Research and Development Informatics, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA. ge@amgen.com|Research and Development Informatics, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA. ge@amgen.com|Research and Development Informatics, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA. ge@amgen.com|Research and Development Informatics, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA. ge@amgen.com|Research and Development Informatics, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA. ge@amgen.com|Research and Development Informatics, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA. ge@amgen.com