National Genetics Reference Laboratory (Manchester), St, Marys Hospital, Manchester, UK. paolo.verderio@istitutotumori.mi.it|National Genetics Reference Laboratory (Manchester), St, Marys Hospital, Manchester, UK. paolo.verderio@istitutotumori.mi.it|National Genetics Reference Laboratory (Manchester), St, Marys Hospital, Manchester, UK. paolo.verderio@istitutotumori.mi.it|National Genetics Reference Laboratory (Manchester), St, Marys Hospital, Manchester, UK. paolo.verderio@istitutotumori.mi.it