Division of Biometry and Risk Assessment, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, USA. jamesJ.chen@fda.hhs.gov|Division of Biometry and Risk Assessment, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, USA. jamesJ.chen@fda.hhs.gov|Division of Biometry and Risk Assessment, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, USA. jamesJ.chen@fda.hhs.gov|Division of Biometry and Risk Assessment, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, USA. jamesJ.chen@fda.hhs.gov