Department of Biostatistics, Virginia Commonwealth University Box 980032, Richmond, VA 23298-0032, USA. rkennedy@vcu.edu|Department of Biostatistics, Virginia Commonwealth University Box 980032, Richmond, VA 23298-0032, USA. rkennedy@vcu.edu|Department of Biostatistics, Virginia Commonwealth University Box 980032, Richmond, VA 23298-0032, USA. rkennedy@vcu.edu|Department of Biostatistics, Virginia Commonwealth University Box 980032, Richmond, VA 23298-0032, USA. rkennedy@vcu.edu|Department of Biostatistics, Virginia Commonwealth University Box 980032, Richmond, VA 23298-0032, USA. rkennedy@vcu.edu