Center for Technological Development in Health, Oswaldo Cruz Institute, Rio de Janeiro, Brazil. paulo@pcarvalho.com|Center for Technological Development in Health, Oswaldo Cruz Institute, Rio de Janeiro, Brazil. paulo@pcarvalho.com|Center for Technological Development in Health, Oswaldo Cruz Institute, Rio de Janeiro, Brazil. paulo@pcarvalho.com|Center for Technological Development in Health, Oswaldo Cruz Institute, Rio de Janeiro, Brazil. paulo@pcarvalho.com|Center for Technological Development in Health, Oswaldo Cruz Institute, Rio de Janeiro, Brazil. paulo@pcarvalho.com|Center for Technological Development in Health, Oswaldo Cruz Institute, Rio de Janeiro, Brazil. paulo@pcarvalho.com