Department of Biostatistics, University at Buffalo Buffalo, NY 14226, USA. yliang@buffalo.edu|Department of Biostatistics, University at Buffalo Buffalo, NY 14226, USA. yliang@buffalo.edu|Department of Biostatistics, University at Buffalo Buffalo, NY 14226, USA. yliang@buffalo.edu|Department of Biostatistics, University at Buffalo Buffalo, NY 14226, USA. yliang@buffalo.edu