Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Washington Street, MC 0477, Blacksburg VA 24061, USA.|Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Washington Street, MC 0477, Blacksburg VA 24061, USA.|Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Washington Street, MC 0477, Blacksburg VA 24061, USA.|Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Washington Street, MC 0477, Blacksburg VA 24061, USA.