Department of Bioinformatics and Computational Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA and Department of Statistics, University of California at Davis, Davis, CA 95616, USA.|Department of Bioinformatics and Computational Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA and Department of Statistics, University of California at Davis, Davis, CA 95616, USA.|Department of Bioinformatics and Computational Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA and Department of Statistics, University of California at Davis, Davis, CA 95616, USA.|Department of Bioinformatics and Computational Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA and Department of Statistics, University of California at Davis, Davis, CA 95616, USA.|Department of Bioinformatics and Computational Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA and Department of Statistics, University of California at Davis, Davis, CA 95616, USA.|Department of Bioinformatics and Computational Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA and Department of Statistics, University of California at Davis, Davis, CA 95616, USA.|Department of Bioinformatics and Computational Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA and Department of Statistics, University of California at Davis, Davis, CA 95616, USA.