Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland, Helsinki Institute for Information Technology HIIT, Department of Computer Science, Aalto University, Espoo, Finland.|Helsinki Institute for Information Technology HIIT, Department of Computer Science, Aalto University, Espoo, Finland.|Helsinki Institute for Information Technology HIIT, Department of Computer Science, Aalto University, Espoo, Finland.|Computational Medicine, University of Oulu, Oulu University Hospital and Biocenter Oulu, Oulu, Finland.|Computational Medicine, University of Oulu, Oulu University Hospital and Biocenter Oulu, Oulu, Finland, NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland.|Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere School of Medicine, Tampere, Finland.|Department of Clinical Physiology and Nuclear Medicine, University of Turku and Turku University Hospital, Turku, Finland, Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.|Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment & Health, School of Public Health, Imperial College London, London, UK, Centre for Life Course Epidemiology, Faculty of Medicine, University of Oulu, Oulu, Finland, Biocenter Oulu, University of Oulu, Oulu, Finland, Unit of Primary Care, Oulu University Hospital, Oulu, Finland.|National Institute for Health and Welfare, Helsinki, Finland.|Computational Medicine, University of Oulu, Oulu University Hospital and Biocenter Oulu, Oulu, Finland, NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, Computational Medicine, School of Social and Community Medicine and the Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.|Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland, Public Health, University of Helsinki, Helsinki, Finland and Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.|Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland.