Program in Molecular Biophysics, Sidney Kimmel Comprehensive Cancer Center and Institute of Computational Medicine, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA.|Program in Molecular Biophysics, Sidney Kimmel Comprehensive Cancer Center and Institute of Computational Medicine, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA.|Program in Molecular Biophysics, Sidney Kimmel Comprehensive Cancer Center and Institute of Computational Medicine, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA.