Institute for Systems Biology, Seattle, WA 98103, USA. pshannon@systemsbiology.org|Institute for Systems Biology, Seattle, WA 98103, USA. pshannon@systemsbiology.org|Institute for Systems Biology, Seattle, WA 98103, USA. pshannon@systemsbiology.org|Institute for Systems Biology, Seattle, WA 98103, USA. pshannon@systemsbiology.org