Roche Pharma Research & Early Development, Roche Innovation Center Munich, Nonnenwald 2, 82377, Penzberg, Germany.|Practical Informatics and Bioinformatics Group, Department of Informatics, Ludwig-Maximilians-Universität München, Amalienstrasse 17, D-80333, Munich, Germany.|Roche Pharma Research & Early Development, Roche Innovation Center Basel, Grenzacherstraße 124, 4052, Basel, Switzerland. fabian.birzele@roche.com.