Department of Biostatistics, Bioinformatics and Biomathematics, Georgetown University Washington DC 20057, USA.|Department of Biostatistics, Bioinformatics and Biomathematics, Georgetown University Washington DC 20057, USA.|Department of Biostatistics, Bioinformatics and Biomathematics, Georgetown University Washington DC 20057, USA.|Department of Biostatistics, Bioinformatics and Biomathematics, Georgetown University Washington DC 20057, USA.