Unit of Systems Toxicology, Finnish Institute of Occupational Health (FIOH), Topeliuksenkatu 41b, 00250, Helsinki, Finland. vittorio.fortino@ttl.fi.|Unit of Systems Toxicology, Finnish Institute of Occupational Health (FIOH), Topeliuksenkatu 41b, 00250, Helsinki, Finland. harri.alenius@ttl.fi.|Unit of Systems Toxicology, Finnish Institute of Occupational Health (FIOH), Topeliuksenkatu 41b, 00250, Helsinki, Finland. dario.greco@ttl.fi.