Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK.|Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK.|Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK.|Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK.|Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK.