Department of Computational Biology and Biostatistics, Dana-Farber Cancer Institute, Brigham and Womens Hospital, Boston, MA, USA.|Department of Computational Biology and Biostatistics, Dana-Farber Cancer Institute, Brigham and Womens Hospital, Boston, MA, USA.|Department of Computational Biology and Biostatistics, Dana-Farber Cancer Institute, Brigham and Womens Hospital, Boston, MA, USA.|Channing Division of Network Medicine, Brigham and Womens Hospital, Boston, MA, USA.|Department of Computational Biology and Biostatistics, Dana-Farber Cancer Institute, Brigham and Womens Hospital, Boston, MA, USA.