Computational Cancer Biology, Division of Molecular Carcinogenesis, Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands.|Department of Protein Evolution, Max Planck Institute for Developmental Biology, Tübingen 72076, Germany.|Institute for Computing and Information Sciences, Radboud University Nijmegen, Nijmegen 6500 GL, The Netherlands.|Computational Cancer Biology, Division of Molecular Carcinogenesis, Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands.