Department of Genomics of Common Disease, Imperial College London, London, W12 0NN, UK. m.kaakinen@imperial.ac.uk.|Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.|Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.|Department of Genomics of Common Disease, Imperial College London, London, W12 0NN, UK.|Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, W2 1PG, UK.|Department of Biostatistics, University of Liverpool, Liverpool, L69 3BX, UK.|Department of Genomics of Common Disease, Imperial College London, London, W12 0NN, UK. i.prokopenko@imperial.ac.uk.