Department of Computer Science, The University of Hong Kong, Hong Kong, China, BGI-Shenzhen, Shenzhen, China, Department of Biology, University of Copenhagen, Copenhagen, Denmark, King Abdulaziz University, Jeddah, Saudi Arabia, The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen and Guangzhou Key Laboratory of Cancer Trans-Omics Research, BGI-Guangzhou, Guangzhou, China.