Novartis Pharma AG, Postfach, Basel, Switzerland. sven.schuierer@novartis.com|Novartis Pharma AG, Postfach, Basel, Switzerland. sven.schuierer@novartis.com|Novartis Pharma AG, Postfach, Basel, Switzerland. sven.schuierer@novartis.com|Novartis Pharma AG, Postfach, Basel, Switzerland. sven.schuierer@novartis.com