The Broad Institute of MIT and Harvard, Cambridge, MA, USA.|School of Mathematics, Statistics, and Computer Science, College of Science, University of Tehran, Tehran, Iran.|Department of Engineering Science, College of Engineering, University of Tehran, and Institute for Research in Fundamental Sciences (IPM), Tehran, Iran.|McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA.|The Broad Institute of MIT and Harvard, Cambridge, MA, USA Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.|McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.