Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.|Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.|Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.|UCL Genetics Institute, University College London, London WC1E6BT, UK.|Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.