Department of Molecular Sciences, AstraZeneca R&D Montreal, 7171 Frederick-Banting Street, St-Laurent, Quebec H4S 1Z9, Canada. jack.cao@astrazeneca.com|Department of Molecular Sciences, AstraZeneca R&D Montreal, 7171 Frederick-Banting Street, St-Laurent, Quebec H4S 1Z9, Canada. jack.cao@astrazeneca.com|Department of Molecular Sciences, AstraZeneca R&D Montreal, 7171 Frederick-Banting Street, St-Laurent, Quebec H4S 1Z9, Canada. jack.cao@astrazeneca.com|Department of Molecular Sciences, AstraZeneca R&D Montreal, 7171 Frederick-Banting Street, St-Laurent, Quebec H4S 1Z9, Canada. jack.cao@astrazeneca.com|Department of Molecular Sciences, AstraZeneca R&D Montreal, 7171 Frederick-Banting Street, St-Laurent, Quebec H4S 1Z9, Canada. jack.cao@astrazeneca.com|Department of Molecular Sciences, AstraZeneca R&D Montreal, 7171 Frederick-Banting Street, St-Laurent, Quebec H4S 1Z9, Canada. jack.cao@astrazeneca.com