Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. xwxu@ualr.edu.|Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. xwxu@ualr.edu.|Ecole Normale Supérieure, Institut de Biologie de lENS, IBENS, 46 rue dUlm, 75005 Paris, France. hrc@ens.fr.