Faculty of Life Sciences, Michael Smith Building, University of Manchester, Oxford Road, Manchester, M13 9PT, UK. jamie.macpherson@postgrad.manchester.ac.uk|Faculty of Life Sciences, Michael Smith Building, University of Manchester, Oxford Road, Manchester, M13 9PT, UK. jamie.macpherson@postgrad.manchester.ac.uk|Faculty of Life Sciences, Michael Smith Building, University of Manchester, Oxford Road, Manchester, M13 9PT, UK. jamie.macpherson@postgrad.manchester.ac.uk