Institute for Systems Biology, Seattle, Washington, United State of America.|Department of Molecular and Medical Pharmacology, University of California - Los Angeles, Los Angeles, California, United State of America.|Department of Molecular and Medical Pharmacology, University of California - Los Angeles, Los Angeles, California, United State of America.|Department of Medicine, University of California - Los Angeles, Los Angeles, California, United State of America.|Institute for Systems Biology, Seattle, Washington, United State of America.|Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, United State of America.|Department of Molecular and Medical Pharmacology, University of California - Los Angeles, Los Angeles, California, United State of America.|Institute for Systems Biology, Seattle, Washington, United State of America.|Institute for Systems Biology, Seattle, Washington, United State of America.