Departments of Medicine, Center for Bioinformatics and Molecular Biostatistics, University of California San Francisco, CA 94143, USA.|Departments of Medicine, Center for Bioinformatics and Molecular Biostatistics, University of California San Francisco, CA 94143, USA.|Departments of Medicine, Center for Bioinformatics and Molecular Biostatistics, University of California San Francisco, CA 94143, USA.