Department of Bioinformatics, Merck & Co., Inc., P.O. Box 2000, RY80-A1, Rahway, NJ 07065, USA. jeffrey_yuan@merck.com|Department of Bioinformatics, Merck & Co., Inc., P.O. Box 2000, RY80-A1, Rahway, NJ 07065, USA. jeffrey_yuan@merck.com|Department of Bioinformatics, Merck & Co., Inc., P.O. Box 2000, RY80-A1, Rahway, NJ 07065, USA. jeffrey_yuan@merck.com|Department of Bioinformatics, Merck & Co., Inc., P.O. Box 2000, RY80-A1, Rahway, NJ 07065, USA. jeffrey_yuan@merck.com|Department of Bioinformatics, Merck & Co., Inc., P.O. Box 2000, RY80-A1, Rahway, NJ 07065, USA. jeffrey_yuan@merck.com|Department of Bioinformatics, Merck & Co., Inc., P.O. Box 2000, RY80-A1, Rahway, NJ 07065, USA. jeffrey_yuan@merck.com|Department of Bioinformatics, Merck & Co., Inc., P.O. Box 2000, RY80-A1, Rahway, NJ 07065, USA. jeffrey_yuan@merck.com