Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. jgould@broad.mit.edu|Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. jgould@broad.mit.edu|Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. jgould@broad.mit.edu|Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. jgould@broad.mit.edu|Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. jgould@broad.mit.edu