State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development.|The Molecular Genetic Diagnosis Center, Shanghai Key Lab of Birth Defect, Translational Medicine Research Center of Children Development and Diseases, Pediatrics Research Institute.|Childrens Hospital of Fudan University, Shanghai 201102, China.|Childrens Hospital of Fudan University, Shanghai 201102, China.|State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development.