Division of Biostatistics and Epidemiology, Cincinnati Childrens Hospital Medical Center, Cincinnati, Ohio, United States of America.|Molecular and Cellular Biology, University of Arizona, Tucson, United States of America.|Department of Pharmacology and Systems Physiology, College of Medicine, University of Cincinnati, Cincinnati, Ohio, United States of America.|Department of Pharmacology and Systems Physiology, College of Medicine, University of Cincinnati, Cincinnati, Ohio, United States of America.|Molecular and Cellular Biology, University of Arizona, Tucson, United States of America.|Molecular and Cellular Biology, University of Arizona, Tucson, United States of America.|Department of Pharmacology and Systems Physiology, College of Medicine, University of Cincinnati, Cincinnati, Ohio, United States of America.