Department of Pharmacology and Toxicology, University of Texas Medical Branch-Galveston, Galveston, USA.|Department of Pharmacology and Toxicology, University of Texas Medical Branch-Galveston, Galveston, USA.|Department of Pharmacology and Toxicology, University of Texas Medical Branch-Galveston, Galveston, USA.|Department of Pharmacology and Toxicology, University of Texas Medical Branch-Galveston, Galveston, USA.