University of Edinburgh, Kings Buildings, West Mains Road, Edinburgh, EH9 3JT, UK. jerome.kelleher@ed.ac.uk.|University of Edinburgh, Kings Buildings, West Mains Road, Edinburgh, EH9 3JT, UK. jerome.kelleher@ed.ac.uk.|Center for Quantitative Sciences, Vanderbilt University, 571 Preston Building Nashville, TN, USA. yu.shyr@vanderbilt.edu.