Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, North Carolina 27710, USA. insuk.sohn@duke.edu|Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, North Carolina 27710, USA. insuk.sohn@duke.edu|Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, North Carolina 27710, USA. insuk.sohn@duke.edu|Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, North Carolina 27710, USA. insuk.sohn@duke.edu|Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, North Carolina 27710, USA. insuk.sohn@duke.edu