Computational Methods for the Analysis of the Diversity and Dynamics of Genomes, Bielefeld University, Universitätsstr. 25, Bielefeld, 33615, Germany. mlux@techfak.uni-bielefeld.de.|Center for Biotechnology - CeBiTec, Bielefeld University, Universitätsstr. 27, Bielefeld, 33615, Germany.|Australian Centre for Ecogenomics, University of Queensland, ST LUCIA, Brisbane, QLD 4072, Australia.|Center for Biotechnology - CeBiTec, Bielefeld University, Universitätsstr. 27, Bielefeld, 33615, Germany.|Center for Biotechnology - CeBiTec, Bielefeld University, Universitätsstr. 27, Bielefeld, 33615, Germany.|, 2800 Mitchell Drive, Walnut Creek, 94598, CA, USA.|Center for Biotechnology - CeBiTec, Bielefeld University, Universitätsstr. 27, Bielefeld, 33615, Germany.|CITEC centre of excellence, Bielefeld University, Inspiration 1, Bielefeld, 33619, Germany.