Institute of Genetic Medicine, Newcastle University, Newcastle Upon Tyne, UK. g.izuogu@ncl.ac.uk.|Institute of Genetic Medicine, Newcastle University, Newcastle Upon Tyne, UK. abd.al-hasan@newcastle.ac.uk.|Security Forces Hostpital, P. O. Box 2748-24268-8541, Makkah, Kingdom of Saudi Arabia. hani940@hotmail.com.|Institute of Genetic Medicine, Newcastle University, Newcastle Upon Tyne, UK. mauro.santibanez-koref@ncl.ac.uk.|Institute of Genetic Medicine, Newcastle University, Newcastle Upon Tyne, UK. mauro.santibanez-koref@ncl.ac.uk.|Institute of Genetic Medicine, Newcastle University, Newcastle Upon Tyne, UK. david.elliot@ncl.ac.uk.|Institute of Genetic Medicine, Newcastle University, Newcastle Upon Tyne, UK. michael.jackson@ncl.ac.uk.