Center for Quantitative Sciences and Department of Medicine and Center for Human Genetics Research, Vanderbilt University, Nashville, TN 37212, USA.|Center for Quantitative Sciences and Department of Medicine and Center for Human Genetics Research, Vanderbilt University, Nashville, TN 37212, USA.|Center for Quantitative Sciences and Department of Medicine and Center for Human Genetics Research, Vanderbilt University, Nashville, TN 37212, USA.|Center for Quantitative Sciences and Department of Medicine and Center for Human Genetics Research, Vanderbilt University, Nashville, TN 37212, USA.|Center for Quantitative Sciences and Department of Medicine and Center for Human Genetics Research, Vanderbilt University, Nashville, TN 37212, USA.