Bioprocess Engineering Group, Spanish National Research Council, IIM-CSIC, Vigo, Spain.|Bioprocess Engineering Group, Spanish National Research Council, IIM-CSIC, Vigo, Spain.|Centre of Biological Engineering, University of Minho, Braga, Portugal.|Joint Research Center for Computational Biomedicine, RWTH-Aachen University, Aachen, Germany.|Bioprocess Engineering Group, Spanish National Research Council, IIM-CSIC, Vigo, Spain.