Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First St SW, Harvick 3rd, Rochester, MN, 55905, USA. KomandurElayavilli.Ravikumar@mayo.edu.|Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First St SW, Harvick 3rd, Rochester, MN, 55905, USA. Wagholikar.Kavishwar@mayo.edu.|Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First St SW, Harvick 3rd, Rochester, MN, 55905, USA. Li.DingCheng@mayo.edu.|Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First St SW, Harvick 3rd, Rochester, MN, 55905, USA. Kocher.Jeanpierre@mayo.edu.|Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First St SW, Harvick 3rd, Rochester, MN, 55905, USA. Liu.Hongfang@mayo.edu.