Channing Laboratory, Brigham and Womens Hospital 75 Francis Street, Boston, MA 02115, USA. stvjc@channing.harvard.edu|Channing Laboratory, Brigham and Womens Hospital 75 Francis Street, Boston, MA 02115, USA. stvjc@channing.harvard.edu|Channing Laboratory, Brigham and Womens Hospital 75 Francis Street, Boston, MA 02115, USA. stvjc@channing.harvard.edu|Channing Laboratory, Brigham and Womens Hospital 75 Francis Street, Boston, MA 02115, USA. stvjc@channing.harvard.edu