Computational and Systems Biology, Genome Institute of Singapore, Singapore 138672, Singapore Computational Biology Program, Faculty of Science.|Computational and Systems Biology, Genome Institute of Singapore, Singapore 138672, Singapore Department of Computer Science, National University of Singapore, Singapore, Singapore.|Computational and Systems Biology, Genome Institute of Singapore, Singapore 138672, Singapore.|Computational and Systems Biology, Genome Institute of Singapore, Singapore 138672, Singapore Department of Computer Science, National University of Singapore, Singapore, Singapore.