Section of Biomolecular Medicine, Department of Surgery and Cancer, Sir Alexander Fleming Building, Imperial College London, London SW7 2AZ, UK.|Section of Biomolecular Medicine, Department of Surgery and Cancer, Sir Alexander Fleming Building, Imperial College London, London SW7 2AZ, UK.|Section of Biomolecular Medicine, Department of Surgery and Cancer, Sir Alexander Fleming Building, Imperial College London, London SW7 2AZ, UK.|Section of Biomolecular Medicine, Department of Surgery and Cancer, Sir Alexander Fleming Building, Imperial College London, London SW7 2AZ, UK.