Research Group Theoretical Systems Biology, Faculty of Biology and Pharmacy, Friedrich Schiller University Jena, 07743 Jena, Department of Bioorganic Chemistry, Experimental Ecology and Evolution Research Group, Max Planck Institute for Chemical Ecology, 07745 Jena, Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knxc3xb6ll Institute, 07745 Jena and Department of Computational Biology, Institute for Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense M, Denmark.