Department of Statistics, Pennsylvania State University, 325 Thomas Building, University Park, 16802, PA, USA. xyz5074@psu.edu.|Department of Molecular Toxicology, Pennsylvania State University, 322 Life Sciences Bldg, University Park, 16802, PA, USA. adp117@psu.edu.|Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, 13001 East 17th Place, Aurora, 80045, CO, USA. debashis.ghosh@ucdenver.edu.