International Research Center for Medical Sciences, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, 860-0811, Japan. chris@kumamoto-u.ac.jp.|Bioinformatics Institute, Agency for Science, Technology and Research (Axe2x88x97STAR), Singapore, 138671, Singapore.|Bioinformatics Institute, Agency for Science, Technology and Research (Axe2x88x97STAR), Singapore, 138671, Singapore.|Department of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, NSW, 2109, Australia. shoba.ranganathan@mq.edu.au.