Bioinformatics and Integrative Genomics, Harvard University, Cambridge, MA 02138, USA, Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School, Boston MA 02215, Department of Medicine, Brigham and Womens Hospital, Harvard Medical School, Boston, MA 02115, USA and Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, USA Bioinformatics and Integrative Genomics, Harvard University, Cambridge, MA 02138, USA, Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School, Boston MA 02215, Department of Medicine, Brigham and Womens Hospital, Harvard Medical School, Boston, MA 02115, USA and Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, USA.|Bioinformatics and Integrative Genomics, Harvard University, Cambridge, MA 02138, USA, Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School, Boston MA 02215, Department of Medicine, Brigham and Womens Hospital, Harvard Medical School, Boston, MA 02115, USA and Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, USA.|Bioinformatics and Integrative Genomics, Harvard University, Cambridge, MA 02138, USA, Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School, Boston MA 02215, Department of Medicine, Brigham and Womens Hospital, Harvard Medical School, Boston, MA 02115, USA and Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, USA Bioinformatics and Integrative Genomics, Harvard University, Cambridge, MA 02138, USA, Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School, Boston MA 02215, Department of Medicine, Brigham and Womens Hospital, Harvard Medical School, Boston, MA 02115, USA and Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, USA.