Department of Population and Quantitative Health Sciences, Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA.|Division of Medical Genetics, University of Washington, Seattle, WA, USA.|Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.|Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas Health Science Center, Houston, TX, USA.|Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.|Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.|Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.|Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.|Nationwide Childrens Hospital, Columbus, OH, USA.|Department of Population and Quantitative Health Sciences, Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA.|Department of Population and Quantitative Health Sciences, Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA.