M.R.C. Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, UK. c.semple@hgu.mrc.ac.uk|M.R.C. Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, UK. c.semple@hgu.mrc.ac.uk|M.R.C. Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, UK. c.semple@hgu.mrc.ac.uk|M.R.C. Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, UK. c.semple@hgu.mrc.ac.uk