Center for Computational Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA. Larry.Hunter@uchsc.edu|Center for Computational Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA. Larry.Hunter@uchsc.edu|Center for Computational Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA. Larry.Hunter@uchsc.edu|Center for Computational Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA. Larry.Hunter@uchsc.edu|Center for Computational Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA. Larry.Hunter@uchsc.edu|Center for Computational Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA. Larry.Hunter@uchsc.edu|Center for Computational Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA. Larry.Hunter@uchsc.edu