Sorbonne Universités, UPMC University Paris 06, UMR 7238, Biologie Computationnelle et Quantitative and CNRS, UMR7238, Laboratory of Computational and Quantitative Biology, F-75005 Paris, France Sorbonne Universités, UPMC University Paris 06, UMR 7238, Biologie Computationnelle et Quantitative and CNRS, UMR7238, Laboratory of Computational and Quantitative Biology, F-75005 Paris, France.