Ontario Institute for Cancer Research, M5G 0A3, Toronto, Canada. Paul.Boutros@oicr.on.ca.|Ontario Institute for Cancer Research, M5G 0A3, Toronto, Canada. Paul.Boutros@oicr.on.ca.|Ontario Institute for Cancer Research, M5G 0A3, Toronto, Canada. Paul.Boutros@oicr.on.ca.|Ontario Institute for Cancer Research, M5G 0A3, Toronto, Canada. Paul.Boutros@oicr.on.ca.|Ontario Institute for Cancer Research, M5G 0A3, Toronto, Canada. Paul.Boutros@oicr.on.ca.|Ontario Institute for Cancer Research, M5G 0A3, Toronto, Canada. Paul.Boutros@oicr.on.ca.|Department of Pharmacology and Systems Therapeutics, Systems Biology Center New York (SBCNY), Icahn School of Medicine at Mount Sinai School, New York, NY 10029, USA. avi.maayan@mssm.edu.