Department of Genetics and Development, Columbia University, New York, NY 10032, USA.|Department of Genetics and Development, Columbia University, New York, NY 10032, USA.|Department of Genetics and Development, Columbia University, New York, NY 10032, USA.|Department of Genetics and Development, Columbia University, New York, NY 10032, USA.|Department of Genetics and Development, Columbia University, New York, NY 10032, USA.