Cambridge Research Institute, Cancer Research UK, Li Ka Shing Centre, Cambridge CB2 0RE, UK. yinyin.yuan@cancer.org.uk|Cambridge Research Institute, Cancer Research UK, Li Ka Shing Centre, Cambridge CB2 0RE, UK. yinyin.yuan@cancer.org.uk|Cambridge Research Institute, Cancer Research UK, Li Ka Shing Centre, Cambridge CB2 0RE, UK. yinyin.yuan@cancer.org.uk|Cambridge Research Institute, Cancer Research UK, Li Ka Shing Centre, Cambridge CB2 0RE, UK. yinyin.yuan@cancer.org.uk