Center for Genome Research, MIT Whitehead Institute, One Kendall Square, Cambridge, MA 02139, USA. chyeang@mit.edu|Center for Genome Research, MIT Whitehead Institute, One Kendall Square, Cambridge, MA 02139, USA. chyeang@mit.edu|Center for Genome Research, MIT Whitehead Institute, One Kendall Square, Cambridge, MA 02139, USA. chyeang@mit.edu|Center for Genome Research, MIT Whitehead Institute, One Kendall Square, Cambridge, MA 02139, USA. chyeang@mit.edu|Center for Genome Research, MIT Whitehead Institute, One Kendall Square, Cambridge, MA 02139, USA. chyeang@mit.edu|Center for Genome Research, MIT Whitehead Institute, One Kendall Square, Cambridge, MA 02139, USA. chyeang@mit.edu|Center for Genome Research, MIT Whitehead Institute, One Kendall Square, Cambridge, MA 02139, USA. chyeang@mit.edu|Center for Genome Research, MIT Whitehead Institute, One Kendall Square, Cambridge, MA 02139, USA. chyeang@mit.edu|Center for Genome Research, MIT Whitehead Institute, One Kendall Square, Cambridge, MA 02139, USA. chyeang@mit.edu|Center for Genome Research, MIT Whitehead Institute, One Kendall Square, Cambridge, MA 02139, USA. chyeang@mit.edu