Institute for Biotechnology and Bioengineering, Center of Biological Engineering, University of Minho. analia@deb.uminho.pt|Institute for Biotechnology and Bioengineering, Center of Biological Engineering, University of Minho. analia@deb.uminho.pt|Institute for Biotechnology and Bioengineering, Center of Biological Engineering, University of Minho. analia@deb.uminho.pt|Institute for Biotechnology and Bioengineering, Center of Biological Engineering, University of Minho. analia@deb.uminho.pt|Institute for Biotechnology and Bioengineering, Center of Biological Engineering, University of Minho. analia@deb.uminho.pt