Howard Hughes Medical Institute, Columbia University, New York, New York, United States of America, Department of Systems Biology, Columbia University, New York, New York, United States of America, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York, United States of America, Center for Computational Biology and Bioinformatics, Columbia University, New York, New York, United States of America.|Howard Hughes Medical Institute, Columbia University, New York, New York, United States of America, Department of Systems Biology, Columbia University, New York, New York, United States of America, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York, United States of America, Center for Computational Biology and Bioinformatics, Columbia University, New York, New York, United States of America.|Howard Hughes Medical Institute, Columbia University, New York, New York, United States of America, Department of Systems Biology, Columbia University, New York, New York, United States of America, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York, United States of America, Center for Computational Biology and Bioinformatics, Columbia University, New York, New York, United States of America.|Howard Hughes Medical Institute, Columbia University, New York, New York, United States of America, Department of Systems Biology, Columbia University, New York, New York, United States of America, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York, United States of America, Center for Computational Biology and Bioinformatics, Columbia University, New York, New York, United States of America.