Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.|Novo Nordisk Research Centre Oxford, Oxford, UK.|Department of Health Sciences Research.|Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.|Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.|Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.|Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.