Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, United States of America.|Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, United States of America.|Department of Biostatistics, University of Michigan, Ann Arbor, MI, United States of America.|Department of Neurology, University of Michigan, Ann Arbor, MI, United States of America.|Department of Biostatistics, University of Michigan, Ann Arbor, MI, United States of America.|Department of Health Behavior and Biological Sciences, University of Michigan, Ann Arbor, MI, United States of America.|Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, United States of America.|Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, United States of America.