Department of Computer Science and Technology, Center for Bioinformatics Harbin Institute of Technology, Harbin, Heilongjiang, China.|Department of Computer Science and Technology, Center for Bioinformatics Harbin Institute of Technology, Harbin, Heilongjiang, China.|Department of Computer Science and Technology, Center for Bioinformatics Harbin Institute of Technology, Harbin, Heilongjiang, China.|Center for Computational and Genomic Medicine, Childrens Hospital of Philadelphia, Philadelphia, PA, USA.