Department of Biostatistics, Boston University, 801 Massachusetts Avenue, Boston, Massachusetts, USA.|Department of Neurology, Boston University, 72 East Concord Street, Boston, Massachusetts, USA.|Department of Neurology, Boston University, 72 East Concord Street, Boston, Massachusetts, USA.|Department of Biostatistics, Boston University, 801 Massachusetts Avenue, Boston, Massachusetts, USA.|Department of Biostatistics, Boston University, 801 Massachusetts Avenue, Boston, Massachusetts, USA.|Department of Biostatistics, Boston University, 801 Massachusetts Avenue, Boston, Massachusetts, USA. adestef@bu.edu.