MRC Centre for Causal Analyses in Translational Epidemiology, MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Clifton BS8 2BN, UK and Intelligent Systems Laboratory, University of Bristol, Bristol BS8 1UB, UK.|MRC Centre for Causal Analyses in Translational Epidemiology, MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Clifton BS8 2BN, UK and Intelligent Systems Laboratory, University of Bristol, Bristol BS8 1UB, UK.|MRC Centre for Causal Analyses in Translational Epidemiology, MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Clifton BS8 2BN, UK and Intelligent Systems Laboratory, University of Bristol, Bristol BS8 1UB, UK.|MRC Centre for Causal Analyses in Translational Epidemiology, MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Clifton BS8 2BN, UK and Intelligent Systems Laboratory, University of Bristol, Bristol BS8 1UB, UK.