UCD Conway Institute of Biomolecular and Biomedical Sciences, University College Dublin, Dublin, 4, Ireland. peter.jehl@ucdconnect.ie.|UCD Conway Institute of Biomolecular and Biomedical Sciences, University College Dublin, Dublin, 4, Ireland. fabian.sievers@ucd.ie.|UCD Conway Institute of Biomolecular and Biomedical Sciences, University College Dublin, Dublin, 4, Ireland. des.higgins@ucd.ie.