Shanghai Key Lab of Intelligent Information Processing, Shanghai, China.|Structural and Computational Biology & Molecular Biophysics Graduate Program, Baylor College of Medicine, Houston, TX, USA.|School of Life Sciences, Fudan University, Shanghai, China.|University of Texas Health Science Center, Houston, TX, USA.|Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.|Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.|Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.|Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.|Department of Ophthalmology and Visual Sciences, University of Texas Health Science Center, Houston, TX, USA.|Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.|Shanghai Key Lab of Intelligent Information Processing, Shanghai, China. wangfei@fudan.edu.cn.|Structural and Computational Biology & Molecular Biophysics Graduate Program, Baylor College of Medicine, Houston, TX, USA. ruichen@bcm.edu.