Genome Informatics, Institute of Human Genetics, University of Duisburg-Essen and Paediatric Oncology, University Childrens Hospital, 45147 Essen, Germany. johannes.koester@uni-due.de|Genome Informatics, Institute of Human Genetics, University of Duisburg-Essen and Paediatric Oncology, University Childrens Hospital, 45147 Essen, Germany. johannes.koester@uni-due.de