Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Ihnesstrasse 63-73, Berlin, 14195, Germany. heinig@molgen.mpg.de.|Quantitative Epigenetics, European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, A. Deusinglaan 1, AV, Groningen, 9713, The Netherlands. m.colome.tatche@umcg.nl.|Quantitative Epigenetics, European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, A. Deusinglaan 1, AV, Groningen, 9713, The Netherlands. a.s.taudt@umcg.nl.|Experimental Genetics Group, Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Strasse 10, 13092Berlin, Germany. carola.rintisch@mdc-berlin.de.|Experimental Genetics Group, Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Strasse 10, 13092Berlin, Germany. sebastian.schaefer@mdc-berlin.de.|Institute of Physiology, Academy of Sciences of the Czeck Republic, Videnska 1083, Prague, 14220, Czech Republic. pravenec@biomed.cas.cz.|Experimental Genetics Group, Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Strasse 10, 13092Berlin, Germany. nhuebner@mdc-berlin.de.|Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Ihnesstrasse 63-73, Berlin, 14195, Germany. vingron@molgen.mpg.de.|Groningen Bioinformatics Center, University of Groningen, Nijenborgh 7, AG, Groningen, 9747, The Netherlands. frank@johanneslab.org.