School of Life Science and Technology, Tongji University, Shanghai 200092, PR China. yqchen@scbit.org|School of Life Science and Technology, Tongji University, Shanghai 200092, PR China. yqchen@scbit.org|School of Life Science and Technology, Tongji University, Shanghai 200092, PR China. yqchen@scbit.org|School of Life Science and Technology, Tongji University, Shanghai 200092, PR China. yqchen@scbit.org