Center for Computational Biology and the Department of Genetics, Washington University, Saint Louis, MO 63110, USA. states@ccb.wustl.edu|Center for Computational Biology and the Department of Genetics, Washington University, Saint Louis, MO 63110, USA. states@ccb.wustl.edu|Center for Computational Biology and the Department of Genetics, Washington University, Saint Louis, MO 63110, USA. states@ccb.wustl.edu