Institut Curie, PSL Research University, CNRS, UMR168, 26 rue dUlm, Paris, 75005, France.|Institut Curie, PSL Research University, CNRS, UMR168, 26 rue dUlm, Paris, 75005, France.|Institut Curie, PSL Research University, CNRS, UMR168, 26 rue dUlm, Paris, 75005, France. herve.isambert@curie.fr.