Division of Cancer Biology, The Institute of Cancer Research, London SW3xe2x80x896JB, UK.|Division of Cancer Biology, The Institute of Cancer Research, London SW3xe2x80x896JB, UK.|Department of Computational Systems Medicine, Imperial College, South Kensington Campus, London SW7xe2x80x892AZ, UK.|Division of Cancer Biology, The Institute of Cancer Research, London SW3xe2x80x896JB, UK.