Department of Biostatistics and Center for Statistical Genetics and Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109, USA. mreppell@umich.edu|Department of Biostatistics and Center for Statistical Genetics and Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109, USA. mreppell@umich.edu|Department of Biostatistics and Center for Statistical Genetics and Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109, USA. mreppell@umich.edu