The Broad Institute of MIT and Harvard, 320 Charles Street, Cambridge, MA 02142, USA. reinhard@broad.mit.edu|The Broad Institute of MIT and Harvard, 320 Charles Street, Cambridge, MA 02142, USA. reinhard@broad.mit.edu|The Broad Institute of MIT and Harvard, 320 Charles Street, Cambridge, MA 02142, USA. reinhard@broad.mit.edu|The Broad Institute of MIT and Harvard, 320 Charles Street, Cambridge, MA 02142, USA. reinhard@broad.mit.edu|The Broad Institute of MIT and Harvard, 320 Charles Street, Cambridge, MA 02142, USA. reinhard@broad.mit.edu|The Broad Institute of MIT and Harvard, 320 Charles Street, Cambridge, MA 02142, USA. reinhard@broad.mit.edu