Department of Biostatistics, St. Jude Childrens Research Hospital, 332 N. Lauderdale St., Memphis, TN 38105-2794, USA. stanley.pounds@stjude.org|Department of Biostatistics, St. Jude Childrens Research Hospital, 332 N. Lauderdale St., Memphis, TN 38105-2794, USA. stanley.pounds@stjude.org