Department of Medicine, Center for Computational Biology and Bioinformatics, University of California San Diego, La Jolla, CA 92093, USA.|Department of Medicine, Center for Computational Biology and Bioinformatics, University of California San Diego, La Jolla, CA 92093, USA.|Department of Medicine, Center for Computational Biology and Bioinformatics, University of California San Diego, La Jolla, CA 92093, USA.|Department of Medicine, Center for Computational Biology and Bioinformatics, University of California San Diego, La Jolla, CA 92093, USA.|Department of Medicine, Center for Computational Biology and Bioinformatics, University of California San Diego, La Jolla, CA 92093, USA.|Department of Medicine, Center for Computational Biology and Bioinformatics, University of California San Diego, La Jolla, CA 92093, USA.