MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK. apic@mrc-lmb.cam.ac.uk|MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK. apic@mrc-lmb.cam.ac.uk|MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK. apic@mrc-lmb.cam.ac.uk