Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.|Department of Medicine, Center for Biomedical Informatics and Biostatistics, BIO5 Institute), University of Arizona, Tucson, AZ, USA.|Department of Computer Science and Engineering, University of Michigan, Ann Arbor, MI, USA.|Department of Electrical Computer and Biomedical Engineering, University of Pavia, Pavia, Italy.|Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji, Kyoto, Japan.