National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA. david-kristensen@uiowa.edu.|Department of Genome Oriented Bioinformatics, Technische Universitxc3xa4t Mxc3xbcnchen, Wissenschaftzentrum Weihenstephan, Maximus-von-Imhof-Forum 3, D-85354, Freising, Germany. usman.saeed08@gmail.com.|Department of Genome Oriented Bioinformatics, Technische Universitxc3xa4t Mxc3xbcnchen, Wissenschaftzentrum Weihenstephan, Maximus-von-Imhof-Forum 3, D-85354, Freising, Germany. d.frishman@wzw.tum.de.|National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA. koonin@ncbi.nlm.nih.gov.