Department of Computational Biology, Graduate School of Frontier Sciences, University of Tokyo, 5-1-5 Kashiwanoha, Chiba-ken 277-8561, Tokyo 135-0064, Japan. rwan@cuhk.edu.hk|Department of Computational Biology, Graduate School of Frontier Sciences, University of Tokyo, 5-1-5 Kashiwanoha, Chiba-ken 277-8561, Tokyo 135-0064, Japan. rwan@cuhk.edu.hk|Department of Computational Biology, Graduate School of Frontier Sciences, University of Tokyo, 5-1-5 Kashiwanoha, Chiba-ken 277-8561, Tokyo 135-0064, Japan. rwan@cuhk.edu.hk