Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA. acmg@bioinfo.mbb.yale.edu|Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA. acmg@bioinfo.mbb.yale.edu|Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA. acmg@bioinfo.mbb.yale.edu