Center for Bioinformatics, University of Pennsylvania, 1429 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104-6021, USA. ggrant@pcbi.upenn.edu|Center for Bioinformatics, University of Pennsylvania, 1429 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104-6021, USA. ggrant@pcbi.upenn.edu|Center for Bioinformatics, University of Pennsylvania, 1429 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104-6021, USA. ggrant@pcbi.upenn.edu