Department of Biomedical Informatics, Arizona State University, Scottsdale, AZ 85259, USA.|Department of Biomedical Informatics, Arizona State University, Scottsdale, AZ 85259, USA.|Institute of Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.|Department of Biomedical Informatics, Arizona State University, Scottsdale, AZ 85259, USA.|Department of Biomedical Informatics, Arizona State University, Scottsdale, AZ 85259, USA.|Institute of Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.