MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK and The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK and The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.