Center for Biomedical Informatics and Biostatistics (CB2) Graduate Interdisciplinary Program in Statistics Department of Medicine BIO5 Institute, The University of Arizona, Tucson, AZ 85721, USA.|Center for Biomedical Informatics and Biostatistics (CB2) Graduate Interdisciplinary Program in Statistics Department of Medicine BIO5 Institute, The University of Arizona, Tucson, AZ 85721, USA.|Division of Bioinformatics, Departments of Biomedical Informatics Division of Medical Oncology, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA.|Center for Biomedical Informatics and Biostatistics (CB2) Department of Medicine BIO5 Institute, The University of Arizona, Tucson, AZ 85721, USA.|Center for Biomedical Informatics and Biostatistics (CB2) Department of Medicine BIO5 Institute, The University of Arizona, Tucson, AZ 85721, USA.|Center for Biomedical Informatics and Biostatistics (CB2) Graduate Interdisciplinary Program in Statistics BIO5 Institute, The University of Arizona, Tucson, AZ 85721, USA.|Center for Biomedical Informatics and Biostatistics (CB2) Department of Medicine BIO5 Institute, The University of Arizona, Tucson, AZ 85721, USA.|Graduate Interdisciplinary Program in Statistics BIO5 Institute, The University of Arizona, Tucson, AZ 85721, USA.|Center for Biomedical Informatics and Biostatistics (CB2) Graduate Interdisciplinary Program in Statistics Department of Medicine BIO5 Institute, The University of Arizona, Tucson, AZ 85721, USA The University of Arizona Cancer Center, Tucson, AZ 85719, USA Institute for Genomics and Systems Biology, The University of Chicago, Chicago, IL, 60637, USA.