Shanghai Research Centre of Biotechnology, Chinese Academy of Sciences, Shanghai, 200233, China. y.cai@umist.ac.uk|Shanghai Research Centre of Biotechnology, Chinese Academy of Sciences, Shanghai, 200233, China. y.cai@umist.ac.uk|Shanghai Research Centre of Biotechnology, Chinese Academy of Sciences, Shanghai, 200233, China. y.cai@umist.ac.uk|Shanghai Research Centre of Biotechnology, Chinese Academy of Sciences, Shanghai, 200233, China. y.cai@umist.ac.uk