LIGM/CNRS, Universitxc3xa9 Paris-Est, 77454 Marne-la-Vallxc3xa9e, France.|Inserm, U900, Bioinformatics, Biostatistics, Epidemiology and Computational Systems Biology of Cancer, 75248 Paris, France, Institut Curie, Centre de Recherche, 26 rue dUlm, 75248 Paris, France and Mines ParisTech, 77300 Fontainebleau, France.|LIGM/CNRS, Universitxc3xa9 Paris-Est, 77454 Marne-la-Vallxc3xa9e, France.