Department of Statistics, Yale University, New Haven, CT 06511, USA.|Department of Pathology, Yale School of Medicine, New Haven, CT 06510, USA.|Program of Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA.|Applied Mathematics Program, Yale University, New Haven, CT 06511, USA.|Departments of Neurology and Immunobiology.|Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA.|Department of Pathology, Yale School of Medicine, New Haven, CT 06510, USA.