The Eli & Edythe L. Broad Institute, Massachusetts Institute of Technology and Harvard University 320 Charles Street, Cambridge, MA 02141, USA. tarjei@broad.mit.edu|The Eli & Edythe L. Broad Institute, Massachusetts Institute of Technology and Harvard University 320 Charles Street, Cambridge, MA 02141, USA. tarjei@broad.mit.edu|The Eli & Edythe L. Broad Institute, Massachusetts Institute of Technology and Harvard University 320 Charles Street, Cambridge, MA 02141, USA. tarjei@broad.mit.edu