Department for Algorithmic Bioinformatics, Heinrich Heine University, Universitxc3xa4tsstraxc3x9fe 1, 40225 Dxc3xbcsseldorf, Germany, Max-Planck Research Group for Computational Genomics and Epidemiology, Max-Planck Institute for Informatics, University Campus E1 4, 66123 Saarbrxc3xbccken, Germany and Computational Biology of Infection Research, Helmholtz Centre for Infection Research, Inhoffenstraxc3x9fe 7, 38124 Braunschweig, Germany Department for Algorithmic Bioinformatics, Heinrich Heine University, Universitxc3xa4tsstraxc3x9fe 1, 40225 Dxc3xbcsseldorf, Germany, Max-Planck Research Group for Computational Genomics and Epidemiology, Max-Planck Institute for Informatics, University Campus E1 4, 66123 Saarbrxc3xbccken, Germany and Computational Biology of Infection Research, Helmholtz Centre for Infection Research, Inhoffenstraxc3x9fe 7, 38124 Braunschweig, Germany.