Laboratory of Computational Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, 5635 Fishers Ln, Bethesda, 20852, USA. juyong.lee@nih.gov.|Center for In Silico Protein Science, Korea Institute for Advanced Study, Seoul, Korea. kiholee@kias.re.kr.|Center for In Silico Protein Science, Korea Institute for Advanced Study, Seoul, Korea. isjoung@kias.re.kr.|Center for In Silico Protein Science, Korea Institute for Advanced Study, Seoul, Korea. newton@kias.re.kr.|Laboratory of Computational Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, 5635 Fishers Ln, Bethesda, 20852, USA. brb@nih.gov.|Center for In Silico Protein Science, Korea Institute for Advanced Study, Seoul, Korea. jlee@kias.re.kr.