Institute of Medical Systems Biology, Ulm University, Ulm 89069, Germany.|Institut für Medizinische Biometrie, Informatik und Epidemiologie, Universität Bonn, Bonn 53127, Germany.|Institute of Medical Systems Biology, Ulm University, Ulm 89069, Germany.|Institute of Medical Systems Biology, Ulm University, Ulm 89069, Germany.|Institute of Experimental Cancer Research.|Department of Internal Medicine III, Ulm University, Ulm 89069, Germany and.|Institute of Medical Systems Biology, Ulm University, Ulm 89069, Germany.|Institute of Medical Systems Biology, Ulm University, Ulm 89069, Germany, Leibniz Institute on Ageing - Fritz Lipmann Institute and FSU Jena, Jena 07745, Germany.