Department of Experimental Medicine, University of Perugia, via del Giochetto, Perugia 06100, Italy.|Department of Experimental Medicine, University of Perugia, via del Giochetto, Perugia 06100, Italy.|Department of Experimental Medicine, University of Perugia, via del Giochetto, Perugia 06100, Italy.|Department of Experimental Medicine, University of Perugia, via del Giochetto, Perugia 06100, Italy.|Department of Experimental Medicine, University of Perugia, via del Giochetto, Perugia 06100, Italy.