Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA Departments of Medicine and Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA and Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.|Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA Departments of Medicine and Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA and Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.|Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA Departments of Medicine and Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA and Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.|Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA Departments of Medicine and Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA and Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.|Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA Departments of Medicine and Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA and Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.|Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA Departments of Medicine and Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA and Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.|Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA Departments of Medicine and Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA and Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.