine, the University of Hong Kong, Hong Kong SAR, China.|Department of Statistics, Harvard University, Cambridge, Boston, 02138-2901xe2x80x89MA, USA, Center for Statistical Science, Tsinghua University, Beijing 100084, China and.|Centre for Genomic Sciences, Department of Health Sciences Research, Center for Individualized Medicine, Mayo Clinic, Scottsdale, AZ 85259, USA and Department of Biomedical Informatics, Arizona State University, Scottsdale, AZ 85259, USA.