Systems Biology Core, NHLBI, NIH, 9000 Rockville Pike, Bethesda, MD, 20892, USA.|Department of Computer Science, XiangNan University, Eastern Wangxian Park, Chenzhou, Hunan, 423000, China. xiaozhangdoctor@126.com.|Department of Physics and Biophysics, Institute of Biosciences of Botucatu, UNESP-São Paulo State University, CEP 18618-970, Botucatu, São Paulo, 510, Brazil.|Department of Physics and Biophysics, Institute of Biosciences of Botucatu, UNESP-São Paulo State University, CEP 18618-970, Botucatu, São Paulo, 510, Brazil.|Systems Biology Core, NHLBI, NIH, 9000 Rockville Pike, Bethesda, MD, 20892, USA. xujing.wang@nih.gov.