Pfizer Global Research & Development, 2800 Plymouth Rd, Ann Arbor, Michigan 48105, USA. Michael.Gieseg@pfizer.com|Pfizer Global Research & Development, 2800 Plymouth Rd, Ann Arbor, Michigan 48105, USA. Michael.Gieseg@pfizer.com|Pfizer Global Research & Development, 2800 Plymouth Rd, Ann Arbor, Michigan 48105, USA. Michael.Gieseg@pfizer.com|Pfizer Global Research & Development, 2800 Plymouth Rd, Ann Arbor, Michigan 48105, USA. Michael.Gieseg@pfizer.com|Pfizer Global Research & Development, 2800 Plymouth Rd, Ann Arbor, Michigan 48105, USA. Michael.Gieseg@pfizer.com|Pfizer Global Research & Development, 2800 Plymouth Rd, Ann Arbor, Michigan 48105, USA. Michael.Gieseg@pfizer.com