The Telethon Institute of Genetics and Medicine, Naples, Italy. gennaro.1.gambardella@kcl.ac.uk.|The Telethon Institute of Genetics and Medicine, Naples, Italy. peluso@tigem.it.|The Telethon Institute of Genetics and Medicine, Naples, Italy. montefusco@tigem.it.|Columbia Initiative in Systems Biology and Center for Computational Biology and Bioinformatics, Columbia University, New York, NY, USA. mb3113@c2b2.columbia.edu.|The Telethon Institute of Genetics and Medicine, Naples, Italy. medina@tigem.it.|Department of Computer Science, University of Sheffield, Sheffield, UK. N.Lawrence@dcs.sheffield.ac.uk.|The Telethon Institute of Genetics and Medicine, Naples, Italy. dibernardo@tigem.it.