Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, California, United States of America.|Quantitative Cell Biology group, MRC Clinical Sciences Centre, Imperial College, London, United Kingdom.|Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, California, United States of America.|Department of Bioengineering and Therapeutic Sciences, California Institute for Quantitative Biosciences, Byers Hall at Mission Bay, University of California, San Francisco, San Francisco, California, United States of America, Department of Pharmaceutical Chemistry, California Institute for Quantitative Biosciences, Byers Hall at Mission Bay, University of California, San Francisco, San Francisco, California, United States of America.|European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany and European Bioinformatics Institute (EMBL-EBI), Cambridge, United Kingdom.|European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany and European Bioinformatics Institute (EMBL-EBI), Cambridge, United Kingdom.|Department of Bioengineering and Therapeutic Sciences, California Institute for Quantitative Biosciences, Byers Hall at Mission Bay, University of California, San Francisco, San Francisco, California, United States of America, Department of Pharmaceutical Chemistry, California Institute for Quantitative Biosciences, Byers Hall at Mission Bay, University of California, San Francisco, San Francisco, California, United States of America.|Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, California, United States of America, Gladstone Institutes, San Francisco, California, United States of America.|European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany and European Bioinformatics Institute (EMBL-EBI), Cambridge, United Kingdom, iBiMED and Department of Health Sciences, University of Aveiro, Aveiro, Portugal.