Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, NY 14853, USA. ww3@sanger.ac.uk|Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, NY 14853, USA. ww3@sanger.ac.uk|Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, NY 14853, USA. ww3@sanger.ac.uk