The BioCentre, University of Reading, Whiteknights, PO Box 221, Reading RG6 6AS, UK. l.j.mcguffin@reading.ac.uk|The BioCentre, University of Reading, Whiteknights, PO Box 221, Reading RG6 6AS, UK. l.j.mcguffin@reading.ac.uk|The BioCentre, University of Reading, Whiteknights, PO Box 221, Reading RG6 6AS, UK. l.j.mcguffin@reading.ac.uk|The BioCentre, University of Reading, Whiteknights, PO Box 221, Reading RG6 6AS, UK. l.j.mcguffin@reading.ac.uk|The BioCentre, University of Reading, Whiteknights, PO Box 221, Reading RG6 6AS, UK. l.j.mcguffin@reading.ac.uk