Wilmer Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.|Wilmer Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.|Wilmer Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.|Wilmer Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.|Wilmer Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.