Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, Food and Drug Administration Jefferson, Little Rock, Arkansas, USA. jamesj.chen@fda.hhs.gov.|Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, Food and Drug Administration Jefferson, Little Rock, Arkansas, USA. jamesj.chen@fda.hhs.gov.|Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, Food and Drug Administration Jefferson, Little Rock, Arkansas, USA. jamesj.chen@fda.hhs.gov.|Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, Food and Drug Administration Jefferson, Little Rock, Arkansas, USA. jamesj.chen@fda.hhs.gov.|Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, Food and Drug Administration Jefferson, Little Rock, Arkansas, USA. jamesj.chen@fda.hhs.gov.|Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, Food and Drug Administration Jefferson, Little Rock, Arkansas, USA. jamesj.chen@fda.hhs.gov.|Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, Food and Drug Administration Jefferson, Little Rock, Arkansas, USA. jamesj.chen@fda.hhs.gov.|Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, Food and Drug Administration Jefferson, Little Rock, Arkansas, USA. jamesj.chen@fda.hhs.gov.|Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, Food and Drug Administration Jefferson, Little Rock, Arkansas, USA. jamesj.chen@fda.hhs.gov.|Department of Computer Science, Old Dominion University, Norfolk, VA 23529, USA. sji@cs.odu.edu.