Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd,, Dallas, Texas 75390, USA. sara.cheek@utsouthwestern.edu|Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd,, Dallas, Texas 75390, USA. sara.cheek@utsouthwestern.edu|Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd,, Dallas, Texas 75390, USA. sara.cheek@utsouthwestern.edu|Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd,, Dallas, Texas 75390, USA. sara.cheek@utsouthwestern.edu|Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd,, Dallas, Texas 75390, USA. sara.cheek@utsouthwestern.edu