Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA.|Biomedical and Translational Informatics Institute, Geisinger, Danville, PA, 17822 USA.|Biomedical and Translational Informatics Institute, Geisinger, Danville, PA, 17822 USA.|Biomedical and Translational Informatics Institute, Geisinger, Danville, PA, 17822 USA.|Biomedical and Translational Informatics Institute, Geisinger, Danville, PA, 17822 USA.