Department of Pharmacology, Columbia Genome Center, and Center for Computational Biology and Bioinformatics, Columbia University, 630 West 168th street, PH 7 W Room 318, New York, NY 10032, USA. ay1@columbia.edu|Department of Pharmacology, Columbia Genome Center, and Center for Computational Biology and Bioinformatics, Columbia University, 630 West 168th street, PH 7 W Room 318, New York, NY 10032, USA. ay1@columbia.edu