Division of Biomedical Statistics and Informatics and Center for Individualized Medicine, Mayo Clinic, Rochester, MN 55905,USA, Department of Computer Science, Emory University, Atlanta, GA 30322,USA.|Department of Operations Research and Financial Engineering, Princeton University, Princeton, NJ 08544, USA and.|Division of Biomedical Statistics and Informatics and Center for Individualized Medicine, Mayo Clinic, Rochester, MN 55905,USA.|Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA 19104, USA.|Division of Biomedical Statistics and Informatics and Center for Individualized Medicine, Mayo Clinic, Rochester, MN 55905,USA.