Department of Molecular Medicine for Pathogenesis, Graduate School of Medicine, Ehime University, Shitsukawa, Toon-city, Ehime, Japan, Division of Bio-Imaging, Proteo-Science Center (PROS), Ehime University, Shitsukawa, Toon-city, Ehime, Japan, Translational Research Center, Ehime University Hospital, Shitsukawa, Toon-city, Ehime, Japan.