Department of Nonclinical Biostatistics, Johnson & Johnson PRD LLC, Raritan, NJ 08869, USA. damaratu@prdus.jnj.com|Department of Nonclinical Biostatistics, Johnson & Johnson PRD LLC, Raritan, NJ 08869, USA. damaratu@prdus.jnj.com|Department of Nonclinical Biostatistics, Johnson & Johnson PRD LLC, Raritan, NJ 08869, USA. damaratu@prdus.jnj.com