Department of Biostatistics, University of Michigan, 1415 Washington Heights, Ann Arbor, USA. zhaolili@umich.edu.|Department of Microbiology and Immunology, School of medicine, University of Michigan, Ann Arbor, USA.|BRCF Bioinformatics Core, University of Michigan, Ann Arbor, USA.|Department of Microbiology and Immunology, School of medicine, University of Michigan, Ann Arbor, USA.|Department of Pathology, School of medicine, University of Michigan, Ann Arbor, USA.