Dept of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts, 02115, USA. steffen@rascal.med.harvard.edu|Dept of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts, 02115, USA. steffen@rascal.med.harvard.edu|Dept of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts, 02115, USA. steffen@rascal.med.harvard.edu|Dept of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts, 02115, USA. steffen@rascal.med.harvard.edu|Dept of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts, 02115, USA. steffen@rascal.med.harvard.edu