Department of Mathematical Modeling, Statistics and Bioinformatics, Ghent University, Coupure Links 653, 9000 Gent, Janssen R&D, Janssen Pharmaceutical Companies of Johnson & Johnson, Turnhoutseweg 30, 2340 Beerse, Applied Mathematics, Informatics and Statistics, Ghent University, Krijgslaan 281 S9, 9000 Gent, Belgium and University of Wollongong, National Institute for Applied Statistics Research Australia (NIASRA), School of Mathematics and Applied Statistics, NSW 2522, Australia Department of Mathematical Modeling, Statistics and Bioinformatics, Ghent University, Coupure Links 653, 9000 Gent, Janssen R&D, Janssen Pharmaceutical Companies of Johnson & Johnson, Turnhoutseweg 30, 2340 Beerse, Applied Mathematics, Informatics and Statistics, Ghent University, Krijgslaan 281 S9, 9000 Gent, Belgium and University of Wollongong, National Institute for Applied Statistics Research Australia (NIASRA), School of Mathematics and Applied Statistics, NSW 2522, Australia.