Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Oxford, OX3 7DQ, UK.|Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Oxford, OX3 7DQ, UK.|Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7BN, UK.|Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7BN, UK.|Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7BN, UK.|Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7BN, UK.|Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7BN, UK.|Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7BN, UK.|Public Health England, Colindale, London, UK.|Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Oxford, OX3 7DQ, UK.|Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Oxford, OX3 7DQ, UK.