Algorithms|Analysis of Variance|Cells, Cultured|DNA, Bacterial|Drosophila Proteins|Gene Expression Regulation, Bacterial|Genome, Bacterial|Humans|Models, Genetic|Models, Statistical|Mutagenesis, Site-Directed|Mycobacterium tuberculosis|Oligonucleotide Array Sequence Analysis|Protein-Serine-Threonine Kinases|Quality Control|Reproducibility of Results|Sensitivity and Specificity