Wellcome Trust Centre of Human Genetics, University of Oxford, Oxford OX3 7BN, UK.|Wellcome Trust Centre of Human Genetics, University of Oxford, Oxford OX3 7BN, UK.|National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, The Churchill Hospital, Old Road OX3 7LE, UK.|Wellcome Trust Centre of Human Genetics, University of Oxford, Oxford OX3 7BN, UK.