Department of Biostatistics and Applied Mathematics, University of Texas M.D. Anderson Cancer Center, TX 77030-4009, USA. jhu@mdanderson.org|Department of Biostatistics and Applied Mathematics, University of Texas M.D. Anderson Cancer Center, TX 77030-4009, USA. jhu@mdanderson.org|Department of Biostatistics and Applied Mathematics, University of Texas M.D. Anderson Cancer Center, TX 77030-4009, USA. jhu@mdanderson.org