Department of Medical Statistics and Bioinformatics, LUMC, Albinusdreef 2, Leiden, 2300, RC, The Netherlands. s.el_bouhaddani@lumc.nl.|Department of Medical Statistics and Bioinformatics, LUMC, Albinusdreef 2, Leiden, 2300, RC, The Netherlands. J.J.Houwing@lumc.nl.|National Institute for Health and Welfare (THL), Mannerheimintie 166, Helsinki, FI-00271, Finland. perttu.salo@thl.fi.|National Institute for Health and Welfare (THL), Mannerheimintie 166, Helsinki, FI-00271, Finland. markus.perola@thl.fi.|Department of Statistics, EEMCS, TU Delft, Mekelweg 4, Delft, 2628, CD, The Netherlands. G.Jongbloed@tudelft.nl.|Department of Medical Statistics and Bioinformatics, LUMC, Albinusdreef 2, Leiden, 2300, RC, The Netherlands. H.Uh@lumc.nl.