Department of Epidemiology and Biostatistics, Center for Bioinformatics and Molecular Biostatistics, University of California, San Francisco, California, USA. Yuanyuan.Xiao@ucsf.edu|Department of Epidemiology and Biostatistics, Center for Bioinformatics and Molecular Biostatistics, University of California, San Francisco, California, USA. Yuanyuan.Xiao@ucsf.edu