Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.|Information Initiative Center, Hokkaido University, Sapporo 060-0811, Japan.|Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.|Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.|Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.