Department of Biostatistics and Bioinformatics, Duke University, Durham, NC 27708, USA. kepler@duke.edu|Department of Biostatistics and Bioinformatics, Duke University, Durham, NC 27708, USA. kepler@duke.edu|Department of Biostatistics and Bioinformatics, Duke University, Durham, NC 27708, USA. kepler@duke.edu|Department of Biostatistics and Bioinformatics, Duke University, Durham, NC 27708, USA. kepler@duke.edu|Department of Biostatistics and Bioinformatics, Duke University, Durham, NC 27708, USA. kepler@duke.edu|Department of Biostatistics and Bioinformatics, Duke University, Durham, NC 27708, USA. kepler@duke.edu