Department of Cellular and Molecular Pharmacology, University of California of San Francisco, 94143, USA. horn@cmpharm.ucsf.edu|Department of Cellular and Molecular Pharmacology, University of California of San Francisco, 94143, USA. horn@cmpharm.ucsf.edu|Department of Cellular and Molecular Pharmacology, University of California of San Francisco, 94143, USA. horn@cmpharm.ucsf.edu