Department of Systems Biology and Translational Medicine, College of Medicine, Texas A & M Health Science Center, Temple, TX 76504, USA. djupiter@tamu.edu|Department of Systems Biology and Translational Medicine, College of Medicine, Texas A & M Health Science Center, Temple, TX 76504, USA. djupiter@tamu.edu|Department of Systems Biology and Translational Medicine, College of Medicine, Texas A & M Health Science Center, Temple, TX 76504, USA. djupiter@tamu.edu