Acrocephalosyndactylia|Amino Acid Sequence|Amino Acid Substitution|Basic Helix-Loop-Helix Transcription Factors|Computer Simulation|Female|Helix-Loop-Helix Motifs|Humans|Models, Chemical|Molecular Dynamics Simulation|Molecular Sequence Data|Mutation|Nuclear Proteins|Protein Multimerization|Protein Structure, Secondary|Twist-Related Protein 1