Department of Biostatistics and Bioinformatics, Emory University, 1518 Clifton Road, Atlanta, 30322, GA, USA.|Department of Biostatistics and Bioinformatics, Emory University, 1518 Clifton Road, Atlanta, 30322, GA, USA.|Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, 423 Guardian Drive, Philadelphia, 19104, PA, USA. qlong@mail.med.upenn.edu.