Ontario Cancer Institute, UHN, 101 College Street, Toronto, Ontario M5G1L7, Canada. yniu@uhnres.utoronto.ca|Ontario Cancer Institute, UHN, 101 College Street, Toronto, Ontario M5G1L7, Canada. yniu@uhnres.utoronto.ca|Ontario Cancer Institute, UHN, 101 College Street, Toronto, Ontario M5G1L7, Canada. yniu@uhnres.utoronto.ca