Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, Virginia, USA.|Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, Virginia, USA.|Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, Virginia, USA.|Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, Virginia, USA.