Lane Center of Computational Biology, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America, Department of Biomedical Engineering, University of California Davis, Davis, California, United States of America.|Division of Mathematics, Science and Technology, Nova Southeastern University, Fort Lauderdale, Florida, United States of America, Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States of America.|Lane Center of Computational Biology, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America.|Lane Center of Computational Biology, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America, Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America.|Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States of America, Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America.