Johnson & Johnson Pharmaceutical Research and Development, Exton, Pennsylvania, USA. pliu24@its.jnj.com|Johnson & Johnson Pharmaceutical Research and Development, Exton, Pennsylvania, USA. pliu24@its.jnj.com|Johnson & Johnson Pharmaceutical Research and Development, Exton, Pennsylvania, USA. pliu24@its.jnj.com|Johnson & Johnson Pharmaceutical Research and Development, Exton, Pennsylvania, USA. pliu24@its.jnj.com