Department of Biosystem Modeling, School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan. inaoka.bmi@tmd.ac.jp|Department of Biosystem Modeling, School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan. inaoka.bmi@tmd.ac.jp|Department of Biosystem Modeling, School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan. inaoka.bmi@tmd.ac.jp