Faculty of Life Sciences, University of Manchester, Manchester, UK. james.eales@postgrad.manchester.ac.uk|Faculty of Life Sciences, University of Manchester, Manchester, UK. james.eales@postgrad.manchester.ac.uk|Faculty of Life Sciences, University of Manchester, Manchester, UK. james.eales@postgrad.manchester.ac.uk|Faculty of Life Sciences, University of Manchester, Manchester, UK. james.eales@postgrad.manchester.ac.uk