State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300071, China. herohonan@126.com.|State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300071, China. 595643971@qq.com.|State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300071, China. yu.guo@htmdc.org.|State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300071, China. cheng.yang@nankai.edu.cn.|State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300071, China. jianpinglin@nankai.edu.cn.|State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300071, China. raozh@nankai.edu.cn.