Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 48109, USA.|Department of Neurology, University of Michigan, Ann Arbor, MI, 48109, USA.|Department of Neurology, University of Michigan, Ann Arbor, MI, 48109, USA.|Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 48109, USA. remills@umich.edu.