Virginia Polytechnic Institute and State University, Virginia Bioinformatics Institute, 1880 Pratt Drive, Blacksburg 24061, USA. alf@vbi.vt.edu <alf@vbi.vt.edu>|Virginia Polytechnic Institute and State University, Virginia Bioinformatics Institute, 1880 Pratt Drive, Blacksburg 24061, USA. alf@vbi.vt.edu <alf@vbi.vt.edu>|Virginia Polytechnic Institute and State University, Virginia Bioinformatics Institute, 1880 Pratt Drive, Blacksburg 24061, USA. alf@vbi.vt.edu <alf@vbi.vt.edu>|Virginia Polytechnic Institute and State University, Virginia Bioinformatics Institute, 1880 Pratt Drive, Blacksburg 24061, USA. alf@vbi.vt.edu <alf@vbi.vt.edu>