Univ. Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, F-33000 Bordeaux, France, INSERM, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, F-33000 Bordeaux, France, INRIA, Team SISTM, F-33000 Bordeaux, France, Vaccine Research Institute-VRI, Hôpital Henri Mondor, Créteil, France, Baylor Institute for Immunology Research, Dallas, Texas, United States of America.