Department of Biostatistics, Johns Hopkins University, 615 N. Wolfe St, Baltimore, MD 21205, USA. kbroman@jhsph.edu|Department of Biostatistics, Johns Hopkins University, 615 N. Wolfe St, Baltimore, MD 21205, USA. kbroman@jhsph.edu|Department of Biostatistics, Johns Hopkins University, 615 N. Wolfe St, Baltimore, MD 21205, USA. kbroman@jhsph.edu|Department of Biostatistics, Johns Hopkins University, 615 N. Wolfe St, Baltimore, MD 21205, USA. kbroman@jhsph.edu