Howard Hughes Medical Institute, Cambridge, Massachusetts, United States of America. sepulcre@nmr.mgh.harvard.edu|Howard Hughes Medical Institute, Cambridge, Massachusetts, United States of America. sepulcre@nmr.mgh.harvard.edu|Howard Hughes Medical Institute, Cambridge, Massachusetts, United States of America. sepulcre@nmr.mgh.harvard.edu|Howard Hughes Medical Institute, Cambridge, Massachusetts, United States of America. sepulcre@nmr.mgh.harvard.edu|Howard Hughes Medical Institute, Cambridge, Massachusetts, United States of America. sepulcre@nmr.mgh.harvard.edu|Howard Hughes Medical Institute, Cambridge, Massachusetts, United States of America. sepulcre@nmr.mgh.harvard.edu