In cancer research, most clinical variables have already been investigated and are now well established. The use of transcriptomic variables has raised two problems: restricting their number and validating their significance. Thus, their contribution to prognosis is currently thought to be overestimated. The aim of this study was to determine to what extent optimism concerning current transcriptomic models may lead to overestimation of the contribution of transcriptomic variables to survival prognosis.