Department of Bioinformatics and Computational Biology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd Houston, TX 77030, USA. jalmeida@mathbiol.org|Department of Bioinformatics and Computational Biology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd Houston, TX 77030, USA. jalmeida@mathbiol.org|Department of Bioinformatics and Computational Biology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd Houston, TX 77030, USA. jalmeida@mathbiol.org