Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Program in Human Genetics and Molecular Biology, Johns Hopkins University School of Medicine, Computational Bioscience Program, University of Colorado, Denver, Department of Molecular Biology and Genetics, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Hospital, Department of Pathology, Johns Hopkins University, High Throughput Biology Center, Johns Hopkins University School of Medicine, Johns Hopkins University, Center for Epigenetics, Johns Hopkins University School of Medicine, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD and Department of Biostatistics and Computational Biology, Dana Farber Cancer Institute, Boston, Massachusetts, MA, USADepartment of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Program in Human Genetics and Molecular Biology, Johns Hopkins University School of Medicine, Computational Bioscience Program, University of Colorado, Denver, Department of Molecular Biology and Genetics, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Hospital, Department of Pathology, Johns Hopkins University, High Throughput Biology Center, Johns Hopkins University School of Medicine, Johns Hopkins University, Center for Epigenetics, Johns Hopkins University School of Medicine, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD and Department of Biostatistics and Computational Biology, Dana Farber Cancer Institute, Boston, Massachusetts, MA, USA.