Howard Hughes Medical Institute, Brigham and Womens Hospital, Boston, Massachusetts 02115, USA. speng2@rics.bwh.harvard.edu <speng2@rics.bwh.harvard.edu>|Howard Hughes Medical Institute, Brigham and Womens Hospital, Boston, Massachusetts 02115, USA. speng2@rics.bwh.harvard.edu <speng2@rics.bwh.harvard.edu>|Howard Hughes Medical Institute, Brigham and Womens Hospital, Boston, Massachusetts 02115, USA. speng2@rics.bwh.harvard.edu <speng2@rics.bwh.harvard.edu>|Howard Hughes Medical Institute, Brigham and Womens Hospital, Boston, Massachusetts 02115, USA. speng2@rics.bwh.harvard.edu <speng2@rics.bwh.harvard.edu>|Howard Hughes Medical Institute, Brigham and Womens Hospital, Boston, Massachusetts 02115, USA. speng2@rics.bwh.harvard.edu <speng2@rics.bwh.harvard.edu>