Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA. matthew.holford@yale.edu|Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA. matthew.holford@yale.edu|Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA. matthew.holford@yale.edu|Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA. matthew.holford@yale.edu