Department of Mathematical Modeling, Statistics and Bioinformatics, Ghent University, Coupure Links 653, Gent, 9000, Belgium. Bie.Verbist@ugent.be.|Department of Applied Mathematics, Informatics and Statistics, Ghent University, Krijgslaan 281 S9, Gent, 9000, Belgium. Lieven.Clement@ugent.be.|Janssen R&D, Janssen Pharmaceutical Companies of J&J, Turnhoutseweg 30, Beerse, 2340, Belgium. JReumers@its.jnj.com.|Janssen R&D, Janssen Pharmaceutical Companies of J&J, Turnhoutseweg 30, Beerse, 2340, Belgium. KThys@its.jnj.com.|Janssen R&D, Janssen Pharmaceutical Companies of J&J, Turnhoutseweg 30, Beerse, 2340, Belgium. avapirev@its.jnj.com.|Janssen R&D, Janssen Pharmaceutical Companies of J&J, Turnhoutseweg 30, Beerse, 2340, Belgium. WTalloen@its.jnj.com.|Janssen R&D, Janssen Pharmaceutical Companies of J&J, Turnhoutseweg 30, Beerse, 2340, Belgium. YWetzel@its.jnj.com.|Department of Mathematical Modeling, Statistics and Bioinformatics, Ghent University, Coupure Links 653, Gent, 9000, Belgium. joris.Meys@Ugent.be.|Janssen R&D, Janssen Pharmaceutical Companies of J&J, Turnhoutseweg 30, Beerse, 2340, Belgium. JAerssen@its.jnj.com.|Janssen R&D, Janssen Pharmaceutical Companies of J&J, Turnhoutseweg 30, Beerse, 2340, Belgium. LBIJNENS@its.jnj.com.|Department of Mathematical Modeling, Statistics and Bioinformatics, Ghent University, Coupure Links 653, Gent, 9000, Belgium. Olivier.Thas@ugent.be.