Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PL, UK.|Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PL, UK.|Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PL, UK.|Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PL, UK.|Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PL, UK.