Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, 55131 Mainz, Germany.|Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, 55131 Mainz, Germany.|Department of Internal Medicine III, University Hospital of Ulm, 89081 Ulm, Germany.|Department of Internal Medicine III, University Hospital of Ulm, 89081 Ulm, Germany.|Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, 55131 Mainz, Germany.