Faculty of Life Sciences and School of Computer Science, University of Manchester, UK. divoli@bioinf.man.ac.uk|Faculty of Life Sciences and School of Computer Science, University of Manchester, UK. divoli@bioinf.man.ac.uk|Faculty of Life Sciences and School of Computer Science, University of Manchester, UK. divoli@bioinf.man.ac.uk|Faculty of Life Sciences and School of Computer Science, University of Manchester, UK. divoli@bioinf.man.ac.uk|Faculty of Life Sciences and School of Computer Science, University of Manchester, UK. divoli@bioinf.man.ac.uk