Biomedical Informatics and Public Health Department, University Hospital HEGP, AP-HP, Paris, France , INSERM UMR_S 872 Team 22: Information Sciences to support Personalized Medicine, Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Paris, France.|INSERM UMR-S 775, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.|Gastroenterology Department, University Hospital HEGP, AP-HP, Paris, France.|Pharmacovigilance Center, University Hospital HEGP, AP-HP, Paris, France.|Biochemistry, Pharmacogenetics and Molecular Oncology Unit, University Hospital HEGP, AP-HP, Paris, France.|INSERM UMR-S 775, Université Paris Descartes, Sorbonne Paris Cité, Paris, France , Biochemistry, Pharmacogenetics and Molecular Oncology Unit, University Hospital HEGP, AP-HP, Paris, France.|Biomedical Informatics and Public Health Department, University Hospital HEGP, AP-HP, Paris, France , INSERM UMR_S 872 Team 22: Information Sciences to support Personalized Medicine, Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Paris, France.|Biomedical Informatics and Public Health Department, University Hospital HEGP, AP-HP, Paris, France , INSERM UMR_S 872 Team 22: Information Sciences to support Personalized Medicine, Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Paris, France.|INSERM UMR-S 775, Université Paris Descartes, Sorbonne Paris Cité, Paris, France , Biochemistry, Pharmacogenetics and Molecular Oncology Unit, University Hospital HEGP, AP-HP, Paris, France.|Biomedical Informatics and Public Health Department, University Hospital HEGP, AP-HP, Paris, France , INSERM UMR_S 872 Team 22: Information Sciences to support Personalized Medicine, Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Paris, France.