Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC 27157, Department of Statistics, The Ohio State University, Columbus, OH 43210 and Department of Evolution, Ecology, and Organismal Biology, The Ohio State University, Columbus, OH 43210, USA.|Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC 27157, Department of Statistics, The Ohio State University, Columbus, OH 43210 and Department of Evolution, Ecology, and Organismal Biology, The Ohio State University, Columbus, OH 43210, USA Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC 27157, Department of Statistics, The Ohio State University, Columbus, OH 43210 and Department of Evolution, Ecology, and Organismal Biology, The Ohio State University, Columbus, OH 43210, USA.