Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.|Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.|Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.|Department of Chemistry, State University of New York at Oswego, Oswego, NY 13126, USA.|Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.|Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.