Oxford Centre for Integrative Systems Biology, Department of Biochemistry, University of Oxford, Oxford, United Kingdom.|Department of Biological Sciences, Virginia Tech, Blacksburg, Virginia, United States of America.|Institut de Génétique et Développement de Rennes, CNRS UMR 6290, Rennes, France.|Oxford Centre for Integrative Systems Biology, Department of Biochemistry, University of Oxford, Oxford, United Kingdom.