Wake Forest University School of Medicine, Public Health Sciences, Section on Biostatistics Medical Center Blvd., MRI-3, Winston-Salem, NC 27157, USA. ileng@wfubmc.edu|Wake Forest University School of Medicine, Public Health Sciences, Section on Biostatistics Medical Center Blvd., MRI-3, Winston-Salem, NC 27157, USA. ileng@wfubmc.edu