University of California San Francisco, Department of Neurology, Institute of Human Genetics, San Francisco, CA 94158-2922, USA. jan.freudenberg@ucsf.edu|University of California San Francisco, Department of Neurology, Institute of Human Genetics, San Francisco, CA 94158-2922, USA. jan.freudenberg@ucsf.edu|University of California San Francisco, Department of Neurology, Institute of Human Genetics, San Francisco, CA 94158-2922, USA. jan.freudenberg@ucsf.edu