Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, Washington, DC 20057-1414, USA. rm285@georgetown.edu|Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, Washington, DC 20057-1414, USA. rm285@georgetown.edu|Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, Washington, DC 20057-1414, USA. rm285@georgetown.edu|Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, Washington, DC 20057-1414, USA. rm285@georgetown.edu|Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, Washington, DC 20057-1414, USA. rm285@georgetown.edu