The Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA. pye@jhu.edu|The Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA. pye@jhu.edu|The Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA. pye@jhu.edu|The Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA. pye@jhu.edu