Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA.|Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA.|Biomedical and Translational Informatics Program, Geisinger Health System, Danville, PA, USA.|Biomedical and Translational Informatics Program, Geisinger Health System, Danville, PA, USA.|Department of Human Genetics, Genentech, Inc, South San Francisco, CA, USA.|Biomedical and Translational Informatics Program, Geisinger Health System, Danville, PA, USA.|Biomedical and Translational Informatics Program, Geisinger Health System, Danville, PA, USA.|Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA.