Somatic DNA recombination, the hallmark of vertebrate adaptive immunity, has the potential to generate a vast diversity of antigen receptor sequences. How this diversity captures antigen specificity remains incompletely understood. In this study we use high throughput sequencing to compare the global changes in T cell receptor xcexb2 chain complementarity determining region 3 (CDR3xcexb2) sequences following immunization with ovalbumin administered with complete Freunds adjuvant (CFA) or CFA alone.