Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, Houston, TX, USA. jeffrey.t.chang@uth.tmc.edu|Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, Houston, TX, USA. jeffrey.t.chang@uth.tmc.edu|Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, Houston, TX, USA. jeffrey.t.chang@uth.tmc.edu|Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, Houston, TX, USA. jeffrey.t.chang@uth.tmc.edu|Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, Houston, TX, USA. jeffrey.t.chang@uth.tmc.edu|Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, Houston, TX, USA. jeffrey.t.chang@uth.tmc.edu