Division of Biostatistics and Epidemiology, Medical University of South Carolina, 135 Cannon St., Charleston, SC, USA. wolfb@musc.edu|Division of Biostatistics and Epidemiology, Medical University of South Carolina, 135 Cannon St., Charleston, SC, USA. wolfb@musc.edu|Division of Biostatistics and Epidemiology, Medical University of South Carolina, 135 Cannon St., Charleston, SC, USA. wolfb@musc.edu