Statistical Cancer Genomics, Paul OGorman Building, UCL Cancer Institute, University College London, London WC1E 6BT, UK, Department of Computer Science, University College London, London WC1E 6BT, UK, Centre of Mathematics and Physics in the Life Sciences and Experimental Biology, University College London, London WC1E 6BT, UK.|Department of Computer Science, University College London, London WC1E 6BT, UK.|Breast Cancer Functional Genomics Laboratory, Cancer Research UK, Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, UK.|Statistical Cancer Genomics, Paul OGorman Building, UCL Cancer Institute, University College London, London WC1E 6BT, UK, CAS-MPG Partner Institute for Computational Biology, Chinese Academy of Sciences, Shanghai Institute for Biological Sciences, 320 Yue Yang Road, Shanghai 200031, China.