Centre for Computational Systems Biology, School of Mathematical Sciences, Fudan University, Shanghai, China.|School of Computer Science and Shanghai Key Lab of Intelligent Information Processing, Fudan University, Shanghai, China.|Quantitative and Computational Biology Program, Department of Biological Sciences, University of Southern California, Los Angeles, California, United States of America.|Centre for Computational Systems Biology, School of Mathematical Sciences, Fudan University, Shanghai, China.|School of Computer Science and Shanghai Key Lab of Intelligent Information Processing, Fudan University, Shanghai, China.