Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. weichun.huang@nih.gov|Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. weichun.huang@nih.gov|Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. weichun.huang@nih.gov|Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. weichun.huang@nih.gov