Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, Toronto, Ontario, Canada.|Department of Biomedical and Health Informatics, The Childrens Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.|The Center for Mitochondrial and Epigenomic Medicine, The Childrens Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.|The Center for Mitochondrial and Epigenomic Medicine, The Childrens Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.|UMR CNRS 6015-INSERM U1083, MitoVasc Institute, Angers University Hospital, Angers, France.|The Center for Mitochondrial and Epigenomic Medicine, The Childrens Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.|Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, Toronto, Ontario, Canada.