Mines ParisTech, Centre for Computational Biology, 35 rue Saint-Honoré, F-77305, Fontainebleau, France. laurent.jacob@mines-paristech.fr|Mines ParisTech, Centre for Computational Biology, 35 rue Saint-Honoré, F-77305, Fontainebleau, France. laurent.jacob@mines-paristech.fr|Mines ParisTech, Centre for Computational Biology, 35 rue Saint-Honoré, F-77305, Fontainebleau, France. laurent.jacob@mines-paristech.fr|Mines ParisTech, Centre for Computational Biology, 35 rue Saint-Honoré, F-77305, Fontainebleau, France. laurent.jacob@mines-paristech.fr