Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany. g.schramm@dkfz.de <g.schramm@dkfz.de>|Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany. g.schramm@dkfz.de <g.schramm@dkfz.de>|Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany. g.schramm@dkfz.de <g.schramm@dkfz.de>|Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany. g.schramm@dkfz.de <g.schramm@dkfz.de>