Laboratory of Disease Genomics and Personalized Medicine & Center of Computational Biology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100029, China, University of Chinese Academy of Sciences, Beijing 100049, China, Department of Computer Science, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA, Department of Epidemiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100730, China and Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637, USA.|Laboratory of Disease Genomics and Personalized Medicine & Center of Computational Biology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100029, China, University of Chinese Academy of Sciences, Beijing 100049, China, Department of Computer Science, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA, Department of Epidemiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100730, China and Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637, USA.|Laboratory of Disease Genomics and Personalized Medicine & Center of Computational Biology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100029, China, University of Chinese Academy of Sciences, Beijing 100049, China, Department of Computer Science, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA, Department of Epidemiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100730, China and Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637, USA.|Laboratory of Disease Genomics and Personalized Medicine & Center of Computational Biology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100029, China, University of Chinese Academy of Sciences, Beijing 100049, China, Department of Computer Science, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA, Department of Epidemiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100730, China and Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637, USA.|Laboratory of Disease Genomics and Personalized Medicine & Center of Computational Biology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100029, China, University of Chinese Academy of Sciences, Beijing 100049, China, Department of Computer Science, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA, Department of Epidemiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100730, China and Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637, USA.|Laboratory of Disease Genomics and Personalized Medicine & Center of Computational Biology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100029, China, University of Chinese Academy of Sciences, Beijing 100049, China, Department of Computer Science, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA, Department of Epidemiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100730, China and Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637, USA.|Laboratory of Disease Genomics and Personalized Medicine & Center of Computational Biology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100029, China, University of Chinese Academy of Sciences, Beijing 100049, China, Department of Computer Science, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA, Department of Epidemiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100730, China and Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637, USA.|Laboratory of Disease Genomics and Personalized Medicine & Center of Computational Biology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100029, China, University of Chinese Academy of Sciences, Beijing 100049, China, Department of Computer Science, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA, Department of Epidemiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100730, China and Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637, USA.|Laboratory of Disease Genomics and Personalized Medicine & Center of Computational Biology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100029, China, University of Chinese Academy of Sciences, Beijing 100049, China, Department of Computer Science, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA, Department of Epidemiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100730, China and Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637, USA.