Department of Family, Population & Preventive Medicine, Stony Brook University, Stony Brook, NY 11794, USA, Department of Pathology, Yale School of Medicine, New Haven, CT 06520, USA.|Departments of Biostatistics and Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.|Department of Biostatistics.|Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, Department of Pathology, Yale School of Medicine, New Haven, CT 06520, USA.|Department of Statistics, University of California, Davis, CA 9516, USA.|Department of Statistics, The Wharton School, University of Pennsylvania, PA 19104, USA and.|Department of Pathology, Stony Brook University, Stony Brook, NY 11794, USA.|Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, Department of Pathology, Yale School of Medicine, New Haven, CT 06520, USA.