MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK. daniel.clutterbuck@hgu.mrc.ac.uk|MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK. daniel.clutterbuck@hgu.mrc.ac.uk|MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK. daniel.clutterbuck@hgu.mrc.ac.uk|MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK. daniel.clutterbuck@hgu.mrc.ac.uk