Laboratory for Metabolic Modeling and Bioinformatics, The Russian Academy of Sciences, 142292 Pushchino, Moscow Region, Russia, Advanced Technology and Informatics Unit, GlaxoWellcome Medicines Research Centre, Gunnels Wood Road, Stevenage,UK.|Laboratory for Metabolic Modeling and Bioinformatics, The Russian Academy of Sciences, 142292 Pushchino, Moscow Region, Russia, Advanced Technology and Informatics Unit, GlaxoWellcome Medicines Research Centre, Gunnels Wood Road, Stevenage,UK.|Laboratory for Metabolic Modeling and Bioinformatics, The Russian Academy of Sciences, 142292 Pushchino, Moscow Region, Russia, Advanced Technology and Informatics Unit, GlaxoWellcome Medicines Research Centre, Gunnels Wood Road, Stevenage,UK.