Center for Bioinformatics, University of Pennsylvania, Philadelphia 19104, USA. sfischer@pcbi.upenn.edu|Center for Bioinformatics, University of Pennsylvania, Philadelphia 19104, USA. sfischer@pcbi.upenn.edu|Center for Bioinformatics, University of Pennsylvania, Philadelphia 19104, USA. sfischer@pcbi.upenn.edu|Center for Bioinformatics, University of Pennsylvania, Philadelphia 19104, USA. sfischer@pcbi.upenn.edu|Center for Bioinformatics, University of Pennsylvania, Philadelphia 19104, USA. sfischer@pcbi.upenn.edu