Division of Biomedical Informatics, University of California at San Diego, Department of Computer Science and Engineering, University of California at San Diego, La Jolla, CA 92093, USA, Biomedical Informatics Program, School of Informatics, University of Applied Sciences Upper Austria, Softwarepark 11, 4232 Hagenberg, Austria and Department of Biostatistics and Biomedical Informatics, Duke University, Durham, NC 27710, USA Division of Biomedical Informatics, University of California at San Diego, Department of Computer Science and Engineering, University of California at San Diego, La Jolla, CA 92093, USA, Biomedical Informatics Program, School of Informatics, University of Applied Sciences Upper Austria, Softwarepark 11, 4232 Hagenberg, Austria and Department of Biostatistics and Biomedical Informatics, Duke University, Durham, NC 27710, USA.