Department of Statistics, University of Leeds, Leeds, LS2 9JT, UK.|Department of Thoracic Surgery, St. James Hospital, Leeds, LS9 7TF, UK.|Department of Statistics, University of Leeds, Leeds, LS2 9JT, UK.|Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, LS9 7TF, UK and King Fahad Medical City, Riyadh, Saudi Arabia.|Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, LS9 7TF, UK and.|Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, LS9 7TF, UK and.