Department of Pharmacology, University of Colorado Denver, Aurora, CO 80045, USA.|Department of Pharmacology, University of Colorado Denver, Aurora, CO 80045, USA.|Department of Pharmacology, University of Colorado Denver, Aurora, CO 80045, USA.|Department of Pharmacology, University of Colorado Denver, Aurora, CO 80045, USA.|Department of Pharmacology, University of Colorado Denver, Aurora, CO 80045, USA.|Department of Pharmacology, University of Colorado Denver, Aurora, CO 80045, USA.