School of Mathematical Sciences and LPMC, Nankai University, Tianjin, 300071, PR China, Department of Biochemistry, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Electrical and Computer Engineering, University of Alberta, Edmonton, Alberta, T6G 2R3, Canada and State Key Laboratory for Medicinal Chemical Biology, Nankai University, Tianjin, 300071, PR China School of Mathematical Sciences and LPMC, Nankai University, Tianjin, 300071, PR China, Department of Biochemistry, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Electrical and Computer Engineering, University of Alberta, Edmonton, Alberta, T6G 2R3, Canada and State Key Laboratory for Medicinal Chemical Biology, Nankai University, Tianjin, 300071, PR China.