Center for Mathematical and Computational Biology, Center for Complex Biological Systems, and Department of Mathematics, University of California at Irvine, Irvine, California, United States of America.|Center for Mathematical and Computational Biology, Center for Complex Biological Systems, and Department of Mathematics, University of California at Irvine, Irvine, California, United States of America.|Center for Mathematical and Computational Biology, Center for Complex Biological Systems, and Department of Mathematics, University of California at Irvine, Irvine, California, United States of America.