Complex and Adaptive Systems Laboratory, University College Dublin, Dublin, Ireland, Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland, School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland.|Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.|Complex and Adaptive Systems Laboratory, University College Dublin, Dublin, Ireland, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland, School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland.|Complex and Adaptive Systems Laboratory, University College Dublin, Dublin, Ireland, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland, School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland.|Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.|Complex and Adaptive Systems Laboratory, University College Dublin, Dublin, Ireland, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland, School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland.