Medical Department, University Leipzig Germany. thomas.villmann@medizin.uni-leipzig.de|Medical Department, University Leipzig Germany. thomas.villmann@medizin.uni-leipzig.de|Medical Department, University Leipzig Germany. thomas.villmann@medizin.uni-leipzig.de|Medical Department, University Leipzig Germany. thomas.villmann@medizin.uni-leipzig.de|Medical Department, University Leipzig Germany. thomas.villmann@medizin.uni-leipzig.de