Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.|Department of Oncology and Department of Biostatistics, Bioinformatics & Biomathematics, Innovation Center for Biomedical Informatics, Georgetown University Medical Center, Washington, DC, USA.|Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.|Department of Statistics and Operations Research, Tel Aviv University, Tel Aviv, Israel.