Department of Statistics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.|Small Molecule Screening Facility, Drug Development Core, UW-Carbone Cancer Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.|Department of Mathematics and Institute for Mathematical Science, National University of Singapore, Singapore.|Small Molecule Screening Facility, Drug Development Core, UW-Carbone Cancer Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.|Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.|Department of Statistics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.|Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennesse, United States of America.|Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.|Department of Computer Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.|Small Molecule Screening Facility, Drug Development Core, UW-Carbone Cancer Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.|Small Molecule Screening Facility, Drug Development Core, UW-Carbone Cancer Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.|Department of Statistics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.