Human Genetic Center, University of Texas Health Science Center at Houston, Houston, TX 77030, USA. mxiong@sph.uth.tmc.edu|Human Genetic Center, University of Texas Health Science Center at Houston, Houston, TX 77030, USA. mxiong@sph.uth.tmc.edu|Human Genetic Center, University of Texas Health Science Center at Houston, Houston, TX 77030, USA. mxiong@sph.uth.tmc.edu