University College London Genetics Institute, University College London, UK and North East Thames Regional Genetics Service, Great Ormond Street Hospital NHS Foundation Trust, London, UK.|University College London Genetics Institute, University College London, UK and North East Thames Regional Genetics Service, Great Ormond Street Hospital NHS Foundation Trust, London, UK.|University College London Genetics Institute, University College London, UK and North East Thames Regional Genetics Service, Great Ormond Street Hospital NHS Foundation Trust, London, UK.|University College London Genetics Institute, University College London, UK and North East Thames Regional Genetics Service, Great Ormond Street Hospital NHS Foundation Trust, London, UK.