Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.|Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.|Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.|Key Laboratory of Big Data and Intelligent Computing, Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, China.|Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.