Institute for Medical Informatics and Biometry, University of Rostock, Rembrandt-Str, 16/17, 18055 Rostock, Germany. thomas.karopka@uni-rostock.de|Institute for Medical Informatics and Biometry, University of Rostock, Rembrandt-Str, 16/17, 18055 Rostock, Germany. thomas.karopka@uni-rostock.de|Institute for Medical Informatics and Biometry, University of Rostock, Rembrandt-Str, 16/17, 18055 Rostock, Germany. thomas.karopka@uni-rostock.de|Institute for Medical Informatics and Biometry, University of Rostock, Rembrandt-Str, 16/17, 18055 Rostock, Germany. thomas.karopka@uni-rostock.de