Mathematical Sciences, Chalmers University of Technology, and Mathematical Sciences, Göteborg University, S-41296, Göteborg, Sweden. magnus.astrand@astrazeneca.com|Mathematical Sciences, Chalmers University of Technology, and Mathematical Sciences, Göteborg University, S-41296, Göteborg, Sweden. magnus.astrand@astrazeneca.com|Mathematical Sciences, Chalmers University of Technology, and Mathematical Sciences, Göteborg University, S-41296, Göteborg, Sweden. magnus.astrand@astrazeneca.com