Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, UK. holdenbj@hotmail.com <holdenbj@hotmail.com>|Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, UK. holdenbj@hotmail.com <holdenbj@hotmail.com>|Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, UK. holdenbj@hotmail.com <holdenbj@hotmail.com>|Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, UK. holdenbj@hotmail.com <holdenbj@hotmail.com>|Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, UK. holdenbj@hotmail.com <holdenbj@hotmail.com>