Department of Microbiology, Miami University, Oxford, Ohio, United States of America, Department of Computer Science and Software Engineering, Miami University, Oxford, Ohio, United States of America.|Centre for Molecular Processing, School of Biosciences, University of Kent, Canterbury, Kent, United Kingdom.|The Buck Institute for Research on Aging, Novato, California, United States of America.|Department of Computer Science and Informatics, Indiana University, Bloomington, Indiana, United States of America.